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Experimental Lung Research Volume 43, 2017 - Issue 9-10
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Original Articles

Dose dependent effects of tadalafil and roflumilast on ovalbumin-induced airway hyperresponsiveness in guinea pigs

Anna UrbanovaDepartment of Pharmacology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia;Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
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Ivana MedvedovaDepartment of Pharmacology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia;Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
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Martin KertysDepartment of Pharmacology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia;Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
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Pavol MikolkaBiomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia;Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
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Petra KosutovaBiomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia;Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
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Daniela MokraBiomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia;Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
&
Juraj MokrýDepartment of Pharmacology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia;Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, SlovakiaCorrespondence[email protected]
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Pages 407-416 | Received 24 Aug 2017, Accepted 27 Sep 2017, Published online: 08 Dec 2017

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Nafeesah Isa, Durrah Mudhafar, Chengsheng Ju, Kenneth K. C. Man, Wallis C. Y. Lau, Lok Yin Cheng & Li Wei. (2022) Effects of Phosphodiesterase-5 Inhibitors in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. COPD: Journal of Chronic Obstructive Pulmonary Disease 19:1, pages 300-308.
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Maria Gabriella Matera, Josuel Ora, Francesco Cavalli, Paola Rogliani & Mario Cazzola. (2021) New Avenues for Phosphodiesterase Inhibitors in Asthma. Journal of Experimental Pharmacology 13, pages 291-302.
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Ryan Varghese, Gargi Digholkar, Jainam Karsiya, Sahil Salvi, Jeenam Shah, Dileep Kumar & Rohit Sharma. (2024) PDE5 inhibitors: breaking new grounds in the treatment of COVID-19. Drug Metabolism and Personalized Therapy 38:4, pages 295-307.
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Ryan Varghese, Gargi Digholkar, Jainam Karsiya, Sahil Salvi, Jeenam Shah, Dileep Kumar & Rohit Sharma. (2023) PDE5 inhibitors: breaking new grounds in the treatment of COVID-19. Drug Metabolism and Personalized Therapy 0:0.
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Lveli Wang, Chuang Xiao, Yaping Liang, Zhiying Weng & Weimin Yang. (2021) Research Advances in COPD Drugs and Novel Targets. Nano LIFE 11:03, pages 2140008.
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Jana Plevkova, Mariana Brozmanova, Alireza Matloobi, Ivan Poliacek, Jan Honetschlager & Tomas Buday. (2021) Animal models of cough. Respiratory Physiology & Neurobiology 290, pages 103656.
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Daniela Mokra & Juraj Mokry. (2021) Phosphodiesterase Inhibitors in Acute Lung Injury: What Are the Perspectives?. International Journal of Molecular Sciences 22:4, pages 1929.
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Shradha Bodkhe, Mayuri Nikam, Atul P. Sherje, Tabassum Khan, Vasanti Suvarna & Kavit Patel. (2020) Current insights on clinical efficacy of roflumilast for treatment of COPD, asthma and ACOS. International Immunopharmacology 88, pages 106906.
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Martin Kertys, Marian Grendar, Petra Kosutova, Daniela Mokra & Juraj Mokry. (2020) Plasma based targeted metabolomic analysis reveals alterations of phosphatidylcholines and oxidative stress markers in guinea pig model of allergic asthma. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866:1, pages 165572.
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Haoxiao Zuo, Isabella Cattani-Cavalieri, Nshunge Musheshe, Viacheslav O. Nikolaev & Martina Schmidt. (2019) Phosphodiesterases as therapeutic targets for respiratory diseases. Pharmacology & Therapeutics 197, pages 225-242.
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Juraj Mokry, Anna Urbanova, Martin Kertys & Daniela Mokra. (2018) Inhibitors of phosphodiesterases in the treatment of cough. Respiratory Physiology & Neurobiology 257, pages 107-114.
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Heng Li, Jianping Zuo & Wei Tang. (2018) Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases. Frontiers in Pharmacology 9.
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Martin Kertys, Anna Urbanova & Juraj Mokry. (2018) Determination of Phosphodiesterase Inhibitors Tadalafil, Roflumilast and Roflumilast N-Oxide Using LC–MS in Guinea Pig Plasma. Journal of Chromatographic Science.
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M Kertys, A Urbanova & J Mokry. (2017) Quantification of Theophylline in Guinea Pig Plasma by LC-MS/MS Using Hydrophilic Interaction Liquid Chromatography Stationary Phase: Method Development, Validation, and Application in Study. Acta Medica Martiniana 17:3, pages 5-15.
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