4,526
Views
75
CrossRef citations to date
0
Altmetric
Review

State-of-the-art behavioral and pharmacological treatments for alcohol use disorder

, , , , , , ORCID Icon, & show all
Pages 124-140 | Received 14 Mar 2018, Accepted 17 Sep 2018, Published online: 29 Oct 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Sophie Köhne, Thomas Hillemacher, Alexander Glahn & Patrick Bach. (2024) Emerging drugs in phase II and III clinical development for the treatment of alcohol use disorder. Expert Opinion on Emerging Drugs 0:0, pages 1-14.
Read now
Jack Donlon, Pooja Kumari, Sajoy P. Varghese, Michael Bai, Ori David Florentin, Emma D. Frost, John Banks, Niyathi Vadlapatla, Olivia Kam, Mujeeb U. Shad, Shafiqur Rahman, Osama A. Abulseoud, Trevor W. Stone & Maju Mathew Koola. (2024) Integrative Pharmacology in the Treatment of Substance Use Disorders. Journal of Dual Diagnosis 20:2, pages 132-177.
Read now
Suzanna Donato & Lara A Ray. (2023) Neurobiology and the Treatment of Alcohol Use Disorder: A Review of the Evidence Base. Substance Abuse and Rehabilitation 14, pages 157-166.
Read now
Savithri Suresh, Anagha S. Deshmukh & Samir Kumar Praharaj. (2023) Efficacy of covert sensitization for a patient with alcohol use disorder with memory impairment: A case report. Journal of Addictive Diseases 41:4, pages 334-340.
Read now
Lidia Z. Meshesha, Tatiana D. Magri, Tosca D. Braun, Marie A. Sillice, Minh D. Nguyen, Vaishnavi Suren & Ana M. Abrantes. (2023) Patient Perspective on the Role of Substance-Free Activities during Alcohol Use Disorder Treatment: A Mixed-Method Study. Alcoholism Treatment Quarterly 41:3, pages 309-321.
Read now
Satish K. Kedia, Nikhil Ahuja, Patrick J. Dillon, Andrew Jones, Santosh Kumar & Sanjaya Satapathy. (2023) Efficacy of Extended-Release Injectable Naltrexone on Alcohol Use Disorder Treatment: A Systematic Review. Journal of Psychoactive Drugs 55:2, pages 233-245.
Read now
Wilco Sliedrecht, Henk Jan Seesink, Cis Vrijmoeth, Ranne de Waart, Reinout W. Wiers, Brian Ostafin, Hanneke Schaap-Jonker, Hendrik Roozen, Katie Witkiewitz & Geert Dom. (2022) Alcohol use disorder relapse factors: an exploratory investigation of craving, alcohol dependence severity, and meaning in life. Addiction Research & Theory 30:5, pages 351-359.
Read now
Alexandra Venegas, Suzanna Donato, Lindsay R. Meredith & Lara A. Ray. (2021) Understanding low treatment seeking rates for alcohol use disorder: A narrative review of the literature and opportunities for improvement. The American Journal of Drug and Alcohol Abuse 47:6, pages 664-679.
Read now
Steven J. Nieto, Wave Baskerville, Suzanna Donato, Spencer Bujarski & Lara Ray. (2021) Lifetime heavy drinking years predict alcohol use disorder severity over and above current alcohol use. The American Journal of Drug and Alcohol Abuse 47:5, pages 630-637.
Read now
Aaron C. Lim, Erica N. Grodin, Rejoyce Green, Alexandra Venegas, Lindsay R. Meredith, Kelly E. Courtney, Nathasha R. Moallem, Philip Sayegh, Edythe D. London & Lara A. Ray. (2020) Executive function moderates naltrexone effects on methamphetamine-induced craving and subjective responses. The American Journal of Drug and Alcohol Abuse 46:5, pages 565-576.
Read now

Articles from other publishers (65)

Ardavan Mohammad Aghaei, Jeremy Weleff, Bradford Martins, Kevin Ing, Rodrigo Fontenele, Brian S. Barnett, Akhil Anand & Anahita Bassir Nia. (2024) Psychotherapeutic Interventions in Clinical Trials of Psychedelics for the Treatment of Alcohol Use Disorder. Current Addiction Reports.
Crossref
Stephan C. Tap. (2024) The potential of 5‐methoxy‐ N,N ‐dimethyltryptamine in the treatment of alcohol use disorder: A first look at therapeutic mechanisms of action . Addiction Biology 29:4.
Crossref
Luke Rozema, Jessica E. Hoyt, Bradley V. Watts & Brian Shiner. (2024) Mining clinical data for novel medications to treat alcohol use disorder. Journal of Substance Use and Addiction Treatment, pages 209381.
Crossref
Fahd François Hilal, Jerome Jeanblanc, Chloé Deschamps, Mickael Naassila, Olivier Pierrefiche & Sami Ben Hamida. (2024) Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies. Journal of Neural Transmission.
Crossref
Pratima Sharma, Akhil Shenoy, Hersh Shroff, Allison Kwong, Nicholas Lim, Anjana Pillai, Deepika Devuni, Lamia Y. Haque, Wendy Balliet & Marina Serper. (2024) Management of alcohol-associated liver disease and alcohol use disorder in liver transplant candidates and recipients: Challenges and opportunities. Liver Transplantation.
Crossref
Hanna M. Hebden, Julia E. Swan, Eric D. Claus, Nathan S. Pentkowski & Katie Witkiewitz. (2024) Longitudinal stability of reward and relief drinking phenotypes in community and treatment‐seeking individuals who engage in heavy drinking. Alcohol, Clinical and Experimental Research 48:3, pages 567-579.
Crossref
Samuel N. Meisel, Cassandra L. Boness, Robert MirandaJr.Jr. & Katie Witkiewitz. (2023) Beyond mediators: A critical review and methodological path forward for studying mechanisms in alcohol use treatment research. Alcohol, Clinical and Experimental Research 48:2, pages 215-229.
Crossref
Kristoffer Høiland, Espen Kristian Ajo Arnevik & Jens Egeland. (2024) Alcohol use disorder and fitness to drive: Discrepancies between health professionals’ evaluations and objective measures of alcohol use and cognitive functioning. Nordic Studies on Alcohol and Drugs.
Crossref
Lauren E. Honan, Rheaclare Fraser-Spears & Lynette C. Daws. (2024) Organic cation transporters in psychiatric and substance use disorders. Pharmacology & Therapeutics 253, pages 108574.
Crossref
Ellen W. Green, Isabelle S. Byers & Sasha Deutsch-Link. (2023) Closing the Care Gap: Management of Alcohol Use Disorder in Patients with Alcohol-associated Liver Disease. Clinical Therapeutics 45:12, pages 1189-1200.
Crossref
Neil Dunne & Jo-Hanna Ivers. (2023) HPA axis function in alcohol use disorder: A systematic review and meta-analysis. Addiction Neuroscience 8, pages 100114.
Crossref
Carolina Barbosa, William N. Dowd, Katherine J. Karriker‐Jaffe & Gary Zarkin. (2023) Modeling the impact of a long‐term horizon and multiple treatment episodes on estimates of the cost‐effectiveness of alcohol treatment in the United States. Alcohol: Clinical and Experimental Research 47:11, pages 2121-2137.
Crossref
Emily A. Levine, Dawn E. Sugarman, Mary Rockas, R. Kathryn McHugh, Chloe Jordan & Shelly F. Greenfield. (2023) Alcohol Treatment Access and Engagement Among Women in the USA: a Targeted Review of the Literature 2012–2022. Current Addiction Reports 10:4, pages 638-648.
Crossref
Gilmar Gutierrez, Dekel Meartsi, Niloofar Nikjoo, Saad Sajid, Elnaz Moghimi & Nazanin Alavi. (2023) Online Psychotherapy for the Management of Alcohol Use Disorder, a Systematic Review and Network Meta-analysis. International Journal of Mental Health and Addiction.
Crossref
James M. Clay, Kiera A. Baker, Roxana D. Mezabrovschi, Giacomo Berti, Grant S. Shields, George M. Slavich, Lorenzo D. Stafford & Matthew O. Parker. (2023) Mediated and moderated associations between cumulative lifetime stressor exposure, emotional dysregulation, impulsivity, and lifetime alcohol use: A cross-sectional scoping study of UK drinkers. Journal of Psychiatric Research 164, pages 140-149.
Crossref
Arielle R. Deutsch, Edward Chau, Nikki Motabar & Mohammad S. Jalali. (2023) Grounding alcohol simulation models in empirical and theoretical alcohol research: a model for a Northern Plains population in the United States. System Dynamics Review 39:3, pages 207-238.
Crossref
Kelly W. Gagnon, Sera Levy, Caleb Figge, Caitlin Wolford Clevenger, Laura Murray, Jeremy C. Kane, Samuel Bosomprah, Anjali Sharma, Van Thi Ha Nghiem, Chipo Chitambi, Michael Vinikoor, Ellen Eaton & Karen Cropsey. (2023) Telemedicine for unhealthy alcohol use in adults living with HIV in Alabama using common elements treatment approach: A hybrid clinical efficacy-implementation trial protocol. Contemporary Clinical Trials Communications 33, pages 101123.
Crossref
Samuel N. Meisel, Hayley Treloar Padovano, Melissa Pielech, Kimberly Goodyear & Robert MirandaJr.Jr.. (2023) Peer‐elicited alcohol craving in adolescents and emerging adults: Bridging the laboratory and natural environment. Alcohol: Clinical and Experimental Research 47:5, pages 975-985.
Crossref
Molly Magill, Stephan Maisto, Brian Borsari, Joseph E. Glass, Kevin Hallgren, Jon Houck, Brian Kiluk & Alexis Kuerbis. (2023) Addictions treatment mechanisms of change science and implementation science: A critical review. Alcohol: Clinical and Experimental Research 47:5, pages 827-839.
Crossref
Catherine F. Moore, C. Austin Zamarripa & Elise M. Weerts. (2023) Oral Cannabidiol does not alter Alcohol Seeking and Self‐Administration in Baboons. Drug and Alcohol Dependence 245, pages 109829.
Crossref
Michał Szulc, Radosław Kujawski, Amanda Pacholak, Marta Poprawska, Kamila Czora-Poczwardowska, Bogna Geppert & Przemysław Ł. Mikołajczak. (2023) Cannabidiol as a Modulator of the Development of Alcohol Tolerance in Rats. Nutrients 15:7, pages 1702.
Crossref
Wheytnie Alexandre, Haseeb Muhammad, Olufunso Agbalajobi, Grace Zhang, Theresa Gmelin, Adeyinka Adejumo, Alan Noll, Naudia L. Jonassaint, Andrea DiMartini, Ramon Bataller & Shari S. Rogal. (2023) Alcohol treatment discussions and clinical outcomes among patients with alcohol-related cirrhosis. BMC Gastroenterology 23:1.
Crossref
Jazmin Eadie, Gilmar Gutierrez, Elnaz Moghimi, Callum Stephenson, Payam Khalafi, Niloofar Nikjoo, Jasleen Jagayat, Tessa Gizzarelli, Taras Reshetukha, Mohsen Omrani, Megan Yang & Nazanin Alavi. (2023) Developing and Implementing a Web-Based Relapse Prevention Psychotherapy Program for Patients With Alcohol Use Disorder: Protocol for a Randomized Controlled Trial. JMIR Research Protocols 12, pages e44694.
Crossref
Monja Hoven, Renée S. Schluter, Arnt F. Schellekens, Ruth J. van Holst & Anna E. Goudriaan. (2022) Effects of 10 add‐on HF‐rTMS treatment sessions on alcohol use and craving among detoxified inpatients with alcohol use disorder: a randomized sham‐controlled clinical trial. Addiction 118:1, pages 71-85.
Crossref
James MacKillop, Roberta Agabio, Sarah W. Feldstein Ewing, Markus Heilig, John F. Kelly, Lorenzo Leggio, Anne Lingford-Hughes, Abraham A. Palmer, Charles D. Parry, Lara Ray & Jürgen Rehm. (2022) Hazardous drinking and alcohol use disorders. Nature Reviews Disease Primers 8:1.
Crossref
Saskia Antwerpes, Marie Costa, Marion Coste, Morgane Bureau, Gwenaelle Maradan, Christophe Cutarella, Jacques Leloutre, Olivier Riccobono-Soulier, Sophie Hedoire, Elodie Frot, Fabienne Vernier, Stéphanie Vassas-Goyard, Tangui Barré, Danielle Casanova & Patrizia Carrieri. (2022) Evaluation of a novel therapeutic education programme for people with alcohol use disorder in France: a mixed-methods intervention study protocol (ETHER). Harm Reduction Journal 19:1.
Crossref
Tanya Scerbina & Robert Gerlai. (2022) Acute Administration of Ethanol and of a D1-Receptor Antagonist Affects the Behavior and Neurochemistry of Adult Zebrafish. Biomedicines 10:11, pages 2878.
Crossref
Laura B. Ferguson, R. Dayne Mayfield & Robert O. Messing. (2022) RNA biomarkers for alcohol use disorder. Frontiers in Molecular Neuroscience 15.
Crossref
Joseph H. Donroe & E. Jennifer Edelman. (2022) Alcohol Use. Annals of Internal Medicine 175:10, pages ITC145-ITC160.
Crossref
Kristoffer Høiland & Jens Egeland. (2022) Behandling av alkoholbrukslidelse: pasientfaktorers betydning for gjennomføring og utfall. Tidsskrift for Norsk psykologforening.
Crossref
Erica N. Grodin, Steven J. Nieto, Lindsay R. Meredith, Elizabeth Burnette, Joseph O'Neill, Jeffry Alger, Edythe D. London, Karen Miotto, Christopher J. Evans, Michael R. Irwin & Lara A. Ray. (2022) Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. Addiction Biology 27:4.
Crossref
Falk W. Lohoff. (2022) Targeting Unmet Clinical Needs in the Treatment of Alcohol Use Disorder. Frontiers in Psychiatry 13.
Crossref
Kasey G. Creswell & Michael A. Sayette. (2022) How laboratory studies of cigarette craving can inform the experimental alcohol craving literature. Alcoholism: Clinical and Experimental Research 46:3, pages 344-358.
Crossref
J. S. Dileep Kumar, Andrei Molotkov, Michael C. Salling, Patrick Carberry, Jaya Prabhakaran, John Castrillon & Akiva Mintz. (2021) In vivo evaluation of a microtubule PET ligand, [11C]MPC-6827, in mice following chronic alcohol consumption. Pharmacological Reports 74:1, pages 241-247.
Crossref
Elizabeth M. Burnette, Steven J. Nieto, Erica N. Grodin, Lindsay R. Meredith, Brian Hurley, Karen Miotto, Artha J. Gillis & Lara A. Ray. (2022) Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder. Drugs 82:3, pages 251-274.
Crossref
V.V. Geiko, M.S. Geiko & T.V. Selyukova. (2022) EFFECT OF INTRANASAL ADMINISTRATION OF DEGYDROEPIANDROSTERONE ON EMOTIONAL STATUS AND ZOOSOCIAL BEHAVIOR OF RATS UNDER CONDITIONS OF PROLONG ALCOHOLIZATION. Fiziolohichnyĭ zhurnal 68:1, pages 45-55.
Crossref
Ana M. Abrantes, Zachary Kunicki, Tosca Braun, Robert MirandaJr.Jr., Claire E. Blevins, Leslie Brick, Graham Thomas, Eliza Marsh, Sage Feltus & Michael D. Stein. (2022) Daily associations between alcohol and sweets craving and consumption in early AUD recovery: Results from an ecological momentary assessment study. Journal of Substance Abuse Treatment 132, pages 108614.
Crossref
Lindsay R. Meredith, Erica N. Grodin, Mitchell P. Karno, Amanda K. Montoya, James MacKillop, Aaron C. Lim & Lara A. Ray. (2021) Preliminary study of alcohol problem severity and response to brief intervention. Addiction Science & Clinical Practice 16:1.
Crossref
James G. Murphy, Ashley A. Dennhardt & Kathryn S. Gex. 2021. Dynamic Pathways to Recovery from Alcohol Use Disorder. Dynamic Pathways to Recovery from Alcohol Use Disorder 179 199 .
. 2021. Dynamic Pathways to Recovery from Alcohol Use Disorder. Dynamic Pathways to Recovery from Alcohol Use Disorder 157 300 .
Fiona Mercer, Joanna Astrid Miler, Bernie Pauly, Hannah Carver, Kristina Hnízdilová, Rebecca Foster & Tessa Parkes. (2021) Peer Support and Overdose Prevention Responses: A Systematic ‘State-of-the-Art’ Review. International Journal of Environmental Research and Public Health 18:22, pages 12073.
Crossref
Zachary L. Mannes, Dvora Shmulewitz, Ofir Livne, Malki Stohl & Deborah S. Hasin. (2021) Correlates of mild, moderate, and severe Alcohol Use Disorder among adults with problem substance use: Validity implications for DSM‐5. Alcoholism: Clinical and Experimental Research 45:10, pages 2118-2129.
Crossref
Elizabeth M. Burnette, Lara A. Ray, Michael R. Irwin & Erica N. Grodin. (2021) Ibudilast attenuates alcohol cue–elicited frontostriatal functional connectivity in alcohol use disorder. Alcoholism: Clinical and Experimental Research 45:10, pages 2017-2028.
Crossref
Suzanna Donato, ReJoyce Green & Lara A. Ray. (2021) Alcohol use disorder severity moderates clinical response to varenicline. Alcoholism: Clinical and Experimental Research 45:9, pages 1877-1887.
Crossref
Fares Qeadan, Nana A. Mensah, Lily Y. Gu, Erin F. Madden, Kamilla L. Venner & Kevin English. (2021) Trends in the Use of Naltrexone for Addiction Treatment among Alcohol Use Disorder Admissions in U.S. Substance Use Treatment Facilities. International Journal of Environmental Research and Public Health 18:16, pages 8884.
Crossref
Peng-Sheng Ting, Ahmet Gurakar, Jason Wheatley, Geetanjali Chander, Andrew M. Cameron & Po-Hung Chen. (2021) Approaching Alcohol Use Disorder After Liver Transplantation for Acute Alcoholic Hepatitis. Clinics in Liver Disease 25:3, pages 645-671.
Crossref
Erica N. Grodin, Spencer Bujarski, Brandon Towns, Elizabeth Burnette, Steven Nieto, Aaron Lim, Johnny Lin, Karen Miotto, Artha Gillis, Michael R. Irwin, Christopher Evans & Lara A. Ray. (2021) Ibudilast, a neuroimmune modulator, reduces heavy drinking and alcohol cue-elicited neural activation: a randomized trial. Translational Psychiatry 11:1.
Crossref
Lara A. Ray & Erica N. Grodin. (2021) Clinical Neuroscience of Addiction: What Clinical Psychologists Need to Know and Why. Annual Review of Clinical Psychology 17:1, pages 465-493.
Crossref
Carolina Barbosa, Jeremy W. Bray, William N. Dowd, Alan Barnosky & Eve Wittenberg. (2020) SF‐6D utility scores for alcohol use disorder status and alcohol consumption risk levels in the US population. Addiction 116:5, pages 1034-1042.
Crossref
Lara A. Ray, Erica N. Grodin, Lorenzo Leggio, Anita J. Bechtholt, Howard Becker, Sarah W. Feldstein Ewing, James David Jentsch, Andrea C. King, Barbara J. Mason, Stephanie O'Malley, James MacKillop, Markus Heilig & George F. Koob. (2020) The future of translational research on alcohol use disorder. Addiction Biology 26:2.
Crossref
Siddharth Sarkar, Esha Sood, Roshan Bhad & Ashwani Mishra. (2021) Validated scales for substance use disorders in the geriatric population: A scoping review. Journal of Geriatric Mental Health 8:2, pages 70.
Crossref
Brandon Hunley, Brendan Willis & Monica Zepeda. 2021. Handbook of Evidence-Based Prevention of Behavioral Disorders in Integrated Care. Handbook of Evidence-Based Prevention of Behavioral Disorders in Integrated Care 293 326 .
Viren H. Makhijani, Preethi Irukulapati, Kalynn Van Voorhies, Brayden Fortino & Joyce Besheer. (2020) Central amygdala mineralocorticoid receptors modulate alcohol self-administration. Neuropharmacology 181, pages 108337.
Crossref
John Kramer, Danielle M Dick, Andrea King, Lara A Ray, Kenneth J Sher, Ashley Vena, Leandro F Vendruscolo & Laura Acion. (2020) Mechanisms of Alcohol Addiction: Bridging Human and Animal Studies. Alcohol and Alcoholism 55:6, pages 603-607.
Crossref
Arpana Agrawal & Vivia V. McCutcheon. (2020) Commentary on Hartwell et al . (2020): Alcohol use disorder treatment response—where is the variability? . Addiction 115:8, pages 1438-1439.
Crossref
Clémence Dousset, Hendrik Kajosch, Anaïs Ingels, Elisa Schröder, Charles Kornreich & Salvatore Campanella. (2020) Preventing relapse in alcohol disorder with EEG-neurofeedback as a neuromodulation technique: A review and new insights regarding its application. Addictive Behaviors 106, pages 106391.
Crossref
Julia E. Swan, Victoria R. Votaw, Elena R. Stein & Katie Witkiewitz. (2020) The Role of Affect in Psychosocial Treatments for Substance Use Disorders. Current Addiction Reports 7:2, pages 108-116.
Crossref
Shari Rogal, Ada Youk, Hongwei Zhang, Walid F. Gellad, Michael J. Fine, Chester B. Good, Maggie Chartier, Andrea DiMartini, Timothy Morgan, Ramon Bataller & Kevin L. Kraemer. (2020) Impact of Alcohol Use Disorder Treatment on Clinical Outcomes Among Patients With Cirrhosis. Hepatology 71:6, pages 2080-2092.
Crossref
Lara A. Ray, Lindsay R. Meredith, Brian D. Kiluk, Justin Walthers, Kathleen M. Carroll & Molly Magill. (2020) Combined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders. JAMA Network Open 3:6, pages e208279.
Crossref
Thomas Köhler. 2020. Klinische Psychologie & Psychotherapie. Klinische Psychologie & Psychotherapie 245 281 .
Peng‐Sheng Ting, Jason Wheatley & Po‐Hung Chen. (2020) Behavioral Treatment for Patients With Alcohol‐Related Liver Disease: A Primer for Hepatologists. Clinical Liver Disease 15:1, pages 31-35.
Crossref
Justin Knox, Deborah S Hasin, Farren R R Larson & Henry R Kranzler. (2019) Prevention, screening, and treatment for heavy drinking and alcohol use disorder. The Lancet Psychiatry 6:12, pages 1054-1067.
Crossref
Brian D. Kiluk, Lara A. Ray, Justin Walthers, Michael Bernstein, Jeffery S. Tonigan & Molly Magill. (2019) Technology‐Delivered Cognitive‐Behavioral Interventions for Alcohol Use: A Meta‐Analysis. Alcoholism: Clinical and Experimental Research 43:11, pages 2285-2295.
Crossref
Carolina Barbosa, William N. Dowd, Arnie P. Aldridge, Christine Timko & Gary A. Zarkin. (2019) Estimating Long-Term Drinking Patterns for People with Lifetime Alcohol Use Disorder. Medical Decision Making 39:7, pages 765-780.
Crossref
Erica N. Grodin & Lara A. Ray. (2019) The Use of Functional Magnetic Resonance Imaging to Test Pharmacotherapies for Alcohol Use Disorder: A Systematic Review. Alcoholism: Clinical and Experimental Research 43:10, pages 2038-2056.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.