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Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 2
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Pharmacogenetics

R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys

Masahiro UtohLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan, and ;Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories Ltd, Kainan, Wakayama, Japan
,
Takashi KusamaLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan, and
,
Tomonori MiuraLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan, and
,
Marina MitsuiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan, and
,
Mirai KawanoLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan, and
,
Takahiro HiranoLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan, and ;Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories Ltd, Kainan, Wakayama, Japan
,
Makiko ShimizuLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan, and
,
Yasuhiro UnoPharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories Ltd, Kainan, Wakayama, Japan
&
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan, and Correspondence[email protected]
 show all
Pages 206-210 | Received 29 Dec 2016, Accepted 26 Jan 2017, Published online: 20 Feb 2017

Citations (8)

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Read on this site (3)

Jiaying Song, Huizhen Dai, Huan Zhang, Yanchao Liu & Wenjing Zhang. (2020) Influence of glycyrrhetinic acid on the pharmacokinetics of warfarin in rats. Xenobiotica 50:5, pages 602-605.
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Takashi Kusama, Akiko Toda, Makiko Shimizu, Shotaro Uehara, Takashi Inoue, Yasuhiro Uno, Masahiro Utoh, Erika Sasaki & Hiroshi Yamazaki. (2018) Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models. Xenobiotica 48:10, pages 1072-1077.
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Akiko Toda, Shotaro Uehara, Takashi Inoue, Masahiro Utoh, Takashi Kusama, Makiko Shimizu, Yasuhiro Uno, Masayuki Mogi, Erika Sasaki & Hiroshi Yamazaki. (2018) Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. Xenobiotica 48:7, pages 720-726.
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Articles from other publishers (5)

Yasuhiro Uno, Shotaro Uehara & Hiroshi Yamazaki. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 329 364 .
Makiko Shimizu, Yasuhiro Uno, Masahiro Utoh & Hiroshi Yamazaki. (2020) Trimethylamine N-oxygenation in cynomolgus macaques genotyped for flavin-containing monooxygenase 3 (FMO3). Drug Metabolism and Pharmacokinetics 35:6, pages 571-573.
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Tao Tan, Lin Xia, Kailing Tu, Jie Tang, Senlin Yin, Lunzhi Dai, Peng Lei, Biao Dong, Hongbo Hu, Yong Fan, Yang Yu & Dan Xie. (2018) Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues. BMC Genomics 19:1.
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Yasuhiro Uno, Shotaro Uehara & Hiroshi Yamazaki. (2018) Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans. Biochemical Pharmacology 153, pages 184-195.
Crossref
Masahiro Utoh, Tomonori Miura, Takashi Kusama, Shotaro Uehara, Makiko Shimizu, Yasuhiro Uno & Hiroshi Yamazaki. (2017) Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models . Biopharmaceutics & Drug Disposition 38:7, pages 439-442.
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