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Research Article

Preparation and characterization of hCG-loaded polylactide or poly(lactide-co-glycolide) microspheres using a modified water-in-oil-in-water (w/o/w) emulsion solvent evaporation technique

Pages 247-260 | Published online: 29 Sep 2008

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Lu Li, Zhiguo Li, Yongxin Guo, Kai Zhang, Weidong Mi & Jing Liu. (2022) Preparation of uniform-sized GeXIVA[1,2]-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency. Drug Delivery 29:1, pages 2283-2295.
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Ravi Vaishya, Varun Khurana, Sulabh Patel & Ashim K Mitra. (2015) Long-term delivery of protein therapeutics. Expert Opinion on Drug Delivery 12:3, pages 415-440.
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Yang Yang, Yongliang Gao & Xingguo Mei. (2013) Effects of formulation parameters on encapsulation efficiency and release behavior of thienorphine loaded PLGA microspheres. Pharmaceutical Development and Technology 18:5, pages 1169-1174.
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Yiran Ma, Xinyi Zhao, Jian Li & Qi Shen. (2012) The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability. International Journal of Nanomedicine 7, pages 559-570.
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Zheng-Xing Su, Ya-Nan Shi, Le-Sheng Teng, Xiang Li, Le-xi Wang, Qing-Fan Meng, Li-Rong Teng & You-Xin Li. (2011) Biodegradable poly(D, L-lactide-co-glycolide) (PLGA) microspheres for sustained release of risperidone: Zero-order release formulation. Pharmaceutical Development and Technology 16:4, pages 377-384.
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Kira Stashevskaya, Elena Markvicheva, Svetlana Strukova, Igor Prudchenko, Vitaly Zubov & Christian Grandfils. (2007) Thrombin receptor agonist peptide entrapped in poly()-lactide-co-glycolide microparticles: Preparation and characterization. Journal of Microencapsulation 24:2, pages 129-142.
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J. X. Zhang, D. Chen, S. J. Wang & K. J. Zhu. (2005) Optimizing double emulsion process to decrease the burst release of protein from biodegradable polymer microspheres. Journal of Microencapsulation 22:4, pages 413-422.
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Ge Jiang, B. C. Thanoo & Patrick P. DeLuca. (2002) Effect of Osmotic Pressure in the Solvent Extraction Phase on BSA Release Profile from PLGA Microspheres. Pharmaceutical Development and Technology 7:4, pages 391-399.
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Yuichi Sato, Tatsuru Moritani, Ryota Inoue & Hirofumi Takeuchi. (2023) Preparation and evaluation of sustained release formulation of PLGA using a new injection system based on ink-jet injection technology. International Journal of Pharmaceutics 635, pages 122731.
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Manoj A. Pawar, Lalitkumar K. Vora, Prasad Kompella, Venkata Kishan Pokuri & Pradeep R. Vavia. (2022) Long-acting microspheres of Human Chorionic Gonadotropin hormone: In-vitro and in-vivo evaluation. International Journal of Pharmaceutics 611, pages 121312.
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Hamed Hajipour, Laya Farzadi, Leila Roshangar, Zeinab Latifi, Houman Kahroba, Vahideh Shahnazi, Kobra Hamdi, Alieh Ghasemzadeh, Amir Fattahi & Mohammad Nouri. (2021) A human chorionic gonadotropin (hCG) delivery platform using engineered uterine exosomes to improve endometrial receptivity. Life Sciences 275, pages 119351.
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Raden Rinova Sisworo, Masato Hasegawa, Kousuke Nakashima, Yu Norimatsu & Yukio Tada. (2020) Generation of Monodispersed Spherical Thermosensitive Gels and Their Swelling and Shrinking Behaviors in Aqueous Polymeric Solutions. Applied Sciences 10:6, pages 2016.
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Jahidur Rashid, Ahmad Alobaida, Taslim A. Al-Hilal, Samia Hammouda, Ivan F. McMurtry, Eva Nozik-Grayck, Kurt R. Stenmark & Fakhrul Ahsan. (2018) Repurposing rosiglitazone, a PPAR-γ agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH. Journal of Controlled Release 280, pages 113-123.
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Chengyu Wu, Stefania Baldursdottir, Mingshi Yang & Huiling Mu. (2018) Lipid and PLGA hybrid microparticles as carriers for protein delivery. Journal of Drug Delivery Science and Technology 43, pages 65-72.
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Dedi NoviendriIrwandi Jaswir, Muhammad Taher, Farahidah Mohamed, Hamzah Mohd SallehIbrahim Ali NoorbatchaFitri Octavianti, Widya Lestari, Ridar Hendri, Hasna AhmadKazuo Miyashita & Alias Abdullah. (2016) Fabrication of Fucoxanthin-Loaded Microsphere(F-LM) By Two Steps Double-Emulsion Solvent Evaporation Method and Characterization of Fucoxanthin before and after Microencapsulation. Journal of Oleo Science 65:8, pages 641-653.
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Xiaolong Tang, Yong Liang, Xinkuang Liu, Shuping Zhou, Liang Liu, Fujina Zhang, Chunmei Xie, Shuyu Cai, Jia Wei, Yongqiang Zhu & Wei Hou. (2015) PLGA-PEG Nanoparticles Coated with Anti-CD45RO and Loaded with HDAC Plus Protease Inhibitors Activate Latent HIV and Inhibit Viral Spread. Nanoscale Research Letters 10:1.
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Robert F. Pagels & Robert K. Prud'homme. (2015) Polymeric nanoparticles and microparticles for the delivery of peptides, biologics, and soluble therapeutics. Journal of Controlled Release 219, pages 519-535.
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Min-Ho Park, Jong-Suep Baek, Cho-A Lee, Dong-Chool Kim & Cheong-Weon Cho. (2014) The effect of Eudragit type on BSA-loaded PLGA nanoparticles. Journal of Pharmaceutical Investigation 44:5, pages 339-349.
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Thomas Schneider, Glenn H. Chapman & Urs O. Häfeli. (2011) Effects of chemical and physical parameters in the generation of microspheres by hydrodynamic flow focusing. Colloids and Surfaces B: Biointerfaces 87:2, pages 361-368.
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Fuminori Ito, Hiroyuki Fujimori, Hiroyoshi Kawakami, Kiyoshi Kanamura & Kimiko Makino. (2011) Technique to encapsulate a low molecular weight hydrophilic drug in biodegradable polymer particles in a liquid–liquid system. Colloids and Surfaces A: Physicochemical and Engineering Aspects 384:1-3, pages 368-373.
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Carla V. Luciani, Kyu Yong Choi, Joong Jin Han & Yunju Jung. (2011) Polymer particles with a pomegranate-like internal structure via micro-dispersive polymerization in a geometrically confined reaction space I. Experimental study. Polymer 52:4, pages 942-948.
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Tapas Pal, Shubhajit Paul & Biswanath Sa. (2011) Polymethylmethacrylate Coated Alginate Matrix Microcapsules for Controlled Release of Diclofenac Sodium. Pharmacology & Pharmacy 02:02, pages 56-66.
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Fuminori Ito, Hiroyuki Fujimori, Hiroyuki Honnami, Hiroyoshi Kawakami, Kiyoshi Kanamura & Kimiko Makino. (2010) Control of drug loading efficiency and drug release behavior in preparation of hydrophilic-drug-containing monodisperse PLGA microspheres. Journal of Materials Science: Materials in Medicine 21:5, pages 1563-1571.
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Bhanuprasanth Koppolu, Maham Rahimi, Sivaniarvindpriya Nattama, Aniket Wadajkar & Kytai Truong Nguyen. (2010) Development of multiple-layer polymeric particles for targeted and controlled drug delivery. Nanomedicine: Nanotechnology, Biology and Medicine 6:2, pages 355-361.
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Li Chun Lin, Shwu Jen Chang, Shyh Ming Kuo, Gregory Cheng‐Chie Niu, Hao Kai Keng & Pei Hua Tsai. (2008) Preparation and evaluation of β‐TCP/polylactide microspheres as osteogenesis materials. Journal of Applied Polymer Science 108:5, pages 3210-3217.
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Meital ZilbermanOrly Grinberg. (2007) HRP-Loaded Bioresorbable Microspheres: Effect of Copolymer Composition and Molecular Weight on Microstructure and Release Profile. Journal of Biomaterials Applications 22:5, pages 391-407.
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Fuminori Ito, Hiroyuki Fujimori & Kimiko Makino. (2008) Factors affecting the loading efficiency of water-soluble drugs in PLGA microspheres. Colloids and Surfaces B: Biointerfaces 61:1, pages 25-29.
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Fuminori Ito, Hiroyuki Fujimori & Kimiko Makino. (2007) Incorporation of water-soluble drugs in PLGA microspheres. Colloids and Surfaces B: Biointerfaces 54:2, pages 173-178.
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Meital Zilberman & Inbal Shraga. (2006) Microsphere‐based bioresorbable structures loaded with proteins for tissue regeneration applications. Journal of Biomedical Materials Research Part A 79A:2, pages 370-379.
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Fude Cui, Kai Shi, Liqiang Zhang, Anjin Tao & Yoshiaki Kawashima. (2006) Biodegradable nanoparticles loaded with insulin–phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation. Journal of Controlled Release 114:2, pages 242-250.
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Weiwei Zhu, Takahisa Masaki, You Han Bae, Ramesh Rathi, Alfred K. Cheung & Steven E. Kern. (2006) Development of a sustained-release system for perivascular delivery of dipyridamole. Journal of Biomedical Materials Research Part B: Applied Biomaterials 77B:1, pages 135-143.
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