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British Journal of Neurosurgery Volume 18, 2004 - Issue 5
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Research Article

Association between dynamic cerebral autoregulation and mortality in severe head injury

RB Panerai Department of Cardiovascular Sciences, Faculty of Medicine University of Leicester, Leicester Royal Infirmary Leicester
,
V Kerins Department of Cardiovascular Sciences, Faculty of Medicine University of Leicester, Leicester Royal Infirmary Leicester
,
L Fan Department of Cardiovascular Sciences, Faculty of Medicine University of Leicester, Leicester Royal Infirmary Leicester
,
PM Yeoman Adult Intensive Care Unit Queen's Medical Centre Nottingham UK
,
T Hope Department of Neurosurgery Queen's Medical Centre Nottingham UK
&
DH Evans Department of Cardiovascular Sciences, Faculty of Medicine University of Leicester, Leicester Royal Infirmary Leicester
Pages 471-479 | Published online: 20 Aug 2009

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Joseph Donnelly, Marcel J Aries & Marek Czosnyka. (2015) Further understanding of cerebral autoregulation at the bedside: possible implications for future therapy. Expert Review of Neurotherapeutics 15:2, pages 169-185.
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Articles from other publishers (69)

Claudia A Smith, Keri LH Carpenter, Peter J Hutchinson, Peter Smielewski & Adel Helmy. (2023) Candidate neuroinflammatory markers of cerebral autoregulation dysfunction in human acute brain injury. Journal of Cerebral Blood Flow & Metabolism 43:8, pages 1237-1253.
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Sérgio Brasil, Ricardo de Carvalho Nogueira, Ângela Salomão Macedo Salinet, Márcia Harumy Yoshikawa, Manoel Jacobsen Teixeira, Wellingson Paiva, Luiz Marcelo Sá Malbouisson, Edson Bor-Seng-Shu & Ronney B. Panerai. (2023) Critical Closing Pressure and Cerebrovascular Resistance Responses to Intracranial Pressure Variations in Neurocritical Patients. Neurocritical Care.
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Ronney B Panerai, Patrice Brassard, Joel S Burma, Pedro Castro, Jurgen AHR Claassen, Johannes J van Lieshout, Jia Liu, Samuel JE Lucas, Jatinder S Minhas, Georgios D Mitsis, Ricardo C Nogueira, Shigehiko Ogoh, Stephen J Payne, Caroline A Rickards, Andrew D Robertson, Gabriel D Rodrigues, Jonathan D Smirl & David M Simpson. (2022) Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update. Journal of Cerebral Blood Flow & Metabolism 43:1, pages 3-25.
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Haiyan Liu & Min Zhou. (2023) The utility of therapeutic hypothermia on cerebral autoregulation. Journal of Intensive Medicine 3:1, pages 27-37.
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Madhuradhar Chegondi, Wei-Chiang Lin, Sayed Naqvi, Prithvi Sendi & Balagangadhar R. Totapally. (2022) The Effect of Electroencephalography Abnormalities on Cerebral Autoregulation in Sedated Ventilated Children. Pediatric Reports 15:1, pages 9-15.
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Marek Czosnyka, Thomas Santarius, Joseph Donnelly, Rokus E. C. van den Dool & Nicolaas H. Sperna Weiland. (2022) Pro-Con Debate: The Clinical (Ir)relevance of the Lower Limit of Cerebral Autoregulation for Anesthesiologists. Anesthesia & Analgesia 135:4, pages 734-743.
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Joseph R. Whittaker, Jessica J. Steventon, Marcello Venzi & Kevin Murphy. (2022) The Spatiotemporal Dynamics of Cerebral Autoregulation in Functional Magnetic Resonance Imaging. Frontiers in Neuroscience 16.
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Maria Fernanda Lobos Vasquez, Roberth Alcivar-Cevallos, Ronney B. Panerai & Max Chacon. (2021) Machine learning techniques versus complexity theory in the cerebral haemodynamics of traumatic brain injury patients. Machine learning techniques versus complexity theory in the cerebral haemodynamics of traumatic brain injury patients.
Alwyn GomezCarleen BatsonLogan FroeseAmanjyot Singh SainbhiFrederick Adam Zeiler. (2021) Utility of Transcranial Doppler in Moderate and Severe Traumatic Brain Injury: A Narrative Review of Cerebral Physiologic Metrics. Journal of Neurotrauma 38:16, pages 2206-2220.
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Lina Bergman, Catherine Cluver, Niclas Carlberg, Michael Belfort, Mary C. Tolcher, Ronney B. Panerai & Teelkien van Veen. (2021) Cerebral perfusion pressure and autoregulation in eclampsia—a case control study. American Journal of Obstetrics and Gynecology 225:2, pages 185.e1-185.e9.
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Xiuyun LiuKei AkiyoshiMitsunori NakanoKen BradyBrian BushRohan NadkarniArchana VenkataramanRaymond C. KoehlerJennifer K. LeeCharles W. HogueMarek CzosnykaPeter SmielewskiCharles H. Brown. (2020) Determining Thresholds for Three Indices of Autoregulation to Identify the Lower Limit of Autoregulation During Cardiac Surgery*. Critical Care Medicine 49:4, pages 650-660.
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Manoel Jacobsen Teixeira, Davi J. Fontoura Solla & Wellingson S. Paiva. 2021. Neurocritical Care for Neurosurgeons. Neurocritical Care for Neurosurgeons 407 430 .
Marta Fedriga & Marek Czosnyka. 2021. Echography and Doppler of the Brain. Echography and Doppler of the Brain 65 73 .
Jie Chen, Jia Liu, Kehui Dong, Yilong Wang, Xingquan Zhao, Yongjun Wang & Xiping Gong. (2020) Impaired Dynamic Cerebral Autoregulation in Cerebral Venous Thrombosis. Frontiers in Neurology 11.
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Lennart Riemann, Erta Beqiri, Alexander Younsi, Marek Czosnyka & Peter Smielewski. (2020) Predictive and Discriminative Power of Pressure Reactivity Indices in Traumatic Brain Injury. Neurosurgery 87:4, pages 655-663.
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Krishma AdatiaRomergryko G. GeocadinRyan HealyWendy ZiaiLuciano Ponce-MejiaMirinda Anderson-WhiteDhaval ShahBatya R. RadzikCaitlin PalmisanoCharles W. HogueCharles BrownJose I. SuarezLucia Rivera-Lara. (2020) Lateral Brain Displacement and Cerebral Autoregulation in Acutely Comatose Patients. Critical Care Medicine 48:7, pages 1018-1025.
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Marek Czosnyka, Peter Hutchinson & Peter Smielewski. (2020) Treatment targets based on autoregulation parameters in neurocritical care patients. Current Opinion in Critical Care 26:2, pages 109-114.
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Marek Czosnyka. (2019) In a Search of Pressure Which Optimizes Autoregulation of Cerebral Blood Flow*. Critical Care Medicine 47:10, pages 1472-1473.
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Man Y. Lam, Victoria J. Haunton, Thompson G. Robinson & Ronney B. Panerai. (2019) Dynamic cerebral autoregulation measurement using rapid changes in head positioning: experiences in acute ischemic stroke and healthy control populations. American Journal of Physiology-Heart and Circulatory Physiology 316:3, pages H673-H683.
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Casandra I. Montoro, Stefan Duschek, Daniel Schuepbach, Miguel Gandarillas & Gustavo A. Reyes del Paso. (2018) Cerebral blood flow variability in fibromyalgia syndrome: Relationships with emotional, clinical and functional variables. PLOS ONE 13:9, pages e0204267.
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Krishma AdatiaRomergryko G. GeocadinRyan HealyWendy ZiaiLuciano Ponce-MejiaMirinda Anderson-WhiteDhaval ShahBatya R. RadzikCaitlin PalmisanoCharles W. HogueCharles BrownLucia Rivera-Lara. (2018) Effect of Body Temperature on Cerebral Autoregulation in Acutely Comatose Neurocritically Ill Patients. Critical Care Medicine 46:8, pages e733-e741.
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Anson Wang, Santiago Ortega-Gutierrez & Nils H. Petersen. (2018) Autoregulation in the Neuro ICU. Current Treatment Options in Neurology 20:6.
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B. Chan, E. Butler, S. A. Frost, A. Chuan & A. Aneman. (2018) Cerebrovascular autoregulation monitoring and patient-centred outcomes after cardiac surgery: a systematic review. Acta Anaesthesiologica Scandinavica 62:5, pages 588-599.
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Casandra I. Montoro, Stefan Duschek & Gustavo A. Reyes del Paso. (2018) Variability in cerebral blood flow velocity at rest and during mental stress in healthy individuals: Associations with cardiovascular parameters and cognitive performance. Biological Psychology 135, pages 149-158.
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Frederick A. ZeilerJoseph DonnellyLeanne CalvielloDavid K. MenonPeter SmielewskiMarek Czosnyka. (2017) Pressure Autoregulation Measurement Techniques in Adult Traumatic Brain Injury, Part I: A Scoping Review of Intermittent/Semi-Intermittent Methods. Journal of Neurotrauma 34:23, pages 3207-3223.
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Jay F. Rilinger, Craig M. Smith, Raye Ann O. deRegnier, Joshua L. Goldstein, Michele G. Mills, Marleta Reynolds, Carl L. Backer, Delilah M. Burrowes, Priya Mehta, Juan Piantino & Mark S. Wainwright. (2017) Transcranial Doppler Identification of Neurologic Injury during Pediatric Extracorporeal Membrane Oxygenation Therapy. Journal of Stroke and Cerebrovascular Diseases 26:10, pages 2336-2345.
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Lucia Rivera-Lara, Andres Zorrilla-Vaca, Romer Geocadin, Wendy Ziai, Ryan HealyRichard ThompsonPeter SmielewskiMarek CzosnykaCharles W. Hogue. (2017) Predictors of Outcome With Cerebral Autoregulation Monitoring: A Systematic Review and Meta-Analysis. Critical Care Medicine 45:4, pages 695-704.
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Cherisse Berry, Jamila Torain, Joseph A. Kufera, Peter F. Hu, Thomas M. Scalea & Deborah M. Stein. (2017) Prospective Evaluation of Post-Traumatic Vasospasm and Post-Injury Functional Outcome Assessment: Is Cerebral Ischemia Going Unrecognized in Patients with Traumatic Brain Injury?. Journal of Behavioral and Brain Science 07:08, pages 338-347.
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Nikil Patel, Ronney B Panerai, Victoria Haunton, Emmanuel Katsogridakis, Nazia P Saeed, Angela Salinet, Fiona Brodie, Nazia Syed, Schnell D’Sa & Thompson G Robinson. (2016) The Leicester cerebral haemodynamics database: normative values and the influence of age and sex. Physiological Measurement 37:9, pages 1485-1498.
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R B Panerai, V J Haunton, M F Hanby, A S M Salinet & T G Robinson. (2016) Statistical criteria for estimation of the cerebral autoregulation index (ARI) at rest. Physiological Measurement 37:5, pages 661-672.
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Stephen Honeybul. (2016) Letter to the Editor: Sudden death following cranioplasty: autoregulatory failure?. Journal of Neurosurgery 124:3, pages 885-887.
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Shruti Agrawal. (2016) Neuroprotective measures in children with traumatic brain injury. World Journal of Critical Care Medicine 5:1, pages 36.
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Stephen PayneStephen Payne. 2016. Cerebral Autoregulation. Cerebral Autoregulation 75 119 .
Yi Zhang, Xiuyun Liu, Luzius Steiner, Peter Smielewski, Eli Feen, John D. Pickard & Marek Czosnyka. 2016. Intracranial Pressure and Brain Monitoring XV. Intracranial Pressure and Brain Monitoring XV 205 209 .
Philip M. Lewis, Marek Czosnyka, Bradley G. Carter, Jeffrey V. Rosenfeld, Eldho Paul, Nitesh Singhal & Warwick Butt. (2015) Cerebrovascular Pressure Reactivity in Children With Traumatic Brain Injury*. Pediatric Critical Care Medicine 16:8, pages 739-749.
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Marek Czosnyka & Chad Miller. (2014) Monitoring of Cerebral Autoregulation. Neurocritical Care 21:S2, pages 95-102.
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Georgios V. Varsos, Karol P. Budohoski, Angelos G. Kolias, Xiuyun Liu, Peter Smielewski, Vassilis G. Varsos, Peter J. Hutchinson, John D. Pickard & Marek Czosnyka. (2014) Relationship of Vascular Wall Tension and Autoregulation Following Traumatic Brain Injury. Neurocritical Care 21:2, pages 266-274.
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Ulf Johnson, Anders Lewén, Elisabeth Ronne-Engström, Tim Howells & Per Enblad. (2014) Should the Neurointensive Care Management of Traumatic Brain Injury Patients be Individualized According to Autoregulation Status and Injury Subtype?. Neurocritical Care 21:2, pages 259-265.
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Aisha S.S. Meel-van den Abeelen, Arenda H.E.A. van Beek, Cornelis H. Slump, Ronney B. Panerai & Jurgen A.H.R. Claassen. (2014) Transfer function analysis for the assessment of cerebral autoregulation using spontaneous oscillations in blood pressure and cerebral blood flow. Medical Engineering & Physics 36:5, pages 563-575.
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Ronney B. Panerai. (2014) Nonstationarity of dynamic cerebral autoregulation. Medical Engineering & Physics 36:5, pages 576-584.
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Nils H. Petersen, Santiago Ortega-Gutierrez, Andres Reccius, Arjun Masurkar, Amy Huang & Randolph S. Marshall. (2013) Comparison of Non-invasive and Invasive Arterial Blood Pressure Measurement for Assessment of Dynamic Cerebral Autoregulation. Neurocritical Care 20:1, pages 60-68.
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Elsa Irene Azevedo & Pedro Miguel Castro. 2014. Vascular Imaging of the Central Nervous System. Vascular Imaging of the Central Nervous System 33 66 .
Emmanuel Katsogridakis, Glen Bush, Lingke Fan, Anthony A Birch, David M Simpson, Robert Allen, John F Potter & Ronney B Panerai. (2012) Detection of Impaired Cerebral Autoregulation Improves by Increasing Arterial Blood Pressure Variability. Journal of Cerebral Blood Flow & Metabolism 33:4, pages 519-523.
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Jawad Naqvi, Kok Hooi Yap, Gulraiz Ahmad & Jonathan Ghosh. (2013) Transcranial Doppler Ultrasound: A Review of the Physical Principles and Major Applications in Critical Care. International Journal of Vascular Medicine 2013, pages 1-13.
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Marek Czosnyka, Bernhard Schmidt, Eric Albert Schmidt, Rohan Ramakrishna, Pierre D. Mourad & Michel Kliot. 2013. Monitoring in Neurocritical Care. Monitoring in Neurocritical Care 445 455.e2 .
Anthony A. Figaji. 2013. Monitoring in Neurocritical Care. Monitoring in Neurocritical Care 56 60.e3 .
Christopher Betrus & Christian W. Kreipke. 2013. Cerebral Blood Flow, Metabolism, and Head Trauma. Cerebral Blood Flow, Metabolism, and Head Trauma 1 27 .
Karol P. Budohoski, Matthias Reinhard, Marcel J. H. Aries, Zofia Czosnyka, Peter Smielewski, John D. Pickard, Peter J. Kirkpatrick & Marek Czosnyka. (2011) Monitoring cerebral autoregulation after head injury. Which component of transcranial Doppler flow velocity is optimal?. Neurocritical Care 17:2, pages 211-218.
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VZ Marmarelis, DC Shin & R Zhang. (2012) Linear and Nonlinear Modeling of Cerebral Flow Autoregulation Using Principal Dynamic Modes. The Open Biomedical Engineering Journal 6:1, pages 42-55.
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I. Michael Leitman. (2012) Understanding the Brain-Heart Axis in Neurological Trauma. Journal of Surgical Research 173:1, pages e33-e35.
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Stuart H. Friess, Todd J. Kilbaugh & Jimmy W. Huh. (2012) Advanced Neuromonitoring and Imaging in Pediatric Traumatic Brain Injury. Critical Care Research and Practice 2012, pages 1-11.
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Enrico Sorrentino, Karol P. Budohoski, Magdalena Kasprowicz, Peter Smielewski, Basil Matta, John D. Pickard & Marek Czosnyka. (2010) Critical Thresholds for Transcranial Doppler Indices of Cerebral Autoregulation in Traumatic Brain Injury. Neurocritical Care 14:2, pages 188-193.
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Anthony A. Figaji. (2009) Practical aspects of bedside cerebral hemodynamics monitoring in pediatric TBI. Child's Nervous System 26:4, pages 431-439.
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Anthony A. Figaji, Eugene ZwaneA. Graham Fieggen, Andrew C. ArgentPeter D. Le Roux, Peter Siesjo & Jonathan C. Peter. (2009) Pressure autoregulation, intracranial pressure, and brain tissue oxygenation in children with severe traumatic brain injury. Journal of Neurosurgery: Pediatrics 4:5, pages 420-428.
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Gill E. Sviri, Rune Aaslid, Colleen M. Douville, Anne Moore & David W. Newell. (2009) Time course for autoregulation recovery following severe traumatic brain injury. Journal of Neurosurgery 111:4, pages 695-700.
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Andrew W. Subudhi, Ronney B. Panerai & Robert C. Roach. (2009) Acute hypoxia impairs dynamic cerebral autoregulation: results from two independent techniques. Journal of Applied Physiology 107:4, pages 1165-1171.
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M Chacón, N Nuñez, C Henríquez & R B Panerai. (2008) Unconstrained parameter estimation for assessment of dynamic cerebral autoregulation. Physiological Measurement 29:10, pages 1179-1193.
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Anthony A. Figaji, A. Graham Fieggen, Andrew C. Argent, Peter D. LeRoux & Jonathan C. Peter. (2008) DOES ADHERENCE TO TREATMENT TARGETS IN CHILDREN WITH SEVERE TRAUMATIC BRAIN INJURY AVOID BRAIN HYPOXIA? A BRAIN TISSUE OXYGENATION STUDY. Neurosurgery 63:1, pages 83-92.
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Anthony A. Figaji, A. Graham Fieggen, Andrew C. Argent, Peter D. LeRoux & Jonathan C. Peter. (2008) DOES ADHERENCE TO TREATMENT TARGETS IN CHILDREN WITH SEVERE TRAUMATIC BRAIN INJURY AVOID BRAIN HYPOXIA? A BRAIN TISSUE OXYGENATION STUDY. Neurosurgery 63:1, pages 83-92.
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R B Panerai, E L Sammons, S M Smith, W E Rathbone, S Bentley, J F Potter & N J Samani. (2008) Continuous estimates of dynamic cerebral autoregulation: influence of non-invasive arterial blood pressure measurements. Physiological Measurement 29:4, pages 497-513.
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P. M. Lewis, J. V. Rosenfeld, R. R. Diehl, H. M. Mehdorn & E. W. Lang. (2008) Phase shift and correlation coefficient measurement of cerebral autoregulation during deep breathing in traumatic brain injury (TBI). Acta Neurochirurgica 150:2, pages 139-147.
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A. A. Figaji, A. G. Fieggen, S. J. I. Sandler, A. C. Argent, P. D. Le Roux & J. C. Peter. (2007) Intracranial pressure and cerebral oxygenation changes after decompressive craniectomy in a child with traumatic brain swelling. Child's Nervous System 23:11, pages 1331-1335.
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Emily L. Sammons, Nilesh J. Samani, Stephen M. Smith, Wendy E. Rathbone, Steve Bentley, John F. Potter & Ronney B. Panerai. (2007) Influence of noninvasive peripheral arterial blood pressure measurements on assessment of dynamic cerebral autoregulation. Journal of Applied Physiology 103:1, pages 369-375.
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Ronney B. Panerai, Michelle Moody, Penelope J. Eames & John F. Potter. (2005) Dynamic cerebral autoregulation during brain activation paradigms. American Journal of Physiology-Heart and Circulatory Physiology 289:3, pages H1202-H1208.
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