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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 6
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Research Article

Interaction with indinavir to enhance systemic exposure of an investigational HIV protease inhibitor in rats, dogs and monkeys

L. Jin Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
,
I.-W. Chen Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
,
M. Chiba Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
&
J. H. Lin Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
Pages 643-654 | Published online: 22 Sep 2008

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Suresh Katragadda, Balasubrahmanyam Budda, Banmeet S Anand & Ashim K Mitra. (2005) Role of efflux pumps and metabolising enzymes in drug delivery. Expert Opinion on Drug Delivery 2:4, pages 683-705.
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Articles from other publishers (5)

Shayne Cox GadAlexander V. Lyubimov & Ihor Bekersky. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Cuyue Tang, Yuhsin Kuo, Nicole T. Pudvah, Joan D. Ellis, Maria S. Michener, Melissa Egbertson, Samuel L. Graham, Jacquelynn J. Cook, Jerome H. Hochman & Thomayant Prueksaritanont. (2009) Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys. Biochemical Pharmacology 78:6, pages 642-647.
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Cuyue Tang, Brian A. Carr, Frédéric Poignant, Bennett Ma, Stacey L. Polsky-Fisher, Yuhsin Kuo, Kristie Strong-Basalyga, Alisha Norcross, Karen Richards, Roy Eisenhandler, Edward J. Carlini, Christina Ng Di Marco, Scott D. Kuduk, Nathan X. Yu, Conrad E. Raab, Tom Rushmore, Clay B. Frederick, Mark G. Bock & Thomayant Prueksaritanont. (2008) CYP2C75-Involved Autoinduction of Metabolism in Rhesus Monkeys of Methyl 3-Chloro-3′-fluoro-4′-{(1 R )-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1′-biphenyl-2-carboxylate (MK-0686), a Bradykinin B 1 Receptor Antagonist . Journal of Pharmacology and Experimental Therapeutics 325:3, pages 935-946.
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Cuyue Tang, Yulin Fang, Catherine Booth-Genthe, Yuhsin Kuo, Scott D. Kuduk, Tom H. Rushmore & Brian A. Carr. (2007) Diclofenac hydroxylation in monkeys: Efficiency, regioselectivity, and response to inhibitors. Biochemical Pharmacology 73:6, pages 880-890.
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Hai-Zhi Bu, William F. Pool, Ellen Y. Wu, Susan R. Raber, Michael A. Amantea & Bhasker V. Shetty. (2004) METABOLISM AND EXCRETION OF CAPRAVIRINE, A NEW NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR, ALONE AND IN COMBINATION WITH RITONAVIR IN HEALTHY VOLUNTEERS. Drug Metabolism and Disposition 32:7, pages 689-698.
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