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Original

Gamma-Hydroxybutyrate Reduces both Withdrawal Syndrome and Hypercortisolism in Severe Abstinent Alcoholics: An Open Study vs. Diazepam

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Pages 379-392 | Published online: 07 Jul 2009

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Giovanni Addolorato, Otto-Michael Lesch, Icro Maremmani, Henriette Walter, Felice Nava, Quentin Raffaillac & Fabio Caputo. (2020) Post-marketing and clinical safety experience with sodium oxybate for the treatment of alcohol withdrawal syndrome and maintenance of abstinence in alcohol-dependent subjects. Expert Opinion on Drug Safety 19:2, pages 159-166.
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Katrin Skala, Fabio Caputo, Antonio Mirijello, Gabriele Vassallo, Mariangela Antonelli, Anna Ferrulli, Henriette Walter, Otto Lesch & Giovanni Addolorato. (2014) Sodium oxybate in the treatment of alcohol dependence: from the alcohol withdrawal syndrome to the alcohol relapse prevention. Expert Opinion on Pharmacotherapy 15:2, pages 245-257.
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Giovanni Addolorato, Lorenzo Leggio, Anna Ferrulli, Fabio Caputo & Antonio Gasbarrini. (2009) The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical data. Expert Opinion on Investigational Drugs 18:5, pages 675-686.
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Christoph Elsing, Wolfgang Stremmel, Uwe Grenda & Thomas Herrmann. (2009) Gamma-Hydroxybutyric Acid versus Clomethiazole for the Treatment of Alcohol Withdrawal Syndrome in a Medical Intensive Care Unit: An Open, Single-Center Randomized Study. The American Journal of Drug and Alcohol Abuse 35:3, pages 189-192.
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Olivier Ameisen. (2008) Are the Effects of Gamma-Hydroxybutyrate (GHB) Treatment Partly Physiological in Alcohol Dependence?. The American Journal of Drug and Alcohol Abuse 34:2, pages 235-236.
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Thomas R. Kosten & Tracie J. Gardner. (2008) New Hot Topics Sections: 1. China's New March Forward in Addiction Treatment: Methadone for the Masses 2. Issues in Formulating DSM V. The American Journal of Drug and Alcohol Abuse 34:2, pages 123-126.
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Julien Guiraud, Rainer Spanagel & Wim van den Brink. 2024. The neurobiology of alcohol use disorder: Neuronal mechanisms, current treatments and novel developments. The neurobiology of alcohol use disorder: Neuronal mechanisms, current treatments and novel developments 187 239 .
Arianna Giorgetti, Francesco Paolo Busardò & Raffaele Giorgetti. (2022) Toxicological Characterization of GHB as a Performance-Enhancing Drug. Frontiers in Psychiatry 13.
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Julien Guiraud, Giovanni Addolorato, Henri-Jean Aubin, Philippe Batel, Andrea de Bejczy, Fabio Caputo, Anna E. Goudriaan, Antoni Gual, Otto Lesch, Icro Maremmani, Pascal Perney, Roch Poulnais, Quentin Raffaillac, Bo Soderpalm, Rainer Spanagel, Henriette Walter & Wim van den Brink. (2021) Treating alcohol dependence with an abuse and misuse deterrent formulation of sodium oxybate: Results of a randomised, double-blind, placebo-controlled study. European Neuropsychopharmacology 52, pages 18-30.
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D A Dornbierer, M Boxler, C D Voegel, B Stucky, A E Steuer, T M Binz, M R Baumgartner, D M Baur, B B Quednow, T Kraemer, E Seifritz, H P Landolt & O G Bosch. (2019) Nocturnal Gamma-Hydroxybutyrate Reduces Cortisol-Awakening Response and Morning Kynurenine Pathway Metabolites in Healthy Volunteers. International Journal of Neuropsychopharmacology 22:10, pages 631-639.
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Jeffrey T. Krook, Erika Duperreault, Dustin Newton, Matthew S. Ross & Trevor J. Hamilton. (2019) Repeated ethanol exposure increases anxiety-like behaviour in zebrafish during withdrawal. PeerJ 7, pages e6551.
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Jakub Siembida & Kaja Karakuła. (2019) GHB receptors - a new trend in psychopharmacology?. Current Problems of Psychiatry 19:4, pages 285-298.
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Oliver G. Bosch, Christoph Eisenegger, Jürg Gertsch, Robin von Rotz, Dario Dornbierer, M. Salomé Gachet, Markus Heinrichs, Thomas C. Wetter, Erich Seifritz & Boris B. Quednow. (2015) Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone. Psychoneuroendocrinology 62, pages 1-10.
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Máté Kapitány‐Fövény, Barbara Mervó, Ornella Corazza, Gyöngyi Kökönyei, Judit Farkas, Róbert Urbán, Gábor Zacher & Zsolt Demetrovics. (2015) Enhancing sexual desire and experience: an investigation of the sexual correlates of gamma‐hydroxybutyrate (GHB) use. Human Psychopharmacology: Clinical and Experimental 30:4, pages 276-284.
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Antonio Mirijello, Cristina D’Angelo, Anna Ferrulli, Gabriele Vassallo, Mariangela Antonelli, Fabio Caputo, Lorenzo Leggio, Antonio Gasbarrini & Giovanni Addolorato. (2015) Identification and Management of Alcohol Withdrawal Syndrome. Drugs 75:4, pages 353-365.
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Christian Klein, Chantal Mathis, Géraldine Leva, Christine Patte-Mensah, Jean-Christophe Cassel, Michel Maitre & Ayikoe G. Mensah-Nyagan. (2015) γ-Hydroxybutyrate (Xyrem) ameliorates clinical symptoms and neuropathology in a mouse model of Alzheimer's disease. Neurobiology of Aging 36:2, pages 832-844.
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Timothy Gould, Lixin Chen, Zsuzsa Emri, Tiina Pirttimaki, Adam C. Errington, Vincenzo Crunelli & H. Rheinallt Parri. (2014) GABA B receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid . Philosophical Transactions of the Royal Society B: Biological Sciences 369:1654, pages 20130607.
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Fabio Caputo, Katrin Skala, Antonio Mirijello, Anna Ferrulli, Henriette Walter, Otto Lesch & Giovanni Addolorato. (2014) Sodium Oxybate in the Treatment of Alcohol Withdrawal Syndrome: A Randomized Double-Blind Comparative Study versus Oxazepam. The GATE 1 Trial. CNS Drugs 28:8, pages 743-752.
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Gillian M. Keating. (2013) Sodium Oxybate: A Review of Its Use in Alcohol Withdrawal Syndrome and in the Maintenance of Abstinence in Alcohol Dependence. Clinical Drug Investigation 34:1, pages 63-80.
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E. COOPER & J. VERNON. (2012) The effectiveness of pharmacological approaches in the treatment of alcohol withdrawal syndrome (AWS): a literature review. Journal of Psychiatric and Mental Health Nursing 20:7, pages 601-612.
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Oliver G Bosch, Boris B Quednow, Erich Seifritz & Thomas C Wetter. (2011) Reconsidering GHB: orphan drug or new model antidepressant?. Journal of Psychopharmacology 26:5, pages 618-628.
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Alison Oliveto, William Brooks Gentry, Rhonda Pruzinsky, Kishorchandra Gonsai, Thomas R. Kosten, Bridget Martell & James Poling. (2010) Behavioral effects of γ-hydroxybutyrate in humans. Behavioural Pharmacology 21:4, pages 332-342.
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Jonathan Cachat, Peter Canavello, Marco Elegante, Brett Bartels, Peter Hart, Carisa Bergner, Rupert Egan, Ashley Duncan, David Tien, Amanda Chung, Keith Wong, Jason Goodspeed, Julia Tan, Chelsea Grimes, Salem Elkhayat, Christopher Suciu, Michael Rosenberg, Kyung Min Chung, Ferdous Kadri, Sudipta Roy, Siddharth Gaikwad, Adam Stewart, Ivan Zapolsky, Thomas Gilder, Sopan Mohnot, Esther Beeson, Hakima Amri, Zofia Zukowska, R. Denis Soignier & Allan V. Kalueff. (2010) Modeling withdrawal syndrome in zebrafish. Behavioural Brain Research 208:2, pages 371-376.
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Laura Amato, Silvia Minozzi, Simona Vecchi & Marina Davoli. (2010) Benzodiazepines for alcohol withdrawal. Cochrane Database of Systematic Reviews.
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Jill Watson, Sara Guzzetti, Carlotta Franchi, Angelo Di Clemente, Silvia Burbassi, Zsuzsa Emri, Nathalie Leresche, H. Rheinallt Parri, Vincenzo Crunelli & Luigi Cervo. (2009) Gamma-hydroxybutyrate does not maintain self-administration but induces conditioned place preference when injected in the ventral tegmental area. The International Journal of Neuropsychopharmacology 13:02, pages 143.
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Maurizio A Leone, Federica Vigna-Taglianti, GianCarlo Avanzi, Romeo Brambilla & Fabrizio Faggiano. (2010) Gamma-hydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses. Cochrane Database of Systematic Reviews.
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F. Caputo, S. Francini, M. Stoppo, F. Lorenzini, T. Vignoli, A. Del Re, C. Comaschi, L. Leggio, G. Addolorato, G. Zoli & M. Bernardi. (2008) Incidence of craving for and abuse of gamma-hydroxybutyric acid (GHB) in different populations of treated alcoholics: an open comparative study. Journal of Psychopharmacology 23:8, pages 883-890.
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Fabio Caputo, Teo Vignoli, Icro Maremmani, Mauro Bernardi & Giorgio Zoli. (2009) Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review. International Journal of Environmental Research and Public Health 6:6, pages 1917-1929.
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Eduardo E. Benarroch. (2009) γ-Hydroxybutyric acid and its relevance in neurology. Neurology 72:3, pages 282-286.
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Patrizia Malaspina, Matthew J Picklo, C Jakobs, O Carter Snead & K Michael Gibson. (2009) Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency. Human Genomics 3:2, pages 106.
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P.S. van Nieuwenhuijzen, I.S. McGregor & G.E. Hunt. (2009) The distribution of γ-hydroxybutyrate-induced Fos expression in rat brain: Comparison with baclofen. Neuroscience 158:2, pages 441-455.
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Lorenzo Leggio, George A. Kenna & Robert M. Swift. (2008) New developments for the pharmacological treatment of alcohol withdrawal syndrome. A focus on non-benzodiazepine GABAergic medications. Progress in Neuro-Psychopharmacology and Biological Psychiatry 32:5, pages 1106-1117.
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. (2008) Current World Literature. Current Opinion in Endocrinology, Diabetes & Obesity 15:3, pages 284-314.
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