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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 1
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Research Article

Plant polyphenols and multidrug resistance: Effects of dietary flavonoids on drug transporters in Caco-2 and MDCKII-MDR1 cell transport models

R. Rodriguez-Proteau Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; Environmental Health Science Center, Oregon State University, Corvallis, OR, USA
,
J. E. Mata Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR, USA
,
C. L. Miranda Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA
,
Y. Fan Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR, USA
,
J. J. Brown Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR, USA
&
D. R. Buhler Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; Environmental Health Science Center, Oregon State University, Corvallis, OR, USA
Pages 41-58 | Received 20 Jun 2005, Published online: 22 Sep 2008

Citations (19)

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Read on this site (2)

J.-S. Taur & R. Rodriguez-Proteau. (2008) Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models. Xenobiotica 38:12, pages 1536-1550.
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Y. Fan & R. Rodriguez-Proteau. (2008) Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models. Xenobiotica 38:2, pages 107-129.
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Articles from other publishers (17)

Joshua Silva, Sheraz Khoja, Liana Asatryan, Eunjoo Pacifici & Daryl L. Davies. (2020) A novel pharmacotherapy approach using P-glycoprotein (PGP/ABCB1) efflux inhibitor combined with ivermectin to reduce alcohol drinking and preference in mice. Alcohol 86, pages 1-8.
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Yulin Wang, Yongjie Li, Dong Shang & Thomas Efferth. (2019) Interactions between artemisinin derivatives and P-glycoprotein. Phytomedicine 60, pages 152998.
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Hanmei Li, Sonja Krstin & Michael Wink. (2018) Modulation of multidrug resistant in cancer cells by EGCG, tannic acid and curcumin. Phytomedicine 50, pages 213-222.
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Nevena Kardum & Maria Glibetic. 2018. 103 144 .
Sugapriya Dhanasekaran & Ravindran Jaganathan. 2018. 213 244 .
Ming Liu, Poul Hansen, Genzhu Wang, Lin Qiu, Jianjun Dong, Hua Yin, Zhonghua Qian, Mei Yang & Jinlai Miao. (2015) Pharmacological Profile of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus). Molecules 20:1, pages 754-779.
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Ilaria Peluso, Husseen Manafikhi, Raffaella Reggi & Maura Palmery. (2014) Interference of flavonoids with fluorescent intracellular probes: Methodological implications in the evaluation of the oxidative burst by flow cytometry. Cytometry Part A 85:8, pages 663-677.
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Priya Batra & Anil K. Sharma. (2013) Anti-cancer potential of flavonoids: recent trends and future perspectives. 3 Biotech 3:6, pages 439-459.
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Kazunori Iwanaga, Manami Hayashi, Yukimi Hamahata, Makoto Miyazaki, Makio Shibano, Masahiko Taniguchi, Kimiye Baba & Masawo Kakemi. (2010) Furanocoumarin Derivatives in Kampo Extract Medicines Inhibit Cytochrome P450 3A4 and P-Glycoprotein. Drug Metabolism and Disposition 38:8, pages 1286-1294.
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Elisabetta Chieli, Nadia Romiti, Idania Rodeiro & Gabino Garrido. (2010) In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica. Chemico-Biological Interactions 186:3, pages 287-294.
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Ko Cattoor, Marc Bracke, Dieter Deforce, Denis De Keukeleire & Arne Heyerick. (2010) Transport of Hop Bitter Acids across Intestinal Caco-2 Cell Monolayers. Journal of Agricultural and Food Chemistry 58:7, pages 4132-4140.
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Meriem Nait Chabane, Abraham Al Ahmad, Jean Peluso, Christian D Muller & Geneviève Ubeaud-Séquier. (2009) Quercetin and naringenin transport across human intestinal Caco-2 cells. Journal of Pharmacy and Pharmacology 61:11, pages 1473-1483.
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Janja Plazar, Metka Filipič & Geny M.M. Groothuis. (2008) Antigenotoxic effect of Xanthohumol in rat liver slices. Toxicology in Vitro 22:2, pages 318-327.
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Melinda von Borstel Smith, Kristi Crofoot, Rosita Rodriguez-Proteau & Theresa M. Filtz. (2007) Effects of phenytoin and carbamazepine on calcium transport in Caco-2 cells. Toxicology in Vitro 21:5, pages 855-862.
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Yan Pang, Dejan Nikolic, Dongwei Zhu, Lucas R. Chadwick, Guido F. Pauli, Norman R. Farnsworth & Richard B. van Breemen. (2007) Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells. Molecular Nutrition & Food Research 51:7, pages 872-879.
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Sheetal Agarwal, Ritesh Jain, Dhananjay Pal & Ashim K. Mitra. (2007) Functional characterization of peptide transporters in MDCKII–MDR1 cell line as a model for oral absorption studies. International Journal of Pharmaceutics 332:1-2, pages 147-152.
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Walter Brand, Maaike E. Schutte, Gary Williamson, Jelmer J. van Zanden, Nicole H.P. Cnubben, John P. Groten, Peter J. van Bladeren & Ivonne M.C.M. Rietjens. (2006) Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients. Biomedicine & Pharmacotherapy 60:9, pages 508-519.
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