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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 8
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Research Article

Disposition of CP-671, 305, a selective phosphodiesterase 4 inhibitor in preclinical species

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Pages 755-770 | Received 04 May 2004, Accepted 09 Aug 2004, Published online: 22 Sep 2008

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Read on this site (4)

Wito Richter, Frank S. Menniti, Han-Ting Zhang & Marco Conti. (2013) PDE4 as a target for cognition enhancement. Expert Opinion on Therapeutic Targets 17:9, pages 1011-1027.
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Kam YJ Zhang, Prabha N Ibrahim, Sam Gillette & Gideon Bollag. (2005) Phosphodiesterase-4 as a potential drug target. Expert Opinion on Therapeutic Targets 9:6, pages 1283-1305.
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Joshua O Odingo. (2005) Inhibitors of PDE4: a review of recent patent literature. Expert Opinion on Therapeutic Patents 15:7, pages 773-787.
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Amit S Kalgutkar & John R Soglia. (2005) Minimising the potential for metabolic activation in drug discovery. Expert Opinion on Drug Metabolism & Toxicology 1:1, pages 91-142.
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Articles from other publishers (13)

Isabelle Karine da Costa Nunes, Everton Tenório de Souza, Italo Rossi Roseno Martins, Gisele Barbosa, Manoel Oliveira de Moraes Junior, Millena de Melo Medeiros, Sheyla Welma Duarte Silva, Tatiane Luciano Balliano, Bagnólia Araújo da Silva, Patrícia Machado Rodrigues Silva, Vinicius de Frias Carvalho, Marco Aurélio Martins & Lidia Moreira Lima. (2020) Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. European Journal of Medicinal Chemistry 204, pages 112492.
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David J. Titus, Nicole M. Wilson, Oscar Alcazar, Dale A. Calixte, W. Dalton Dietrich, Mark E. Gurney & Coleen M. Atkins. (2018) A negative allosteric modulator of PDE4D enhances learning after traumatic brain injury. Neurobiology of Learning and Memory 148, pages 38-49.
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Etzer Darout, Elnaz Menhaji‐Klotz & Thomas A. Chappie. 2014. Phosphodiesterases and Their Inhibitors. Phosphodiesterases and Their Inhibitors 45 64 .
David Fox3rd3rd, Alex B. Burgin & Mark E. Gurney. (2014) Structural basis for the design of selective phosphodiesterase 4B inhibitors. Cellular Signalling 26:3, pages 657-663.
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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach & Dennis A. Smith. 2012. Reactive Drug Metabolites. Reactive Drug Metabolites 335 355 .
Suvi T. M. Orr, Sharon L. Ripp, T. Eric Ballard, Jaclyn L. Henderson, Dennis O. Scott, R. Scott Obach, Hao Sun & Amit S. Kalgutkar. (2012) Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks. Journal of Medicinal Chemistry 55:11, pages 4896-4933.
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Amit S. Kalgutkar. (2011) Handling reactive metabolite positives in drug discovery: What has retrospective structure–toxicity analyses taught us?. Chemico-Biological Interactions 192:1-2, pages 46-55.
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Sharron H. Francis, Miles D. Houslay & Marco Conti. 2011. Phosphodiesterases as Drug Targets. Phosphodiesterases as Drug Targets 47 84 .
Mark E. Flanagan, Todd A. Blumenkopf, William H. Brissette, Matthew F. Brown, Jeffrey M. Casavant, Chang Shang-Poa, Jonathan L. Doty, Eileen A. Elliott, Michael B. Fisher, Michael Hines, Craig Kent, Elizabeth M. Kudlacz, Brett M. Lillie, Kelly S. Magnuson, Sandra P. McCurdy, Michael J. Munchhof, Bret D. Perry, Perry S. Sawyer, Timothy J. Strelevitz, Chakrapani Subramanyam, Jianmin Sun, David A. Whipple & Paul S. Changelian. (2010) Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection. Journal of Medicinal Chemistry 53:24, pages 8468-8484.
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Amit S. Kalgutkar, Bo Feng, Hang T. Nguyen, Kosea S. Frederick, Scott D. Campbell, Heather L. Hatch, Yi-An Bi, Diana C. Kazolias, Ralph E. Davidson, Rouchelle J. Mireles, David B. Duignan, Edna F. Choo & Sabrina X. Zhao. (2007) Role of Transporters in the Disposition of the Selective Phosphodiesterase-4 Inhibitor (+)-2-[4-({[2-(Benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic Acid in Rat and Human. Drug Metabolism and Disposition 35:11, pages 2111-2118.
Crossref
Kam Zhang. 2006. Cyclic Nucleotide Phosphodiesterases in Health and Disease. Cyclic Nucleotide Phosphodiesterases in Health and Disease.
George Muller & Jeffrey Mckenna. 2006. Cyclic Nucleotide Phosphodiesterases in Health and Disease. Cyclic Nucleotide Phosphodiesterases in Health and Disease.
Frank S. Menniti, W. Stephen Faraci & Christopher J. Schmidt. (2006) Phosphodiesterases in the CNS: targets for drug development. Nature Reviews Drug Discovery 5:8, pages 660-670.
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