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Research Articles

Naringenin: a potential natural remedy against methotrexate-induced hepatotoxicity in rats

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Pages 491-498 | Received 08 Nov 2019, Accepted 04 Jan 2020, Published online: 28 Jan 2020

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Abeer Khalid Al-Ghumlas, Manan A. Alhakbany & Aida A. Korish. (2023) Antiapoptotic and anticoagulant effects of camel milk and camel urine in methotrexate-induced hepatotoxicity. CyTA - Journal of Food 21:1, pages 357-365.
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Zejin Liu, Xinli Niu & Junpeng Wang. (2023) Naringenin as a natural immunomodulator against T cell-mediated autoimmune diseases: literature review and network-based pharmacology study. Critical Reviews in Food Science and Nutrition 63:32, pages 11026-11043.
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Mukaddes Gürler, Engin Burak Selçuk, Beyza Güzide Özerol, Kevser Tanbek, Elif Taşlıdere, Azibe Yıldız, Fatma Hilal Yağın & Elif Gürel. (2023) Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats. Drug and Chemical Toxicology 46:4, pages 708-716.
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Filiz Kazak, Ahmet Uyar, Pinar Coskun & Turan Yaman. Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats. Biotechnic & Histochemistry 0:0, pages 1-13.
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Articles from other publishers (16)

Ghada Khawaja & Youmna El-Orfali. (2024) Silibinin’s Effects against Methotrexate-Induced Hepatotoxicity in Adjuvant-Induced Arthritis Rat Model. Pharmaceuticals 17:4, pages 431.
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Ana T. Rufino, Marisa Freitas, Carina Proença, José M. P. Ferreira de Oliveira, Eduarda Fernandes & Daniela Ribeiro. (2023) Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy. Medicinal Research Reviews 44:2, pages 497-538.
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Alaa Behairy, Ashraf Elkomy, Faten Elsayed, Mohamed M. S. Gaballa, Ahmed Soliman & Mohamed Aboubakr. (2023) Spirulina and Thymoquinone Protect Against Methotrexate-Induced Hepatic Injury in Rats. Revista Brasileira de Farmacognosia 34:1, pages 154-167.
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Ji Cai, Hongli Wen, He Zhou, Dan Zhang, Dongfeng Lan, Songpo Liu, Chunyang Li, Xiaofang Dai, Tao Song, Xianyao Wang, Yuqi He, Zhixu He, Jun Tan & Jidong Zhang. (2023) Naringenin: A flavanone with anti-inflammatory and anti-infective properties. Biomedicine & Pharmacotherapy 164, pages 114990.
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Shimaa S. Khaled, Hanan A. Soliman, Mohammed Abdel-Gabbar, Noha A. Ahmed, El-Shaymaa El-Nahass & Osama M. Ahmed. (2023) Naringin and naringenin counteract taxol-induced liver injury in Wistar rats via suppression of oxidative stress, apoptosis and inflammation. Environmental Science and Pollution Research 30:39, pages 90892-90905.
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Shuhan Gao, Xiaojing Chen, Zhiqian Yu, Rong Du, Baizhong Chen, Yuxin Wang, Xiaoting Cai, Jiepei Xu, Jiamin Chen, Huiying Duan, Yi Cai & Guodong Zheng. (2023) Progress of research on the role of active ingredients of Citri Reticulatae Pericarpium in liver injury. Phytomedicine 115, pages 154836.
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Pottathil Shinu, Girdhari Lal Gupta, Manu Sharma, Shahzad Khan, Manoj Goyal, Anroop B. Nair, Manish Kumar, Wafaa E. Soliman, Aminur Rahman, Mahesh Attimarad, Katharigatta N. Venugopala & Abdullah Abdulhamid Ahmed Altaweel. (2023) Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential. Plants 12:5, pages 1086.
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Asmae El Ghouizi, Meryem Bakour, Hassan Laaroussi, Driss Ousaaid, Naoual El Menyiy, Christophe Hano & Badiaa Lyoussi. (2023) Bee Pollen as Functional Food: Insights into Its Composition and Therapeutic Properties. Antioxidants 12:3, pages 557.
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Zehra CalisDervis DasdelenAbdulkerim Kasim BaltaciRasim Mogulkoc. (2022) Naringenin Prevents Inflammation, Apoptosis, and DNA Damage in Potassium Oxonate-Induced Hyperuricemia in Rat Liver Tissue: Roles of Cytochrome C, NF-κB, Caspase-3, and 8-Hydroxydeoxyguanosine. Metabolic Syndrome and Related Disorders 20:8, pages 473-479.
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Zi Wang, Hao-Min Zhang, Yuan-Rui Guo & Ling-Ling Li. (2022) Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study. World Journal of Clinical Cases 10:21, pages 7224-7241.
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Rajib Hossain, Divya Jain, Rasel A. Khan, Muhammad T. Islam, Mohammad S. Mubarak & Abu Saim Mohammad Saikat. (2022) Natural-Derived Molecules as a Potential Adjuvant in Chemotherapy: Normal Cell Protectors and Cancer Cell Sensitizers. Anti-Cancer Agents in Medicinal Chemistry 22:5, pages 836-850.
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Lamiaa A. Khatab, Ihab T. Abdel-Raheem & Asser I. Ghoneim. (2021) Protective effects of melatonin and l-carnitine against methotrexate-induced toxicity in isolated rat hepatocytes. Naunyn-Schmiedeberg's Archives of Pharmacology 395:1, pages 87-97.
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Sueda TÜRK, Filiz KAZAK, Pinar PEKER & Mehmet Ali KISAÇAM. (2021) Rutin Attenuates Methotrexate-Induced Hepatic Oxidative Stress in Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 16:3, pages 291-297.
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AA Dar, A Fehaid, S Alkhatani, S Alarifi, WS Alqahtani, G Albasher, R Almeer, S Alfarraj & AE Abdel Moneim. (2021) The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats. Human & Experimental Toxicology 40:7, pages 1194-1207.
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Vanessa Lucília Silveira de Medeiros, Fabiana Cristina Fulco Santos, Lílian Maria Lapa Montenegro, Maria da Conceição Silva, Valdênia Maria Oliveira de Souza, Reginaldo Gonçalvez de Lima Neto, Líbia Cristina Rocha Vilela Moura & Vera Magalhães. (2020) TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients. PLOS ONE 15:12, pages e0242098.
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Jianzhi Wu, Guangrui Huang, Yajing Li & Xiaojiaoyang Li. (2020) Flavonoids from Aurantii Fructus Immaturus and Aurantii Fructus: promising phytomedicines for the treatment of liver diseases. Chinese Medicine 15:1.
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