Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 4
578
Views
32
CrossRef citations to date
0
Altmetric
Research Article

Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5

, &
Pages 287-299 | Received 13 Sep 2006, Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Dennis Rokitta, Kay Pfeiffer, Christina Streich, Henrik Gerwin & Uwe Fuhr. (2013) The effect of organic solvents on enzyme kinetic parameters of human CYP3A4 and CYP1A2 in vitro. Toxicology Mechanisms and Methods 23:8, pages 576-583.
Read now
Helen E. Cubitt, Karen R. Yeo, Eleanor M. Howgate, Amin Rostami-Hodjegan & Zoe E. Barter. (2011) Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model. Xenobiotica 41:8, pages 623-638.
Read now
David J. Greenblatt, Karthik Venkatakrishnan, Jerold S. Harmatz, Sarah J. Parent & Lisa L. von Moltke. (2010) Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro. Xenobiotica 40:10, pages 713-720.
Read now
C. Woodland, T. T. Huang, E. Gryz, R. Bendayan & J. P. Fawcett. (2008) Expression, Activity and Regulation of CYP3A in Human and Rodent Brain. Drug Metabolism Reviews 40:1, pages 149-168.
Read now
Yi-Tong Liu, Hai-Ping Hao, Chang-Xiao Liu, Guang-Ji Wang & Hong-Guang Xie. (2007) Drugs as CYP3A Probes, Inducers, and Inhibitors. Drug Metabolism Reviews 39:4, pages 699-721.
Read now

Articles from other publishers (27)

Ya-Lin Huang, Cristian De Gregorio, Verónica Silva, Álvaro A. Elorza, Patricio Léniz, Víctor Aliaga-Tobar, Vinicius Maracaja-Coutinho, Mauricio Budini, Fernando Ezquer & Marcelo Ezquer. (2023) Administration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen. Cells 12:4, pages 636.
Crossref
Said El Rhabori, Abdellah El Aissouq, Samir Chtita & Fouad Khalil. (2022) Design of novel quinoline derivatives as antibreast cancer using 3D-QSAR, molecular docking and pharmacokinetic investigation. Anti-Cancer Drugs 33:9, pages 789-802.
Crossref
Said El Rhabori, Abdellah El Aissouq, Samir Chtita & Fouad Khalil. (2022) 3D-QSAR, molecular docking and ADMET studies of thioquinazolinone derivatives against breast cancer. Journal of the Indian Chemical Society 99:10, pages 100675.
Crossref
Houcemeddine Othman, Jorge E. B. da Rocha & Scott Hazelhurst. (2021) Single Nucleotide Polymorphism Induces Divergent Dynamic Patterns in CYP3A5: A Microsecond Scale Biomolecular Simulation of Variants Identified in Sub-Saharan African Populations. International Journal of Molecular Sciences 22:15, pages 7786.
Crossref
Sara N. Salerno, Andrea Edginton, Jacqueline G. Gerhart, Matthew M. Laughon, Namasivayam Ambalavanan, Gregory M. Sokol, Chi D. Hornik, Dan Stewart, Mary Mills, Karen Martz & Daniel Gonzalez. (2020) Physiologically‐Based Pharmacokinetic Modeling Characterizes the CYP3A‐Mediated Drug‐Drug Interaction Between Fluconazole and Sildenafil in Infants. Clinical Pharmacology & Therapeutics 109:1, pages 253-262.
Crossref
William C. Wright, Jude Chenge & Taosheng Chen. (2019) Structural perspectives of the CYP3A family and their small molecule modulators in drug metabolism. Liver Research 3:3-4, pages 132-142.
Crossref
Amanda L. Cirello, Jennifer L. Dumouchel, Mithat Gunduz, Christine E. Dunne & Upendra A. Argikar. (2017) In vitro ocular metabolism and bioactivation of ketoconazole in rat, rabbit and human. Drug Metabolism and Pharmacokinetics 32:2, pages 121-126.
Crossref
Wenpeng Zhang, Yanyan Li, Peng Zou, Man Wu, Zhenqing Zhang & Tao Zhang. (2016) The Effects of Pharmaceutical Excipients on Gastrointestinal Tract Metabolic Enzymes and Transporters—an Update. The AAPS Journal 18:4, pages 830-843.
Crossref
Michael A. Zientek & Kuresh Youdim. (2015) Reaction Phenotyping: Advances in the Experimental Strategies Used to Characterize the Contribution of Drug-Metabolizing Enzymes. Drug Metabolism and Disposition 43:1, pages 163-181.
Crossref
Rüdiger Kaspera, Brian J. Kirby, Tariku Sahele, Ann C. Collier, Evan D. Kharasch, Jashvant D. Unadkat & Rheem A. Totah. (2014) Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo. Biochemical Pharmacology 91:1, pages 109-118.
Crossref
Xiaohai Li, Valer Jeso, Scott Heyward, Gregory S. Walker, Raman Sharma, Glenn C. Micalizio & Michael D. Cameron. (2014) Characterization of T-5 N -Oxide Formation as the First Highly Selective Measure of CYP3A5 Activity . Drug Metabolism and Disposition 42:3, pages 334-342.
Crossref
Ashish Dhir, Dorota Zolkowska & Michael A. Rogawski. (2013) Seizure protection by intrapulmonary delivery of midazolam in mice. Neuropharmacology 73, pages 425-431.
Crossref
Philip MartinMarco GiardielloTom O. McDonaldSteven P. RannardAndrew Owen. (2013) Mediation of in Vitro Cytochrome P450 Activity by Common Pharmaceutical Excipients. Molecular Pharmaceutics 10:7, pages 2739-2748.
Crossref
Alexander V. LyubimovHiroshi Komura & Masahiro Iwaki. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 41 .
Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen & Michael A. Zientek. (2012) Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs. Drug Metabolism and Disposition 40:9, pages 1686-1697.
Crossref
K. Rowland Yeo, R.L. Walsky, M. Jamei, A. Rostami-Hodjegan & G.T. Tucker. (2011) Prediction of time-dependent CYP3A4 drug–drug interactions by physiologically based pharmacokinetic modelling: Impact of inactivation parameters and enzyme turnover. European Journal of Pharmaceutical Sciences 43:3, pages 160-173.
Crossref
Siamak Cyrus Khojasteh, Saileta Prabhu, Jane R. Kenny, Jason S. Halladay & Anthony Y. H. Lu. (2011) Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity. European Journal of Drug Metabolism and Pharmacokinetics 36:1, pages 1-16.
Crossref
Ophelia Q. P. Yin, Brian Tomlinson & Moses S. S. Chow. (2013) CYP3A5 but Not CYP2D6 Polymorphism Contributes Significantly to the Variability in Dextropropoxyphene Disposition. The Journal of Clinical Pharmacology 50:10, pages 1136-1141.
Crossref
Jane R. Kenny, Dermot F. McGinnity, Ken Grime & Robert J. Riley. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 38 .
Toshiro Niwa, Norie Murayama & Hiroshi Yamazaki. (2010) Comparison of the Contributions of Cytochromes P450 3A4 and 3A5 in Drug Oxidation Rates and Substrate Inhibition. Journal of Health Science 56:3, pages 239-256.
Crossref
NJ Liptrott, M Penny, PG Bray, J Sathish, SH Khoo, DJ Back & A Owen. (2009) The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC. British Journal of Pharmacology 156:3, pages 497-508.
Crossref
Hege Christensen, Liv Mathiesen, Lillian W. Postvoll, Bjørn Winther & Espen Molden. (2009) Different Enzyme Kinetics of Midazolam in Recombinant CYP3A4 Microsomes from Human and Insect Sources. Drug Metabolism and Pharmacokinetics 24:3, pages 261-268.
Crossref
Christopher Kohl. 2008. Drug Bioavailability. Drug Bioavailability 333 357 .
Olavi Pelkonen, Miia Turpeinen, Jukka Hakkola, Paavo Honkakoski, Janne Hukkanen & Hannu Raunio. (2008) Inhibition and induction of human cytochrome P450 enzymes: current status. Archives of Toxicology 82:10, pages 667-715.
Crossref
Laurie P. Volak, Senait Ghirmai, John R. Cashman & Michael H. Court. (2008) Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor. Drug Metabolism and Disposition 36:8, pages 1594-1605.
Crossref
Kristina E. Estes, Kristin H. Busse & Scott R. Penzak. (2016) Pharmacogenetic Considerations in the Management of HIV Infection. Journal of Pharmacy Practice 20:3, pages 234-245.
Crossref
Nick Plant. (2007) The human cytochrome P450 sub-family: Transcriptional regulation, inter-individual variation and interaction networks. Biochimica et Biophysica Acta (BBA) - General Subjects 1770:3, pages 478-488.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.