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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 2
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Research Article

Induction of cytochrome P450 enzymes in rat liver by two conazoles, myclobutanil and triadimefon

G. Sun National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle ParkNC, USA
,
R. D. Grindstaff National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle ParkNC, USA
,
S.-F. Thai National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle ParkNC, USA
,
G. R. Lambert National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle ParkNC, USA
,
D. B. Tully National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle ParkNC, USA
,
D. J. Dix National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle ParkNC, USA
&
S. Nesnow National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle ParkNC, USA
 show all
Pages 180-193 | Received 08 Sep 2006, Accepted 12 Oct 2006, Published online: 22 Sep 2008

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Barbara Maino, Simona Paparone, Cinzia Severini, Maria Teresa Ciotti, Velia D’agata, Pietro Calissano & Sebastiano Cavallaro. (2017) Drug target identification at the crossroad of neuronal apoptosis and survival. Expert Opinion on Drug Discovery 12:3, pages 249-259.
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Articles from other publishers (25)

You-ning Ma, Li-hua Sun, Shu-ying Li, Yan-xia Ni, Zhao-yun Cao, Ming-xue Chen & Ren-xiang Mou. (2020) Modulation of steroid metabolism and xenobiotic biotransformation responses in zebrafish (Danio rerio) exposed to triadimefon. Environmental Pollution 262, pages 114145.
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Weiyu Hao, Yanfeng Zhang, Yun Xie, Baoyuan Guo, Jing Chang, Jianzhong Li, Peng Xu & Huili Wang. (2019) Myclobutanil accumulation, transcriptional alteration, and tissue injury in lizards (Eremias argus) treated with myclobutanil enantiomers. Ecotoxicology and Environmental Safety 171, pages 247-255.
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Luyao Zhang, Jinling Diao, Li Chen, Zikang Wang, Wenjun Zhang, Yao Li, Zhongnan Tian & Zhiqiang Zhou. (2019) Hepatotoxicity and reproductive disruption in male lizards (Eremias argus) exposed to glufosinate-ammonium contaminated soil. Environmental Pollution 246, pages 190-197.
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Weiyu Hao, Xiao Hu, Feilong Zhu, Jing Chang, Jitong Li, Wei Li, Huili Wang, Baoyuan Guo, Jianzhong Li, Peng Xu & Yanfeng Zhang. (2018) Enantioselective Distribution, Degradation, and Metabolite Formation of Myclobutanil and Transcriptional Responses of Metabolic-Related Genes in Rats. Environmental Science & Technology 52:15, pages 8830-8837.
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E. Hodgson & S.A. Meyer. 2018. Comprehensive Toxicology. Comprehensive Toxicology 538 574 .
Jitong Li, Yinghuan Wang, Wei Li, Peng Xu, Baoyuan Guo, Jianzhong Li & Huili Wang. (2017) Tissue distribution and metabolism of triadimefon and triadimenol enantiomers in Chinese lizards ( Eremias argus ). Ecotoxicology and Environmental Safety 142, pages 284-292.
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Jitong Li, Jing Chang, Wei Li, Baoyuan Guo, Jianzhong Li & Huili Wang. (2017) Disruption of sex-hormone levels and steroidogenic-related gene expression on Mongolia Racerunner (Eremias argus) after exposure to triadimefon and its enantiomers. Chemosphere 171, pages 554-563.
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Stephen Nesnow. 2016. Toxicogenomics in Predictive Carcinogenicity. Toxicogenomics in Predictive Carcinogenicity 280 351 .
M. Nagai, Y. Konno, M. Satsukawa, S. Yamashita & K. Yoshinari. (2016) Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds. Drug Metabolism and Disposition 44:8, pages 1390-1398.
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T. Heise, F. Schmidt, C. Knebel, S. Rieke, W. Haider, R. Pfeil, C. Kneuer, L. Niemann & P. Marx-Stoelting. (2014) Hepatotoxic effects of (tri)azole fungicides in a broad dose range. Archives of Toxicology 89:11, pages 2105-2117.
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Nathália Orlandini Costa, Milene Leivas Vieira, Vanessa Sgarioni, Marina Rangel F. Pereira, Bruno Garcia Montagnini, Suzana de Fátima Paccola Mesquita & Daniela Cristina Ceccatto Gerardin. (2015) Evaluation of the reproductive toxicity of fungicide propiconazole in male rats. Toxicology 335, pages 55-61.
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Shu Lin Zhuang, Ling Ling Bao, Hai Fei Wang, Min Zhang, Chang Yang, Xin Yi Zhou, Yuan Wu, Kanwal Rehman & Hua Naranmandura. (2015) The Involvement of ER-stress and ROS Generation in Difenoconazole-Induced Hepatocellular Toxicity. Toxicology Research 4:5, pages 1195-1203.
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Chun-Hung Lin, Pei-Hsin Chou & Pei-Jen Chen. (2014) Two azole fungicides (carcinogenic triadimefon and non-carcinogenic myclobutanil) exhibit different hepatic cytochrome P450 activities in medaka fish. Journal of Hazardous Materials 277, pages 150-158.
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Ernest Hodgson. 2012. Pesticide Biotransformation and Disposition. Pesticide Biotransformation and Disposition 149 178 .
Stephen Nesnow, Rachel D. Grindstaff, Guy Lambert, William T. Padgett, Maribel Bruno, Yue Ge, Pei-Jen Chen, Charles E. Wood & Lynea Murphy. (2011) Propiconazole increases reactive oxygen species levels in mouse hepatic cells in culture and in mouse liver by a cytochrome P450 enzyme mediated process. Chemico-Biological Interactions 194:1, pages 79-89.
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Vidya V. Iyer, Meric A. Ovacik, Ioannis P. Androulakis, Charles M. Roth & Marianthi G. Ierapetritou. (2010) Transcriptional and metabolic flux profiling of triadimefon effects on cultured hepatocytes. Toxicology and Applied Pharmacology 248:3, pages 165-177.
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Vidya V. Iyer, Ioannis P. Androulakis, Charles M. Roth & Marianthi G. Ierapetritou. (2010) Effects of Triadimefon on the Metabolism of Cultured Hepatocytes. Effects of Triadimefon on the Metabolism of Cultured Hepatocytes.
Ernest Hodgson. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 941 959 .
E. Hodgson & S.A. Meyer. 2010. Comprehensive Toxicology. Comprehensive Toxicology 475 500 .
Amber K. Goetz & David J. Dix. (2009) Mode of Action for Reproductive and Hepatic Toxicity Inferred from a Genomic Study of Triazole Antifungals. Toxicological Sciences 110:2, pages 449-462.
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Stephen Nesnow, William Ward, Tanya Moore, Hongzu Ren & Susan D. Hester. (2009) Discrimination of Tumorigenic Triazole Conazoles from Phenobarbital by Transcriptional Analyses of Mouse Liver Gene Expression. Toxicological Sciences 110:1, pages 68-83.
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Haishan Li, Tao Chen, John Cottrell & Hongbing Wang. (2009) Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary Hepatocytes. Drug Metabolism and Disposition 37:5, pages 1098-1106.
Crossref
Pei-Jen Chen, William T. Padgett, Tanya Moore, Witold Winnik, Guy R. Lambert, Sheau-Fung Thai, Susan D. Hester & Stephen Nesnow. (2009) Three conazoles increase hepatic microsomal retinoic acid metabolism and decrease mouse hepatic retinoic acid levels in vivo. Toxicology and Applied Pharmacology 234:2, pages 143-155.
Crossref
Susan D. Hester & Stephen Nesnow. (2008) Transcriptional responses in thyroid tissues from rats treated with a tumorigenic and a non-tumorigenic triazole conazole fungicide. Toxicology and Applied Pharmacology 227:3, pages 357-369.
Crossref
Christopher S. Mazur & John F. Kenneke. (2007) Cross-Species Comparison of Conazole Fungicide Metabolites Using Rat and Rainbow Trout (Onchorhynchus mykiss) Hepatic Microsomes and Purified Human CYP 3A4. Environmental Science & Technology 42:3, pages 947-954.
Crossref

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