Advanced search
Publication Cover
Journal of Psychosomatic Obstetrics & Gynecology Volume 26, 2005 - Issue 2
Submit an article Journal homepage
106
Views
47
CrossRef citations to date
0
Altmetric
Original Article

Psychological side-effects of clomiphene citrate and human menopausal gonadotrophin

So-Hyun Choi Women's Health Program, University Health Network, University of Toronto, Ontario, CanadaCorrespondence[email protected]
,
Heather Shapiro Department of Obstetrics and Gynaecology, University of Toronto, Ontario, Canada
,
Gail E Robinson Department of Psychiatry, University Health Network, University of Toronto, Ontario, Canada
,
Jane Irvine Department of Psychology, University Health Network, University of Toronto, York University
,
Jan Neuman Division of Gynaecologic Oncology, University Health Network, University of Toronto, Ontario, Canada
,
Barry Rosen Division of Gynaecologic Oncology, University Health Network, University of Toronto, Ontario, Canada
,
Joan Murphy Department of Obstetrics and Gynaecology, University of Toronto, Ontario, Canada; Division of Gynaecologic Oncology, University Health Network, University of Toronto, Ontario, Canada
&
Donna Stewart Women's Health Program, University Health Network, University of Toronto, Ontario, Canada; Department of Obstetrics and Gynaecology, University of Toronto, Ontario, Canada; Department of Psychiatry, University Health Network, University of Toronto, Ontario, Canada
 show all
Pages 93-100 | Received 01 Apr 2003, Accepted 13 Mar 2004, Published online: 07 Jul 2009

Citations (47)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Hans Christian Bordado Henriksen, Anders Palmstrøm Jørgensen, Christine Wisløff & Ingrid Amalia Havnes. (2023) Challenges recruiting men with a desire to cease anabolic-androgenic steroid use to a pilot involving hormone therapy intervention. Drugs: Education, Prevention and Policy 0:0, pages 1-13.
Read now
Ophra Leyser-Whalen. (2014) “Crazy Woman Juice”: Making Sense of Women's Clomiphene Infertility Treatments. Women's Reproductive Health 1:2, pages 73-89.
Read now
Olga B. A. van den Akker. (2013) For your eyes only: Bio-behavioural and psycho-social research priorities. Human Fertility 16:1, pages 89-93.
Read now
Christopher M. Celano, Oliver Freudenreich, Carlos Fernandez-Robles, Theodore A. Stern, Mario A. Caro & Jeff C. Huffman. (2011) Depressogenic effects of medications: a review. Dialogues in Clinical Neuroscience 13:1, pages 109-125.
Read now

Articles from other publishers (43)

Ahmed Abu-Zaid, Abdulrahim Gari, Hussein Sabban, Majed Saeed Alshahrani, Khalid Khadawardi, Ehab Badghish, Rayan AlSghan, Ibtihal Abdulaziz Bukhari, Abdullah Alyousef, Mohammed Abuzaid, Saud Abdullah Alsharif, Osama Alomar, Aliyah Hadi Alamery & Saeed Baradwan. (2023) Comparison of Letrozole and Clomiphene Citrate in Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis. Reproductive Sciences 31:4, pages 883-905.
Crossref
Srihita Patibandla, Joshua J Gallagher, Laasya Patibandla, Ali Z Ansari, Shayaan Qazi & Samuel F Brown. (2024) Ayurvedic Herbal Medicines: A Literature Review of Their Applications in Female Reproductive Health. Cureus.
Crossref
T. Strowitzki. 2024. Klinische Endokrinologie für Frauenärzte. Klinische Endokrinologie für Frauenärzte 271 328 .
Olabode Oluwadare Akintoye, Ayodeji Johnson Ajibare, Isaac Adeola Oriyomi, Babatunde Ajayi Olofinbiyi, Grace Oyiza Yusuf, Damilola Christanah Afuye, Temitope Kabirat Babalola, Oluwadamilola Esther Faturoti, Seun Oludipe & Victor Bamidele Owoyele. (2023) Synergistic action of carvedilol and clomiphene in mitigating the behavioral phenotypes of letrozole-model of PCOS rats by modulating the NRF2/NFKB pathway. Life Sciences 324, pages 121737.
Crossref
Mohd Zahoor ul haq Shah, Vinoy Kumar Shrivastava, Manzoor Ahmad Mir & Kehinde S. Olaniyi. (2023) Role of diacerein on steroidogenesis and folliculogenesis related genes in ovary of letrozole-induced PCOS mice. Chemico-Biological Interactions 377, pages 110468.
Crossref
Gabriela A. Barber & Julia R. Steinberg. (2022) The association between pregnancy intention, fertility treatment use, and postpartum depression. Social Science & Medicine 314, pages 115439.
Crossref
Aanchal Sharma & Deepti Shrivastava. (2022) Psychological Problems Related to Infertility. Cureus.
Crossref
Neha Shroff Hudepohl & Kelsey Smith. (2022) Infertility and Its Association with Depression, Anxiety, and Emotional Distress: A Current Review. Advances in Psychiatry and Behavioral Health 2:1, pages 119-132.
Crossref
Anna M. Gorczyca, Felicia L. Steger, Lauren T. Ptomey, Robert N. Montgomery, Riley Mickelsen, Patricia Smith, Joseph E. Donnelly & Courtney A. Marsh. (2022) The impact of a group based, remotely delivered weight loss intervention in women with polycystic ovary syndrome on ovulation, quality of life and body composition. Frontiers in Reproductive Health 4.
Crossref
Yasmine F. Ibrahim, Mohammed Alorabi, Walaa Yehia Abdelzaher, Nisreen DM Toni, Khaled Thabet, AbdelRahman Hegazy, Haitham Ahmed Bahaa, Gaber El-Saber Batiha, Nermeen N. Welson, Mohamed A. Morsy, Katharigatta N. Venugopala & Asmaa Mohamed Abdel-Aziz. (2022) Diacerein ameliorates letrozole-induced polycystic ovarian syndrome in rats. Biomedicine & Pharmacotherapy 149, pages 112870.
Crossref
Bianca Santos Martins Gonçalves, Flora França Nogueira Mariotti, Giovana Ponsone, Thalita Aparecida Avelino Soares, Paula Cristina Barbosa Garcia Perão, Marcos Mônico-Neto, Leonardo Moro Cariste, Auro Maluf, Gustavo da Silva Soares Nascimento, Hanna Karen Moreira Antunes, Isabel Cristina Céspedes, Milena de Barros Viana & Luciana Le Sueur-Maluf. (2022) High and fluctuating levels of ovarian hormones induce an anxiogenic effect, which can be modulated under stress conditions: Evidence from an assisted reproductive rodent model. Hormones and Behavior 137, pages 105087.
Crossref
Ginevra Mills & Togas Tulandi. 2022. Clinical Reproductive Medicine and Surgery. Clinical Reproductive Medicine and Surgery 353 366 .
Reham I. Amer, Ghada E. Yassin, Reem A. Mohamed & Ahmed M. Fayez. (2021) Pharmaceutical and Pharmacological Evaluation of the Effect of Nano-Formulated Spironolactone and Progesterone on Inflammation and Hormonal Levels for Managing Hirsutism Experimentally Induced in Rats. AAPS PharmSciTech 22:5.
Crossref
Amelia Swanson & Andrea Mechanick Braverman. (2021) Psychological Components of Infertility. Family Court Review 59:1, pages 67-82.
Crossref
Amir Raoofi, Ali Delbari, Davood Mahdian, Mohammad-Shafi Mojadadi, Maedeh Akhlaghi, Ghazaleh Dadashizadeh, Vahid Ebrahimi, Abdollah Amini, Rahim Golmohammadi, Sara Sadat Javadinia & Amin Mousavi Khaneghah. (2021) Effects of curcumin nanoparticle on the histological changes and apoptotic factors expression in testis tissue after methylphenidate administration in rats. Acta Histochemica 123:1, pages 151656.
Crossref
Enitome E. Bafor, Adaeze P. Uchendu, Omorede E. Osayande, Osemelomen Omoruyi, Uyi G. Omogiade, Evuarherhere E. Panama, Olusola O. Elekofehinti, Ebube L. Oragwuncha & Asanat Momodu. (2020) Ascorbic Acid and Alpha-Tocopherol Contribute to the Therapy of Polycystic Ovarian Syndrome in Mouse Models. Reproductive Sciences 28:1, pages 102-120.
Crossref
Mina Mehraban, Gholamali Jelodar & Farhad Rahmanifar. (2020) A combination of spearmint and flaxseed extract improved endocrine and histomorphology of ovary in experimental PCOS. Journal of Ovarian Research 13:1.
Crossref
Saeed Sherafatmanesh, Maryam Ekramzadeh, Nader Tanideh, Mohammad-Taghi Golmakani & Farhad Koohpeyma. (2020) The effects of thylakoid-rich spinach extract and aqueous extract of caraway (Carum carvi L.) in letrozole-induced polycystic ovarian syndrome rats. BMC Complementary Medicine and Therapies 20:1.
Crossref
Gabriela Simionescu, Ovidiu-Dumitru Ilie, Alin Ciobica, Bogdan Doroftei, Radu Maftei, Delia Grab, Jack McKenna, Nitasha Dhunna, Ioannis Mavroudis & Emil Anton. (2020) Mini-Review on the Possible Interconnections between the Gut-Brain Axis and the Infertility-Related Neuropsychiatric Comorbidities. Brain Sciences 10:6, pages 384.
Crossref
Alexandre González-Rodríguez, Jesús Cobo, Virginia Soria, Judith Usall, Clemente Garcia-Rizo, Miquel Bioque, José Antonio Monreal & Javier Labad. (2020) Women Undergoing Hormonal Treatments for Infertility: A Systematic Review on Psychopathology and Newly Diagnosed Mood and Psychotic Disorders. Frontiers in Psychiatry 11.
Crossref
Seyedeh Maedeh Fatemi Abhari, Ramzan Khanbabaei, Nasim Hayati Roodbari, Kazem Parivar & Parichehreh Yaghmaei. (2020) Curcumin-loaded super-paramagnetic iron oxide nanoparticle affects on apoptotic factors expression and histological changes in a prepubertal mouse model of polycystic ovary syndrome-induced by dehydroepiandrosterone - A molecular and stereological study. Life Sciences 249, pages 117515.
Crossref
Nimisha Kakadia, Payal Patel, Shrikalp Deshpande & Gaurang Shah. (2019) Effect of Vitex negundo L. seeds in letrozole induced polycystic ovarian syndrome. Journal of Traditional and Complementary Medicine 9:4, pages 336-345.
Crossref
Hyun Yang, Seung Yeon Lee, Sang R. Lee, Bo-Jeong Pyun, Hye Jin Kim, Young Ho Lee, Sun Woo Kwon, Dong Ho Suh, Choong Hwan Lee, Eui-Ju Hong & Hye Won Lee. (2018) Therapeutic Effect of Ecklonia cava Extract in Letrozole-Induced Polycystic Ovary Syndrome Rats. Frontiers in Pharmacology 9.
Crossref
Jana Hroudová. (2018) Iatrogenic, drug‑induced depressions. Praktické lékárenství 14:2, pages 63-66.
Crossref
Togas Tulandi & Hélène S. Weibel. 2017. Clinical Reproductive Medicine and Surgery. Clinical Reproductive Medicine and Surgery 289 298 .
P. Sushma Reddy, Nazia Begum, Sumith Mutha & Vasudha Bakshi. (2016) Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome. Asian Pacific Journal of Reproduction 5:2, pages 116-122.
Crossref
Julia C. Knight, Amrita S. Pandit, Anne M. Rich, Gino T. Trevisani & Terry Rabinowitz. (2015) Clomiphene-Associated Suicide Behavior in a Man Treated for Hypogonadism: Case Report and Review of The Literature. Psychosomatics 56:5, pages 598-602.
Crossref
Katherine Williams. 2015. Fertility Counseling. Fertility Counseling 85 96 .
. 2015. Fertility Counseling. Fertility Counseling 45 96 .
Canan Dura Deveci, Berfu Demir, Ozlem Sengul, Berna Dilbaz & Umit Goktolga. (2014) Clomiphene citrate ‘stair-step’ protocol vs. traditional protocol in patients with polycystic ovary syndrome: a randomized controlled trial. Archives of Gynecology and Obstetrics 291:1, pages 179-184.
Crossref
Myles Doyle & Angela Carballedo. (2018) Infertility and mental health. Advances in Psychiatric Treatment 20:5, pages 297-303.
Crossref
José Daniel Machado Rodrigues, Maria Georgina Santos Lapa & Ian Fraser Brockington. (2014) Psychotic episode secondary to gonadotrophins. General Hospital Psychiatry 36:5, pages 549.e7-549.e8.
Crossref
Pallavi Sinha & Amit Garg. (2014) Could clomiphene kindle acute manic episode in a male patient? A case report. General Hospital Psychiatry 36:5, pages 549.e5-549.e6.
Crossref
Eszter Kirilly, Xénia Gonda, Gabriella Juhász & György Bagdy. (2013) Anxiogenic and depressogenic side-effects of non-psychiatric drugs. Orvosi Hetilap 154:34, pages 1327-1336.
Crossref
. (2013) Use of clomiphene citrate in infertile women: a committee opinion. Fertility and Sterility 100:2, pages 341-348.
Crossref
Olga B. A. van den Akker. 2012. Reproductive Health Psychology. Reproductive Health Psychology 144 180 .
K. E. Williams, P. G. Stemmle, L. M. Westphal & N. L. Rasgon. (2011) Mood disorders in oocyte donor candidates: brief report and implications for future research. Human Reproduction 26:4, pages 847-852.
Crossref
Richard C McEachin, Haiming Chen, Maureen A Sartor, Scott F Saccone, Benjamin J Keller, Alan R Prossin, James D Cavalcoli & Melvin G McInnis. (2010) A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder. BMC Systems Biology 4:1.
Crossref
Mark Gibson. 2010. Reproductive Endocrinology and Infertility. Reproductive Endocrinology and Infertility 525 543 .
Akiko MORI. (2009) Supporting stress management for women undergoing the early stages of fertility treatment: A cluster‐randomized controlled trial*. Japan Journal of Nursing Science 6:1, pages 37-49.
Crossref
Thomas Strowitzki. 2009. Klinische Endokrinologie für Frauenärzte. Klinische Endokrinologie für Frauenärzte 633 712 .
Katherine E. Williams, Wendy K. Marsh & Natalie L. Rasgon. (2007) Mood disorders and fertility in women: a critical review of the literature and implications for future research. Human Reproduction Update 13:6, pages 607-616.
Crossref
. (2005) Current awareness: Pharmacoepidemiology and drug safety. Pharmacoepidemiology and Drug Safety 15:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.