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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 2
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Research Article

CYP2C subfamily, primarily CYP2C9, catalyses the enantioselective demethylation of the endocrine disruptor pesticide methoxychlor in human liver microsomes: use of inhibitory monoclonal antibodies in P450 identification

Y. Hu Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USACorrespondence[email protected]
,
K. Krausz Laboratory of Molecular Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA
,
H. V. Gelboin Laboratory of Molecular Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA
&
D. Kupfer Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Pages 117-132 | Received 28 Jul 2003, Published online: 22 Sep 2008

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James R. Reed & Wayne L. Backes. (2016) The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes. Drug Metabolism Reviews 48:3, pages 453-469.
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Bernard Testa. (2015) Types of stereoselectivity in drug metabolism: a heuristic approach. Drug Metabolism Reviews 47:2, pages 239-251.
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Shangara S. Dehal. (2006) David Kupfer, Ph.D. A Mentor and a Scientist. Drug Metabolism Reviews 38:1-2, pages 13-22.
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David M. Stresser. (2006) David Kupfer: A Career Retrospective. Drug Metabolism Reviews 38:1-2, pages 3-12.
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K. Ohyama, S. Maki, K. Sato & Y. Kato. (2005) Comparative in vitro metabolism of methoxychlor in male and female rats: Metabolism of demethylated methoxychlor metabolites by precision-cut rat liver slices. Xenobiotica 35:7, pages 683-695.
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K. Ohyama, S. Maki, K. Sato & Y. Kato. (2005) Comparative in vitro metabolism of the suspected pro-oestrogenic compound, methoxychlor in precision-cut liver slices from male and female rats. Xenobiotica 35:4, pages 331-342.
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Articles from other publishers (16)

Michael N. Clifford, Asimina Kerimi & Gary Williamson. (2020) Bioavailability and metabolism of chlorogenic acids (acyl‐quinic acids) in humans. Comprehensive Reviews in Food Science and Food Safety 19:4, pages 1299-1352.
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K.K. Wolf & M.F. Paine. 2018. Comprehensive Toxicology. Comprehensive Toxicology 74 98 .
E. Hodgson & S.A. Meyer. 2018. Comprehensive Toxicology. Comprehensive Toxicology 538 574 .
Sylvie E. Kandel & Jed N. Lampe. (2014) Role of Protein–Protein Interactions in Cytochrome P450-Mediated Drug Metabolism and Toxicity. Chemical Research in Toxicology 27:9, pages 1474-1486.
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Cesar Kenaan, Erin V. Shea, Hsia-lien Lin, Haoming Zhang, Matthew J. Pratt-Hyatt & Paul F. Hollenberg. (2013) Interactions between CYP2E1 and CYP2B4: Effects on Affinity for NADPH-Cytochrome P450 Reductase and Substrate Metabolism. Drug Metabolism and Disposition 41:1, pages 101-110.
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Alexander V. LyubimovKristopher W. Krausz & Harry V. Gelboin. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 20 .
Poulomi Bhattacharya & Aileen F. Keating. (2012) Impact of environmental exposures on ovarian function and role of xenobiotic metabolism during ovotoxicity. Toxicology and Applied Pharmacology 261:3, pages 227-235.
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Andrew G Smith. 2012. Mammalian Toxicology of Insecticides. Mammalian Toxicology of Insecticides 37 103 .
Jean-Pierre Cravedi & Daniel Zalko. 2011. Hormone-Disruptive Chemical Contaminants in Food. Hormone-Disruptive Chemical Contaminants in Food 93 114 .
Erin C. Peck & David L. Eaton. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 525 549 .
K.K. Wolf, M.F. Paine & P.B. Watkins. 2010. Comprehensive Toxicology. Comprehensive Toxicology 53 75 .
Leah D. Stuchal, Kevin M. Kleinow, John J. Stegeman & Margaret O. James. (2006) DEMETHYLATION OF THE PESTICIDE METHOXYCHLOR IN LIVER AND INTESTINE FROM UNTREATED, METHOXYCHLOR-TREATED, AND 3-METHYLCHOLANTHRENE-TREATED CHANNEL CATFISH ( ICTALURUS PUNCTATUS ): EVIDENCE FOR ROLES OF CYP1 AND CYP3A FAMILY ISOZYMES . Drug Metabolism and Disposition 34:6, pages 932-938.
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Mary F. Paine, Heather L. Hart, Shana S. Ludington, Robert L. Haining, Allan E. Rettie & Darryl C. Zeldin. (2006) THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”. Drug Metabolism and Disposition 34:5, pages 880-886.
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Harry V. Gelboin & Kristopher Krausz. (2006) Monoclonal Antibodies and Multifunctional Cytochrome P450: Drug Metabolism as Paradigm. The Journal of Clinical Pharmacology 46:3, pages 353-372.
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Arun K. Agrawal, Cornelis E.C.A. Hop, Jianmei Pang, Maria V. Silva Elipe, Ranjit C. Desai, Kwan H. Leung & Ronald B. Franklin. (2005) In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes. Journal of Pharmaceutical and Biomedical Analysis 37:2, pages 351-358.
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Eszter Hazai & David Kupfer. (2005) INTERACTIONS BETWEEN CYP2C9 AND CYP2C19 IN RECONSTITUTED BINARY SYSTEMS INFLUENCE THEIR CATALYTIC ACTIVITY: POSSIBLE RATIONALE FOR THE INABILITY OF CYP2C19 TO CATALYZE METHOXYCHLOR DEMETHYLATION IN HUMAN LIVER MICROSOMES. Drug Metabolism and Disposition 33:1, pages 157-164.
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