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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 9
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Original

Metabolism of N-substituted 7-methoxy-4-(aminomethyl) -coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction points

P. H. J. Keizers Department of Pharmacochemistry, Division of Molecular Toxicology, Leiden Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands
,
B. R. Van Dijk Department of Pharmacochemistry, Division of Molecular Toxicology, Leiden Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands
,
C. De Graaf Department of Pharmacochemistry, Division of Molecular Toxicology, Leiden Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands
,
B. M. A. Van Vugt-Lussenburg Department of Pharmacochemistry, Division of Molecular Toxicology, Leiden Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands
,
N. P. E. Vermeulen Department of Pharmacochemistry, Division of Molecular Toxicology, Leiden Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands
&
J. N. M. Commandeur Department of Pharmacochemistry, Division of Molecular Toxicology, Leiden Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The NetherlandsCorrespondence[email protected]
Pages 763-771 | Received 18 Feb 2006, Accepted 21 Apr 2006, Published online: 11 Aug 2009

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Bo Wang, Li-Ping Yang, Xiao-Zhuang Zhang, Shui-Qing Huang, Mark Bartlam & Shu-Feng Zhou. (2009) New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. Drug Metabolism Reviews 41:4, pages 573-643.
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Articles from other publishers (5)

Amelia Nathania Dong, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy & Chin Eng Ong. (2023) Interactions of coumarin and amine ligands with six cytochrome P450 2D6 allelic variants: Molecular docking. Computational Toxicology 27, pages 100284.
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Barbara M. A. van Vugt-Lussenburg, Liliana Capinha, Jelle Reinen, Martijn Rooseboom, Michel Kranendonk, Rob C. A. Onderwater & Paul Jennings. (2022) “ Commandeuring ” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism . Chemical Research in Toxicology 35:7, pages 1184-1201.
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Amelia Nathania Dong, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy, Beow Chin Yiap & Chin Eng Ong. (2022) Role of P34S, G169R, R296C, and S486T Substitutions in Ligand Access and Catalysis for Cytochrome P450 2D6 Allelic Variants CYP2D6*14A and CYP2D6*14B. Drug Metabolism and Bioanalysis Letters 15:1, pages 51-63.
Crossref
John T. Rodgers, Nadezhda Y. Davydova, Erickson M. Paragas, Jeffrey P. Jones & Dmitri R. Davydov. (2018) Kinetic mechanism of time-dependent inhibition of CYP2D6 by 3,4-methylenedioxymethamphetamine (MDMA): Functional heterogeneity of the enzyme and the reversibility of its inactivation. Biochemical Pharmacology 156, pages 86-98.
Crossref
Shufeng Zhou. 2016. Cytochrome P450 2D6. Cytochrome P450 2D6 341 414 .

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