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Original Article

A systematic review of experimental and clinical studies of sildenafil citrate for intrauterine growth restriction and pre-term labour

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Pages 255-259 | Published online: 02 Jul 2009

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Read on this site (9)

Heba M. Aboud, Amira H. Hassan, Adel A. Ali & Abdel-Razik H. Abdel-Razik. (2018) Novel in situ gelling vaginal sponges of sildenafil citrate-based cubosomes for uterine targeting. Drug Delivery 25:1, pages 1328-1339.
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Rana Choudhary, Kavita Desai, Hetal Parekh & Kedar Ganla. (2016) Sildenafil citrate for the management of fetal growth restriction and oligohydramnios. International Journal of Women's Health 8, pages 367-372.
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Eftihios Trakakis, Vassilios Vaggopoulos, Vasileios D. Sioulas, Periklis Panagopoulos, Ioannis Grammatikakis, Peny Ambatzi & Dimitrios Kassanos. (2014) The contribution of sildenafil (Viagra) to ovarian stimulation with gonadotropins in a woman with poor ovarian response. Gynecological Endocrinology 30:7, pages 478-480.
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Srinivasan Shanmugam, Young-Hun Kim, Jeong-Hee Park, Ho Taek Im, Young Taek Sohn, Kyeong Soo Kim, Yong-Il Kim, Chul Soon Yong, Jong Oh Kim, Han-Gon Choi & Jong Soo Woo. (2014) Sildenafil vaginal suppositories: preparation, characterization, in vitro and in vivo evaluation. Drug Development and Industrial Pharmacy 40:6, pages 803-812.
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Mohammad Amin Rezvanfar, Hamid Reza Rahimi & Mohammad Abdollahi. (2012) ADMET considerations for phosphodiesterase-5 inhibitors. Expert Opinion on Drug Metabolism & Toxicology 8:10, pages 1231-1245.
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Robert A Kloner, Gary Comstock, Laurence A Levine, Steven Tiger & Vera J Stecher. (2011) Investigational noncardiovascular uses of phosphodiesterase-5 inhibitors. Expert Opinion on Pharmacotherapy 12:15, pages 2297-2313.
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Ozlem Ozdegirmenci, Tuncay Kucukozkan, Elvin Akdag, Turgut Topal, Ali Haberal, Hakan Kayir, Sukru Oter, Mesut Akyol & Tayfun Uzbay. (2011) Effects of sildenafil and tadalafil on ischemia/reperfusion injury in fetal rat brain. The Journal of Maternal-Fetal & Neonatal Medicine 24:2, pages 317-323.
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Articles from other publishers (38)

Arvind Sehgal, Theodore Dassios, Marcel F. Nold, Claudia A. Nold-Petry & Anne Greenough. (2022) Fetal growth restriction and neonatal-pediatric lung diseases: Vascular mechanistic links and therapeutic directions. Paediatric Respiratory Reviews 44, pages 19-30.
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Sabrina Paola Demirdjian, Cesar Hernan Meller, Maria Celeste Berruet, Gonzalo Dosdoglirian & Adolfo Etchegaray. (2022) Perinatal outcomes of two consecutive strategies for the management of fetal growth restriction: a before–after study. Archives of Gynecology and Obstetrics 307:1, pages 319-326.
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Anastasiia A. Zakharova, Svetlana S. Efimova & Olga S. Ostroumova. (2021) Phosphodiesterase Type 5 Inhibitors Greatly Affect Physicochemical Properties of Model Lipid Membranes. Membranes 11:11, pages 893.
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Anshu AnshuDr.Dr., Usha KumariDr.Dr. & Debarshi JanaDr.Dr.. (2021) USE OF SLIDENAFIL CITRATE IN CASES OF INTRAUTERINE GROWTH RESTRICTION AT OBSTETRICS AND GYNAECOLOGY DEPARTMENT OF JLNMCH, BHAGALPUR, BIHAR. INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, pages 23-24.
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Maryam Damghanian, Farnaz Farnam & Roghieh Kharaghani. (2020) The Effects of Sildenafil on Fetal Doppler Indices: A Systematic Review and Meta-Analysis. Journal of Advances in Medical and Biomedical Research 28:131, pages 307-315.
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L. J. Renshall, E. C. Cottrell, E. Cowley, C. P. Sibley, P. N. Baker, E. B. Thorstensen, S. L. Greenwood, M. Wareing & M. R. Dilworth. (2020) Antenatal sildenafil citrate treatment increases offspring blood pressure in the placental-specific Igf2 knockout mouse model of FGR . American Journal of Physiology-Heart and Circulatory Physiology 318:2, pages H252-H263.
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Andre Gie, Ignacio Valenzuela, Thomas Salaets, Jan Deprest & Jaan Toelen. 2020. Tantalizing Therapeutics in Bronchopulmonary Dysplasia. Tantalizing Therapeutics in Bronchopulmonary Dysplasia 169 191 .
Anouk Pels, Janus C. Jakobsen, Wessel Ganzevoort, Christiana A. Naaktgeboren, Wes Onland, Aleid G. van Wassenaer-Leemhuis & Christian Gluud. (2019) Detailed statistical analysis plan for the Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction) randomised clinical trial on sildenafil versus placebo for pregnant women with severe early onset fetal growth restriction. Trials 20:1.
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MA Maher, TM Sayyed & SW El‐khadry. (2018) Retracted: Nifedipine alone or combined with sildenafil citrate for management of threatened preterm labour: a randomised trial . BJOG: An International Journal of Obstetrics & Gynaecology 126:6, pages 729-735.
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I. A. Tyuzikov, A. V. Smirnov, L. V. Smirnova & I. V. Lesnikova. (2019) Non-classical effects of sildenafil in clinical medicine: an interdisciplinary approach. Medical Council:21, pages 192-202.
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Mohammed Maged, Alaa Wageh, Maher Shams & Abdlgawad Elmetwally. (2018) Use of sildenafil citrate in cases of intrauterine growth restriction (IUGR); a prospective trial. Taiwanese Journal of Obstetrics and Gynecology 57:4, pages 483-486.
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Robert B. WaltonLuckey C. ReedSarah M. EstradaStacey S. SchmiedeckeDiana L. Villazana-KretzerPeter G. NapolitanoNicholas Ieronimakis. (2018) Evaluation of Sildenafil and Tadalafil for Reversing Constriction of Fetal Arteries in a Human Placenta Perfusion Model. Hypertension 72:1, pages 167-176.
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Victor Hugo Gonçalves-Rizzi, José Sérgio Possomato-Vieira, Regina Aparecida Nascimento, Mayara Caldeira-Dias & Carlos Alan Dias-Junior. (2018) Maternal hypertension and feto-placental growth restriction is reversed by sildenafil: Evidence of independent effects of circulating nitric oxide levels. European Journal of Pharmacology 822, pages 119-127.
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Colin P Sibley. (2017) Treating the dysfunctional placenta. Journal of Endocrinology 234:2, pages R81-R97.
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Innocenzo Bianca, Giovanna Geraci, Michele Massimo Gulizia, Gabriele Egidy Assenza, Chiara Barone, Marcello Campisi, Annalisa Alaimo, Rachele Adorisio, Francesca Comoglio, Silvia Favilli, Gabriella Agnoletti, Maria Gabriella Carmina, Massimo Chessa, Berardo Sarubbi, Maurizio Mongiovì, Maria Giovanna Russo, Sebastiano Bianca, Giuseppe Canzone, Marco Bonvicini, Elsa Viora & Marco Poli. (2017) Consensus Document of the Italian Association of Hospital Cardiologists (ANMCO), Italian Society of Pediatric Cardiology (SICP), and Italian Society of Gynaecologists and Obstetrics (SIGO): pregnancy and congenital heart diseases. European Heart Journal Supplements 19:suppl_D, pages D256-D292.
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Mohammad Ahmed Maher, Tarek Mohammad Sayyed & Nabih Elkhouly. (2017) Sildenafil Citrate Therapy for Oligohydramnios. Obstetrics & Gynecology 129:4, pages 615-620.
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Magalie Ladouceur, Louise Benoit, Jelena Radojevic, Adeline Basquin, Claire Dauphin, Sébastien Hascoet, Pamela Moceri, Charlene Bredy, Laurence Iserin, Marielle Gouton & Jacky Nizard. (2017) Pregnancy outcomes in patients with pulmonary arterial hypertension associated with congenital heart disease. Heart 103:4, pages 287-292.
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N. D. Paauw, B. B. van Rijn, A. T. Lely & J. A. Joles. (2017) Pregnancy as a critical window for blood pressure regulation in mother and child: programming and reprogramming. Acta Physiologica 219:1, pages 241-259.
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Liam Dunn, Vicki Flenady & Sailesh Kumar. (2016) Reducing the risk of fetal distress with sildenafil study (RIDSTRESS): a double-blind randomised control trial. Journal of Translational Medicine 14:1.
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S. Bairagi, K.E. Quinn, A.R. Crane, R.L. Ashley, P.P. Borowicz, J.S. Caton, R.R. Redden, A.T. Grazul-Bilska & L.P. Reynolds. (2016) Maternal environment and placental vascularization in small ruminants. Theriogenology 86:1, pages 288-305.
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A. TrapaniJrJr, L. F. Gonçalves, T. F. Trapani, M. J. Franco, R. N. Galluzzo & M. M. S. Pires. (2016) Comparison between transdermal nitroglycerin and sildenafil citrate in intrauterine growth restriction: effects on uterine, umbilical and fetal middle cerebral artery pulsatility indices. Ultrasound in Obstetrics & Gynecology 48:1, pages 61-65.
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Elizabeth Cottrell & Colin Sibley. (2015) From Pre-Clinical Studies to Clinical Trials: Generation of Novel Therapies for Pregnancy Complications. International Journal of Molecular Sciences 16:12, pages 12907-12924.
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Adam Loveridge, Jenny Bacon & Brendan Madden. 2015. Treatment of Pulmonary Hypertension. Treatment of Pulmonary Hypertension 81 145 .
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Mark Robert Dilworth, Irene Andersson, Lewis James Renshall, Elizabeth Cowley, Philip Baker, Susan Greenwood, Colin Peter Sibley & Mark Wareing. (2013) Sildenafil Citrate Increases Fetal Weight in a Mouse Model of Fetal Growth Restriction with a Normal Vascular Phenotype. PLoS ONE 8:10, pages e77748.
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Zeenat Safdar. (2012) Pulmonary arterial hypertension in pregnant women. Therapeutic Advances in Respiratory Disease 7:1, pages 51-63.
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T. H. Lin, Y. N. Su, J. C. Shih, H. C. Hsu & C. N. Lee. (2012) Resolution of high uterine artery pulsatility index and notching following sildenafil citrate treatment in a growth‐restricted pregnancy. Ultrasound in Obstetrics & Gynecology 40:5, pages 609-610.
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S Herraiz, B Pellicer, V Serra, O Cauli, J Cortijo, V Felipo & A Pellicer. (2012) Sildenafil citrate improves perinatal outcome in fetuses from pre‐eclamptic rats. BJOG: An International Journal of Obstetrics & Gynaecology 119:11, pages 1394-1402.
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B Pellicer, S Herraiz, O Cauli, R Rodrigo, M Asensi, J Cortijo, V Serra, E Morcillo, V Felipo, C Simón & A Pellicer. (2011) Haemodynamic effects of long-term administration of sildenafil in normotensive pregnant and non-pregnant rats. BJOG: An International Journal of Obstetrics & Gynaecology 118:5, pages 615-623.
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Faisal Mohamed Abou-Tarboush, Mohamed Fathy Abdel-Samad & Mokhlid Hamed Al-Meteri. (2011) Developmental toxicity of orally administered sildenafil citrate (Viagra) in SWR/J mice. Saudi Journal of Biological Sciences 18:2, pages 135-139.
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Edmund Hey. 2011. Neonatal Formulary 6. Neonatal Formulary 6 33 280 .
Faisal Mohamed Abou-Tarboush & Mohamed Fathy Abdel-Samad. (2010) Cytogenetic effects of sildenafil citrate (Viagra) on SWR/J mouse bone marrow cells. Saudi Journal of Biological Sciences 17:4, pages 315-319.
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Sarah A. Hale, Cresta W. Jones, George Osol, Adrienne Schonberg, Gary J. Badger & Ira M. Bernstein. (2010) Sildenafil Increases Uterine Blood Flow in Nonpregnant Nulliparous Women. Reproductive Sciences 17:4, pages 358-365.
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Jennifer M. Sasser & Chris Baylis. (2010) Effects of sildenafil on maternal hemodynamics and fetal growth in normal rat pregnancy. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 298:2, pages R433-R438.
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Chrisen H Maharaj, Daniel O'Toole, Tadhg Lynch, John Carney, James Jarman, Brendan D Higgins, John J Morrison & John G Laffey. (2009) Effects and mechanisms of action of sildenafil citrate in human chorionic arteries. Reproductive Biology and Endocrinology 7:1.
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Valerie J. Wiebe & James P. Howard. (2009) Pharmacologic Advances in Canine and Feline Reproduction. Topics in Companion Animal Medicine 24:2, pages 71-99.
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Suzanne L. Miller, Jan M. Loose, Graham Jenkin & Euan M. Wallace. (2009) The effects of sildenafil citrate (Viagra) on uterine blood flow and well being in the intrauterine growth-restricted fetus. American Journal of Obstetrics and Gynecology 200:1, pages 102.e1-102.e7.
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E. Bedard, K. Dimopoulos & M. A. Gatzoulis. (2008) Has there been any progress made on pregnancy outcomes among women with pulmonary arterial hypertension?. European Heart Journal 30:3, pages 256-265.
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