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Drug and Chemical Toxicology Volume 32, 2009 - Issue 1
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Research Article

In vitro and in vivo hepatic metabolism of the fungal neurotoxin penitrem A

Angel Moldes-Anaya Section of Chemistry and Toxicology, National Veterinary Institute, Oslo, NorwayCorrespondence[email protected]
,
Alistair L. Wilkins Chemistry Department, University of Waikato, Hamilton, New Zealand
,
Thomas Rundberget Section of Chemistry and Toxicology, National Veterinary Institute, Oslo, Norway
&
Christiane K. Fæste Section of Chemistry and Toxicology, National Veterinary Institute, Oslo, Norway
Pages 26-37 | Accepted 19 Aug 2008, Published online: 26 Jan 2009

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G. S. Eriksen, K. Hultin Jäderlund, A. Moldes-Anaya, J. Schönheit, A. Bernhoft, G. Jæger, T. Rundberget & I. Skaar. (2010) Poisoning of dogs with tremorgenic Penicillium toxins. Medical Mycology 48:1, pages 188-196.
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Articles from other publishers (17)

Luna Bridgeman, Cristina Juan, Ana Juan-García & Houda Berrada. (2023) Individual and combined effect of acrylamide, fumitremorgin C and penitrem A on human neuroblastoma SH-SY5Y cells. Food and Chemical Toxicology 182, pages 114114.
Crossref
Nicola Bates. (2022) Tremorgenic mycotoxicosis in dogs. Companion Animal 27:2, pages 1-6.
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C. OteroC. ArredondoA. Echeverría-VegaF. Gordillo-Fuenzalida. (2020) Penicillium spp. mycotoxins found in food and feed and their health effects . World Mycotoxin Journal 13:3, pages 323-343.
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Amritha Johny, Lada Ivanova, Tone-Kari Knutsdatter Østbye & Christiane Kruse Fæste. (2020) Biotransformation of phytoestrogens from soy in enzymatically characterized liver microsomes and primary hepatocytes of Atlantic salmon. Ecotoxicology and Environmental Safety 197, pages 110611.
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Silvio Uhlig, Lada Ivanova, Pauline Voorspoels & Christiane Kruse Fæste. (2020) In Vitro Toxicokinetics and Phase I Biotransformation of the Mycotoxin Penitrem A in Dogs. Toxins 12:5, pages 293.
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Richard Fjellaksel, Angel Moldes-Anaya, Terje Vasskog, Ana Oteiza, Montserrat Martin-Armas, Ole Kristian Hjelstuen, Jørn H. Hansen, Patrick J. Riss & Rune Sundset. (2020) Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH-receptor ligands for brain SPECT imaging . Journal of Labelled Compounds and Radiopharmaceuticals 63:2, pages 72-84.
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László Kozák, Zoltán Szilágyi, László Tóth, István Pócsi & István Molnár. (2019) Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications. Applied Microbiology and Biotechnology 103:4, pages 1599-1616.
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Svetlana A. Kalinina, Annika Jagels, Sebastian Hickert, Lucas M. Mauriz Marques, Benedikt Cramer & Hans-Ulrich Humpf. (2018) Detection of the Cytotoxic Penitrems A–F in Cheese from the European Single Market by HPLC-MS/MS. Journal of Agricultural and Food Chemistry 66:5, pages 1264-1269.
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H.F. Berntsen, I.L. Bogen, M.B. Wigestrand, F. Fonnum, S.I. Walaas & A. Moldes-Anaya. (2017) The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations. Toxicology 392, pages 64-70.
Crossref
Christiane K. Fæste & Angel Moldes-Anaya. (2016) Biotransformation of the fungal neurotoxin Thomitrem A by primary rat hepatocytes. Toxicon 124, pages 36-43.
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Silvio Uhlig, Wolfgang Egge-Jacobsen, Trude Vrålstad & Christopher O. Miles. (2014) Indole-diterpenoid profiles of Claviceps paspali and Claviceps purpurea from high-resolution Fourier transform Orbitrap mass spectrometry . Rapid Communications in Mass Spectrometry 28:14, pages 1621-1634.
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G.S. Eriksen, A. Moldes-Anaya & C.K. Fæste. (2013) Penitrem A and analogues: toxicokinetics, toxicodynamics including mechanism of action and clinical significance. World Mycotoxin Journal 6:3, pages 263-272.
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H.F. Berntsen, M.B. Wigestrand, I.L. Bogen, F. Fonnum, S.I. Walaas & A. Moldes-Anaya. (2013) Mechanisms of penitrem-induced cerebellar granule neuron death in vitro: Possible involvement of GABAA receptors and oxidative processes. NeuroToxicology 35, pages 129-136.
Crossref
Angel Moldes-Anaya, Thomas Rundberget, Christiane K. Fæste, Gunnar S. Eriksen & Aksel Bernhoft. (2012) Neurotoxicity of Penicillium crustosum secondary metabolites: Tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice. Toxicon 60:8, pages 1428-1435.
Crossref
Junfeng Wang, Peipei Liu, Yi Wang, Hui Wang, Jing Li, Yibin Zhuang & Weiming Zhu. (2012) Antimicrobial Aromatic Polyketides from Gorgonian-Associated Fungus, Penicillium commune 518. Chinese Journal of Chemistry 30:6, pages 1236-1242.
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Angel S. Moldes-Anaya, Frode Fonnum, Gunnar S. Eriksen, Thomas Rundberget, S. Ivar Walaas & Mattis B. Wigestrand. (2011) In vitro neuropharmacological evaluation of penitrem-induced tremorgenic syndromes: Importance of the GABAergic system. Neurochemistry International 59:7, pages 1074-1081.
Crossref
Martin WeidenbörnerMartin Weidenbörner. 2011. Mycotoxins and Their Metabolites in Humans and Animals. Mycotoxins and Their Metabolites in Humans and Animals 1 459 .

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