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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 10
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Research Article

PEGylation of somatropin (recombinant human growth hormone): Impact on its clearance in humans

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Pages 1340-1351 | Received 06 Apr 2008, Accepted 18 Aug 2008, Published online: 16 Oct 2008

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Mohsen Doostmohammadi, Atefeh Ameri, Reza Mohammadinejad, Negar Dehghannoudeh, Ibrahim M Banat, Mandana Ohadi & Gholamreza Dehghannoudeh. (2019) Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications. Drug Design, Development and Therapy 13, pages 3405-3418.
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Javier Sueiras-Diaz, Ying Zhang, Anastasia Velentza, Buyung Santoso & Suijin Yang. (2017) Total chemical synthesis of a biologically active and homogeneous analog of Human Growth Hormone [Nle 14,125,170 ,Glu 29,91 ,Gln 74 ,Asn 107 ,Asp 109 ]hGH-NH 2 by sequential native chemical ligation. Tetrahedron Letters 58:25, pages 2448-2455.
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Victoria L. Elliott, George T. Edge, Marie M. Phelan, Lu-Yun Lian, Rob Webster, Rory F. Finn, B. Kevin Park & Neil R. Kitteringham. (2012) Evidence for Metabolic Cleavage of a PEGylated Protein in Vivo Using Multiple Analytical Methodologies . Molecular Pharmaceutics 9:5, pages 1291-1301.
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Zhi Xin Zhang, Ying Ke Liu, Hui Pan, Lin Pan, Qiong Zhang, Hui Min Su, Qiu Ling Zhao, Hong Li & Chun He. (2012) The effect of polyethylene glycol recombinant human growth hormone on growth and glucose metabolism in hypophysectomized rats. Growth Hormone & IGF Research 22:1, pages 30-35.
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Thomas V. Flintegaard, Peter Thygesen, Henrik Rahbek-Nielsen, Steven B. Levery, Claus Kristensen, Henrik Clausen & Gert Bolt. (2010) N-Glycosylation Increases the Circulatory Half-Life of Human Growth Hormone. Endocrinology 151:11, pages 5326-5336.
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Jianfeng Xu, Shigeru Okada, Li Tan, Kenneth J. Goodrum, John J. Kopchick & Marcia J. Kieliszewski. (2010) Human growth hormone expressed in tobacco cells as an arabinogalactan-protein fusion glycoprotein has a prolonged serum life. Transgenic Research 19:5, pages 849-867.
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