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Review Articles

Cancer Protective Properties of Cocoa: A Review of the Epidemiologic Evidence

Pages 573-579 | Received 29 Oct 2008, Accepted 02 Feb 2009, Published online: 03 Sep 2009

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Mee Young Hong, Emily Nulton, Mahshid Shelechi, LisaM. Hernández & Tricia Nemoseck. (2013) Effects of Dark Chocolate on Azoxymethane-Induced Colonic Aberrant Crypt Foci. Nutrition and Cancer 65:5, pages 677-685.
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Dongyue Wang, Yi Chen, Jiakun Li, Erman Wu, Tong Tang, Rajeev K. Singla, Bairong Shen & Ming Zhang. (2024) Natural Products for the Treatment of Age-Related Macular Degeneration. Phytomedicine, pages 155522.
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Marta Sánchez, Pedro Ferreira-Santos, Joana S. Gomes-Dias, Cláudia Botelho, Amanda Laca & Cristina M.R. Rocha. (2023) Ohmic heating-based extraction of biocompounds from cocoa bean shell. Food Bioscience 54, pages 102886.
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Alessandro La Mantia, Federica Ianni, Aurélie Schoubben, Marco Cespi, Klemen Lisjak, Davide Guarnaccia, Roccaldo Sardella & Paolo Blasi. (2023) Effect of Cocoa Roasting on Chocolate Polyphenols Evolution. Antioxidants 12:2, pages 469.
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Luz del Mar Rivas-Chacón, Joaquín Yanes-Díaz, Beatriz de Lucas, Juan Ignacio Riestra-Ayora, Raquel Madrid-García, Ricardo Sanz-Fernández & Carolina Sánchez-Rodríguez. (2023) Cocoa Polyphenol Extract Inhibits Cellular Senescence via Modulation of SIRT1 and SIRT3 in Auditory Cells. Nutrients 15:3, pages 544.
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Denny Cortez, Luz Quispe-Sanchez, Marilu Mestanza, Manuel Oliva-Cruz, Ives Yoplac, Cesar Torres & Segundo G. Chavez. (2023) Changes in bioactive compounds during fermentation of cocoa (Theobroma cacao) harvested in Amazonas-Peru. Current Research in Food Science 6, pages 100494.
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Howard D Sesso, JoAnn E Manson, Aaron K Aragaki, Pamela M Rist, Lisa G Johnson, Georgina Friedenberg, Trisha Copeland, Allison Clar, Samia Mora, M Vinayaga Moorthy, Ara Sarkissian, William R Carrick & Garnet L Anderson. (2022) Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial. The American Journal of Clinical Nutrition 115:6, pages 1490-1500.
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Priyanka P. Patil, Vishal S. Patil, Pukar Khanal, Harish R. Darasaguppe, Rajitha Charla, Arati Bhatkande, Basanagouda M. Patil & Subarna Roy. (2022) Network pharmacology and in vitro testing of Theobroma cacao extract’s antioxidative activity and its effects on cancer cell survival. PLOS ONE 17:4, pages e0259757.
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Terence Yew Chin Tan, Xin Yi Lim, Julie Hsiao Hui Yeo, Shaun Wen Huey Lee & Nai Ming Lai. (2021) The Health Effects of Chocolate and Cocoa: A Systematic Review. Nutrients 13:9, pages 2909.
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María Ángeles Martin & Sonia Ramos. (2021) Impact of cocoa flavanols on human health. Food and Chemical Toxicology 151, pages 112121.
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James A. Greenberg, Marian L. Neuhouser, Lesley F. Tinker, Dorothy S. Lane, Electra D. Paskett, Linda V. Van Horn, Sylvia Wassertheil-Smoller, James M. Shikany, Lihong Qi, Shawnita Sealy-Jefferson & JoAnn E. Manson. (2021) Chocolate Candy and Incident Invasive Cancer Risk in the Women’s Health Initiative: An Observational Prospective Analysis. Journal of the Academy of Nutrition and Dietetics 121:2, pages 314-326.e4.
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Paloma K Barrera-Reyes, Josué Cortés-Fernández de Lara, Melissa González-Soto & M Elizabeth Tejero. (2020) Effects of Cocoa-Derived Polyphenols on Cognitive Function in Humans. Systematic Review and Analysis of Methodological Aspects. Plant Foods for Human Nutrition 75:1, pages 1-11.
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Judith E. Allgrove & Glen Davison. 2018. Polyphenols: Mechanisms of Action in Human Health and Disease. Polyphenols: Mechanisms of Action in Human Health and Disease 207 219 .
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María Ángeles Martín & Sonia Ramos. (2017) Health beneficial effects of cocoa phenolic compounds: a mini-review. Current Opinion in Food Science 14, pages 20-25.
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Shruti Sanjay Taparia & Aparna Khanna. (2016) Procyanidin-rich extract of natural cocoa powder causes ROS-mediated caspase-3 dependent apoptosis and reduction of pro-MMP-2 in epithelial ovarian carcinoma cell lines. Biomedicine & Pharmacotherapy 83, pages 130-140.
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Yong Wang, Liang Zhao, Yazhen Huo, Feng Zhou, Wei Wu, Feng Lu, Xue Yang, Xiaoxuan Guo, Peng Chen, Qianchun Deng & Baoping Ji. (2016) Protective Effect of Proanthocyanidins from Sea Buckthorn (Hippophae Rhamnoides L.) Seed against Visible Light-Induced Retinal Degeneration in Vivo. Nutrients 8:5, pages 245.
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Luis Goya, María Martín, Beatriz Sarriá, Sonia Ramos, Raquel Mateos & Laura Bravo. (2016) Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals and Humans. Nutrients 8:4, pages 212.
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María Martín, Luis Goya & Sonia Ramos. (2016) Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer. Diseases 4:1, pages 6.
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Ivan M. Petyaev & Yuriy K. Bashmakov. (2016) Cocobiota: Implications for Human Health. Journal of Nutrition and Metabolism 2016, pages 1-3.
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Dan Ju & Gertraud Maskarinec. 2016. Fruits, Vegetables, and Herbs. Fruits, Vegetables, and Herbs 271 292 .
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Marco Fidaleo, Anna Fracassi, Antonio Zuorro, Roberto Lavecchia, Sandra Moreno & Claudia Sartori. (2014) Cocoa protective effects against abnormal fat storage and oxidative stress induced by a high-fat diet involve PPARα signalling activation. Food Funct. 5:11, pages 2931-2939.
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