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Original Articles

Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer

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Pages 1326-1334 | Received 21 Dec 2014, Accepted 20 Jul 2015, Published online: 16 Oct 2015

Keep up to date with the latest research on this topic with citation updates for this article.

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Abdul Mueed, Sahar Shibli, Muhammad Jahangir, Saqib Jabbar & Zeyuan Deng. (2023) A comprehensive review of flaxseed (Linum usitatissimum L.): health-affecting compounds, mechanism of toxicity, detoxification, anticancer and potential risk. Critical Reviews in Food Science and Nutrition 63:32, pages 11081-11104.
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Shireen Chikara, Kaitlin Lindsey, Harsharan Dhillon, Sujan Mamidi, Jeffrey Kittilson, Melpo Christofidou-Solomidou & Katie M. Reindl. (2017) Enterolactone Induces G1-phase Cell Cycle Arrest in Nonsmall Cell Lung Cancer Cells by Downregulating Cyclins and Cyclin-dependent Kinases. Nutrition and Cancer 69:4, pages 652-662.
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Articles from other publishers (26)

İrem BAYAR & Senem AKKOÇ. (2023) A Mini Review on Components of Flax Seed and Their Effects on Breast Cancer. Tarım Bilimleri Dergisi.
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Fernanda Cardoso da Silva, Douglas Cardoso Brandão, Everton Allan Ferreira, Raoni Pais Siqueira, Helen Soares Valença Ferreira, Ademar Alves Da Silva Filho & Thaise Gonçalves Araújo. (2023) Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer. Pharmaceuticals 16:10, pages 1466.
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Dan Liao, Yanyan Liu, Cuifen Li, Bin He, Guanghui Zhou, Yejia Cui & Haohai Huang. (2023) Arctigenin hinders the invasion and metastasis of cervical cancer cells via the FAK/paxillin pathway. Heliyon 9:6, pages e16683.
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Abdul Mueed, Zeyuan Deng, Sameh A. Korma, Sahar Shibli & Muhammad Jahangir. (2023) Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives. Food & Function 14:5, pages 2286-2303.
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Ekaterina I. MikhaevichDanila V. SorokinAlexander M. Scherbakov. (2023) Honokiol inhibits the growth of hormone-resistant breast cancer cells: its promising effect in combination with metformin. Research in Pharmaceutical Sciences 18:5, pages 580-591.
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Md Sohel, Md. Nurul Islam, Md. Arju Hossain, Tayeba Sultana, Amit Dutta, Md. Sohanur Rahman, Suraiya Aktar, Khairul Islam & Abdullah Al Mamun. (2022) Pharmacological Properties to Pharmacological Insight of Sesamin in Breast Cancer Treatment: A Literature-Based Review Study. International Journal of Breast Cancer 2022, pages 1-13.
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Fayth L. Miles, Sandi L. Navarro, Carly B. Garrison, Timothy W. Randolph, Yuzheng Zhang, Ali Shojaie, Mario Kratz, Meredith A.J. Hullar, Daniel Raftery, Marian L. Neuhouser, Paul D. Lampe & Johanna W. Lampe. (2021) Urinary enterolactone is associated with plasma proteins related to immunity and cancer development in healthy participants on controlled diets. Human Nutrition & Metabolism 25, pages 200128.
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Klaudia Gustaw, Iwona Niedźwiedź, Kamila Rachwał & Magdalena Polak-Berecka. (2021) New Insight into Bacterial Interaction with the Matrix of Plant-Based Fermented Foods. Foods 10:7, pages 1603.
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Ankur Kumar Tanwar, Neha Dhiman, Amit Kumar & Vikas Jaitak. (2021) Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach. European Journal of Medicinal Chemistry 213, pages 113037.
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Guili Zheng, Cong Zhang & Chen Zhong. (2021) Identification of potential prognostic biomarkers for breast cancer using WGCNA and PPI integrated techniques. Annals of Diagnostic Pathology 50, pages 151675.
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Stephanie Tannous, Tony Haykal, Jana Dhaini, Mohammad Hassan Hodroj & Sandra Rizk. (2020) The anti-cancer effect of flaxseed lignan derivatives on different acute myeloid leukemia cancer cells. Biomedicine & Pharmacotherapy 132, pages 110884.
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Om Prakash, Shazia Usmani, Amresh Gupta, Ruchi Singh, Namrata Singh & Akash Ved. (2020) Bioactive Polyphenols as Promising Natural Medicinal Agents Against Cancer: The Emerging Trends and Prospective Goals. Current Bioactive Compounds 16:3, pages 243-264.
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Jialing Min, Zitong Wang, Chenglin Liang, Wenjie Li, Jie Shao, Kunrui Zhu, Lu Zhou, Jing Cheng, Shihong Luo, Lehan Yu, Yudong Wu, Mingyong Xie & Xiaojuan Hu. (2020) Detection of Phytoestrogen Metabolites in Breastfed Infants’ Urine and the Corresponding Breast Milk by Liquid Chromatography–Tandem Mass Spectrometry. Journal of Agricultural and Food Chemistry 68:11, pages 3485-3494.
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Dominik SzwajgierRoman PaduchWirginia Kukuła-KochMagdalena Polak-BereckaAdam Waśko. (2020) Study on Biological Activity of Bread Enriched with Natural Polyphenols in Terms of Growth Inhibition of Tumor Intestine Cells. Journal of Medicinal Food 23:2, pages 181-190.
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Aniket V. Mali, Subhash B. Padhye, Shrikant Anant, Mahabaleshwar V. Hegde & Shivajirao S. Kadam. (2019) Anticancer and antimetastatic potential of enterolactone: Clinical, preclinical and mechanistic perspectives. European Journal of Pharmacology 852, pages 107-124.
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S. Franklyn De Silva & Jane Alcorn. (2019) Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets. Pharmaceuticals 12:2, pages 68.
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Laura W. Bowers, Claire G. Lineberger, Nikki A. Ford, Emily L. Rossi, Arunima Punjala, Kristina K. Camp, Bruce K. Kimler, Carol J. Fabian & Stephen D. Hursting. (2018) The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth. Breast Cancer Research and Treatment 173:3, pages 545-557.
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Bridget Baxter, Renee Oppel & Elizabeth Ryan. (2018) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors. Nutrients 11:1, pages 28.
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Radoslava Vlčková, Zuzana Andrejčáková, Drahomíra Sopková, Zdenka Hertelyová, Katarzyna Kozioł, Marek Koziorowski & Soňa Gancarčíková. (2018) Supplemental flaxseed modulates ovarian functions of weanling gilts via the action of selected fatty acids. Animal Reproduction Science 193, pages 171-181.
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Javed Iqbal, Banzeer Ahsan Abbasi, Riffat Batool, Tariq Mahmood, Barkat Ali, Ali Talha Khalil, Sobia Kanwal, Sayed Afzal Shah & Riaz Ahmad. (2018) Potential phytocompounds for developing breast cancer therapeutics: Nature’s healing touch. European Journal of Pharmacology 827, pages 125-148.
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Muhammad Younas, Christophe Hano, Nathalie Giglioli-Guivarc'h & Bilal Haider Abbasi. (2018) Mechanistic evaluation of phytochemicals in breast cancer remedy: current understanding and future perspectives. RSC Advances 8:52, pages 29714-29744.
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Janet M. Gray, Sharima Rasanayagam, Connie Engel & Jeanne Rizzo. (2017) State of the evidence 2017: an update on the connection between breast cancer and the environment. Environmental Health 16:1.
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Shireen Chikara, Kaitlin Lindsey, Pawel Borowicz, Melpo Christofidou-Solomidou & Katie M. Reindl. (2017) Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines. BMC Complementary and Alternative Medicine 17:1.
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Karina Chávez-Suárez, María Ortega-Vélez, Ana Valenzuela-Quintanar, Marcia Galván-Portillo, Lizbeth López-Carrillo, Julián Esparza-Romero, María Saucedo-Tamayo, María Robles-Burgueño, Susana Palma-Durán, María Gutiérrez-Coronado, Melissa Campa-Siqueiros, Patricia Grajeda-Cota & Graciela Caire-Juvera. (2017) Phytoestrogen Concentrations in Human Urine as Biomarkers for Dietary Phytoestrogen Intake in Mexican Women. Nutrients 9:10, pages 1078.
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Yingqian Ci, Jinping Qiao & Mei Han. (2016) Molecular Mechanisms and Metabolomics of Natural Polyphenols Interfering with Breast Cancer Metastasis. Molecules 21:12, pages 1634.
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Yue Zhou, Jie Zheng, Ya Li, Dong-Ping Xu, Sha Li, Yu-Ming Chen & Hua-Bin Li. (2016) Natural Polyphenols for Prevention and Treatment of Cancer. Nutrients 8:8, pages 515.
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