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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 2
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Research Article

Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A

Pages 171-185 | Published online: 22 Sep 2008

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Read on this site (7)

Motoya Suzuki, Hiroshi Komura, Tomonori Yoshikawa, Seiji Enya, Akemi Nagao, Hiroaki Takubo & Motohiro Kogayu. (2014) Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (−/−) rats into absorption study of multiple transporter substrate. Xenobiotica 44:11, pages 1039-1045.
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Ryuji Kato, Akina Higashitani, Takako Irie, Yugo Kusukawa, Yu Yamamoto, Machiko Nakagawa, Yoko Urashima, Makoto Nagata, Tetsuya Hayashi, Yoshio Ijiri & Kazuhiko Tanaka. (2012) Influence of capsaicin on fluctuation of digoxin pharmacokinetics in lipopolysaccharide-treated rats. Xenobiotica 42:8, pages 798-807.
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Orianne Videau, Sylvain Pitarque, Sylvie Troncale, Patrick Hery, Etienne Thévenot, Marcel Delaforge & Henri Bénech. (2012) Can a cocktail designed for phenotyping pharmacokinetics and metabolism enzymes in human be used efficiently in rat?. Xenobiotica 42:4, pages 349-354.
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Nobutomo Ikarashi, Mai Kagami, Yasushi Kobayashi, Makoto Ishii, Takahiro Toda, Wataru Ochiai & Kiyoshi Sugiyama. (2011) Changes in the pharmacokinetics of digoxin in polyuria in streptozotocin-induced diabetic mice and lithium carbonate-treated mice. Xenobiotica 41:6, pages 486-493.
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Arturo Anadón & Luis G Valerio Jr. (2010) Highlights of the XII International Congress on Toxicology, 19 – 23 July 2010, Barcelona, Spain. Expert Opinion on Drug Metabolism & Toxicology 6:11, pages 1445-1450.
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Kaplan Yusuf Cem, Oransay Kubilay, Eminoglu Ozlem, Ellidokuz Hulya & Gelal Ayse. (2007) Effect of Repeated Low-Dose Organophosphorothionate Pesticide Exposure on Digoxin Pharmacokinetics in Rats; a Possible Interaction Involving P-Glycoprotein. Toxicology Mechanisms and Methods 17:8, pages 459-466.
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C. Ioannides. (2002) Pharmacokinetic interactions between herbal remedies and medicinal drugs. Xenobiotica 32:6, pages 451-478.
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Hee Jin Jeong, Song Hee Lee & Hee Eun Kang. (2021) Changes in digoxin pharmacokinetics associated with hepatic P‐glycoprotein upregulation in rats with non‐alcoholic fatty liver disease. Fundamental & Clinical Pharmacology 35:6, pages 1100-1108.
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Shuyao Wang, Chun Chen, Chi Guan, Liping Qiu, Lei Zhang, Shaofeng Zhang, Hongyu Zhou, Hongwen Du, Chen Li, Yaqiong Wu, Hang Chang & Tao Wang. (2021) Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats. Pharmacology Research & Perspectives 9:5.
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