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Simone Esposito, Laura Orsatti & Vincenzo Pucci. (2022) Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations. Xenobiotica 52:8, pages 828-839.
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Jaydeep Yadav, Mehdi El Hassani, Jasleen Sodhi, Volker M. Lauschke, Jessica H. Hartman & Laura E. Russell. (2021) Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data. Drug Metabolism Reviews 53:2, pages 207-233.
Read now
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Keiichi Morita, Motohiro Kato, Toshiyuki Kudo & Kiyomi Ito. (2020) In vitro–in vivo extrapolation of metabolic clearance using human liver microsomes: factors showing variability and their normalization. Xenobiotica 50:9, pages 1064-1075.
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Tetsuo Yamagata, Ugo Zanelli, Dieter Gallemann, Dominique Perrin, Hugues Dolgos & Carl Petersson. (2017) Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set. Xenobiotica 47:9, pages 741-751.
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Rowan A. Stringer, Eckhard Weber, Andrew Culshaw, Jeff McKenna, Gareth Williams, Jonathan Rose & Bindi Sohal. (2014) Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist. Xenobiotica 44:10, pages 902-912.
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C. Desbans, C. Hilgendorf, M. Lutz, P. Bachellier, T. Zacharias, J. C. Weber, H. Dolgos, L. Richert & A.-L. Ungell. (2014) Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors. Xenobiotica 44:1, pages 17-27.
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Anna-Karin Sohlenius-Sternbeck, Christopher Jones, Douglas Ferguson, Brian J. Middleton, Denis Projean, Eva Floby, Johan Bylund & Lovisa Afzelius. (2012) Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes. Xenobiotica 42:9, pages 841-853.
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Joanne A. Foster, J. Brian Houston & David Hallifax. (2011) Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance. Xenobiotica 41:2, pages 124-136.
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Piyun Chao, Annette S Uss & KC Cheng. (2010) Use of intrinsic clearance for prediction of human hepatic clearance. Expert Opinion on Drug Metabolism & Toxicology 6:2, pages 189-198.
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Thierry Lavé, Kathryn Chapman, Paul Goldsmith & Malcolm Rowland. (2009) Human clearance prediction: shifting the paradigm. Expert Opinion on Drug Metabolism & Toxicology 5:9, pages 1039-1048.
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Articles from other publishers (57)
Ewelina Gabor-Worwa, Anna Kowal-Chwast, Nilesh Gaud, Dawid Gogola, Peter Littlewood, Marek Smoluch, Krzysztof Brzózka & Kamil Kus. (2024) Uridine 5′-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro–In Vivo Extrapolation (IVIVE). European Journal of Drug Metabolism and Pharmacokinetics 49:3, pages 393-403.
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Zhengyin Yan, Li Ma, Pasquale Carione, Julie Huang, Nicky Hwang, Jane R. Kenny & Cornelis E.C.A. Hop. (2024) Introducing the Dynamic Well-Stirred Model for Predicting Hepatic Clearance and Extraction Ratio. Journal of Pharmaceutical Sciences 113:4, pages 1094-1112.
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Crossref
Jonghwa Lee, Jessica L. Beers, Raeanne M. Geffert & Klarissa D. Jackson. (2024) A Review of CYP-Mediated Drug Interactions: Mechanisms and In Vitro Drug-Drug Interaction Assessment. Biomolecules 14:1, pages 99.
Crossref
Crossref
Nanna Tynelius, Christoffer Bundgaard & Claudia E. Müller. (2023) Evaluation of a Five-Probe Metabolic Control Cocktail in Long-Term Cocultured Human Hepatocytes. Journal of Pharmaceutical Sciences 112:8, pages 2297-2300.
Crossref
Crossref
Tashinga E. Bapiro, Scott Martin, Stephen D. Wilkinson, Alexandra L. Orton, Niresh Hariparsad, Stephanie Harlfinger & Dermot F. McGinnity. (2023) The Disconnect in Intrinsic Clearance Determined in Human Hepatocytes and Liver Microsomes Results from Divergent Cytochrome P450 Activities. Drug Metabolism and Disposition 51:7, pages 892-901.
Crossref
Crossref
Urban Fagerholm, Sven Hellberg, Jonathan Alvarsson & Ola Spjuth. (2022)
In Silico
Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and a Comparison with Laboratory Methods
. Alternatives to Laboratory Animals 51:1, pages 39-54.
Crossref
Crossref
Urban Fagerholm, Ola Spjuth & Sven Hellberg. (2022) The Impact of Reference Data Selection for the Prediction Accuracy of Intrinsic Hepatic Metabolic Clearance. Journal of Pharmaceutical Sciences 111:9, pages 2645-2649.
Crossref
Crossref
Lena C. Preiss, Volker M. Lauschke, Katrin Georgi & Carl Petersson. (2022) Multi-Well Array Culture of Primary Human Hepatocyte Spheroids for Clearance Extrapolation of Slowly Metabolized Compounds. The AAPS Journal 24:2.
Crossref
Crossref
Sheri Smith, Michael Lyman, Bennett Ma, Donald Tweedie & Karsten Menzel. (2021) Reaction Phenotyping of Low-Turnover Compounds in Long-Term Hepatocyte Cultures Through Persistent Selective Inhibition of Cytochromes P450. Drug Metabolism and Disposition 49:11, pages 995-1002.
Crossref
Crossref
Urban Fagerholm, Sven Hellberg & Ola Spjuth. (2021) Advances in Predictions of Oral Bioavailability of Candidate Drugs in Man with New Machine Learning Methodology. Molecules 26:9, pages 2572.
Crossref
Crossref
Christine Wegler, Pär Matsson, Veronica Krogstad, Jozef Urdzik, Hege Christensen, Tommy B. Andersson & Per Artursson. (2021) Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes. Molecular Pharmaceutics 18:4, pages 1792-1805.
Crossref
Crossref
Andrew M. Brandon, Lysbeth H. Antonides, Jennifer Riley, Ola Epemolu, Denise A. McKeown, Kevin D. Read & Craig McKenzie. (2021) A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market. Molecules 26:5, pages 1396.
Crossref
Crossref
Michel Bteich, Patrick Poulin & Sami Haddad. (2021) Comparative Assessment of Extrapolation Methods Based on the Conventional Free Drug Hypothesis and Plasma Protein-Mediated Hepatic Uptake Theory for the Hepatic Clearance Predictions of Two Drugs Extensively Bound to Both the Albumin And Alpha-1-Acid Glycoprotein. Journal of Pharmaceutical Sciences 110:3, pages 1385-1391.
Crossref
Crossref
Szymon Ulenberg, Mariusz Belka, Paweł Georgiev, Grzegorz Ślifirski, Marek Król, Franciszek Herold & Tomasz Bączek. (2020) The influence of phase II enzymes on in vitro half-life of pirydo[1,2-c]pirymidine derivatives as structural analogues of arylpiperazine. Microchemical Journal 159, pages 105550.
Crossref
Crossref
Luca Docci, Florian Klammers, Aynur Ekiciler, Birgit Molitor, Kenichi Umehara, Isabelle Walter, Stephan Krähenbühl, Neil Parrott & Stephen Fowler. (2020) In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes. The AAPS Journal 22:6.
Crossref
Crossref
Beth Williamson, Stephanie Harlfinger & Dermot F. McGinnity. (2020) Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance. Drug Metabolism and Disposition 48:11, pages 1137-1146.
Crossref
Crossref
Christine M. Bowman & Leslie Z. Benet. (2019) In Vitro–In Vivo Inaccuracy: The CYP3A4 Anomaly. Drug Metabolism and Disposition 47:12, pages 1368-1371.
Crossref
Crossref
Karolina Słoczyńska, Agnieszka Gunia-Krzyżak, Paulina Koczurkiewicz, Katarzyna Wójcik-Pszczoła, Dorota Żelaszczyk, Justyna Popiół & Elżbieta Pękala. (2019) Metabolic stability and its role in the discovery of new chemical entities. Acta Pharmaceutica 69:3, pages 345-361.
Crossref
Crossref
Christine M. Bowman & Leslie Z. Benet. (2019) Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties. Pharmaceutical Research 36:8.
Crossref
Crossref
Christine M. Bowman & Leslie Z. Benet. (2019) In Vitro-In Vivo Extrapolation and Hepatic Clearance-Dependent Underprediction. Journal of Pharmaceutical Sciences 108:7, pages 2500-2504.
Crossref
Crossref
Ryuji Watari, Motoharu KakikiChihiro YamasakiYuji IshidaChise TatenoYukie Kuroda, Seiichi Ishida & Kazutomi Kusano. (2019) Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates <i>via</i> a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice. Biological and Pharmaceutical Bulletin 42:3, pages 348-353.
Crossref
Crossref
Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani & Donald Tweedie. (2019) Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac. Drug Metabolism and Disposition 47:1, pages 58-66.
Crossref
Crossref
Iiro M. A. Kiiski, Tea Pihlaja, Lauri Urvas, Joanna Witos, Susanne K. Wiedmer, Ville P. Jokinen & Tiina M. Sikanen. (2018) Overcoming the Pitfalls of Cytochrome P450 Immobilization through the Use of Fusogenic Liposomes. Advanced Biosystems 3:1.
Crossref
Crossref
Mark A. T. Blaskovich, Karl A. Hansford, Yujing Gong, Mark S. Butler, Craig Muldoon, Johnny X. Huang, Soumya Ramu, Alberto B. Silva, Mu Cheng, Angela M. Kavanagh, Zyta Ziora, Rajaratnam Premraj, Fredrik Lindahl, Tanya A. Bradford, June C. Lee, Tomislav Karoli, Ruby Pelingon, David J. Edwards, Maite Amado, Alysha G. Elliott, Wanida Phetsang, Noor Huda Daud, Johan E. Deecke, Hanna E. Sidjabat, Sefetogi Ramaologa, Johannes Zuegg, Jason R. Betley, Andrew P. G. Beevers, Richard A. G. Smith, Jason A. Roberts, David L. Paterson & Matthew A. Cooper. (2018) Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications 9:1.
Crossref
Crossref
F. L. Wood, J. B. Houston & D. Hallifax. (2017) Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology. Drug Metabolism and Disposition 45:11, pages 1178-1188.
Crossref
Crossref
Souzan B. Yanni. 2015. Translational ADMET for Drug Therapy. Translational ADMET for Drug Therapy
221
240
.
Chelsea M. Hosey, Fabio Broccatelli & Leslie Z. Benet. (2014) Predicting when Biliary Excretion of Parent Drug is a Major Route of Elimination in Humans. The AAPS Journal 16:5, pages 1085-1096.
Crossref
Crossref
L. Song, Q. Du, X. Jiang & L. Wang. (2014)
Effect of
CYP1A2
polymorphism on the pharmacokinetics of agomelatine in Chinese healthy male volunteers
. Journal of Clinical Pharmacy and Therapeutics 39:2, pages 204-209.
Crossref
Crossref
Urban Fagerholm. 2014. Predictive ADMET. Predictive ADMET
89
101
.
Kevin Beaumont, James R. Gosset & Chris E. Keefer. 2014. Predictive ADMET. Predictive ADMET
291
318
.
Patrik Lundquist, Johan Lööf, Anna-Karin Sohlenius-Sternbeck, Eva Floby, Jenny Johansson, Johan Bylund, Janet Hoogstraate, Lovisa Afzelius & Tommy B. Andersson. (2014) The Impact of Solute Carrier (SLC) Drug Uptake Transporter Loss in Human and Rat Cryopreserved Hepatocytes on Clearance Predictions. Drug Metabolism and Disposition 42:3, pages 469-480.
Crossref
Crossref
Seigo Sanoh & Shigeru Ohta. (2013) Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics. Biopharmaceutics & Drug Disposition 35:2, pages 71-86.
Crossref
Crossref
Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani & Donald Tweedie. (2013) Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac. Drug Metabolism and Disposition 41:12, pages 2024-2032.
Crossref
Crossref
Patricio Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E. P. Goldring, María José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M. Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak-Ublick, Edward L. LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A. Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiss, Agata Widera, Courtney G. Woods, Jinghai James Xu, Kathy M. Yarborough & Jan G. Hengstler. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology 87:8, pages 1315-1530.
Crossref
Crossref
Ya-Wen Hsiao, Urban Fagerholm & Ulf Norinder. (2013)
In Silico
Categorization of
in Vivo
Intrinsic Clearance Using Machine Learning
. Molecular Pharmaceutics 10:4, pages 1318-1321.
Crossref
Crossref
Hua Lv, Xiaoping Zhang, Jyoti Sharma, M. V. Ramana Reddy, E. Premkumar Reddy & James M. Gallo. (2012) Integrated Pharmacokinetic-Driven Approach to Screen Candidate Anticancer Drugs for Brain Tumor Chemotherapy. The AAPS Journal 15:1, pages 250-257.
Crossref
Crossref
Yoshihisa Shitara, Kazuya Maeda, Kazuaki Ikejiri, Kenta Yoshida, Toshiharu Horie & Yuichi Sugiyama. (2013) Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption. Biopharmaceutics & Drug Disposition 34:1, pages 45-78.
Crossref
Crossref
Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara, Yaichiro Kotake, Yoshitaka Tayama, Naoto Uramaru, Hiroki Ohshita, Chise Tateno, Toru Horie, Shigeyuki Kitamura & Shigeru Ohta. (2012) Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes. Drug Metabolism and Disposition 40:12, pages 2267-2272.
Crossref
Crossref
Li Di, Christopher Keefer, Dennis O. Scott, Timothy J. Strelevitz, George Chang, Yi-An Bi, Yurong Lai, Jonathon Duckworth, Katherine Fenner, Matthew D. Troutman & R. Scott Obach. (2012) Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design. European Journal of Medicinal Chemistry 57, pages 441-448.
Crossref
Crossref
Alexander V. LyubimovJasminder Sahi, Cornelia Smith, LaHoma Easterwood, Susan Grepper & Edward LeCluyse. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
53
.
Cornelia M. Smith, Christina K. Nolan, Manda A. Edwards, Jean B. Hatfield, Todd W. Stewart, Stephen S. Ferguson, Edward L. Lecluyse & Jasminder Sahi. (2012) A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes. Journal of Pharmaceutical Sciences 101:10, pages 3989-4002.
Crossref
Crossref
Peng Zou, Yanke Yu, Nan Zheng, Yongsheng Yang, Hayley J. Paholak, Lawrence X. Yu & Duxin Sun. (2012) Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation. The AAPS Journal 14:2, pages 262-281.
Crossref
Crossref
Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara, Yaichiro Kotake, Yoshitaka Tayama, Hiroki Ohshita, Chise Tateno, Toru Horie, Shigeyuki Kitamura & Shigeru Ohta. (2012) Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver. Drug Metabolism and Disposition 40:2, pages 322-328.
Crossref
Crossref
Alexander V. LyubimovHan‐Joo Maeng, Edwin C. Y. Chow, Jianghong Fan & K. Sandy Pang. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
48
.
Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi & J. Brian Houston. (2012) Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs. Drug Metabolism and Disposition 40:1, pages 104-110.
Crossref
Crossref
Shahab Sheikh-Bahaei & C. Anthony Hunt. (2011) Enabling Clearance Predictions to Emerge from In Silico Actions of Quasi-Autonomous Hepatocyte Components. Drug Metabolism and Disposition 39:10, pages 1910-1920.
Crossref
Crossref
Kevin Beaumont, Iain Gardner, Kathryn Chapman, Michael Hall & Malcolm Rowland. (2011) Toward an integrated human clearance prediction strategy that minimizes animal use. Journal of Pharmaceutical Sciences 100:10, pages 4518-4535.
Crossref
Crossref
H. K. Crewe, Z. E. Barter, K. Rowland Yeo & A. Rostami‐Hodjegan. (2011) Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter‐system extrapolation factors. Biopharmaceutics & Drug Disposition 32:6, pages 303-318.
Crossref
Crossref
Takao Watanabe, Hiroyuki Kusuhara, Tomoko Watanabe, Yasuyuki Debori, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Brian W. Ogilvie, Andrew Parkinson, Zhuohan Hu & Yuichi Sugiyama. (2011) Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments. Drug Metabolism and Disposition 39:6, pages 1031-1038.
Crossref
Crossref
Sekihiro Tamaki, Hiroshi Komura, Motohiro Kogayu & Shizuo Yamada. (2011) Comparative Assessment of Empirical and Physiological Approaches on Predicting Human Clearances. Journal of Pharmaceutical Sciences 100:3, pages 1147-1155.
Crossref
Crossref
David Hallifax, Joanne A. Foster & J. Brian Houston. (2010) Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View. Pharmaceutical Research 27:10, pages 2150-2161.
Crossref
Crossref
M. Teresa Donato, David Hallifax, Laura Picazo, José V. Castell, J. Brian Houston, M. José Gomez-Lechón & Agustin Lahoz. (2010) Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo. Drug Metabolism and Disposition 38:9, pages 1449-1455.
Crossref
Crossref
Zheng Yang, Lisa M. Zadjura, Anthony M. Marino, Celia J. D'Arienzo, Jacek Malinowski, Christoph Gesenberg, Pin‐Fang Lin, Richard J. Colonno, Tao Wang, John F. Kadow, Nicholas A. Meanwell & Steven B. Hansel. (2010) Utilization of in vitro Caco‐2 permeability and liver microsomal half‐life screens in discovering BMS‐488043, a novel HIV‐1 attachment inhibitor with improved pharmacokinetic properties. Journal of Pharmaceutical Sciences 99:4, pages 2135-2152.
Crossref
Crossref
Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda, Hiroshi Kanamaru, Yoshikazu Saito, Zhuohan Hu & Yuichi Sugiyama. (2010) Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans. Drug Metabolism and Disposition 38:2, pages 215-222.
Crossref
Crossref
Liyue Huang, Loren Berry, Sindhura Ganga, Brett Janosky, April Chen, Jonathan Roberts, Adria E. Colletti & Min-Hwa Jasmine Lin. (2010) Relationship between Passive Permeability, Efflux, and Predictability of Clearance from In Vitro Metabolic Intrinsic Clearance. Drug Metabolism and Disposition 38:2, pages 223-231.
Crossref
Crossref
J. Brian Houston & Aleksandra Galetin. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions
169
215
.
Rowan A. Stringer, Claire Strain-Damerell, Paul Nicklin & J. Brian Houston. (2009) Evaluation of Recombinant Cytochrome P450 Enzymes as an in Vitro System for Metabolic Clearance Predictions. Drug Metabolism and Disposition 37:5, pages 1025-1034.
Crossref
Crossref