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Drug and Chemical Toxicology Volume 32, 2009 - Issue 4
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Research Article

Mitigation of mitochondrial dysfunction and regulation of eNOS expression during experimental myocardial necrosis by alpha-mangostin, a xanthonic derivative from Garcinia mangostana

Pandima Devi SampathCenter for Advanced Studies in Botany, University of Madras, Chennai, India
&
Vijayaragavan KannanCenter for Advanced Studies in Botany, University of Madras, Chennai, IndiaCorrespondence[email protected] [email protected]
Pages 344-352 | Received 23 Jun 2009, Accepted 02 Jul 2009, Published online: 01 Oct 2009

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Mohamed Yousif Ibrahim, Najihah Mohd Hashim, Syam Mohan, Mahmood Ameen Abdulla, Behnam Kamalidehghan, Mostafa Ghaderian, Firouzeh Dehghan, Landa Zeenelabdin Ali, Ismail Adam Arbab, Maizatulakmal Yahayu, Gwendoline Ee Cheng Lian, Fatemeh Ahmadipour & Hapipah Mohd Ali. (2014) α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo. Drug Design, Development and Therapy 8, pages 1629-1647.
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Articles from other publishers (27)

Manzar Alam, Summya Rashid, Kisa Fatima, Mohd Adnan, Alaa Shafie, Mohammad Salman Akhtar, A.H. Ganie, Sayed M. Eldin, Asimul Islam, Ilyas Khan & Md. Imtaiyaz Hassan. (2023) Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits. Biomedicine & Pharmacotherapy 163, pages 114710.
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Oliver John, Annals Mushunje, Noumie Surugau & Rhanye Guad. (2022) The metabolic and molecular mechanisms of α‑mangostin in cardiometabolic disorders (Review). International Journal of Molecular Medicine 50:3.
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H Latifah, O T Akbar, A Irawan, C R Kholibrina & A Aswandi. (2022) Local wisdom on processing and utilization of geronggang’s oil for daily remedy and healthcare. IOP Conference Series: Earth and Environmental Science 977:1, pages 012026.
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Yan Zhao, Wanrong Yu, Jiangyun Liu, Haohao Wang, Rui Du & Zhaowei Yan. (2022) Protective effect of α-mangostin derivatives on hypoxia/reoxygenation-induced apoptosis in H9C2 cells and their mechanism. Phytochemistry Letters 47, pages 174-179.
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Farhad Eisvand, Mohsen Imenshahidi, Mahboobeh Ghasemzadeh Rahbardar, Seyed Abbas Tabatabaei Yazdi, Maryam Rameshrad, Bibi Marjan Razavi & Hossein Hosseinzadeh. (2021) Cardioprotective effects of alpha‐mangostin on doxorubicin‐induced cardiotoxicity in rats. Phytotherapy Research 36:1, pages 506-524.
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Nurmila Sari, Yasufumi Katanasaka, Yuga Sugiyama, Yusuke Miyazaki, Yoichi Sunagawa, Masafumi Funamoto, Kana Shimizu, Satoshi Shimizu, Koji Hasegawa & Tatsuya Morimoto. (2021) Alpha Mangostin Derived from <i>Garcinia magostana</i> Linn Ameliorates Cardiomyocyte Hypertrophy and Fibroblast Phenotypes <i>in Vitro</i>. Biological and Pharmaceutical Bulletin 44:10, pages 1465-1472.
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Gestina Aliska, Alief Dhuha, Rahmatini Rahmatini, Rita Hamdani, Nita Afriani, Tofrizal Tofrizal, Hirowati Ali, Nisa Pratiwi, Vinta Nuranisyah, Liganda Endo Mahata & Dedy Kurnia. (2021) Ramipril Increases Adma Concentration in Acute Myocardial Infarction in Rats Induced by Isoproterenol. Open Access Macedonian Journal of Medical Sciences 9:A, pages 693-697.
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Galia Lara-Sotelo, Lorenza Díaz, Rocío García-Becerra, Euclides Avila, Heriberto Prado-Garcia, Gabriela Morales-Guadarrama, María de Jesús Ibarra-Sánchez, José Esparza-López, Fernando Larrea & Janice García-Quiroz. (2021) α-Mangostin Synergizes the Antineoplastic Effects of 5-Fluorouracil Allowing a Significant Dose Reduction in Breast Cancer Cells. Processes 9:3, pages 458.
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Hui-Hsuan Tsai, Chia-Wen Chen, Pei-Ling Yu, Yu-Ling Lin & Rong-Hong Hsieh. (2020) Mangosteen pericarp components alleviate progression of prostatic hyperplasia and mitochondrial dysfunction in rats. Scientific Reports 10:1.
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Shahira M. Ezzat, Maha M. Salama & Mohamed A. Salem. 2020. Phytochemicals as Lead Compounds for New Drug Discovery. Phytochemicals as Lead Compounds for New Drug Discovery 67 94 .
Laura María Reyes-Fermín, Sabino Hazael Avila-Rojas, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Isabel Rivero & José Pedraza-Chaverri. (2019) The Protective Effect of Alpha-Mangostin against Cisplatin-Induced Cell Death in LLC-PK1 Cells is Associated to Mitochondrial Function Preservation. Antioxidants 8:5, pages 133.
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Oliver D. John, Lindsay Brown & Sunil K. Panchal. 2019. Nutraceuticals and Natural Product Derivatives. Nutraceuticals and Natural Product Derivatives 39 80 .
Prince Allawadhi, Amit Khurana, Nilofer Sayed, Preeti Kumari & Chandraiah Godugu. (2018) Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention. Phytotherapy Research 32:10, pages 1908-1932.
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Zhao Fang, Wanjun Luo & Yanli Luo. (2018) Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts. Molecular Medicine Reports.
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Zheng Wei Wong, Punniyakoti Veeraveedu Thanikachalam & Srinivasan Ramamurthy. (2017) Molecular understanding of the protective role of natural products on isoproterenol-induced myocardial infarction: A review. Biomedicine & Pharmacotherapy 94, pages 1145-1166.
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Sukanya Phungphong, Anusak Kijtawornrat, Pieter P. de Tombe, Jonggonnee Wattanapermpool, Tepmanas Bupha-Intr & Sunit Suksamrarn. (2017) Acute inhibitory effect of alpha-mangostin on sarcoplasmic reticulum calcium-ATPase and myocardial relaxation. Journal of Biochemical and Molecular Toxicology 31:10, pages e21942.
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Chung-Pu Wu, Sung-Han Hsiao, Megumi Murakami, Yu-Jen Lu, Yan-Qing Li, Yang-Hui Huang, Tai-Ho Hung, Suresh. V. Ambudkar & Yu-Shan Wu. (2017) Alpha-Mangostin Reverses Multidrug Resistance by Attenuating the Function of the Multidrug Resistance-Linked ABCG2 Transporter. Molecular Pharmaceutics 14:8, pages 2805-2814.
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Guanhua Du, Lan Sun, Rui Zhao, Lida Du, Junke Song, Li Zhang, Guorong He, Yongxiang Zhang & Juntian Zhang. (2016) Polyphenols: Potential source of drugs for the treatment of ischaemic heart disease. Pharmacology & Therapeutics 162, pages 23-34.
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Xin Li, Yuanzhi Lao, Hong Zhang, Xiaoyu Wang, Hongsheng Tan, Zhixiu Lin & Hongxi Xu. (2015) The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation. BMC Cancer 15:1.
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Shuyu Zhan, Wenjing Guo, Qing Shao, Xiaohui Fan, Zheng Li & Yiyu Cheng. (2014) A pharmacokinetic and pharmacodynamic study of drug–drug interaction between ginsenoside Rg1, ginsenoside Rb1 and schizandrin after intravenous administration to rats. Journal of Ethnopharmacology 152:2, pages 333-339.
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N.P. Sudheesh, T.A. Ajith & K.K. Janardhanan. (2013) Ganoderma lucidum ameliorate mitochondrial damage in isoproterenol-induced myocardial infarction in rats by enhancing the activities of TCA cycle enzymes and respiratory chain complexes. International Journal of Cardiology 165:1, pages 117-125.
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Winnie Lai Ting Kan, Chun Yin, Hong Xi Xu, Gang Xu, Kenneth Kin Wah To, Chi Hin Cho, John Anthony Rudd & Ge Lin. (2012) Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1‐mediated G 0 /G 1 cell cycle arrest and apoptosis . International Journal of Cancer 132:3, pages 707-716.
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Xiaobing Li, Xiao Wang, Yafang Guo, Ning Deng, Ping Zheng, Qingbin Xu, Yang Wu & Guidong Dai. (2012) Regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuates isoproterenol-induced acute myocardial injury in rats. Journal of Pharmacy and Pharmacology 64:8, pages 1107-1118.
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T. K. LimT. K. Lim. 2012. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 83 108 .
M. Hemshekhar, K. Sunitha, M. Sebastin Santhosh, S. Devaraja, K. Kemparaju, B. S. Vishwanath, S. R. Niranjana & K. S. Girish. (2011) An overview on genus garcinia: phytochemical and therapeutical aspects. Phytochemistry Reviews 10:3, pages 325-351.
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Li Li, Isabelle Brunner, Ah-Reum Han, Matthias Hamburger, Alan Douglas Kinghorn, Reginald Frye & Veronika Butterweck. (2011) Pharmacokinetics of α-mangostin in rats after intravenous and oral application. Molecular Nutrition & Food Research 55:S1, pages S67-S74.
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Vaddi Damodara Reddy, Pannuru Padmavathi, Godugu Kavitha, Sriram Gopi & Nallanchakravarthula Varadacharyulu. (2011) Emblica officinalis Ameliorates Alcohol-Induced Brain Mitochondrial Dysfunction in Rats . Journal of Medicinal Food 14:1-2, pages 62-68.
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