Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 2
Submit an article Journal homepage
305
Views
9
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice

Miho Yamazaki-NishiokaLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan,
,
Makiko ShimizuLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan,
,
Hiroshi SuemizuLaboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki-ku, Japan, and
,
Megumi NishiwakiLaboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki-ku, Japan, and ;Technical Service Department, CLEA Japan, Inc, Fujinomiya, Japan
,
Marina MitsuiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan,
&
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan, Correspondence[email protected]
Pages 117-123 | Received 01 Jan 2017, Accepted 25 Jan 2017, Published online: 21 Feb 2017

Citations (9)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Takeshi Sawada, Yoshiyuki Yamaura, Satonori Higuchi, Haruo Imawaka & Hiroshi Yamazaki. (2020) Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver. Xenobiotica 50:5, pages 526-535.
Read now
Miho Yamazaki-Nishioka, Minoru Kogiku, Masayuki Noda, Sumio Endo, Mitsuru Takekawa, Hirohisa Kishi, Miki Ota, Yuki Notsu, Makiko Shimizu & Hiroshi Yamazaki. (2019) Pharmacokinetics of anticoagulants apixaban, dabigatran, edoxaban and rivaroxaban in elderly Japanese patients with atrial fibrillation treated in one general hospital. Xenobiotica 49:9, pages 1001-1006.
Read now

Articles from other publishers (7)

John Richard Cashman. 2024. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
Crossref
Han Saem Son, Jiae Lee, Hye In Lee, Narae Kim, You-Jin Jo, Gong-Rak Lee, Seong-Eun Hong, Minjeong Kwon, Nam Young Kim, Hyun Jin Kim, Jin Ha Park, Soo Young Lee & Woojin Jeong. (2020) Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1 expression. Acta Pharmaceutica Sinica B 10:3, pages 462-474.
Crossref
Yoichi NaritomiSeigo Sanoh & Shigeru Ohta. (2019) Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with <i>in Vitro</i>–<i>in Vivo</i> Extrapolation and Allometric Scaling. Biological and Pharmaceutical Bulletin 42:3, pages 327-336.
Crossref
Tomonori Miura, Shotaro Uehara, Sawa Mizuno, Manae Yoshizawa, Norie Murayama, Yusuke Kamiya, Makiko Shimizu, Hiroshi Suemizu & Hiroshi Yamazaki. (2019) Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate. Chemical Research in Toxicology 32:2, pages 333-340.
Crossref
Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang & Xinxin Ding. (2018) P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. Drug Metabolism and Disposition 46:11, pages 1734-1744.
Crossref
Keith Fraser, Dylan M. Bruckner & Jonathan S. Dordick. (2018) Advancing Predictive Hepatotoxicity at the Intersection of Experimental, in Silico , and Artificial Intelligence Technologies . Chemical Research in Toxicology 31:6, pages 412-430.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.