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Research Article

5-Fluorouracil-loaded microspheres prepared by spray-drying poly(D,L-lactide) and poly(lactide-co-glycolide) polymers: Characterization and drug release

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Pages 671-682 | Received 09 Nov 2004, Accepted 26 Apr 2005, Published online: 03 Oct 2008

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Mina Heidari, Jacob Golenser & Andreas Greiner. (2022) Meeting the Needs of a Potent Carrier for Malaria Treatment: Encapsulation of Artemisone in Poly(lactide‐ co ‐glycolide) Micro‐ and Nanoparticles . Particle & Particle Systems Characterization 39:5, pages 2100152.
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Nozad Rashid Hussein, Huner Kamal Omer, Abdelbary M.A. Elhissi & Waqar Ahmed. 2020. Advances in Medical and Surgical Engineering. Advances in Medical and Surgical Engineering 279 311 .
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Nattawut Leelakanok, Sean Geary & Aliasger Salem. (2018) Fabrication and Use of Poly(d,l-lactide-co-glycolide)-Based Formulations Designed for Modified Release of 5-Fluorouracil. Journal of Pharmaceutical Sciences 107:2, pages 513-528.
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Sanjeev K. Pandey, Dinesh K. Patel, Akhilendra K. Maurya, Ravi Thakur, Durga P. Mishra, Manjula Vinayak, Chandana Haldar & Pralay Maiti. (2016) Controlled release of drug and better bioavailability using poly(lactic acid-co-glycolic acid) nanoparticles. International Journal of Biological Macromolecules 89, pages 99-110.
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Sanjeev K. Pandey, Dinesh K. Patel, Ravi Thakur, Durga P. Mishra, Pralay Maiti & Chandana Haldar. (2015) Anti-cancer evaluation of quercetin embedded PLA nanoparticles synthesized by emulsified nanoprecipitation. International Journal of Biological Macromolecules 75, pages 521-529.
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N. Ashwanikumar, Nisha Asok Kumar, S. Asha Nair & G.S. Vinod Kumar. (2014) 5-Fluorouracil–lipid conjugate: Potential candidate for drug delivery through encapsulation in hydrophobic polyester-based nanoparticles. Acta Biomaterialia 10:11, pages 4685-4694.
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Thanh Huong Hoang Thi, Mohamed Lemdani & Marie-Pierre Flament. (2013) Optimizing the taste-masked formulation of acetaminophen using sodium caseinate and lecithin by experimental design. International Journal of Pharmaceutics 453:2, pages 408-415.
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Lucía Martín-Banderas, Eva Sáez-Fernández, Mª Ángeles Holgado, Mª Matilde Durán-Lobato, José C. Prados, Consolación Melguizo & José L. Arias. (2013) Biocompatible gemcitabine-based nanomedicine engineered by Flow Focusing® for efficient antitumor activity. International Journal of Pharmaceutics 443:1-2, pages 103-109.
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Cheng Zhang, Guodong Li, Yihan Wang, Fuying Cui, Jien Zhang & Qingshan Huang. (2012) Preparation and characterization of 5-fluorouracil-loaded PLLA–PEG/PEG nanoparticles by a novel supercritical CO2 technique. International Journal of Pharmaceutics 436:1-2, pages 272-281.
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A. Fenández, C. Teijón, M. Benito, I. Iglesias, R. Lozano, J. M. Teijón & M. D. Blanco. (2011) Tamoxifen‐loaded microspheres based on mixtures of poly( D , L ‐lactide‐ co ‐glycolide) and poly( D , L ‐lactide) polymers: Effect of polymeric composition on drug release and in vitro antitumoral activity . Journal of Applied Polymer Science 124:4, pages 2987-2998.
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Nina Schafroth, Cordin Arpagaus, Umesh Y. Jadhav, Sushil Makne & Dennis Douroumis. (2012) Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process. Colloids and Surfaces B: Biointerfaces 90, pages 8-15.
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Tetty Kemala, Emil Budianto & Bambang Soegiyono. (2012) Preparation and characterization of microspheres based on blend of poly(lactic acid) and poly(ɛ-caprolactone) with poly(vinyl alcohol) as emulsifier. Arabian Journal of Chemistry 5:1, pages 103-108.
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M. Dolores Blanco, Sandra Guerrero, Marta Benito, Ana Fernández, César Teijón, Rosa Olmo, Issa Katime & José M. Teijón. (2011) In Vitro and In Vivo Evaluation of a Folate-Targeted Copolymeric Submicrohydrogel Based on N-Isopropylacrylamide as 5-Fluorouracil Delivery System. Polymers 3:3, pages 1107-1125.
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Kristen Bowey & Ronald J. Neufeld. (2010) Systemic and Mucosal Delivery of Drugs within Polymeric Microparticles Produced by Spray Drying. BioDrugs 24:6, pages 359-377.
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Steven Abbott. 2010. Poly(Lactic Acid). Poly(Lactic Acid) 83 95 .
M Dolores Blanco, Sandra Guerrero, César Teijón, Rosa Olmo, Lorenzo Pastrana, Issa Katime & José M Teijón. (2008) Preparation and characterization of nanoparticulate poly( N -isopropylacryl- amide) hydrogel for the controlled release of anti-tumour drugs . Polymer International 57:11, pages 1215-1225.
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José Arias. (2008) Novel Strategies to Improve the Anticancer Action of 5-Fluorouracil by Using Drug Delivery Systems. Molecules 13:10, pages 2340-2369.
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Fernando Sánchez-Patán, Maria-Angeles Aller, Carmen Cuellar, Marta Rodero, Maria-Teresa Corcuera, Maria-Paz Nava, Fernando Gómez, Maria-Dolores Blanco, Sandra Guerrero, R. Anchuelo, Enriqueta Muñiz, Maria-Jose Alonso, Jose-Maria Teijón & J. Arias. (2008) Mast cell inhibition by ketotifen reduces splanchnic inflammatory response in a portal hypertension model in rats. Experimental and Toxicologic Pathology 60:4-5, pages 347-355.
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Sandra Guerrero, Enriqueta Muñíz, César Teijón, Rosa Olmo, José M. Teijón & M.Dolores Blanco. (2008) Ketotifen-Loaded Microspheres Prepared by Spray-Drying Poly (D,L-Lactide) and Poly(D,L-Lactide-co-Glycolide) Polymers: Characterization and In Vivo Evaluation. Journal of Pharmaceutical Sciences 97:8, pages 3153-3169.
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Reinhard Vehring. (2007) Pharmaceutical Particle Engineering via Spray Drying. Pharmaceutical Research 25:5, pages 999-1022.
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Shishu, Neeta Gupta & Nidhi Aggarwal. (2007) Stomach-specific drug delivery of 5-fluorouracil using floating alginate beads. AAPS PharmSciTech 8:2, pages E143-E149.
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Roberto L. Sastre, Rosa Olmo, César Teijón, Enriqueta Muñíz, José M. Teijón & M. Dolores Blanco. (2007) 5-Fluorouracil plasma levels and biodegradation of subcutaneously injected drug-loaded microspheres prepared by spray-drying poly(d,l-lactide) and poly(d,l-lactide-co-glycolide) polymers. International Journal of Pharmaceutics 338:1-2, pages 180-190.
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Chul Ho Park, Min Young Kim, Ji Youn Yoo, Ki-Hyun Kim, Jong-Chan Lee & Jonghwi Lee. (2007) Preparation of Polymer/Drug Nano- and Micro-Particles by Electrospraying. Macromolecular Symposia 249-250:1, pages 116-119.
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M. Dolores Blanco, Roberto L. Sastre, César Teijón, Rosa Olmo & José M. Teijón. (2006) Degradation behaviour of microspheres prepared by spray-drying poly(d,l-lactide) and poly(d,l-lactide-co-glycolide) polymers. International Journal of Pharmaceutics 326:1-2, pages 139-147.
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Ai-Zheng Chen, Xi-Ming Pu, Yun-Qing Kang, Li Liao, Ya-Dong Yao & Guang-Fu Yin. (2006) Preparation of 5-Fluorouracil-Poly(L-lactide) Microparticles Using Solution-Enhanced Dispersion by Supercritical CO2. Macromolecular Rapid Communications 27:15, pages 1254-1259.
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