Advanced search
Publication Cover
Journal of Obstetrics and Gynaecology Volume 23, 2003 - Issue 2
Submit an article Journal homepage
125
Views
40
CrossRef citations to date
0
Altmetric
Research Article

A randomised, double-blind placebo-controlled trial of ascorbic acid supplementation for the prevention of preterm labour

P. S. Steyn Department of Obstetrics and Gynaecology, Tygerberg Hospital and University of Stellenbosch, South Africa and Research Unit for Perinatal Mortality of the Medical Research Council of South Africa
,
H. J. Odendaal Department of Obstetrics and Gynaecology, Tygerberg Hospital and University of Stellenbosch, South Africa and Research Unit for Perinatal Mortality of the Medical Research Council of South Africa
,
J. Schoeman Department of Obstetrics and Gynaecology, Tygerberg Hospital and University of Stellenbosch, South Africa and Research Unit for Perinatal Mortality of the Medical Research Council of South Africa
,
C. Stander Department of Human Nutrition, Tygerberg Hospital and University of Stellenbosch, South Africa
,
N. Fanie Department of Human Nutrition, Tygerberg Hospital and University of Stellenbosch, South Africa
&
D. Grové Department of Obstetrics and Gynaecology, Tygerberg Hospital and University of Stellenbosch, South Africa and Research Unit for Perinatal Mortality of the Medical Research Council of South Africa
Pages 150-155 | Published online: 02 Jul 2009

Citations (40)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Tina B. Mikkelsen, Marie Louise østerdal, Vibeke K. Knudsen, Margaretha Haugen, Helle M. Meltzer, Leiv Bakketeig & Sjurdur F. Olsen. (2008) Association between a Mediterranean-type diet and risk of preterm birth among Danish women: a prospective cohort study. Acta Obstetricia et Gynecologica Scandinavica 87:3, pages 325-330.
Read now
Matthew J. Mingione$suffix/text()$suffix/text(), Eva K. Pressman & James R. Woods. (2006) Prevention of PPROM: Current and future strategies. The Journal of Maternal-Fetal & Neonatal Medicine 19:12, pages 783-789.
Read now
J. Schoeman, P. S. Steyn, H. J. Odendaal & D. Grové. (2005) Bacterial vaginosis diagnosed at the first antenatal visit better predicts preterm labour than diagnosis later in pregnancy. Journal of Obstetrics and Gynaecology 25:8, pages 751-753.
Read now

Articles from other publishers (37)

Jelmer R. Prins, Mirthe H. Schoots, Jule I. Wessels, Marjo J.E. Campmans-Kuijpers, Gerjan J. Navis, Harry van Goor, Sarah A. Robertson, Eline M. van der Beek, Luis Sobrevia & Sanne J. Gordijn. (2022) The influence of the dietary exposome on oxidative stress in pregnancy complications. Molecular Aspects of Medicine 87, pages 101098.
Crossref
Mai-Lei Kinshella, Shazmeen Omar, Kerri Scherbinsky, Marianne Vidler, Laura Magee, Peter von Dadelszen, Sophie Moore & Rajavel Elango. (2021) Effects of Maternal Nutritional Supplements and Dietary Interventions on Placental Complications: An Umbrella Review, Meta-Analysis and Evidence Map. Nutrients 13:2, pages 472.
Crossref
Naomi C. A. Juliana, Meghan J. M. Suiters, Salwan Al-Nasiry, Servaas A. Morré, Remco P. H. Peters & Elena Ambrosino. (2020) The Association Between Vaginal Microbiota Dysbiosis, Bacterial Vaginosis, and Aerobic Vaginitis, and Adverse Pregnancy Outcomes of Women Living in Sub-Saharan Africa: A Systematic Review. Frontiers in Public Health 8.
Crossref
Sumedha Gupta, Harsha S. Gaikwad, Banashree Nath & Achla Batra. (2020) Can vitamin C and interleukin 6 levels predict preterm premature rupture of membranes: evaluating possibilities in North Indian population. Obstetrics & Gynecology Science 63:4, pages 432-439.
Crossref
Cindy T. McEvoy, Kristin F. Milner, Ashley J. Scherman, Diane G. Schilling, Christina J. Tiller, Brittany Vuylsteke, Lyndsey E. Shorey-Kendrick, Eliot R. Spindel, Robert Schuff, Julie Mitchell, Dawn Peters, Jill Metz, David Haas, Keith Jackson, Robert S. Tepper & Cynthia D. Morris. (2017) Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco smoke exposure on infant lung function and respiratory health. Contemporary Clinical Trials 58, pages 66-77.
Crossref
Olukunmi O Balogun, Katharina da Silva Lopes, Erika Ota, Yo Takemoto, Alice Rumbold, Mizuki Takegata & Rintaro Mori. (2016) Vitamin supplementation for preventing miscarriage. Cochrane Database of Systematic Reviews 2016:5.
Crossref
Mandana Amir Shaghaghi, Olena Kloss & Peter Eck. (2016) Genetic Variation in Human Vitamin C Transporter Genes in Common Complex Diseases. Advances in Nutrition 7:2, pages 287-298.
Crossref
Alice Rumbold, Erika Ota, Chie Nagata, Sadequa Shahrook & Caroline A Crowther. (2015) Vitamin C supplementation in pregnancy. Cochrane Database of Systematic Reviews 2016:3.
Crossref
Ashok Agarwal, Eva Tvrda & Aditi Mulgund. 2015. Handbook of Fertility. Handbook of Fertility 283 290 .
Paul Kiondo, Gakenia Wamuyu-Maina, Julius Wandabwa, Gabriel S Bimenya, Nazarius Mbona Tumwesigye & Pius Okong. (2014) The effects of vitamin C supplementation on pre-eclampsia in Mulago Hospital, Kampala, Uganda: a randomized placebo controlled clinical trial. BMC Pregnancy and Childbirth 14:1.
Crossref
Natalie A.M. Cooper & Rachel Moores. (2014) A review of the literature regarding nutritional supplements and their effect on vaginal flora and preterm birth. Current Opinion in Obstetrics & Gynecology 26:6, pages 487-492.
Crossref
Zakia M. Ibrahim, Rasha I. Farhan, Huda A. Hussien & Galal L. Mohamed. (2013) Plasma vitamin C levels and preterm prelabor rupture of membrane among Egyptian pregnant women. Evidence Based Womenʼs Health Journal 3:1, pages 14-19.
Crossref
Peter Brocklehurst, Adrienne Gordon, Emer Heatley & Stephen J Milan. (2013) Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database of Systematic Reviews.
Crossref
Daphna K. Dror & Lindsay H. Allen. (2012) Interventions with Vitamins B6, B12 and C in Pregnancy. Paediatric and Perinatal Epidemiology 26:s1, pages 55-74.
Crossref
Adriana Magalhaes Ribeiro Salles, Tais Freire Galvao, Marcus Tolentino Silva, Lucilia Casulari Domingues Motta & Mauricio Gomes Pereira. (2012) Antioxidants for Preventing Preeclampsia: A Systematic Review. The Scientific World Journal 2012, pages 1-10.
Crossref
J.-L. Schlienger. (2011) État des lieux des compléments alimentaires chez la femme enceinte. Médecine des Maladies Métaboliques 5:5, pages 521-532.
Crossref
Emma Derbyshire. 2011. Nutrition in the Childbearing Years. Nutrition in the Childbearing Years 126 148 .
J. A. Osaikhuwuomwan, E. E. Okpere, C. A. Okonkwo, A. B. Ande & E. S. Idogun. (2010) Plasma vitamin C levels and risk of preterm prelabour rupture of membranes. Archives of Gynecology and Obstetrics 284:3, pages 593-597.
Crossref
Alice Rumbold, Philippa Middleton, Ning Pan & Caroline A Crowther. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Brian M. Mercer, Adli Abdelrahim, Robert M. Moore, Jillian Novak, Deepak Kumar, Joseph M. Mansour, Marina Perez-Fournier, Cynthia J. Milluzzi & John J. Moore. (2010) The Impact of Vitamin C Supplementation in Pregnancy and In Vitro Upon Fetal Membrane Strength and Remodeling. Reproductive Sciences 17:7, pages 685-695.
Crossref
Hairong Xu, Ricardo Perez-Cuevas, Xu Xiong, Hortensia Reyes, Chantal Roy, Pierre Julien, Graeme Smith, Peter von Dadelszen, Line Leduc, Fran?ois Audibert, Jean-Marie Moutquin, Bruno Piedboeuf, Bryna Shatenstein, Socorro Parra-Cabrera, Pierre Choquette, Stephanie Winsor, Stephen Wood, Alice Benjamin, Mark Walker, Michael Helewa, Johanne Dub?Georges Tawagi, Gareth Seaward, Arne Ohlsson, Laura A. Magee, Femi Olatunbosun, Robert Gratton, Roberta Shear, Nestor Demianczuk, Jean-Paul Collet, Shuqin Wei & William D. Fraser. (2010) An international trial of antioxidants in the prevention of preeclampsia (INTAPP). American Journal of Obstetrics and Gynecology 202:3, pages 239.e1-239.e10.
Crossref
Hiba A. Bawadi, Oqba Al-Kuran, Lily-Ann A. Al-Bastoni, Reema F. Tayyem, AbdalNasser Jaradat, Georgianna Tuuri, Soha N. Al-Beitawi & Lama M. Al-Mehaisen. (2010) Gestational nutrition improves outcomes of vaginal deliveries in Jordan: an epidemiologic screening. Nutrition Research 30:2, pages 110-117.
Crossref
Hairong Xu, Bryna Shatenstein, Zhong-Cheng Luo, Shuqin Wei & William Fraser. (2009) Role of nutrition in the risk of preeclampsia. Nutrition Reviews 67:11, pages 639-657.
Crossref
Robert M. Moore, Jillian B. Novak, Deepak Kumar, Joseph M. Mansour, Brian M. Mercer & John J. Moore. (2009) Alpha-Lipoic Acid Inhibits Tumor Necrosis Factor-Induced Remodeling and Weakening of Human Fetal Membranes1. Biology of Reproduction 80:4, pages 781-787.
Crossref
Alice Rumbold, Lelia Duley, Caroline A Crowther & Ross R Haslam. (2008) Antioxidants for preventing pre-eclampsia. Cochrane Database of Systematic Reviews.
Crossref
Harald Leitich & Herbert Kiss. (2007) Asymptomatic bacterial vaginosis and intermediate flora as risk factors for adverse pregnancy outcome. Best Practice & Research Clinical Obstetrics & Gynaecology 21:3, pages 375-390.
Crossref
Helen Margaret McDonald, Peter Brocklehurst & Adrienne Gordon. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
L Poston, AL Briley, PT Seed, FJ Kelly & AH Shennan. (2006) Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. The Lancet 367:9517, pages 1145-1154.
Crossref
Hans Christian Erichsen, Stephanie A. Mulherin Engel, Peter K. Eck, Robert Welch, Meredith Yeager, Mark Levine, Anna Maria Siega-Riz, Andrew F. Olshan & Stephen J. Chanock. (2006) Genetic Variation in the Sodium-dependent Vitamin C Transporters, SLC23A1, and SLC23A2 and Risk for Preterm Delivery. American Journal of Epidemiology 163:3, pages 245-254.
Crossref
Sajal Gupta, Ashok Agarwal & Rakesh K. Sharma. (2005) The Role of Placental Oxidative Stress and Lipid Peroxidation in Preeclampsia. Obstetrical & Gynecological Survey 60:12, pages 807-816.
Crossref
A Rumbold, L Duley, C Crowther & R Haslam. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
L.R. Lucio, A. Escudero, E. Rodr?guez-Vega, M.P. V?zquez-Caama?o, O. Vaquerizo & F.J. Herrera. (2005) Asociaci?n entre las infecciones del tracto urinario y el parto pret?rmino. Progresos de Obstetricia y Ginecolog?a 48:8, pages 373-378.
Crossref
Alice Rumbold, Philippa Middleton & Caroline A Crowther. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Esther Casanueva, Carmina Ripoll, Maricruz Tolentino, Rosa Maria Morales, Frania Pfeffer, Pablo Vilchis & Felipe Vadillo-Ortega. (2005) Vitamin C supplementation to prevent premature rupture of the chorioamniotic membranes: a randomized trial. The American Journal of Clinical Nutrition 81:4, pages 859-863.
Crossref
Alice Rumbold & Caroline A Crowther. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
H McDonald, P Brocklehurst & J Parsons. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Ngina Connors & David Merrill. (2004) Antioxidants for Prevention of Preterm Delivery. Clinical Obstetrics and Gynecology 47:4, pages 822-832.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.