Citations (295)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (20)
Yifan Liu, Kaimin Wu, Yinkun Fu, Wenyan Li & Xu-Yun Zhao. (2023) Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes. Redox Report 28:1.
Read now
Read now
Kenneth C. Cassidy & Ping Yi. (2018) Qualitative and quantitative prediction of human in vivo metabolic pathways in a human hepatocyte-murine stromal cell co-culture model. Xenobiotica 48:12, pages 1192-1205.
Read now
Read now
Kathryn Elisa Burns, Phillip Shepherd, Graeme Finlay, Malcolm Drummond Tingle & Nuala Ann Helsby. (2018) Indirect regulation of CYP2C19 gene expression via DNA methylation. Xenobiotica 48:8, pages 781-792.
Read now
Read now
Banumathi K. Cole, Ryan E. Feaver, Brian R. Wamhoff & Ajit Dash. (2018) Non-alcoholic fatty liver disease (NAFLD) models in drug discovery. Expert Opinion on Drug Discovery 13:2, pages 193-205.
Read now
Read now
Yohan Kim, Kyojin Kang, Sangtae Yoon, Ji Sook Kim, Su A. Park, Wan Doo Kim, Seung Bum Lee, Ki-Young Ryu, Jaemin Jeong & Dongho Choi. (2018) Prolongation of liver-specific function for primary hepatocytes maintenance in 3D printed architectures. Organogenesis 14:1, pages 1-12.
Read now
Read now
Mostafa MM El-Miligy, Samia M Rida, Fawzia A Ashour, Mona H Badr, Ehab M El-Bassiony, Maha A El-Demellawy & Ashraf M Omar. (2018) Dual Inhibitors of Hepatitis C Virus and Hepatocellular Carcinoma: Design, Synthesis and Docking Studies. Future Science OA 4:1.
Read now
Read now
Ajit Dash, Robert A. Figler, Arun J. Sanyal & Brian R. Wamhoff. (2017) Drug-induced steatohepatitis. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 193-204.
Read now
Read now
Aurelie Vivares, Sandrine Salle-Lefort, Catherine Arabeyre-Fabre, Robert Ngo, Geraldine Penarier, Michele Bremond, Patricia Moliner, Jean-François Gallas, Gerard Fabre & Sylvie Klieber. (2015) Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device. Xenobiotica 45:1, pages 29-44.
Read now
Read now
Vinicius Rosa, Wei Seong Toh, Tong Cao & Winston Shim. (2014) Inducing pluripotency for disease modeling, drug development and craniofacial applications. Expert Opinion on Biological Therapy 14:9, pages 1233-1240.
Read now
Read now
Ajit Dash, Brett R Blackman & Brian R Wamhoff. (2012) Organotypic systems in drug metabolism and toxicity: challenges and opportunities. Expert Opinion on Drug Metabolism & Toxicology 8:8, pages 999-1014.
Read now
Read now
Ya-He Liu, Sui-Lin Mo, Hui-Chang Bi, Bing-Fang Hu, Chun Guang Li, Yi-Tao Wang, Ling Huang, Min Huang, Wei Duan, Jun-Ping Liu, Ming Qian Wei & Shu-Feng Zhou. (2011) Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study. Xenobiotica 41:4, pages 259-280.
Read now
Read now
Masashi Honma, Masanari Kozawa & Hiroshi Suzuki. (2010) Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems. Expert Opinion on Drug Discovery 5:5, pages 491-511.
Read now
Read now
Ajit Dash, Walker Inman, Keith Hoffmaster, Samantha Sevidal, Joan Kelly, R Scott Obach, Linda G Griffith & Steven R Tannenbaum. (2009) Liver tissue engineering in the evaluation of drug safety. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1159-1174.
Read now
Read now
Maria A Croyle. (2009) Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1189-1211.
Read now
Read now
María José Gómez-Lechón, José V Castell & María Teresa Donato. (2008) An update on metabolism studies using human hepatocytes in primary culture. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 837-854.
Read now
Read now
Inge AM de Graaf, Geny MM Groothuis & Peter Olinga. (2007) Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 879-898.
Read now
Read now
Michael Michael & Margaret M Doherty. (2007) Drug metabolism by tumours: its nature, relevance and therapeutic implications. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 783-803.
Read now
Read now
Nicola J. Hewitt, María José Gómez Lechón, J. Brian Houston, David Hallifax, Hayley S. Brown, Patrick Maurel, J. Gerald Kenna, Lena Gustavsson, Christina Lohmann, Christian Skonberg, Andre Guillouzo, Gregor Tuschl, Albert P. Li, Edward LeCluyse, Geny M. M. Groothuis & Jan G. Hengstler. (2007) Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies. Drug Metabolism Reviews 39:1, pages 159-234.
Read now
Read now
Jos V Castell, Ramiro Jover, Celia P Martnez-Jimnez & Mara Jos Gmez-Lechn. (2006) Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies. Expert Opinion on Drug Metabolism & Toxicology 2:2, pages 183-212.
Read now
Read now
Yaming Su, Sung‐hack Lee & Patrick J. Sinko. (2004) Practical Aspects of Transporter Model Systems: A Case Study Involving SQV. Drug Metabolism Reviews 36:2, pages 377-389.
Read now
Read now
Articles from other publishers (275)
Disha Shah, Bhavarth Dave, Mehul R. Chorawala, Bhupendra G. Prajapati, Sudarshan Singh, Gehan M. Elossaily, Mohd Nazam Ansari & Nemat Ali. (2024)
An Insight on Microfluidic Organ-on-a-Chip Models for PM
2.5
-Induced Pulmonary Complications
. ACS Omega 9:12, pages 13534-13555.
Crossref
Crossref
Shauna D. O’Donovan, Rachel Cavill, Florian Wimmenauer, Alexander Lukas, Tobias Stumm, Evgueni Smirnov, Michael Lenz, Gokhan Ertaylan, Danyel G. J. Jennen, Natal A. W. van Riel, Kurt Driessens, Ralf L. M. Peeters & Theo M. C. M. de Kok. (2023) Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data. PLOS ONE 18:11, pages e0292030.
Crossref
Crossref
Hakan Bülbül, Şehriman Atalay & Aliye Gediz Ertürk. (2023) Synthesis, spectroscopic characterizations, and comparison of experimental, and theoretical results of N-(3‑chloro-2-methyl phenyl)-2-(4-methoxybenzylidene)hydrazine-1-carbothioamide. Journal of Molecular Structure 1291, pages 136002.
Crossref
Crossref
Eva Sanchez-Quant, Maria Lucia Richter, Maria Colomé-Tatché & Celia Pilar Martinez-Jimenez. (2023) Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge. Genome Biology 24:1.
Crossref
Crossref
Sandra Albenque-Rubio, Jean Guillon, Anita Cohen, Patrice Agnamey, Solène Savrimoutou, Stéphane Moreau, Jean-Louis Mergny, Luisa Ronga, Ioannis Kanavos, Serge Moukha, Pascale Dozolme & Pascal Sonnet. (2023) Synthesis and Antimalarial Evaluation of New 1,3,5-tris[(4-(Substituted-aminomethyl)phenyl)methyl]benzene Derivatives: A Novel Alternative Antiparasitic Scaffold. Drugs and Drug Candidates 2:3, pages 653-672.
Crossref
Crossref
Grace Sanghee Lee, Michael A. Purdy & Youkyung Choi. (2023) Cell Culture Systems for Studying Hepatitis B and Hepatitis D Virus Infections. Life 13:7, pages 1527.
Crossref
Crossref
Marialuce Giorgini, Mercedes Taroncher, Josefa Tolosa, María-José Ruiz & Yelko Rodríguez-Carrasco. (2023) Amitraz and Its Metabolites: Oxidative Stress-Mediated Cytotoxicity in HepG2 Cells and Study of Their Stability and Characterization in Honey. Antioxidants 12:4, pages 885.
Crossref
Crossref
Marialuce Giorgini, Mercedes Taroncher, María-José Ruiz, Yelko Rodríguez-Carrasco & Josefa Tolosa. (2023) In Vitro and Predictive Computational Toxicology Methods for the Neurotoxic Pesticide Amitraz and Its Metabolites. Brain Sciences 13:2, pages 252.
Crossref
Crossref
Marco RisselJulian PohlSimon MoosburnerJoseph M.G.V. Gaßner, Rosa HornerKarl H. HillebrandtDominik P. ModestJohann PratschkeIgor M. SauerNathanael Raschzok. (2023) Effect of Preoperative Chemotherapy on the Isolation Outcome of Primary Human Hepatocytes. Tissue Engineering Part C: Methods 29:2, pages 63-71.
Crossref
Crossref
Samuel J.I. Blackford, Tracy T.L. Yu, Michael D.A. Norman, Adam M. Syanda, Michail Manolakakis, Dariusz Lachowski, Ziqian Yan, Yunzhe Guo, Elena Garitta, Federica Riccio, Geraldine M. Jowett, Soon Seng Ng, Santiago Vernia, Armando E. del Río Hernández, Eileen Gentleman & S. Tamir Rashid. (2023) RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling. Biomaterials 293, pages 121982.
Crossref
Crossref
Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F. K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell & Daniel Levner. (2022) Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology. Communications Medicine 2:1.
Crossref
Crossref
Jean Guillon, Anita Cohen, Clotilde Boudot, Sarah Monic, Solène Savrimoutou, Stéphane Moreau, Sandra Albenque-Rubio, Camille Lafon-Schmaltz, Alexandra Dassonville-Klimpt, Jean-Louis Mergny, Luisa Ronga, Mikel Bernabeu de Maria, Jeremy Lamarche, Cristina Dal Lago, Eric Largy, Valérie Gabelica, Serge Moukha, Pascale Dozolme, Patrice Agnamey, Nadine Azas, Catherine Mullié, Bertrand Courtioux & Pascal Sonnet. (2022) Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-Bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux. Pathogens 11:11, pages 1339.
Crossref
Crossref
Shimpei Terasaka, Akane Hayashi, Yuko Nukada & Masayuki Yamane. (2022) Investigating the uncertainty of prediction accuracy for the application of physiologically based pharmacokinetic models to animal-free risk assessment of cosmetic ingredients. Regulatory Toxicology and Pharmacology 135, pages 105262.
Crossref
Crossref
Sandra Doß, Corinne Blessing, Katharina Haller, Georg Richter & Martin Sauer. (2022) Influence of Antibiotics on Functionality and Viability of Liver Cells In Vitro. Current Issues in Molecular Biology 44:10, pages 4639-4657.
Crossref
Crossref
Melissa Anne Tutty, Dania Movia & Adriele Prina-Mello. (2022) Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials. Drug Delivery and Translational Research 12:9, pages 2048-2074.
Crossref
Crossref
Sandy Lemm, Susanne Köhler, Robert Wodtke, Friedrich Jung, Jan-Heiner Küpper, Jens Pietzsch & Markus Laube. (2022) Investigation of Radiotracer Metabolic Stability In Vitro with CYP-Overexpressing Hepatoma Cell Lines. Cells 11:15, pages 2447.
Crossref
Crossref
Fang-Chun Liao, Yang-Kao Wang, Ming-Yang Cheng & Ting-Yuan Tu. (2022) A Preliminary Investigation of Embedding In Vitro HepaRG Spheroids into Recombinant Human Collagen Type I for the Promotion of Liver Differentiation. Polymers 14:9, pages 1923.
Crossref
Crossref
Liping Chen, Ping Guo, Wenxue Li, Xinhang Jiang, Qun Zhao, Daochuan Li, Qing Wang, Yongmei Xiao, Xiumei Xing, Yaqin Pang, Michael Aschner, Lihua Zhang & Wen Chen. (2022) Protein phosphatase 2A regulates cytotoxicity and drug resistance by dephosphorylating AHR and MDR1. Journal of Biological Chemistry 298:5, pages 101918.
Crossref
Crossref
Sara Abdelfatah, Janine Naß, Caroline Knorz, Sabine M. Klauck, Jan-Heiner Küpper & Thomas Efferth. (2021) Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells. Cell Biology and Toxicology 38:2, pages 325-345.
Crossref
Crossref
Ali Mohammad Pourbagher-Shahri, Jonathan Schimmel, Farshad M. Shirazi, Samaneh Nakhaee & Omid Mehrpour. (2022) Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review. Toxicology Letters 355, pages 47-61.
Crossref
Crossref
Nandita Saxena, Pooja Phatak & Vinita Chauhan. (2022) Differential toxicity of abrin in human cell lines of different organ origin. Toxicology in Vitro 78, pages 105250.
Crossref
Crossref
Qiyue Zhang, Shiori Taniguchi, Kanako So, Masahiro Tsuda, Yuriko Higuchi, Mitsuru Hashida & Fumiyoshi Yamashita. (2022) CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis. The Journal of Toxicological Sciences 47:8, pages 337-348.
Crossref
Crossref
Patarajarin AkarapipadKattika Kaarj, Yan Liang & Jeong-Yeol Yoon. (2021) Environmental Toxicology Assays Using Organ-on-Chip. Annual Review of Analytical Chemistry 14:1, pages 155-183.
Crossref
Crossref
Jia-Li Xing, Yu-Xin Wang & Shun-Da Du. (2021)
Application and research progress of
in vitro
liver cancer cell culture models
. World Chinese Journal of Digestology 29:11, pages 563-570.
Crossref
Crossref
Fabio Alejandro Aguilar Mora, Nshunge Musheshe, Asmaa Oun, Manon Buist-Homan, Frank Lezoualc’h, Xiaodong Cheng, Martina Schmidt & Han Moshage. (2021) Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors. Molecular Pharmacology 99:4, pages 294-307.
Crossref
Crossref
Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones & Phillip D. Yates. (2021) Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment. Drug Metabolism and Disposition 49:1, pages 94-110.
Crossref
Crossref
C. Nelson Hayes & Kazuaki Chayama. 2021. Hepatitis B Virus and Liver Disease. Hepatitis B Virus and Liver Disease
29
49
.
Laura M. de Jong, Wim Jiskoot, Jesse J. Swen & Martijn L. Manson. (2020) Distinct Effects of Inflammation on Cytochrome P450 Regulation and Drug Metabolism: Lessons from Experimental Models and a Potential Role for Pharmacogenetics. Genes 11:12, pages 1509.
Crossref
Crossref
Xuan G. Luong, Sarah K. Stevens, Andreas Jekle, Tse-I Lin, Kusum Gupta, Dinah Misner, Sushmita Chanda, Sucheta Mukherjee, Caroline Williams, Antitsa Stoycheva, Lawrence M. Blatt, Leonid N. Beigelman, Julian A. Symons, Pierre Raboisson, David McGowan, Koen Vandyck & Jerome Deval. (2020) Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH). PLOS ONE 15:12, pages e0240338.
Crossref
Crossref
James T. Shoemaker, Wanrui Zhang, Selin I. Atlas, Richard A. Bryan, S. Walker Inman & Jelena Vukasinovic. (2020) A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro. Frontiers in Molecular Biosciences 7.
Crossref
Crossref
Leah M. Norona, Aaron Fullerton, Chris Lawson, Leslie Leung, Jochen Brumm, Tomomi Kiyota, Jonathan Maher, Cyrus Khojasteh & William R. Proctor. (2020) In vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk. Archives of Toxicology 94:9, pages 3185-3200.
Crossref
Crossref
Tasnia Sharin, Doug Crump & Jason M. O'Brien. (2020) Evaluation of the Aryl Hydrocarbon Receptor Response in LMH 3D Spheroids. Environmental Toxicology and Chemistry 39:9, pages 1693-1701.
Crossref
Crossref
Ramona Nudischer, Kasper Renggli, Andreas Hierlemann, Adrian B. Roth & Cristina Bertinetti-Lapatki. (2020) Characterization of a long-term mouse primary liver 3D tissue model recapitulating innate-immune responses and drug-induced liver toxicity. PLOS ONE 15:7, pages e0235745.
Crossref
Crossref
Fanny Mathias, Anita Cohen, Youssef Kabri, Núria Waddington Negrão, Maxime D. Crozet, Roberto Docampo, Nadine Azas & Patrice Vanelle. (2020) Synthesis and in vitro evaluation of new 5-substituted 6-nitroimidazooxazoles as antikinetoplastid agents. European Journal of Medicinal Chemistry 191, pages 112146.
Crossref
Crossref
Jyoti Kumari, Arun K. Teotia, Anjali A. Karande & Ashok Kumar. (2019) A minimally‐invasive cryogel based approach for the development of human ectopic liver in a mouse model. Journal of Biomedical Materials Research Part B: Applied Biomaterials 108:3, pages 1022-1032.
Crossref
Crossref
Beyza Bulutoglu, Camilo Rey-Bedón, Safak Mert, Lipeng Tian, Yoon-Young Jang, Martin L. Yarmush & O. Berk Usta. (2020) A comparison of hepato-cellular in vitro platforms to study CYP3A4 induction. PLOS ONE 15:2, pages e0229106.
Crossref
Crossref
Susanne Steinbrecht, Nadine Pfeifer, Natalie Herzog, Nadine Katzenberger, Christian Schulz, Sarah Kammerer & Jan-Heiner Küpper. (2020) HepG2-1A2 C2 and C7: Lentivirus vector-mediated stable and functional overexpression of cytochrome P450 1A2 in human hepatoblastoma cells. Toxicology Letters 319, pages 155-159.
Crossref
Crossref
Andreas R. Baudy, Monicah A. Otieno, Philip Hewitt, Jinping Gan, Adrian Roth, Douglas Keller, Radhakrishna Sura, Terry R. Van Vleet & William R. Proctor. (2020) Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry. Lab on a Chip 20:2, pages 215-225.
Crossref
Crossref
Gustav Holmgren, Benjamin Ulfenborg, Annika Asplund, Karin Toet, Christian X Andersson, Ann Hammarstedt, Roeland Hanemaaijer, Barbara Küppers-Munther & Jane Synnergren. (2020) Characterization of Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mature Features and Potential for Modeling Metabolic Diseases. International Journal of Molecular Sciences 21:2, pages 469.
Crossref
Crossref
Seiichi Ishida. 2020. Organ-on-a-chip. Organ-on-a-chip
181
213
.
Miyako Yoshioka, Takato Takenouchi, Hiroshi Kitani, Keerthi S. Guruge & Noriko Yamanaka. (2019) Synergistic induction of drug-metabolizing enzymes in co-cultures of bovine hepatocytic and sinusoidal cell lines. In Vitro Cellular & Developmental Biology - Animal 56:1, pages 2-9.
Crossref
Crossref
Vahid Hosseini, Nazila Fathi Maroufi, Sepideh Saghati, Nahideh Asadi, Masoud Darabi, Saeed Nazari Soltan Ahmad, Hosseini Hosseinkhani & Reza Rahbarghazi. (2019) Current progress in hepatic tissue regeneration by tissue engineering. Journal of Translational Medicine 17:1.
Crossref
Crossref
Taiki Abe, Ryota Shizu, Takamitsu Sasaki, Yuki Shimizu, Takuomi Hosaka, Susumu Kodama, Atsushi Matsuzawa & Kouichi Yoshinari. (2019) Functional Interaction between Pregnane X Receptor and Yes-Associated Protein in Xenobiotic-Dependent Liver Hypertrophy and Drug Metabolism. Journal of Pharmacology and Experimental Therapeutics 371:3, pages 590-601.
Crossref
Crossref
Casey C. Clark, Julio Aleman, Lysette Mutkus & Aleksander Skardal. (2019) A mechanically robust thixotropic collagen and hyaluronic acid bioink supplemented with gelatin nanoparticles. Bioprinting 16, pages e00058.
Crossref
Crossref
Scott D. Collins, Gloria Yuen, Thomas Tu, Magdalena A. Budzinska, Kevin Spring, Katherine Bryant & Nicholas A. Shackel. 2019. Hepatocellular Carcinoma. Hepatocellular Carcinoma
47
67
.
Johanna Ebmeyer, Luise Franz, Ramonique Lim, Birgit Niemann, Hansruedi Glatt, Albert Braeuning, Alfonso Lampen & Stefanie Hessel‐Pras. (2019) Sensitization of Human Liver Cells Toward Fas‐Mediated Apoptosis by the Metabolically Activated Pyrrolizidine Alkaloid Lasiocarpine. Molecular Nutrition & Food Research 63:12.
Crossref
Crossref
Jung Bok Lee, Jeong Su Park, Young Min Shin, Da Hyun Lee, Jeong‐Kee Yoon, Dae‐Hyun Kim, Ung Hyun Ko, YongTae Kim, Soo Han Bae & Hak‐Joon Sung. (2019) Implantable Vascularized Liver Chip for Cross‐Validation of Disease Treatment with Animal Model. Advanced Functional Materials 29:23.
Crossref
Crossref
S. Steinbrecht, S. Kammerer & J.-H. Küpper. (2019) HepG2 cells with recombinant cytochrome P450 enzyme overexpression: Their use and limitation as in vitro liver model. Journal of Cellular Biotechnology 5:1, pages 55-64.
Crossref
Crossref
Alexander Gleich, Bastian Kaiser, Walther Honscha, Herbert Fuhrmann & Axel Schoeniger. (2019) Evaluation of the hepatocyte-derived cell line BFH12 as an in vitro model for bovine biotransformation. Cytotechnology 71:1, pages 231-244.
Crossref
Crossref
So‐Ryeon Hwang, Nga Thi Thu Tham, Soo‐ho Lee, Ji‐Hyun Bang, Hee Yi, Young‐Il Park, Hyun‐Kyoung Lee, Hwan‐Goo Kang, Yong‐Sang Kim, Gye‐Hyeong Woo & Hyun‐Ok Ku. (2018) Comparison of microRNA expressions for the identification of chemical hazards in in vivo and in vitro hepatic injury models. Journal of Applied Toxicology 39:2, pages 333-342.
Crossref
Crossref
Pranav Joshi, Soo‐Yeon Kang, Akshata Datar & Moo‐Yeal Lee. (2018) High‐Throughput Assessment of Mechanistic Toxicity of Chemicals in Miniaturized 3D Cell Culture. Current Protocols in Toxicology 79:1.
Crossref
Crossref
Marc Ruoß, Georg Damm, Massoud Vosough, Lisa Ehret, Carl Grom-Baumgarten, Martin Petkov, Silvio Naddalin, Ruth Ladurner, Daniel Seehofer, Andreas Nussler & Sahar Sajadian. (2019) Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity. International Journal of Molecular Sciences 20:2, pages 347.
Crossref
Crossref
Nga T. T. ThamSo-Ryeon HwangJi-Hyun BangHee YiYoung-Il ParkSeok-Jin KangHwan-Goo KangYong-Sang KimHyun-Ok Ku. (2019)
High-content analysis of
in vitro
hepatocyte injury induced by various hepatotoxicants
. Journal of Veterinary Science 20:1, pages 34.
Crossref
Crossref
Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani & Donald Tweedie. (2019) Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac. Drug Metabolism and Disposition 47:1, pages 58-66.
Crossref
Crossref
Susanne Steinbrecht, Rosalie König, Kai-Uwe Schmidtke, Natalie Herzog, Katrin Scheibner, Anne Krüger-Genge, Friedrich Jung, Sarah Kammerer & Jan-Heiner Küpper. (2019) Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4. Toxicology 412, pages 37-47.
Crossref
Crossref
Vânia Vilas-Boas, Axelle Cooreman, Eva Gijbels, Raf Van Campenhout, Emma Gustafson, Steven Ballet, Pieter Annaert, Bruno Cogliati & Mathieu Vinken. 2019. Drug-induced Liver Injury. Drug-induced Liver Injury
1
30
.
Ajit Dash & William R. Proctor. 2019. Microfluidic Cell Culture Systems. Microfluidic Cell Culture Systems
159
186
.
Bronislav Jurásek, František Králík, Silvie Rimpelová, Jan Čejka, Vladimír Setnička, Tomáš Ruml, Martin Kuchař & Michal Kohout. (2018)
Synthesis, absolute configuration and
in vitro
cytotoxicity of deschloroketamine enantiomers: rediscovered and abused dissociative anaesthetic
. New Journal of Chemistry 42:24, pages 19360-19368.
Crossref
Crossref
Sarah Kammerer & Jan-Heiner Küpper. (2018) Human hepatocyte systems for in vitro toxicology analysis. Journal of Cellular Biotechnology 3:2, pages 85-93.
Crossref
Crossref
Zhengbao Zhang, Qing Bai, Yu Chen, Lina Ye, Xiaoting Wu, Xiang Long, Lin Ye, Jianjun Liu & Hui Li. (2018) Conditionally reprogrammed human normal bronchial epithelial cells express comparable levels of cytochromes p450 and are sensitive to BaP induction. Biochemical and Biophysical Research Communications 503:3, pages 2132-2138.
Crossref
Crossref
Qiao Wu, Juan Liu, Lijin Liu, Yu Chen, Jie Wang, Ling Leng, Qunfang Yu, Zhongping Duan & Yunfang Wang. (2018) Establishment of an ex Vivo Model of Nonalcoholic Fatty Liver Disease Using a Tissue-Engineered Liver. ACS Biomaterials Science & Engineering 4:8, pages 3016-3026.
Crossref
Crossref
Pranav Joshi, Akshata Datar, Kyeong-Nam Yu, Soo-Yeon Kang & Moo-Yeal Lee. (2018) High-content imaging assays on a miniaturized 3D cell culture platform. Toxicology in Vitro 50, pages 147-159.
Crossref
Crossref
Christina Y.S. Chan, Owain Roberts, Rajith K.R. Rajoli, Neill J. Liptrott, Marco Siccardi, Lisa Almond & Andrew Owen. (2018) Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach. Drug Metabolism and Pharmacokinetics 33:4, pages 179-187.
Crossref
Crossref
Yuri L. Boteon, Lorraine Wallace, Amanda P. C. S. Boteon, Darius F. Mirza, Hynek Mergental, Ricky H. Bhogal & Simon Afford. (2018) An effective protocol for pharmacological defatting of primary human hepatocytes which is non-toxic to cholangiocytes or intrahepatic endothelial cells. PLOS ONE 13:7, pages e0201419.
Crossref
Crossref
Martin Sauer, Cristof Haubner, Georg Richter, Johannes Ehler, Thomas Mencke, Steffen Mitzner, Stefan Margraf, Jens Altrichter, Sandra Doß & Gabriele Nöldge-Schomburg. (2018) Impaired Cell Viability and Functionality of Hepatocytes After Incubation With Septic Plasma—Results of a Second Prospective Biosensor Study. Frontiers in Immunology 9.
Crossref
Crossref
Rangarajan Sambathkumar, Renate Akkerman, Sumitava Dastidar, Philip Roelandt, Manoj Kumar, Manmohan Bajaj, Ana Rita Mestre Rosa, Nicky Helsen, Veerle Vanslembrouck, Eric Kalo, Satish Khurana, Jos Laureys, Conny Gysemans, Marijke M. Faas, Paul de Vos & Catherine M. Verfaillie. (2018) Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells. PLOS ONE 13:5, pages e0197046.
Crossref
Crossref
Jonathan A. Kyffin, Parveen Sharma, Joseph Leedale, Helen E. Colley, Craig Murdoch, Pratibha Mistry & Steven D. Webb. (2018) Impact of cell types and culture methods on the functionality of in vitro liver systems – A review of cell systems for hepatotoxicity assessment. Toxicology in Vitro 48, pages 262-275.
Crossref
Crossref
Jooyeon Park, Joyeon Kim, Kathryn Michele Sullivan, Seungyun Baik, Eunkyung Ko, Myung-Joo Kim, Young Jun Kim & Hyunjoon Kong. (2017) Decellularized Matrix Produced by Mesenchymal Stem Cells Modulates Growth and Metabolic Activity of Hepatic Cell Cluster. ACS Biomaterials Science & Engineering 4:2, pages 456-462.
Crossref
Crossref
Hiroshi Kimura, Yasuyuki Sakai & Teruo Fujii. (2018) Organ/body-on-a-chip based on microfluidic technology for drug discovery. Drug Metabolism and Pharmacokinetics 33:1, pages 43-48.
Crossref
Crossref
Ryuji Watari, Motoharu KakikiAyumi Oshikata, Toshiaki Takezawa, Chihiro YamasakiYuji IshidaChise TatenoYukie Kuroda, Seiichi Ishida & Kazutomi Kusano. (2018) A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers. The Journal of Toxicological Sciences 43:8, pages 521-529.
Crossref
Crossref
Li-Ping Liu, Yu-Mei Li, Ning-Ning Guo, Lu-Yuan Wang, Hiroko Isoda, Nobuhiro Ohkohchi, Hideki Taniguchi & Yun-Wen Zheng. 2018. Stem Cells and Cancer in Hepatology. Stem Cells and Cancer in Hepatology
115
144
.
Abdul M. Oseini, Banumathi K. Cole, Danny Issa, Ryan E. Feaver & Arun J. Sanyal. (2018) Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis. Hepatology International 12:1, pages 6-16.
Crossref
Crossref
Thamil Selvee Ramasamy, Agnes Lee Chen Ong & Wei Cui. 2018. Novel Biomaterials for Regenerative Medicine. Novel Biomaterials for Regenerative Medicine
41
66
.
Kazuaki Chayama & C. Nelson Hayes. 2018. Hepatitis B Virus and Liver Disease. Hepatitis B Virus and Liver Disease
25
43
.
Sofie O’Brien, Yonsil Park, Samira Azarin & Wei-Shou Hu. 2018. Cell Culture Technology. Cell Culture Technology
1
21
.
Hsiao-Yun Chang, Chao-Jung Chen, Wei-Chih Ma, Wai-Kok Cheng, Yen-Ning Lin, Ying-Ray Lee, Jih-Jung Chen & Yun-Ping Lim. (2017) Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity. Phytomedicine 36, pages 37-49.
Crossref
Crossref
Toshikazu Fukushima, Hiroe Hara-Yamamura, Koji Nakashima, Lea Chua Tan & Satoshi Okabe. (2017) Multiple-endpoints gene alteration-based (MEGA) assay: A toxicogenomics approach for water quality assessment of wastewater effluents. Chemosphere 188, pages 312-319.
Crossref
Crossref
Niresh Hariparsad, Diane Ramsden, Jairam Palamanda, Joshua G. Dekeyser, Odette A. Fahmi, Jane R. Kenny, Heidi Einolf, Michael Mohutsky, Magalie Pardon, Y. Amy Siu, Liangfu Chen, Michael Sinz, Barry Jones, Robert Walsky, Shannon Dallas, Suresh K. Balani, George Zhang, David Buckley & Donald Tweedie. (2017) Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control. Drug Metabolism and Disposition 45:10, pages 1049-1059.
Crossref
Crossref
William R. Proctor, Alison J. Foster, Jennifer Vogt, Claire Summers, Brian Middleton, Mark A. Pilling, Daniel Shienson, Monika Kijanska, Simon Ströbel, Jens M. Kelm, Paul Morgan, Simon Messner & Dominic Williams. (2017) Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury. Archives of Toxicology 91:8, pages 2849-2863.
Crossref
Crossref
Xiaohui Li, Pinghe Yin & Ling Zhao. (2017) Effects of individual and combined toxicity of bisphenol A, dibutyl phthalate and cadmium on oxidative stress and genotoxicity in HepG 2 cells. Food and Chemical Toxicology 105, pages 73-81.
Crossref
Crossref
Xian Wu, Xiangkun YangAnirban Majumder, Raymond Swetenburg, Forrest T. Goodfellow, Michael G. BartlettSteven L. Stice. (2017) From the Cover: AstrocytesAre Protective Against Chlorpyrifos Developmental Neurotoxicity in Human Pluripotent Stem Cell-Derived Astrocyte-Neuron Cocultures. Toxicological Sciences 157:2, pages 410-420.
Crossref
Crossref
José Pérez-del Palacio, Caridad Díaz, Noemí Vergara, Francesca Algieri, Alba Rodríguez-Nogales, Nuria de Pedro, M. Elena Rodríguez-Cabezas, Olga Genilloud, Julio Gálvez & Francisca Vicente. (2017) Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production. Frontiers in Pharmacology 8.
Crossref
Crossref
A. Dash, R.A. Figler, B.R. Blackman, S. Marukian, M.S. Collado, M.J. Lawson, S.A. Hoang, A.J. Mackey, D. Manka, B.K. Cole, R.E. Feaver, A.J. Sanyal & B.R. Wamhoff. (2017) Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicology in Vitro 39, pages 93-103.
Crossref
Crossref
Kazuo Takayama & Hiroyuki Mizuguchi. (2017) Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening. Drug Metabolism and Pharmacokinetics 32:1, pages 12-20.
Crossref
Crossref
Yohan KimKyojin KangJaemin JeongSeung Sam PaikJi Sook KimSu A ParkWan Doo KimJisun ParkDongho Choi. (2017) Three-dimensional (3D) printing of mouse primary hepatocytes to generate 3D hepatic structure. Annals of Surgical Treatment and Research 92:2, pages 67.
Crossref
Crossref
Sandra Doß, Heike Potschka, Fanny Doß, Steffen Mitzner & Martin Sauer. (2017) Hepatotoxicity of Antimycotics Used for Invasive Fungal Infections: In Vitro Results. BioMed Research International 2017, pages 1-10.
Crossref
Crossref
Suhaili Shamsi, Huong Tran, Renee Seok Jin Tan, Zee Jian Tan & Lee Yong Lim. (2017) Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities. Drug Metabolism and Disposition 45:1, pages 49-55.
Crossref
Crossref
Viktoriia Burkina, Martin Krøyer Rasmussen, Nadezhda Pilipenko & Galia Zamaratskaia. (2017) Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450. Toxicology 375, pages 10-27.
Crossref
Crossref
A. Ramachandran & H. Jaeschke. 2017. Liver Pathophysiology. Liver Pathophysiology
101
112
.
James A. Heslop, Cliff Rowe, Joanne Walsh, Rowena Sison-Young, Roz Jenkins, Laleh Kamalian, Richard Kia, David Hay, Robert P. Jones, Hassan Z. Malik, Stephen Fenwick, Amy E. Chadwick, John Mills, Neil R. Kitteringham, Chris E. P. Goldring & B. Kevin Park. (2016) Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile. Archives of Toxicology 91:1, pages 439-452.
Crossref
Crossref
Obeid M. Malekshah, Xuguang Chen, Alireza Nomani, Siddik Sarkar & Arash Hatefi. (2016) Enzyme/Prodrug Systems for Cancer Gene Therapy. Current Pharmacology Reports 2:6, pages 299-308.
Crossref
Crossref
Xi Chen, Rhonda Murdoch, Daniel J. Shafer, Kolapo M. Ajuwon & Todd J. Applegate. (2016) Cytotoxicity of various chemicals and mycotoxins in fresh primary duck embryonic fibroblasts: a comparison to HepG2 cells. Journal of Applied Toxicology 36:11, pages 1437-1445.
Crossref
Crossref
Ia Hultman, Charlotta Vedin, Anna Abrahamsson, Susanne Winiwarter & Malin Darnell. (2016) Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds. Molecular Pharmaceutics 13:8, pages 2796-2807.
Crossref
Crossref
Ylva Terelius, Robert A. Figler, Svetlana Marukian, Maria S. Collado, Mark J. Lawson, Aaron J. Mackey, David Manka, Charles W. QuallsJr.Jr., Brett R. Blackman, Brian R. Wamhoff & Ajit Dash. (2016) Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chemico-Biological Interactions 255, pages 31-44.
Crossref
Crossref
C. Nelson Hayes & Kazuaki Chayama. (2016) HBV culture and infectious systems. Hepatology International 10:4, pages 559-566.
Crossref
Crossref
Chaojun Jia, Lijun Luo, Katsuhisa Kurogi, Juming Yu, Chunyang Zhou & Ming‐Cheh Liu. (2015) Identification of the Human SULT Enzymes Involved in the Metabolism of Rotigotine. The Journal of Clinical Pharmacology 56:6, pages 754-760.
Crossref
Crossref
Catherine C. Bell, Delilah F. G. Hendriks, Sabrina M. L. Moro, Ewa Ellis, Joanne Walsh, Anna Renblom, Lisa Fredriksson Puigvert, Anita C. A. Dankers, Frank Jacobs, Jan Snoeys, Rowena L. Sison-Young, Rosalind E. Jenkins, Åsa Nordling, Souren Mkrtchian, B. Kevin Park, Neil R. Kitteringham, Christopher E. P. Goldring, Volker M. Lauschke & Magnus Ingelman-Sundberg. (2016) Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Scientific Reports 6:1.
Crossref
Crossref
Fanny Knöspel, Frank Jacobs, Nora Freyer, Georg Damm, An De Bondt, Ilse van den Wyngaert, Jan Snoeys, Mario Monshouwer, Marco Richter, Nadja Strahl, Daniel Seehofer & Katrin Zeilinger. (2016) In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System. International Journal of Molecular Sciences 17:4, pages 584.
Crossref
Crossref
E. Kraynov, A. V. Kamath, M. Walles, E. Tarcsa, A. Deslandes, R. A. Iyer, A. Datta-Mannan, P. Sriraman, M. Bairlein, J. J. Yang, M. Barfield, G. Xiao, E. Escandon, W. Wang, D. A. Rock, N. V. Chemuturi & D. J. Moore. (2015) Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper. Drug Metabolism and Disposition 44:5, pages 617-623.
Crossref
Crossref
Kimberly A. Chapman, Maria S. Collado, Robert A. Figler, Stephen A. Hoang, Allison J. Armstrong, Wanxing Cui, Michael Purdy, Michael B. Simmers, Nada A. Yazigi, Marshall L. Summar, Brian R. Wamhoff & Ajit Dash. (2016) Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes. Molecular Genetics and Metabolism 117:3, pages 355-362.
Crossref
Crossref
Yuuki Nishida & Akiyoshi Taniguchi. (2015) A three-dimensional collagen-sponge-based culture system coated with simplified recombinant fibronectin improves the function of a hepatocyte cell line. In Vitro Cellular & Developmental Biology - Animal 52:3, pages 271-277.
Crossref
Crossref
Annika Asplund, Arvind Pradip, Mariska van Giezen, Anders Aspegren, Helena Choukair, Marie Rehnström, Susanna Jacobsson, Nidal Ghosheh, Dorra El Hajjam, Sandra Holmgren, Susanna Larsson, Jörg Benecke, Mariela Butron, Annelie Wigander, Karin Noaksson, Peter Sartipy, Petter Björquist, Josefina Edsbagge & Barbara Küppers-Munther. (2015) One Standardized Differentiation Procedure Robustly Generates Homogenous Hepatocyte Cultures Displaying Metabolic Diversity from a Large Panel of Human Pluripotent Stem Cells. Stem Cell Reviews and Reports 12:1, pages 90-104.
Crossref
Crossref
Lei Xia, Xin Hong, Rashidah Binte Sakban, Yinghua Qu, Nisha Hari Singh, Michael McMillian, Shannon Dallas, Jose Silva, Carlo Sensenhauser, Sylvia Zhao, Heng Keang Lim & Hanry Yu. (2015)
Cytochrome P450 induction response in tethered spheroids as a three‐dimensional human hepatocyte
in vitro
model
. Journal of Applied Toxicology 36:2, pages 320-329.
Crossref
Crossref
B. Lucendo-Villarin, H. Rashidi, K. Cameron & D. C. Hay. (2016) Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering. Journal of Materials Chemistry B 4:20, pages 3433-3442.
Crossref
Crossref
Arnout Schepers, Cheri Li, Arnav Chhabra, Benjamin Tschudy Seney & Sangeeta Bhatia. (2016) Engineering a perfusable 3D human liver platform from iPS cells. Lab on a Chip 16:14, pages 2644-2653.
Crossref
Crossref
Michaël Maes, Mathieu Vinken & Hartmut Jaeschke. (2016) Experimental models of hepatotoxicity related to acute liver failure. Toxicology and Applied Pharmacology 290, pages 86-97.
Crossref
Crossref
Jun Terashima, Shinpei Goto, Hiroki Hattori, Sawaka Hoshi, Midori Ushirokawa, Kenzo Kudo, Wataru Habano & Shogo Ozawa. (2015) CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures. Drug Metabolism and Pharmacokinetics 30:6, pages 434-440.
Crossref
Crossref
Anke Lange, Marion Sebire, Pawel Rostkowski, Takeshi Mizutani, Shinichi Miyagawa, Taisen Iguchi, Elizabeth M. Hill & Charles R. Tyler. (2015) Environmental chemicals active as human antiandrogens do not activate a stickleback androgen receptor but enhance a feminising effect of oestrogen in roach. Aquatic Toxicology 168, pages 48-59.
Crossref
Crossref
Kate Cameron, Howard Marriage, David Hay & Claire Medine. 2015. Stem Cells in Regenerative Medicine. Stem Cells in Regenerative Medicine
171
192
.
Alyssa M. Keil, Douglas M. Frederick, Erina Y. Jacinto, Erica L. Kennedy, Randy J. Zauhar, Nathan M. West, Ruy Tchao & Peter J. Harvison. (2015) Cytotoxicity of thiazolidinedione-, oxazolidinedione- and pyrrolidinedione-ring containing compounds in HepG2 cells. Toxicology in Vitro 29:7, pages 1887-1896.
Crossref
Crossref
Diane Ramsden, Jin Zhou & Donald J. Tweedie. (2015) Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac. Drug Metabolism and Disposition 43:9, pages 1307-1315.
Crossref
Crossref
Anita Cohen, Peggy Suzanne, Jean-Charles Lancelot, Pierre Verhaeghe, Aurélien Lesnard, Louise Basmaciyan, Sébastien Hutter, Michèle Laget, Aurélien Dumètre, Lucie Paloque, Eric Deharo, Maxime D. Crozet, Pascal Rathelot, Patrick Dallemagne, Audrey Lorthiois, Carol Hopkins Sibley, Patrice Vanelle, Alexis Valentin, Dominique Mazier, Sylvain Rault & Nadine Azas. (2015) Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium. European Journal of Medicinal Chemistry 95, pages 16-28.
Crossref
Crossref
Jong Min Choi, Soo Jin Oh, Sang Yoon Lee, Ji Hye Im, Jung Min Oh, Chang Seon Ryu, Hui Chan Kwak, Ji-Yoon Lee, Keon Wook Kang & Sang Kyum Kim. (2014) HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics. Archives of Pharmacal Research 38:5, pages 691-704.
Crossref
Crossref
Frederic Moulin & Oliver Flint. 2015. Antitargets and Drug Safety. Antitargets and Drug Safety
125
158
.
Michelle M. Angrish, Michael C. Madden & Joachim D. Pleil. (2015)
Probe Molecule (PrM) Approach in Adverse Outcome Pathway (AOP) Based High-Throughput Screening (HTS):
In Vivo
Discovery for Developing
in Vitro
Target Methods
. Chemical Research in Toxicology 28:4, pages 551-559.
Crossref
Crossref
Samuel Liebel, Ciro Alberto de Oliveira Ribeiro, Valéria Freitas de Magalhães, Rodrigo de Cássio da Silva, Stéfani Cibele Rossi, Marco Antônio Ferreira Randi & Francisco Filipak Neto. (2015) Low concentrations of cylindrospermopsin induce increases of reactive oxygen species levels, metabolism and proliferation in human hepatoma cells (HepG2). Toxicology in Vitro 29:3, pages 479-488.
Crossref
Crossref
Richard Kia, Lorna Kelly, Rowena L. C. Sison-Young, Fang Zhang, Chris S. Pridgeon, James A. Heslop, Pete Metcalfe, Neil R. Kitteringham, Melissa Baxter, Sean Harrison, Neil A. Hanley, Zoë D. Burke, Mike P. Storm, Melanie J. Welham, David Tosh, Barbara Küppers-Munther, Josefina Edsbagge, Philip J. Starkey Lewis, Frank Bonner, Ernie Harpur, James Sidaway, Joanne Bowes, Stephen W. Fenwick, Hassan Malik, Chris E. P. Goldring & B. Kevin Park. (2015) MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity. Toxicological Sciences 144:1, pages 173-185.
Crossref
Crossref
Yun-Ping Lim, Ching-Hao Cheng, Wei-Cheng Chen, Shih-Yu Chang, Dong-Zong Hung, Jih-Jung Chen, Lei Wan, Wei-Chih Ma, Yu-Hsien Lin, Cing-Yu Chen, Tsuyoshi Yokoi, Miki Nakajima & Chao-Jung Chen. (2014) Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity. Archives of Toxicology 89:1, pages 57-72.
Crossref
Crossref
María Teresa Donato, Laia Tolosa & María José Gómez-Lechón. 2015. Protocols in In Vitro Hepatocyte Research. Protocols in In Vitro Hepatocyte Research
77
93
.
Laia Tolosa, María Teresa Donato & María José Gómez-Lechón. 2015. Protocols in In Vitro Hepatocyte Research. Protocols in In Vitro Hepatocyte Research
333
348
.
S A A Patel, U Bhambra, M P Charalambous, R M David, R J Edwards, T Lightfoot, A R Boobis & N J Gooderham. (2014) Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3. British Journal of Cancer 111:12, pages 2287-2296.
Crossref
Crossref
Tomas Smutny, Michal Bitman, Michal Urban, Michaela Dubecka, Radim Vrzal, Zdeněk Dvorak & Petr Pavek. (2014) U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Archives of Toxicology 88:12, pages 2243-2259.
Crossref
Crossref
Swetha Rudraiah, Philip R. Rohrer, Igor Gurevich, Michael J. Goedken, Theodore Rasmussen, Ronald N. Hines & José E. Manautou. (2014) Tolerance to Acetaminophen Hepatotoxicity in the Mouse Model of Autoprotection Is Associated with Induction of Flavin-Containing Monooxygenase-3 (FMO3) in Hepatocytes. Toxicological Sciences 141:1, pages 263-277.
Crossref
Crossref
Kati-Sisko Vellonen, Melina Malinen, Eliisa Mannermaa, Astrid Subrizi, Elisa Toropainen, Yan-Ru Lou, Heidi Kidron, Marjo Yliperttula & Arto Urtti. (2014) A critical assessment of in vitro tissue models for ADME and drug delivery. Journal of Controlled Release 190, pages 94-114.
Crossref
Crossref
Piyanuch Wonganan, Kristina Jonsson-Schmunk, Shellie M. Callahan, Jin Huk Choi & Maria A. Croyle. (2014) Evaluation of the HC-04 Cell Line as an In Vitro Model for Mechanistic Assessment of Changes in Hepatic Cytochrome P450 3A during Adenovirus Infection. Drug Metabolism and Disposition 42:7, pages 1191-1201.
Crossref
Crossref
C. Downey, F. Daly & K.M. O’Boyle. (2014) An in vitro approach to assessing a potential drug interaction between MDMA (ecstasy) and caffeine. Toxicology in Vitro 28:2, pages 231-239.
Crossref
Crossref
Joost van Delft, Karen Mathijs, Jan Polman, Maarten Coonen, Ewa Szalowska, Geert R. Verheyen, Freddy van Goethem, Marja Driessen, Leo van de Ven, Sreenivasa Ramaiahgari & Leo S. Price. 2014. Toxicogenomics-Based Cellular Models. Toxicogenomics-Based Cellular Models
193
212
.
Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani & Donald Tweedie. (2013) Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac. Drug Metabolism and Disposition 41:12, pages 2024-2032.
Crossref
Crossref
Maria Ulvestad, Pär Nordell, Annika Asplund, Marie Rehnström, Susanna Jacobsson, Gustav Holmgren, Lindsay Davidson, Gabriella Brolén, Josefina Edsbagge, Petter Björquist, Barbara Küppers-Munther & Tommy B. Andersson. (2013) Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells. Biochemical Pharmacology 86:5, pages 691-702.
Crossref
Crossref
Mitchell R. McGill & Hartmut Jaeschke. (2013) Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research 30:9, pages 2174-2187.
Crossref
Crossref
Yasuhiro Ishihara. (2013) Enhancement of Quinone Hepatotoxicity by Cytochrome P450 InhibitionチトクロムP450阻害によるキノン肝毒性の亢進. YAKUGAKU ZASSHI 133:8, pages 873-878.
Crossref
Crossref
Patricio Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E. P. Goldring, María José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M. Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak-Ublick, Edward L. LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A. Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiss, Agata Widera, Courtney G. Woods, Jinghai James Xu, Kathy M. Yarborough & Jan G. Hengstler. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology 87:8, pages 1315-1530.
Crossref
Crossref
Marina Blazquez, Aitor Carretero, James K. EllisToby J. AthersuchRachel Cavill, Timothy M. D. EbbelsHector C. KeunJosé V. Castell, Agustín Lahoz & Roque Bort. (2013) A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein β (C/EBPβ), Hepatocyte Nuclear Factor 4α (HNF4α), and Constitutive Androstane Receptor (CAR). Journal of Proteome Research 12:6, pages 2732-2741.
Crossref
Crossref
Nicola J. Hewitt, Robert J. Edwards, Ellen Fritsche, Carsten Goebel, Pierre Aeby, Julia Scheel, Kerstin Reisinger, Gladys Ouédraogo, Daniel Duche, Joan Eilstein, Alain Latil, Julia Kenny, Claire Moore, Jochen Kuehnl, Joao Barroso, Rolf Fautz & Stefan Pfuhler. (2013) Use of Human In Vitro Skin Models for Accurate and Ethical Risk Assessment: Metabolic Considerations. Toxicological Sciences 133:2, pages 209-217.
Crossref
Crossref
Tatyana Y. Doktorova, Reha Yildirimman, Mathieu Vinken, Mireia Vilardell, Tamara Vanhaecke, Hans Gmuender, Roque Bort, Gabriella Brolen, Gustav Holmgren, Ruoya Li, Christophe Chesne, Joost van Delft, Jos Kleinjans, Jose Castell, Petter Bjorquist, Ralf Herwig & Vera Rogiers. (2013) Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models. Carcinogenesis 34:6, pages 1393-1402.
Crossref
Crossref
Agustín Lahoz, Maya R. Vilà, Myriam Fabre, Josep M. Miquel, Manuel Rivas, Jessica Maines, José V. Castell & M. José Gómez-Lechón. (2013) An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors. Toxicology in Vitro 27:4, pages 1410-1415.
Crossref
Crossref
Yuuki Nishida & Akiyoshi Taniguchi. (2013) Induction of albumin expression in HepG2 cells using immobilized simplified recombinant fibronectin protein. In Vitro Cellular & Developmental Biology - Animal 49:6, pages 400-407.
Crossref
Crossref
Laia Tolosa, M. José Gómez-Lechón, Gabriela Pérez-Cataldo, José V. Castell & M. Teresa Donato. (2013) HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved. Archives of Toxicology 87:6, pages 1115-1127.
Crossref
Crossref
Yoshimi Korenori, Shunsuke Tanigawa, Takuma Kumamoto, Si Qin, Yosuke Daikoku, Koji Miyamori, Masashi Nagai & De-Xing Hou. (2013)
Modulation of Nrf2/Keap1 system by Wasabi 6-methylthiohexyl isothiocyanate in ARE-mediated
NQO1
expression
. Molecular Nutrition & Food Research 57:5, pages 854-864.
Crossref
Crossref
Gengbei Shi & Robin N. Coger. (2013) Use of perfluorocarbons to enhance the performance of perfused three‐dimensional hepatic cultures. Biotechnology Progress 29:3, pages 718-726.
Crossref
Crossref
J. Fraczek, J. Bolleyn, T. Vanhaecke, V. Rogiers & M. Vinken. (2012) Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies. Archives of Toxicology 87:4, pages 577-610.
Crossref
Crossref
Han Hui CheongJeyakumar MasilamaniChun Yong Eric ChanSui Yung ChanToan Thang Phan. (2013) Metabolically Functional Hepatocyte-Like Cells from Human Umbilical Cord Lining Epithelial Cells. ASSAY and Drug Development Technologies 11:2, pages 130-138.
Crossref
Crossref
M Jin, A Ande, A Kumar & S Kumar. (2013) Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Cell Death & Disease 4:3, pages e554-e554.
Crossref
Crossref
Britt Wassmur, Johanna Gräns, Elisabeth Norström, Margareta Wallin & Malin C. Celander. (2013) Interactions of pharmaceuticals and other xenobiotics on key detoxification mechanisms and cytoskeleton in Poeciliopsis lucida hepatocellular carcinoma, PLHC-1 cell line. Toxicology in Vitro 27:1, pages 111-120.
Crossref
Crossref
Kazuo Takayama, Kenji Kawabata, Yasuhito Nagamoto, Keisuke Kishimoto, Katsuhisa Tashiro, Fuminori Sakurai, Masashi Tachibana, Katsuhiro Kanda, Takao Hayakawa, Miho Kusuda Furue & Hiroyuki Mizuguchi. (2013) 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. Biomaterials 34:7, pages 1781-1789.
Crossref
Crossref
Ji Ling, Jamie Lewis, Donna Douglas, Norman M. Kneteman & Dennis E. Vance. (2013) Characterization of lipid and lipoprotein metabolism in primary human hepatocytes. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1831:2, pages 387-397.
Crossref
Crossref
N. C. Talbot, T. J. Caperna & W. M. Garrett. (2013) GROWTH AND DEVELOPMENT SYMPOSIUM: Development, characterization, and use of a porcine epiblast-derived liver stem cell line: ARS-PICM-1912. Journal of Animal Science 91:1, pages 66-77.
Crossref
Crossref
Catharina Ellerström, Raimund Strehl & Johan Hyllner. 2013. Pluripotent Stem Cells. Pluripotent Stem Cells
239
251
.
Laia Tolosa, M. Teresa Donato, Gabriela Pérez-Cataldo, José Vicente Castell & M. José Gómez-Lechón. (2012) Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment. Toxicology in Vitro 26:8, pages 1272-1277.
Crossref
Crossref
Stefan A. Hoffmann, Ursula Müller‐Vieira, Klaus Biemel, Daniel Knobeloch, Sandra Heydel, Marc Lübberstedt, Andreas K. Nüssler, Tommy B. Andersson, Jörg C. Gerlach & Katrin Zeilinger. (2012) Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies. Biotechnology and Bioengineering 109:12, pages 3172-3181.
Crossref
Crossref
Malin Darnell, Maria Ulvestad, Ewa Ellis, Lars Weidolf & Tommy B. Andersson. (2012) In Vitro Evaluation of Major In Vivo Drug Metabolic Pathways Using Primary Human Hepatocytes and HepaRG Cells in Suspension and a Dynamic Three-Dimensional Bioreactor System. Journal of Pharmacology and Experimental Therapeutics 343:1, pages 134-144.
Crossref
Crossref
Maria Ulvestad, Malin Darnell, Espen Molden, Ewa Ellis, Anders Åsberg & Tommy B. Andersson. (2012) Evaluation of Organic Anion-Transporting Polypeptide 1B1 and CYP3A4 Activities in Primary Human Hepatocytes and HepaRG Cells Cultured in a Dynamic Three-Dimensional Bioreactor System. Journal of Pharmacology and Experimental Therapeutics 343:1, pages 145-156.
Crossref
Crossref
Anusha Ande, Ravinder Earla, Mengyao Jin, Peter S. Silverstein, Ashim K. Mitra, Anil Kumar & Santosh Kumar. (2012) An LC–MS/MS method for concurrent determination of nicotine metabolites and the role of CYP2A6 in nicotine metabolite-mediated oxidative stress in SVGA astrocytes. Drug and Alcohol Dependence 125:1-2, pages 49-59.
Crossref
Crossref
Joanna Edyta Fraczek, Mathieu Vinken, Dirk Tourwé, Tamara Vanhaecke & Vera Rogiers. (2011) Synergetic effects of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes. Investigational New Drugs 30:4, pages 1715-1724.
Crossref
Crossref
Martin Sauer, Cristof Haubner, Thomas Mencke, Gabriele Nöldge-Schomburg, Steffen Mitzner, Jens Altrichter & Jan Stange. (2012) Impaired cell functions of hepatocytes incubated with plasma of septic patients. Inflammation Research 61:6, pages 609-616.
Crossref
Crossref
Laia Tolosa, Sandra Pinto, M. Teresa Donato, Agustín Lahoz, José V. Castell, J. Enrique O’Connor & M. José Gómez-Lechón. (2012) Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs. Toxicological Sciences 127:1, pages 187-198.
Crossref
Crossref
David HayHumphrey Hodgson, Amy Thomas & Clare Selden. 2012. Regenerative Medicine, Stem Cells and the Liver. Regenerative Medicine, Stem Cells and the Liver
98
114
.
Si Qin, Jihua Chen, Shunsuke Tanigawa & De-Xing Hou. (2012) Gene expression profiling and pathway network analysis of hepatic metabolic enzymes targeted by baicalein. Journal of Ethnopharmacology 140:1, pages 131-140.
Crossref
Crossref
Timothy A. MoellerSunita J. ShuklaMenghang Xia. (2012) Assessment of Compound Hepatotoxicity Using Human Plateable Cryopreserved Hepatocytes in a 1536-Well-Plate Format. ASSAY and Drug Development Technologies 10:1, pages 78-87.
Crossref
Crossref
Danielle K. Sevior, Olavi Pelkonen & Jorma T. Ahokas. (2012) Hepatocytes: The powerhouse of biotransformation. The International Journal of Biochemistry & Cell Biology 44:2, pages 257-261.
Crossref
Crossref
Hiroyuki Tsuchiya, Tamihide Matsunaga, Kaori Aikawa, Noboru Kamada, Katsunori Nakamura, Hinako Ichikawa, Katsunori Sasaki & Shigeru Ohmori. (2012) Evaluation of Human Embryonic Stem Cell-derived Hepatocyte-like Cells for Detection of CYP1A Inducers. Drug Metabolism and Pharmacokinetics 27:6, pages 598-604.
Crossref
Crossref
Kaoru Kobayashi, Akane Yoshida, Yoko Ejiri, Sachiko Takagi, Hanaka Mimura, Masaya Hosoda, Tomokazu Matsuura & Kan Chiba. (2012) Increased Expression of Drug-metabolizing Enzymes in Human Hepatocarcinoma FLC-4 Cells Cultured on Micro-space Cell Culture Plates. Drug Metabolism and Pharmacokinetics 27:5, pages 478-485.
Crossref
Crossref
Yasuhiro Ishihara, Kaori Tsuji, Satomi Ishii, Kyoko Kashiwagi & Norio Shimamoto. (2012) Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells. Biological and Pharmaceutical Bulletin 35:4, pages 634-638.
Crossref
Crossref
Adisak Wongkajornsilp, Khanit Sa-ngiamsuntorn & Suradej Hongeng. 2012. Liver Stem Cells. Liver Stem Cells
73
87
.
Antonino Sgroi, Gang Mai, Philippe Morel, Reto M. Baertschiger, Carmen Gonelle-Gispert, Véronique Serre-Beinier & Leo H. Buhler. (2011) Transplantation of Encapsulated Hepatocytes during Acute Liver Failure Improves Survival without Stimulating Native Liver Regeneration. Cell Transplantation 20:11-12, pages 1791-1803.
Crossref
Crossref
Douglas M. Frederick, Erina Y. Jacinto, Niti N. Patel, Thomas H. Rushmore, Ruy Tchao & Peter J. Harvison. (2011) Cytotoxicity of 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT) and analogues in wild type and CYP3A4 stably transfected HepG2 cells. Toxicology in Vitro 25:8, pages 2113-2119.
Crossref
Crossref
Paul M. van Midwoud, Marjolijn T. Merema, Elisabeth Verpoorte & Geny M.M. Groothuis. (2011) Microfluidics Enables Small-Scale Tissue-Based Drug Metabolism Studies with Scarce Human Tissue. JALA: Journal of the Association for Laboratory Automation 16:6, pages 468-476.
Crossref
Crossref
Caroline Castera-Ducros, Nadine Azas, Pierre Verhaeghe, Sébastien Hutter, Philippe Garrigue, Aurélien Dumètre, Litaty Mbatchi, Michèle Laget, Vincent Remusat, France Sifredi, Sylvain Rault, Pascal Rathelot & Patrice Vanelle. (2011) Targeting the human malaria parasite Plasmodium falciparum: In vitro identification of a new antiplasmodial hit in 4-phenoxy-2-trichloromethylquinazoline series. European Journal of Medicinal Chemistry 46:9, pages 4184-4191.
Crossref
Crossref
Malin Darnell, Thomas Schreiter, Katrin Zeilinger, Thomas Urbaniak, Therese Söderdahl, Ingrid Rossberg, Birgitta Dillnér, Anna-Lena Berg, Jörg C. Gerlach & Tommy B. Andersson. (2011) Cytochrome P450-Dependent Metabolism in HepaRG Cells Cultured in a Dynamic Three-Dimensional Bioreactor. Drug Metabolism and Disposition 39:7, pages 1131-1138.
Crossref
Crossref
Yosuke Nakao, Hiroshi Kimura, Yasuyuki Sakai & Teruo Fujii. (2011) Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device. Biomicrofluidics 5:2.
Crossref
Crossref
Atsushi Iwamura, Tatsuki Fukami, Hiroko Hosomi, Miki Nakajima & Tsuyoshi Yokoi. (2011) CYP2C9-Mediated Metabolic Activation of Losartan Detected by a Highly Sensitive Cell-Based Screening Assay. Drug Metabolism and Disposition 39:5, pages 838-846.
Crossref
Crossref
Peter Sartipy & Petter Björquist. (2011) Concise Review: Human Pluripotent Stem Cell-Based Models for Cardiac and Hepatic Toxicity Assessment. Stem Cells 29:5, pages 744-748.
Crossref
Crossref
CHUKWUEMEKA ANENE-NZELU, YAN WANG, HANRY YU & LEO HWA LIANG. (2011) LIVER TISSUE MODEL FOR DRUG TOXICITY SCREENING. Journal of Mechanics in Medicine and Biology 11:02, pages 369-390.
Crossref
Crossref
Mitchell R. McGill, Hui-Min Yan, Anup Ramachandran, Gordon J. Murray, Douglas E. Rollins & Hartmut Jaeschke. (2011) HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity. Hepatology 53:3, pages 974-982.
Crossref
Crossref
Paul M. van Midwoud, Elisabeth Verpoorte & Geny M. M. Groothuis. (2011) Microfluidic devices for in vitro studies on liver drug metabolism and toxicity. Integrative Biology 3:5, pages 509.
Crossref
Crossref
L. Le Hegarat, J. Dumont, R. Josse, S. Huet, R. Lanceleur, A. Mourot, J.-M. Poul, C. Guguen-Guillouzo, A. Guillouzo & V. Fessard. (2010) Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays. Mutagenesis 25:6, pages 555-560.
Crossref
Crossref
Neil C. Talbot, Le Ann Blomberg, Wesley M. Garrett & Thomas J. Caperna. (2010) Feeder-independent continuous culture of the PICM-19 pig liver stem cell line. In Vitro Cellular & Developmental Biology - Animal 46:9, pages 746-757.
Crossref
Crossref
M. Teresa Donato, David Hallifax, Laura Picazo, José V. Castell, J. Brian Houston, M. José Gomez-Lechón & Agustin Lahoz. (2010) Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo. Drug Metabolism and Disposition 38:9, pages 1449-1455.
Crossref
Crossref
Carlos J. Alméciga‐Díaz, Adriana M. Montaño, Shunji Tomatsu & Luis A. Barrera. (2010) Adeno‐associated virus gene transfer in Morquio A disease – effect of promoters and sulfatase‐modifying factor 1. The FEBS Journal 277:17, pages 3608-3619.
Crossref
Crossref
Melissa A. Baxter, Cliff Rowe, Jane Alder, Sean Harrison, Karen Piper Hanley, B. Kevin Park, Neil R. Kitteringham, Chris E. Goldring & Neil A. Hanley. (2010) Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening. Stem Cell Research 5:1, pages 4-22.
Crossref
Crossref
Displaying 200 of 295 citing articles. Use the download link below to view the full list of citing articles.
Download full citations list