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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 8
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Research Article

Metabolic and structural viability of precision-cut rat lung slices in culture

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Pages 771-780 | Received 27 May 2004, Published online: 22 Sep 2008

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Read on this site (5)

Jean-Paul Morin, Jean-Marc Baste, Arnaud Gay, Clément Crochemore, Cécile Corbière & Christelle Monteil. (2013) Precision cut lung slices as an efficient tool for in vitro lung physio-pharmacotoxicology studies. Xenobiotica 43:1, pages 63-72.
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I. M. Westra, B. T. Pham, G. M. M. Groothuis & P. Olinga. (2013) Evaluation of fibrosis in precision-cut tissue slices. Xenobiotica 43:1, pages 98-112.
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Teresa A Liberati, Michelle R Randle & Linda A Toth. (2010) In vitro lung slices: a powerful approach for assessment of lung pathophysiology. Expert Review of Molecular Diagnostics 10:4, pages 501-508.
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Inge AM de Graaf, Geny MM Groothuis & Peter Olinga. (2007) Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 879-898.
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Articles from other publishers (23)

Kolene E. Bailey, Christopher Pino, Mallory L. Lennon, Anne Lyons, Jeffrey G. Jacot, Steven R. Lammers, Melanie Königshoff & Chelsea M. Magin. (2020) Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports Extended Ex Vivo Culture . American Journal of Respiratory Cell and Molecular Biology 62:1, pages 14-22.
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Maria Elisa Giuliani, Erica Sparaventi, Ilaria Lanzoni, Lucia Pittura, Francesco Regoli & Stefania Gorbi. (2019) Precision-Cut Tissue Slices (PCTS) from the digestive gland of the Mediterranean mussel Mytilus galloprovincialis: An ex vivo approach for molecular and cellular responses in marine invertebrates. Toxicology in Vitro 61, pages 104603.
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F. Oesch, E. Fabian & Robert Landsiedel. (2019) Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models. Archives of Toxicology 93:12, pages 3419-3489.
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Yildiz Yilmaz, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl & Gian Camenisch. (2019) Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS). Drug Metabolism Letters 13:1, pages 53-63.
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Vanessa Neuhaus, Dirk Schaudien, Tatiana Golovina, Ulla-Angela Temann, Carolann Thompson, Torsten Lippmann, Claus Bersch, Olaf Pfennig, Danny Jonigk, Peter Braubach, Hans-Gerd Fieguth, Gregor Warnecke, Vidadi Yusibov, Katherina Sewald & Armin Braun. (2017) Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality. Journal of Occupational Medicine and Toxicology 12:1.
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Pilar Carranza-Rosales, Irma Edith Carranza-Torres, Nancy Elena Guzmán-Delgado, Gerardo Lozano-Garza, Licet Villarreal-Treviño, Carmen Molina-Torres, Javier Vargas Villarreal, Lucio Vera-Cabrera & Jorge Castro-Garza. (2017) Modeling tuberculosis pathogenesis through ex vivo lung tissue infection. Tuberculosis 107, pages 126-132.
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Tinne C.J. Mertens, Harry Karmouty-Quintana, Christian Taube & Pieter S. Hiemstra. (2017) Use of airway epithelial cell culture to unravel the pathogenesis and study treatment in obstructive airway diseases. Pulmonary Pharmacology & Therapeutics 45, pages 101-113.
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Esther Y Cheah, Tracy S Mann, Philip C Burcham & Peter J Henry. (2017) Functional characterisation and application of an ex vivo perfusion-superfusion system in murine airways. Journal of Pharmacological and Toxicological Methods 84, pages 66-77.
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L. Lauenstein, S. Switalla, F. Prenzler, S. Seehase, O. Pfennig, C. Förster, H. Fieguth, A. Braun & K. Sewald. (2014) Assessment of immunotoxicity induced by chemicals in human precision-cut lung slices (PCLS). Toxicology in Vitro 28:4, pages 588-599.
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Elizabeth R. Jacobs, Sreedhar Bodiga, Irshad Ali, Aaron M. Falck, John R. Falck, Meetha Medhora & Anuradha Dhanasekaran. (2012) Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices. Experimental Cell Research 318:16, pages 2143-2152.
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Ahmad Faizal Abdull Razis, Renato Iori & Costas Ioannides. (2010) The natural chemopreventive phytochemical R ‐sulforaphane is a far more potent inducer of the carcinogen‐detoxifying enzyme systems in rat liver and lung than the S ‐isomer . International Journal of Cancer 128:12, pages 2775-2782.
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Ahmad Faizal Abdull Razis, Manuela Bagatta, Gina Rosalinda De Nicola, Renato Iori & Costas Ioannides. (2011) Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin. Lung Cancer 71:3, pages 298-305.
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Christian Ginzkey, Gudrun Friehs, Christian Koehler, Stephan Hackenberg, Hans-Ullrich Voelker, Elmar Richter & Norbert H. Kleinsasser. (2010) Nicotine and methyl methane sulfonate in mini organ cultures of human parotid gland tissue. Toxicology Letters 197:2, pages 69-74.
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Elmar Richter, Johannes Engl, Susanne Friesenegger & Anthony R. Tricker. (2009) Biotransformation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in Lung Tissue from Mouse, Rat, Hamster, and Man. Chemical Research in Toxicology 22:6, pages 1008-1017.
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Natalya Hanlon, Nick Coldham, Maurice J. Sauer & Costas Ioannides. (2009) Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane. Chemico-Biological Interactions 177:2, pages 115-120.
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M. Henjakovic, K. Sewald, S. Switalla, D. Kaiser, M. Müller, T.Z. Veres, C. Martin, S. Uhlig, N. Krug & A. Braun. (2008) Ex vivo testing of immune responses in precision-cut lung slices. Toxicology and Applied Pharmacology 231:1, pages 68-76.
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D. S. Pushparajah, M. Umachandran, K. E. Plant, N. Plant & C. Ioannides. (2008) Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; comparison with rat liver and lung. Mutagenesis 23:4, pages 299-308.
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Daphnee S. Pushparajah, Meera Umachandran, Kathryn E. Plant, Nick Plant & Costas Ioannides. (2008) Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: Studies using precision-cut tissue slices. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 640:1-2, pages 153-161.
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Daphnee S. Pushparajah, Meera Umachandran, Tariq Nazir, Kathryn E. Plant, Nick Plant, David F.V. Lewis & Costas Ioannides. (2008) Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size. Toxicology in Vitro 22:1, pages 128-145.
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Meera Umachandran & Costas Ioannides. (2007) Interactions between polycyclic aromatic hydrocarbons in precision-cut rat lung slices. Toxicology 240:3, pages 164-165.
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Daphnee S. Pushparajah, Meera Umachandran, Kathryn E. Plant, Nick Plant & Costas Ioannides. (2007) Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities. Toxicology 231:1, pages 68-80.
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Meera Umachandran & Costas Ioannides. (2006) Stability of cytochromes P450 and phase II conjugation systems in precision-cut rat lung slices cultured up to 72h. Toxicology 224:1-2, pages 14-21.
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Pilar Prieto, Alan W. Baird, Bas J. Blaauboer, Jose Vicente Castell Ripoll, Raffaella Corvi, Wolfgang Dekant, Paul Dietl, Alessandra Gennari, Laura Gribaldo, Julian L. Griffin, Thomas Hartung, Jerry J. Heindel, Peter Hoet, Paul Jennings, Luciana Marocchio, Jens Noraberg, Patricia Pazos, Carl Westmoreland, Armin Wolf, Jayne Wright & Walter Pfaller. (2019) The Assessment of Repeated Dose Toxicity In Vitro : A Proposed Approach . Alternatives to Laboratory Animals 34:3, pages 315-341.
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