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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 6
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Research Article

Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome P4501A2

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Pages 603-613 | Published online: 22 Sep 2008

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Yuan Shi, Wenlong Zhang, Meiting Jiang, Lijun Huang, Yangxu Zhou, Jiayu Chen, Duo Liu, Gaofeng Liu & Mei Dong. (2020) Effects of sulfotanshinone sodium injection on the pharmacokinetics and pharmacodynamics of warfarin in rats in vivo. Xenobiotica 50:6, pages 705-712.
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D. Chen, X.-X. Lin, W.-H. Huang, W. Zhang, Z.-R. Tan, J.-B. Peng, Y.-C. Wang, Y. Guo, D.-L. Hu & Y. Chen. (2016) Sodium tanshinone IIA sulfonate and its interactions with human CYP450s. Xenobiotica 46:12, pages 1085-1092.
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Y. Chen, J.-H. Tu, Y.-J. He, W. Zhang, G. Wang, Z.-R. Tan, G. Zhou, L. Fan & H.-H. Zhou. (2009) Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers. Xenobiotica 39:7, pages 508-513.
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H.-X. Liu, Y. Hu, Y. Liu, Y.-Q. He, W. Li & L. Yang. (2009) Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6. Xenobiotica 39:5, pages 382-390.
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Articles from other publishers (35)

Ying Liu, Yu Chen, Jingyu Zhang, Guangyun Ran, Zihao Cheng, Xin Wang, Yufen Liao, Xu Mao, Ying Peng, Weiwei Li & Jiang Zheng. (2024) Dihydrotanshinone I–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism. Drug Metabolism and Disposition 52:3, pages 188-197.
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Ziru Dai, Yue Wu, Yuan Xiong, Jingjing Wu, Min Wang, Xiao Sun, Xinxin Ding, Ling Yang, Xiaobo Sun & Guangbo Ge. (2023) CYP1A inhibitors: Recent progress, current challenges, and future perspectives. Medicinal Research Reviews 44:1, pages 169-234.
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Fei Chang, Zhong Bing He & Quan Zhou. (2019) Solid-Phase Preparation of Al-TiO 2 for Efficient Separation of Bioderived Product Danshensu . Journal of Chemistry 2019, pages 1-7.
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Gabriele D'Uva, Denisa Baci, Adriana Albini & Douglas M. Noonan. (2018) Cancer chemoprevention revisited: Cytochrome P450 family 1B1 as a target in the tumor and the microenvironment. Cancer Treatment Reviews 63, pages 1-18.
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Nan Wu, Wei-Cong Ma, Sheng-Jun Mao, Yong Wu & Hui Jin. (2017) Total Synthesis of Tanshinone I. Journal of Natural Products 80:5, pages 1697-1700.
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Feng Chen, Li Li & Dan-Dan Tian. (2017) Salvia miltiorrhiza Roots against Cardiovascular Disease: Consideration of Herb-Drug Interactions . BioMed Research International 2017, pages 1-12.
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Dong-sheng Ouyang, Wei-hua Huang, Dan Chen, Wei Zhang, Zhi-rong Tan, Jing-bo Peng, Yi-cheng Wang, Ying Guo, Dong-li Hu, Jian Xiao & Yao Chen. (2016) Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro. Chinese Medicine 11:1.
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Yanqiao Zang, Ying Dai, Guanhua Du & Mei Gao. 2015. Dan Shen (Salvia miltiorrhiza) in Medicine. Dan Shen (Salvia miltiorrhiza) in Medicine 191 211 .
Guanhua Du & Juntian Zhang. 2015. Dan Shen (Salvia miltiorrhiza) in Medicine. Dan Shen (Salvia miltiorrhiza) in Medicine 3 17 .
Beikang Ge, Zhen Zhang & Zhong Zuo. (2014) Updates on the Clinical Evidenced Herb-Warfarin Interactions. Evidence-Based Complementary and Alternative Medicine 2014, pages 1-18.
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Jiawang Liu, Jayalakshmi Sridhar & Maryam Foroozesh. (2013) Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships. Molecules 18:12, pages 14470-14495.
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John H. K. Yeung. 2013. Evidence and Rational Based Research on Chinese Drugs. Evidence and Rational Based Research on Chinese Drugs 237 282 .
Yan-Hui Zhang, You-Jin Zhang, Yan-Lei Guo, Wen-Juan Li & Chao Yu. (2013) Astragaloside IV inhibited the activity of CYP1A2 in liver microsomes and influenced theophylline pharmacokinetics in rats. Journal of Pharmacy and Pharmacology 65:1, pages 149-155.
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Xuelin Zhou, Yan Wang, Penelope M.Y. Or, David C.C. Wan, Yiu Wa Kwan & John H.K. Yeung. (2012) Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes. Phytomedicine 19:7, pages 648-657.
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Wayne Y.W. Lee, Xuelin Zhou, Penelope M.Y. Or, Yiu Wa Kwan & John H.K. Yeung. (2012) Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes. Phytomedicine 19:2, pages 169-176.
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Si Gao, Zhiping Liu, Hong Li, Peter J. Little, Peiqing Liu & Suowen Xu. (2012) Cardiovascular actions and therapeutic potential of tanshinone IIA. Atherosclerosis 220:1, pages 3-10.
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Qing-Lan Wang, Quoc Wu, Yan-Yan Tao, Cheng-Hai Liu & Hani El-Nezami. (2011) Salvianolic acid B modulates the expression of drug-metabolizing enzymes in HepG2 cells. Hepatobiliary & Pancreatic Diseases International 10:5, pages 502-508.
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Xin Wang & John H.K. Yeung. (2011) Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship. Fitoterapia 82:4, pages 539-545.
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Rong Zhang, Jianguo Sun, Liping Ma, Xiaolan Wu, Guoyu Pan, Haiping Hao, Fang Zhou, Jiye A, Changhui Liu, Hua Ai, Lili Shang, Haiyan Gao, Ying Peng, Ping Wan, Hui Wu & Guangji Wang. (2011) Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line. Toxicology and Applied Pharmacology 252:1, pages 18-27.
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Xin Wang, Ching Mei Cheung, Wayne Y.W. Lee, Penelope M.Y. Or & John H.K. Yeung. (2010) Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro. Phytomedicine 17:11, pages 868-875.
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Xin Wang & John H K Yeung. (2010) Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats . Journal of Pharmacy and Pharmacology 62:8, pages 1077-1083.
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X. Wang, W.Y.W. Lee, P.M.Y. Or & J.H.K. Yeung. (2010) Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat. Phytomedicine 17:3-4, pages 203-211.
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Windy W.P. Wu & John H.K. Yeung. (2010) Inhibition of warfarin hydroxylation by major tanshinones of Danshen (Salvia miltiorrhiza) in the rat in vitro and in vivo. Phytomedicine 17:3-4, pages 219-226.
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Xin Wang, Wayne Y.W. Lee, Penelope M.Y. Or & John H.K. Yeung. (2009) Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates. Phytomedicine 16:8, pages 712-725.
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Furong Qiu, Rong Zhang, Jianguo Sun, Jiye A, Haiping Hao, Ying Peng, Hua Ai & Guangji Wang. (2008) Inhibitory Effects of Seven Components of Danshen Extract on Catalytic Activity of Cytochrome P450 Enzyme in Human Liver Microsomes. Drug Metabolism and Disposition 36:7, pages 1308-1314.
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Furong Qiu, Guangji Wang, Yanan Zhao, Hua Sun, Guoguang Mao, Jiyi A & Jian Sun. (2007) Effect of danshen extract on pharmacokinetics of theophylline in healthy volunteers. British Journal of Clinical Pharmacology 65:2, pages 270-274.
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Jing-Yan Han, Jing-Yu Fan, Yoshinori Horie, Soichiro Miura, De-Hua Cui, Hiromasa Ishii, Toshifumi Hibi, Hiroshi Tsuneki & Ikuko Kimura. (2008) Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacology & Therapeutics 117:2, pages 280-295.
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Fan He, Hui‐chang Bi, Zhi‐yong Xie, Zhong Zuo, Jian‐kang Li, Xin Li, Li‐zi Zhao, Xiao Chen & Min Huang. (2007) Rapid determination of six metabolites from multiple cytochrome P450 probe substrates in human liver microsome by liquid chromatography/mass spectrometry: application to high‐throughput inhibition screening of terpenoids. Rapid Communications in Mass Spectrometry 21:5, pages 635-643.
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Xihong Wang, Susan L. Morris‐Natschke & Kuo‐Hsiung Lee. (2006) New developments in the chemistry and biology of the bioactive constituents of tanshen. Medicinal Research Reviews 27:1, pages 133-148.
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Peng Li, Guang‐Ji Wang, Jing Li, Hai‐Ping Hao & Chao‐Nan Zheng. (2006) Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/tandem mass spectrometry. Journal of Mass Spectrometry 41:5, pages 670-684.
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Peng Li, Guang‐Ji Wang, Jing Li, Hai‐Ping Hao & Chao‐Nan Zheng. (2006) Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 20:5, pages 815-822.
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Peng Li, Guang-Ji Wang, Jing Li, Hai-Ping Hao & Chao-Nan Zheng. (2006) Identification of tanshinone IIA metabolites in rat liver microsomes by liquid chromatography–tandem mass spectrometry. Journal of Chromatography A 1104:1-2, pages 366-369.
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Dan Yuan, Ying-ni Pan, Wen-wei Fu, Toshiaki Makino & Yoshihiro Kano. (2005) Quantitative Analysis of the Marker Compounds in Salvia miltiorrihiza Root and Its Phytomedicinal Preparations. Chemical and Pharmaceutical Bulletin 53:5, pages 508-514.
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Jie-Young Song, Medea Akhalaia, Alexander Platonov, Hyung-Doo Kim, In-Sung Jung, Young-Soo Han & Yeon-Sook Yun. (2004) Effects of polysaccharide ginsan fromPanax ginseng on liver function. Archives of Pharmacal Research 27:5.
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C.K. Wong, P.S. Tse, E.L.Y. Wong, P.C. Leung, K.P. Fung & C.W.K. Lam. (2004) Immunomodulatory effects of Yun Zhi and Danshen capsules in health subjects—a randomized, double-blind, placebo-controlled, crossover study. International Immunopharmacology 4:2, pages 201-211.
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