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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 6
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Research Article

Functional characterization of three human cytochrome P450 2E1 variants with amino acid substitutions

N. Hanioka Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
,
T. Tanaka-Kagawa Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
,
Y. Miyata Department of Pharmaceutical Fundamental Science, Kyoritsu College of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan
,
E. Matsushima Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
,
Y. Makino Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
,
A. Ohno Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
,
R. Yoda Department of Pharmaceutical Fundamental Science, Kyoritsu College of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan
,
H. Jinno Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
&
M. Ando Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
 show all
Pages 575-586 | Published online: 22 Sep 2008

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Yoshiya Yamamura, Noriyuki Koyama & Ken Umehara. (2015) Comprehensive kinetic analysis and influence of reaction components for chlorzoxazone 6-hydroxylation in human liver microsomes with CYP antibodies. Xenobiotica 45:4, pages 353-360.
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Benoit Roig, Wissem Mnif, Aziza Ibn Hadj Hassine, Ines Zidi, Sandrine Bayle, Aghleb Bartegi & Olivier Thomas. (2013) Endocrine Disrupting Chemicals and Human Health Risk Assessment: A Critical Review. Critical Reviews in Environmental Science and Technology 43:21, pages 2297-2351.
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Pat Neafsey, Gary Ginsberg, Dale Hattis, Douglas O. Johns, Kathryn Z. Guyton & Babasaheb Sonawane. (2009) Genetic Polymorphism in CYP2E1: Population Distribution of CYP2E1 Activity. Journal of Toxicology and Environmental Health, Part B 12:5-6, pages 362-388.
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Gary Ginsberg, Susan Smolenski, Patricia Neafsey, Dale Hattis, Katy Walker, Kathryn Z. Guyton, Douglas O. Johns & Babasaheb Sonawane. (2009) The Influence of Genetic Polymorphisms on Population Variability in Six Xenobiotic-Metabolizing Enzymes. Journal of Toxicology and Environmental Health, Part B 12:5-6, pages 307-333.
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Grover P Miller. (2008) Advances in the interpretation and prediction of CYP2E1 metabolism from a biochemical perspective. Expert Opinion on Drug Metabolism & Toxicology 4:8, pages 1053-1064.
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Y. Guo, Y. Wang, D. Si, P. J. Fawcett, D. Zhong & H. Zhou. (2005) Catalytic activities of human cytochrome P450 2C9*1, 2C9*3 and 2C9*13. Xenobiotica 35:9, pages 853-861.
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Ting Wang, Huihui Du, Jingsong Ma, Lu Shen, Muyun Wei, Xianglong Zhao, Luan Chen, Mo Li, Guorong Li, Qinghe Xing, Lin He & Shengying Qin. (2020) Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese. PeerJ 8, pages e9628.
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Huihui Du, Zhiyun Wei, Yucai Yan, Yuyu Xiong, Xiaoqing Zhang, Lu Shen, Yunfeng Ruan, Xi Wu, Qingqing Xu, Lin He & Shengying Qin. (2016) Functional Characterization of Human CYP2C9 Allelic Variants in COS-7 Cells. Frontiers in Pharmacology 7.
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Avanthika Venkatachalam, Abhinav Parashar & Kelath Murali Manoj. (2016) Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme ‘active site’ pocket plays a relatively ‘passive role’ in some enzyme-substrate interactions. In Silico Pharmacology 4:1.
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F. Peter Guengerich. 2015. Cytochrome P450. Cytochrome P450 523 785 .
Martin Otto Behm. 2013. Pediatric Drug Development. Pediatric Drug Development 292 305 .
Ran Huo, Kefu Tang, Zhiyun Wei, Lu Shen, Yuyu Xiong, Xi Wu, Jiamin Niu, Xia Han, Zhengan Tian, Lun Yang, Guoyin Feng, Lin He & Shengying Qin. (2012) Genetic Polymorphisms in CYP2E1: Association with Schizophrenia Susceptibility and Risperidone Response in the Chinese Han Population. PLoS ONE 7:5, pages e34809.
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Vita Dolžan. 2012. Pharmacogenetics and Individualized Therapy. Pharmacogenetics and Individualized Therapy 13 80 .
Johannes N. van den Anker, Matthias Schwab & Gregory L. Kearns. 2011. Pediatric Clinical Pharmacology. Pediatric Clinical Pharmacology 51 75 .
Matthew Pratt-Hyatt, Hsia-lien Lin & Paul F. Hollenberg. (2010) Mechanism-Based Inactivation of Human CYP2E1 by Diethyldithocarbamate. Drug Metabolism and Disposition 38:12, pages 2286-2292.
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Nobumitsu Hanioka, Maki Yamamoto, Toshiko Tanaka-Kagawa, Hideto Jinno & Shizuo Narimatsu. (2009) Functional characterization of human cytochrome P450 2E1 allelic variants: in vitro metabolism of benzene and toluene by recombinant enzymes expressed in yeast cells. Archives of Toxicology 84:5, pages 363-371.
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C. Viaggi, F. Vaglini, C. Pardini, A. Caramelli & G.U. Corsini. (2009) MPTP-induced model of Parkinson's disease in cytochrome P450 2E1knockout mice. Neuropharmacology 56:8, pages 1075-1081.
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Nur Duale, Thomas Bjellaas, Jan Alexander, Georg Becher, Margaretha Haugen, Jan Erik Paulsen, Henrik Frandsen, Pelle Thonning Olesen & Gunnar Brunborg. (2009) Biomarkers of Human Exposure to Acrylamide and Relation to Polymorphisms in Metabolizing Genes. Toxicological Sciences 108:1, pages 90-99.
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Nobumitsu Hanioka, Maki Yamamoto, Hiroyuki Iwabu, Hideto Jinno, Toshiko Tanaka-Kagawa, Shinsaku Naito, Takefumi Shimizu, Kazufumi Masuda, Takashi Katsu & Shizuo Narimatsu. (2007) Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes. Life Sciences 81:19-20, pages 1436-1445.
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Ryan SwinneyStephanie HsuGail Tomlinson. (2023) Phase I and Phase II Enzyme Polymorphisms and Childhood Cancer. Journal of Investigative Medicine 54:6, pages 303-320.
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Yeomin Yoon, Hyung-Doo Park, Kyoung Un Park, Jin Q. Kim, Yoon-Seok Chang & Junghan Song. (2006) Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. European Journal of Clinical Pharmacology 62:8, pages 627-631.
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Yingjie Guo, Yifan Zhang, Ying Wang, Xiaoyan Chen, Dayong Si, Dafang Zhong, J. Paul Fawcett & Hui Zhou. (2005) ROLE OF CYP2C9 AND ITS VARIANTS (CYP2C9 * 3 AND CYP2C9 * 13) IN THE METABOLISM OF LORNOXICAM IN HUMANS . Drug Metabolism and Disposition 33:6, pages 749-753.
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Hiroyuki Hichiya, Toshiko Tanaka-Kagawa, Akiko Soyama, Hideto Jinno, Satoru Koyano, Noriko Katori, Erika Matsushima, Shigehisa Uchiyama, Hiroshi Tokunaga, Hideo Kimura, Narihiro Minami, Masaaki Katoh, Kenji Sugai, Yu-ichi Goto, Tomohide Tamura, Noboru Yamamoto, Yuichiro Ohe, Hideo Kunitoh, Hiroshi Nokihara, Teruhiko Yoshida, Hironobu Minami, Nagahiro Saijo, Masanori Ando, Shogo Ozawa, Yoshiro Saito & Jun-ichi Sawada. (2005) FUNCTIONAL CHARACTERIZATION OF FIVE NOVEL CYP2C8 VARIANTS, G171S, R186X, R186G, K247R, AND K383N, FOUND IN A JAPANESE POPULATION. Drug Metabolism and Disposition 33:5, pages 630-636.
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Silvio Bandiera, Simone Weidlich, Volker Harth, Peter Broede, Yun Ko & Thomas Friedberg. (2005) Proteasomal Degradation of Human CYP1B1: Effect of the Asn453Ser Polymorphism on the Post-Translational Regulation of CYP1B1 Expression. Molecular Pharmacology 67:2, pages 435-443.
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