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Obstetric Short Communication

Can post-mortem examination of the placenta help determine the cause of stillbirth?

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Pages 225-228 | Published online: 02 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Duygu Tugrul Ersak, Atakan Tanacan, Bergen Laleli Koç, Selcan Sınacı, Özgür Kara & Dilek Şahin. (2023) The utility of complete blood parameter indices to predict stillbirths. The Journal of Maternal-Fetal & Neonatal Medicine 36:1.
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Nicolas Belhomme, Alain Lescoat, Alice Ballerie, Florence Rouget, Gwenaelle Le Bouar, Philippe Loget, Leïla Caillault & Patrick Jego. (2020) Elucidating in utero fetal demise: time to reassemble the pieces of the puzzle?. The Journal of Maternal-Fetal & Neonatal Medicine 33:21, pages 3720-3722.
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Articles from other publishers (59)

Beatrix B. Thompson, Parker H. Holzer & Harvey J. Kliman. (2023) Placental Pathology Findings in Unexplained Pregnancy Losses. Reproductive Sciences 31:2, pages 488-504.
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Rasheed Fatima, Shilpa Karamchedu, Haricharan B.V, Tejeswari Jana, Suresh K & Florence N K. (2023) Role of fetal autopsy and its importance in intrauterine fetal death: Histopathological diagnosis. Journal of Research in Applied and Basic Medical Sciences 9:4, pages 233-242.
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Rinshi Abid Elayedatt, Vivek Krishnan & Vidya Chandraprabha. (2023) Fetal Autopsy—A Game Changer!. Journal of Fetal Medicine 10:03, pages 099-104.
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Haleh Soltanghoraee, Maziar Moradi-Lakeh, Narjes Khalili & Azadeh Soltani. (2022) A retrospective autopsy study of 42 cases of stillbirth in Avicenna Research Institute. BMC Pregnancy and Childbirth 22:1.
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Vardendra G. Kulkarni, K. Byranahalli Sunilkumar, T.S. Nagaraj, Zeeshan Uddin, Imran Ahmed, Kay Hwang, Shivaprasad S. Goudar, Gowdar Guruprasad, Sarah Saleem, Shiyam Sunder Tikmani, Sangappa M. Dhaded, S. Yogeshkumar, Manjunath S. Somannavar, Elizabeth M. McClure & Robert L. Goldenberg. (2021) Maternal and fetal vascular lesions of malperfusion in the placentas associated with fetal and neonatal death: results of a prospective observational study. American Journal of Obstetrics and Gynecology 225:6, pages 660.e1-660.e12.
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Nicole Graham, Louise Stephens, Edward D. Johnstone & Alexander E. P. Heazell. (2021) Can information regarding the index stillbirth determine risk of adverse outcome in a subsequent pregnancy? Findings from a single‐center cohort study. Acta Obstetricia et Gynecologica Scandinavica 100:7, pages 1326-1335.
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D. Nuzum, B. Fitzgerald, M. J. Evans & K. O’Donoghue. (2021) Maternity Healthcare Chaplains and Perinatal Post-Mortem Support and Understanding in the United Kingdom and Ireland: An Exploratory Study. Journal of Religion and Health 60:3, pages 1924-1936.
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Irene Maria BeuneStefanie Elisabeth DamhuisWessel GanzevoortJohn Ciaran HutchinsonTeck Yee KhongEoghan E. MooneyNeil James SebireSanne Jehanne Gordijn. (2021) Consensus Definition of Fetal Growth Restriction in Intrauterine Fetal Death: A Delphi Procedure. Archives of Pathology & Laboratory Medicine 145:4, pages 428-436.
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Nicole Graham, Louise Stephens & Alexander EP Heazell. (2020) Care in pregnancies subsequent to stillbirth or perinatal death. The Obstetrician & Gynaecologist 23:1, pages 48-59.
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N Gulati, FL Mackie, P Cox, T Marton, AEP Heazell, RK Morris & MD Kilby. (2020) Cause of intrauterine and neonatal death in twin pregnancies (CoDiT): development of a novel classification system. BJOG: An International Journal of Obstetrics & Gynaecology 127:12, pages 1507-1515.
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Margaret J Evans, Elizabeth S Draper & Lucy K Smith. (2020) Impact of sociodemographic and clinical factors on offer and parental consent to postmortem following stillbirth or neonatal death: a UK population-based cohort study. Archives of Disease in Childhood - Fetal and Neonatal Edition 105:5, pages 532-537.
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Nicole Graham & Alexander E.P. Heazell. (2020) When the Fetus Goes Still and the Birth Is Tragic. Obstetrics and Gynecology Clinics of North America 47:1, pages 183-196.
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J. Ciaran Hutchinson, Susan C. Shelmerdine & Neil J. Sebire. 2020. Fetal Medicine. Fetal Medicine 121 130.e1 .
Lakshmi Thirumalaikumar, Kalaivani Ramalingam & Tamas Marton. (2019) Placental histopathological abnormalities and poor perinatal outcomes. The Obstetrician & Gynaecologist 21:2, pages 135-142.
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Percy Pacora, Roberto Romero, Sunil Jaiman, Offer Erez, Gaurav Bhatti, Bogdan Panaitescu, Neta Benshalom-Tirosh, Eun Jung Jung, Chaur-Dong Hsu, Sonia S. Hassan, Lami Yeo & Nicholas Kadar. (2019) Mechanisms of death in structurally normal stillbirths. Journal of Perinatal Medicine 47:2, pages 222-240.
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Anitha Ananthan, Ruchi Nanavati, Pragati Sathe & Haribalakrishna Balasubramanian. (2019) Placental Findings in Singleton Stillbirths: A Case-control Study. Journal of Tropical Pediatrics 65:1, pages 21-28.
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Gitta Turowski, W. Tony Parks, Susan Arbuckle, Anne F. Jacobsen & Alexander Heazell. (2018) The structure and utility of the placental pathology report. APMIS 126:7, pages 638-646.
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Aleena M Wojcieszek, Emily Shepherd, Philippa Middleton, Glenn Gardener, David A Ellwood, Elizabeth M McClure, Katherine J Gold, Teck Yee Khong, Robert M Silver, Jan Jaap HM Erwich & Vicki Flenady. (2018) Interventions for investigating and identifying the causes of stillbirth. Cochrane Database of Systematic Reviews 2018:4.
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Tinnakorn Chaiworapongsa, Roberto Romero, Offer Erez, Adi L. Tarca, Agustin Conde-Agudelo, Piya Chaemsaithong, Chong Jai Kim, Yeon Mee Kim, Jung-Sun Kim, Bo Hyun Yoon, Sonia S. Hassan, Lami Yeo & Steven J. Korzeniewski. (2017) The prediction of fetal death with a simple maternal blood test at 24-28 weeks: a role for angiogenic index-1 (PlGF/sVEGFR-1 ratio). American Journal of Obstetrics and Gynecology 217:6, pages 682.e1-682.e13.
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Kia Lannaman, Roberto Romero, Tinnakorn Chaiworapongsa, Yeon Mee Kim, Steven J. Korzeniewski, Eli Maymon, Nardhy Gomez-Lopez, Bogdan Panaitescu, Sonia S. Hassan, Lami Yeo, Bo Hyun Yoon, Chong Jai Kim & Offer Erez. (2017) Fetal death: an extreme manifestation of maternal anti-fetal rejection. Journal of Perinatal Medicine 45:7, pages 851-868.
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Kate Bartlett, Jane Zuccollo, Lynn Sadler & Vicki Masson. (2016) Rethinking placental pathology in the PSANZ classification of unexplained stillbirth at term . Australian and New Zealand Journal of Obstetrics and Gynaecology 57:3, pages 248-252.
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J.W. Nijkamp, N.J. Sebire, K. Bouman, F.J. Korteweg, J.J.H.M. Erwich & S.J. Gordijn. (2017) Perinatal death investigations: What is current practice?. Seminars in Fetal and Neonatal Medicine 22:3, pages 167-175.
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Supuni Kapurubandara, Sarah J. Melov, Evangeline R. Shalou, Monika Mukerji, Stephen Yim, Ujvala Rao, Zain Battikhi, Nirusha Karunaratne, Roshini Nayyar & Thushari I. Alahakoon. (2017) A perinatal review of singleton stillbirths in an Australian metropolitan tertiary centre. PLOS ONE 12:2, pages e0171829.
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P. Cox, T. Marton, B. Hargitai, A. Coetzee, C. Bowen, D. Penman, M. Evans, C. Gannon, P. French, M. Cohen, S. Holden, J. Allotey, C. Evans, A. Murphy, K. Turner, C. Cullinane, J. Stahlschmidt, G. Kokai, M. Al Adnani, A. Marnerides, B. Vadgama & J. McPartland. (2017) Re: Stillbirth collection by Man et al . Ultrasound in Obstetrics & Gynecology 49:2, pages 281-282.
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F. Jones, P. Thibon, M. Guyot, A. Molin, C. Jeanne-Pasquier, B. Guillois, G. Benoist & M. Dreyfus. (2017) Practice of pathological examinations in stillbirths: A 10-year retrospective study. Journal of Gynecology Obstetrics and Human Reproduction 46:1, pages 61-67.
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Imogen Ptacek, Anna Smith, Ainslie Garrod, Sian Bullough, Nicola Bradley, Gauri Batra, Colin P. Sibley, Rebecca L. Jones, Paul Brownbill & Alexander E. P. Heazell. (2016) Quantitative assessment of placental morphology may identify specific causes of stillbirth. BMC Clinical Pathology 16:1.
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J. Man, J. C. Hutchinson, A. E. Heazell, M. Ashworth, I. Jeffrey & N. J. Sebire. (2016) Stillbirth and intrauterine fetal death: role of routine histopathological placental findings to determine cause of death. Ultrasound in Obstetrics & Gynecology 48:5, pages 579-584.
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J. Man, J. C. Hutchinson, M. Ashworth, I. Jeffrey, A. E. Heazell & N. J. Sebire. (2016) Organ weights and ratios for postmortem identification of fetal growth restriction: utility and confounding factors. Ultrasound in Obstetrics & Gynecology 48:5, pages 585-590.
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L.E. Higgins, L. Simcox, C.P. Sibley, A.E.P. Heazell & E.D. Johnstone. (2016) Third trimester placental volume and biometry measurement: A method-development study. Placenta 42, pages 51-58.
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Steven J. Korzeniewski, Roberto Romero, Tinnakorn Chaiworapongsa, Piya Chaemsaithong, Chong Jai Kim, Yeon Mee Kim, Jung-Sun Kim, Bo Hyun Yoon, Sonia S. Hassan & Lami Yeo. (2016) Maternal plasma angiogenic index-1 (placental growth factor/soluble vascular endothelial growth factor receptor-1) is a biomarker for the burden of placental lesions consistent with uteroplacental underperfusion: a longitudinal case-cohort study. American Journal of Obstetrics and Gynecology 214:5, pages 629.e1-629.e17.
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Go Eun Bae, Nara Yoon, Misun Choi, Soohyun Hwang, Hyewon Hwang & Jung-Sun Kim. (2016) Acute Placental Villitis as Evidence of Fetal Sepsis: An Autopsy Case Report. Pediatric and Developmental Pathology 19:2, pages 165-168.
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Neil J. Sebire. 2016. Fetal Medicine. Fetal Medicine 356 366 .
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Carolina Gillio-MeinaH. Ronald ZielkeDouglas D. Fraser. (2016) Translational Research in Pediatrics IV: Solid Tissue Collection and Processing. Pediatrics 137:1.
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Alexander Heazell. (2015) The placenta and adverse pregnancy outcomes – opening the black box?. BMC Pregnancy and Childbirth 15:S1.
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A.E.P. Heazell, S.A. Worton, L.E. Higgins, E. Ingram, E.D. Johnstone, R.L. Jones & C.P. Sibley. (2015) IFPA Gábor Than Award Lecture: Recognition of placental failure is key to saving babies' lives. Placenta 36, pages S20-S28.
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Annemiek C. Dutman & Peter G. J. Nikkels. (2016) Umbilical Hypercoiling in 2nd- and 3rd-Trimester Intrauterine Fetal Death. Pediatric and Developmental Pathology 18:1, pages 10-16.
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Alexander Heazell & Alan Fenton. 2015. Keeling’s Fetal and Neonatal Pathology. Keeling’s Fetal and Neonatal Pathology 1 13 .
Kana Bal, Saubhik Basu & Runa Bal. (2014) HISTOLOGY OF PLACENTA IN INTRAUTERINE GROWTH RESTRICTED PREGNANCY. Journal of Evolution of Medical and Dental Sciences 3:64, pages 14037-14043.
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I. Ptacek, N.J. Sebire, J.A. Man, P. Brownbill & A.E.P. Heazell. (2014) Systematic review of placental pathology reported in association with stillbirth. Placenta 35:8, pages 552-562.
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N. J. Sebire. (2014) Detection of fetal growth restriction at autopsy in non‐anomalous stillborn infants. Ultrasound in Obstetrics & Gynecology 43:3, pages 241-244.
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Annemiek M. Roescher, Albert Timmer, Jan Jaap H. M. Erwich & Arend F. Bos. (2014) Placental Pathology, Perinatal Death, Neonatal Outcome, and Neurological Development: A Systematic Review. PLoS ONE 9:2, pages e89419.
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A. Garrod, G. Batra, I. Ptacek & A.E.P. Heazell. (2013) Duration and method of tissue storage alters placental morphology – Implications for clinical and research practice. Placenta 34:11, pages 1116-1119.
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Colin A. Walsh, Fionnuala M. McAuliffe, Gitta Turowski, Borghild Roald & Eoghan E. Mooney. (2013) A survey of obstetricians' views on placental pathology reporting. International Journal of Gynecology & Obstetrics 121:3, pages 275-277.
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Alexander E.P. Heazell, Susannah Leisher, Mairie Cregan, Vicki Flenady, J. Frederik Frøen, Ida K. Gravensteen, Mariëtte de Groot‐Noordenbos, Paul de Groot, Sue Hale, Belinda Jennings, Karen McNamara, Caron Millard & Jan Jaap H. M. Erwich. (2012) Sharing experiences to improve bereavement support and clinical care after stillbirth: report of the 7th annual meeting of the international stillbirth alliance. Acta Obstetricia et Gynecologica Scandinavica 92:3, pages 352-361.
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Suzanne M. Jacques, William J. Kupsky, Tamar Giorgadze & Faisal Qureshi. (2014) Fetal Central Nervous System Injury in Third Trimester Stillbirth: A Clinicopathologic Study of 63 Cases. Pediatric and Developmental Pathology 15:5, pages 375-384.
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AEP Heazell, M‐J McLaughlin, EB Schmidt, P Cox, V Flenady, TY Khong & S Downe. (2012) A difficult conversation? The views and experiences of parents and professionals on the consent process for perinatal postmortem after stillbirth. BJOG: An International Journal of Obstetrics & Gynaecology 119:8, pages 987-997.
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Soo Downe, Carol Kingdon, Rosey Kennedy, Hazel Norwell, Mary-Jo McLaughlin & Alexander E.P. Heazell. (2012) Post-mortem examination after stillbirth: views of UK-based practitioners. European Journal of Obstetrics & Gynecology and Reproductive Biology 162:1, pages 33-37.
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Lynne K. Warrander, Gauri Batra, Giovanna Bernatavicius, Susan L. Greenwood, Philip Dutton, Rebecca L. Jones, Colin P. Sibley & Alexander E. P. Heazell. (2012) Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function. PLoS ONE 7:4, pages e34851.
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Ruth Cockerill, Melissa K. Whitworth & Alexander E. P. Heazell. (2011) Do medical certificates of stillbirth provide accurate and useful information regarding the cause of death?. Paediatric and Perinatal Epidemiology 26:2, pages 117-123.
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