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Drug and Chemical Toxicology Volume 45, 2022 - Issue 5
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Research Articles

Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress

Shipra Bhatta PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India;b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, IndiaView further author information
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Ankita Sharmaa PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India;b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, IndiaView further author information
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Ashish Dograa PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India;b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, IndiaView further author information
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Priyanka Sharmac Plant Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, IndiaView further author information
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Amit Kumard Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, IndiaView further author information
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Pankul Kotwala PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India;b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, IndiaView further author information
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Swarnendu Bage Instrumentation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India;f Proteomics Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, IndiaView further author information
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Prashant Misrab Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India;c Plant Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, IndiaView further author information
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Gurdarshan Singha PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India;b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, IndiaView further author information
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Ajay Kumara PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India;b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, IndiaView further author information
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Payare Lal Sangwanb Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India;d Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, IndiaCorrespondence[email protected]
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Utpal Nandia PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India;b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, IndiaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-7868-0240View further author information
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Pages 2352-2360 | Received 22 Apr 2021, Accepted 27 May 2021, Published online: 07 Jul 2021

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Jianhong Zhang, Xinhui Wu, Baiyin Zhong, Qicheng Liao, Xin Wang, Yuankang Xie & Xiao He. (2023) Review on the Diverse Biological Effects of Glabridin. Drug Design, Development and Therapy 17, pages 15-37.
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Ashish Dogra, Dilpreet Kour, Abhishek Gour, Mahir Bhardwaj, Swarnendu Bag, Shakti Kumar Dhiman, Ajay Kumar, Gurdarshan Singh & Utpal Nandi. (2023) Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP. Drug and Chemical Toxicology 46:3, pages 597-608.
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Articles from other publishers (10)

Emre Kaya, Seval Yilmaz, Feyza Aksu & Ahmet Kavaklı. (2024) Evaluation of the effects of overdose Acetaminophen toxicity in rats: Ozone, which can be preferred as a complementary therapy. Revista Científica de la Facultad de Ciencias Veterinarias XXXIV:1, pages 1-9.
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Mahir Bhardwaj, Dilpreet Kour, Garima Rai, Srija Bhattacharya, Diksha Manhas, Bhavna Vij, Ajay Kumar, Debaraj Mukherjee, Zabeer Ahmed, Sumit G. Gandhi & Utpal Nandi. (2024) EIDD-1931 Treatment Tweaks CYP3A4 and CYP2C8 in Arthritic Rats to Expedite Drug Interaction: Implication in Oral Therapy of Molnupiravir. ACS Omega 9:12, pages 13982-13993.
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Xiaoyangzi Li, Ruyang Lao, Jiawei Lei, Yuting Chen, Qi Zhou, Ting Wang & Yingpeng Tong. (2023) Natural Products for Acetaminophen-Induced Acute Liver Injury: A Review. Molecules 28:23, pages 7901.
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Mahir Bhardwaj, Abhishek Gour, Ajaz Ahmed, Sumit Dhiman, Diksha Manhas, Parul Khajuria, Priya Wazir, Debaraj Mukherjee & Utpal Nandi. (2023) Impact of Disease States on the Oral Pharmacokinetics of EIDD-1931 (an Active Form of Molnupiravir) in Rats for Implication in the Dose Adjustment. Molecular Pharmaceutics 20:9, pages 4597-4610.
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Ashiya Jamwal, Jagdish Chand, Anshurekha Dash, Shipra Bhatt, Sumit Dhiman, Priya Wazir, Buddh Singh, Anindya Goswami & Utpal Nandi. (2023) Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of breast cancer. Chemico-Biological Interactions 382, pages 110605.
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Yaşar Şahin, Alparslan Kadir Devrim, Mehmet Eray Alçığır, Ali Şenol, Hüsamettin Ekici, Tuba Devrim, Mert Sudağıdan, Ebru Yıldırım, Miyase Çınar, Merve Bişkin Türkmen & Seydi Ali Peker. (2023) The effect of krill oil on Wnt/β-catenin signaling pathway in acetaminophen-induced acute liver injury in mice. Turkish Journal of Biochemistry 48:3, pages 264-271.
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Juan Long, Hongbing Liu, Zhimin Qiu, Zhong Xiao & Zhongqiu Lu. (2023) Glabridin Therapy Reduces Chronic Allodynia, Spinal Microgliosis, and Dendritic Spine Generation by Inhibiting Fractalkine-CX3CR1 Signaling in a Mouse Model of Tibial Fractures. Brain Sciences 13:5, pages 739.
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Pankul Kotwal, Parul Khajuria, Sumit Dhiman, Dilpreet Kour, Shakti Kumar Dhiman, Ajay Kumar & Utpal Nandi. (2023) Molecular mechanism for the involvement of CYP2E1/NF-κB axis in bedaquiline-induced hepatotoxicity. Life Sciences 315, pages 121375.
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Jae Ho Choi, Gyung Min Go & Tatsuya Unno. (2022) Diatom frustule silica extracted from Melosira nummuloides ameliorates acetaminophen-induced acute liver injury in mice. Applied Biological Chemistry 65:1.
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Ashish Dogra, Dilpreet Kour, Mahir Bhardwaj, Sumit Dhiman, Amit Kumar, Bhavna Vij, Ajay Kumar & Utpal Nandi. (2022) Glabridin Plays Dual Action to Augment the Efficacy and Attenuate the Hepatotoxicity of Methotrexate in Arthritic Rats. ACS Omega 7:38, pages 34341-34351.
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