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Original Article

Acetyl-L-Carnitine Prevents Selenite-Induced Cataractogenesis in an Experimental Animal Model

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Pages 961-971 | Received 14 Jul 2007, Accepted 09 Sep 2007, Published online: 02 Jul 2009

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Hatice Tuba Atalay, Ahmet Yucel Ucgul, Ummuhani Ozel Turkcu, Mehmet Cuneyt Ozmen, Samet Yilmaz & Ayse Bilgihan. (2020) The Effect of Sildenafil on Selenite-Induced Cataract in Rats. Current Eye Research 45:9, pages 1082-1088.
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M. Isai, R. Elanchezhian, M. Sakthivel, A. Chinnakkaruppan, M. Rajamohan, C. Nelson Jesudasan, P. A. Thomas & P. Geraldine. (2009) Anticataractogenic Effect of an Extract of the Oyster Mushroom, Pleurotus ostreatus, in an Experimental Animal Model. Current Eye Research 34:4, pages 264-273.
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Bahri Aydin, Ramazan Yagci, Fatma M. Yılmaz, Mesut Erdurmus, Remzi Karadağ, Ugurcan Keskin, Mustafa Durmus & Ramazan Yigitoglu. (2009) Prevention of Selenite-Induced Cataractogenesis by N-Acetylcysteine in Rats. Current Eye Research 34:3, pages 196-201.
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Articles from other publishers (25)

Xi Zhang, Bingqing Liu, Kevin Lal, Haihua Liu, Myhoa Tran, Manyu Zhou, Chimdindu Ezugwu, Xin Gao, Terry Dang, My-Lien Au, Erica Brown, Hongli Wu & Yan Liao. (2023) Antioxidant System and Endoplasmic Reticulum Stress in Cataracts. Cellular and Molecular Neurobiology 43:8, pages 4041-4058.
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Xin Yang, Fengyan Zhang, Xuhui Liu, Jia Meng, Shanshan Du, Jingzhi Shao, Jingjing Liu & Mengyuan Fang. (2022) FOXO4 mediates resistance to oxidative stress in lens epithelial cells by modulating the TRIM25/Nrf2 signaling. Experimental Cell Research 420:1, pages 113340.
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Ao Lu, Ping Duan, Jing Xie, Hui Gao, Mengmeng Chen, Yu Gong, Jiawen Li & Haiwei Xu. (2022) Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review. European Journal of Pharmacology 934, pages 175299.
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Min Seok Song, Hun Ju Sim, Seonmi Kang, Sangwan Park, Kangmoon Seo & So Yeong Lee. (2020) Pharmacological inhibition of Kv3 on oxidative stress-induced cataract progression. Biochemical and Biophysical Research Communications 533:4, pages 1255-1261.
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Aaron Hilliard, Patricia Mendonca, Tanya D. Russell & Karam F. A. Soliman. (2020) The Protective Effects of Flavonoids in Cataract Formation through the Activation of Nrf2 and the Inhibition of MMP-9. Nutrients 12:12, pages 3651.
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Segewkal H. Heruye, Leonce N. Maffofou Nkenyi, Neetu U. Singh, Dariush Yalzadeh, Kalu K. Ngele, Ya-Fatou Njie-Mbye, Sunny E. Ohia & Catherine A. Opere. (2020) Current Trends in the Pharmacotherapy of Cataracts. Pharmaceuticals 13:1, pages 15.
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Yasaswi Maddirala, Shakila Tobwala, Humeyra Karacal & Nuran Ercal. (2017) Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats. BMC Ophthalmology 17:1.
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Xiu-Fen Liu, Ji-Long Hao, Tian Xie, Tayyab Hamid Malik, Cheng-Bo Lu, Cong Liu, Chang Shu, Cheng-Wei Lu & Dan-Dan Zhou. (2017) Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress. Aging Cell 16:5, pages 934-942.
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Muniyandi Anbukkarasi, Philip A. Thomas, Joen-Rong Sheu & Pitchairaj Geraldine. (2017) In vitro antioxidant and anticataractogenic potential of silver nanoparticles biosynthesized using an ethanolic extract of Tabernaemontana divaricata leaves. Biomedicine & Pharmacotherapy 91, pages 467-475.
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Mahalingam Sundararajan, Philip A. Thomas, Karuppan Babyshalini & Pitchairaj Geraldine. (2017) Identification of phytoconstituents and in-vitro evaluation of the putative anticataractogenic effect of an ethanolic root extract of Leucas aspera. Biomedicine & Pharmacotherapy 85, pages 87-101.
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Shui‑Ping Yang, Xiu‑Zhen Yang & Guo‑Ping Cao. (2015) Acetyl‑l‑carnitine prevents homocysteine‑induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells. Molecular Medicine Reports.
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Lamiaa M. Farghaly, Waleed A. Ghobashy, Youssef Shoukry & Mona F. El-Azab. (2014) Ameliorative effect of acetyl-l-carnitine and/or nifedipine against selenite-induced cataractogenesis in young albino rats. European Journal of Pharmacology 729, pages 1-9.
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Pitchairaj Geraldine, Arumugam R. Muralidharan, Rajan Elanchezhian, P. Archana Teresa & Philip A. Thomas. 2014. Handbook of Nutrition, Diet and the Eye. Handbook of Nutrition, Diet and the Eye 493 504 .
V. Sasikala, B. N. Rooban, V. Sahasranamam & Annie Abraham. (2013) Rutin ameliorates free radical mediated cataract by enhancing the chaperone activity of α-crystallin. Graefe's Archive for Clinical and Experimental Ophthalmology 251:7, pages 1747-1755.
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Asha Radha, Sudha Devi Rukhmini, Sasikala Vilasini, Priya Rajan Sakunthala, Balachandran Sreedharan, Mohanan Puzhavoorparambil Velayudhan & Annie Abraham. (2012) Bioactive Derivatives of Curcumin Attenuate Cataract Formation In Vitro . Chemical Biology & Drug Design 80:6, pages 887-892.
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Thirugnanasambandhar Sivasubramania Anitha, Thangaraj Annadurai, Philip A. Thomas & Pitchairaj Geraldine. (2010) Prevention of Selenite-Induced Cataractogenesis by an Ethanolic Extract of Cineraria maritima: An Experimental Evaluation of the Traditional Eye Medication. Biological Trace Element Research 143:1, pages 425-436.
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B. N. Rooban, V. Sasikala, V. Sahasranamam & Annie Abraham. (2011) Amelioration of selenite toxicity and cataractogenesis in cultured rat lenses by Vitex negundo. Graefe's Archive for Clinical and Experimental Ophthalmology 249:5, pages 685-692.
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Joshua W. Carey, Eylem Y. Pinarci, Suman Penugonda, Humeyra Karacal & Nuran Ercal. (2011) In vivo inhibition of l-buthionine-(S,R)-sulfoximine-induced cataracts by a novel antioxidant, N-acetylcysteine amide. Free Radical Biology and Medicine 50:6, pages 722-729.
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B. N. Rooban, V. Sasikala, V. Sahasranamam & Annie Abraham. (2010) Vitex negundo Modulates Selenite-Induced Opacification and Cataractogensis in Rat Pups. Biological Trace Element Research 138:1-3, pages 282-292.
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V. SasikalaB.N. RoobanS.G. Siva PriyaV. SahasranamamAnnie Abraham. (2010) Moringa oleifera Prevents Selenite-Induced Cataractogenesis in Rat Pups . Journal of Ocular Pharmacology and Therapeutics 26:5, pages 441-447.
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R. Elanchezhian, M. Sakthivel, P. Geraldine & P.A. Thomas. (2010) Regulatory effect of acetyl-l-carnitine on expression of lenticular antioxidant and apoptotic genes in selenite-induced cataract. Chemico-Biological Interactions 184:3, pages 346-351.
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Zuzana Kyselova. (2010) Different experimental approaches in modelling cataractogenesis. Interdisciplinary Toxicology 3:1.
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R. Elanchezhian, M. Sakthivel, P. Geraldine & P.A. Thomas. (2009) The effect of acetyl-l-carnitine on lenticular calpain activity in prevention of selenite-induced cataractogenesis. Experimental Eye Research 88:5, pages 938-944.
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B.N. Rooban, Y. Lija, P.G. Biju, V. Sasikala, V. Sahasranamam & Annie Abraham. (2009) Vitex negundo attenuates calpain activation and cataractogenesis in selenite models. Experimental Eye Research 88:3, pages 575-582.
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Ei Tae KimJung Hyub Oh. (2009) Effect of Glutathione With Sea Tangle Extract on Prevention of Selenite-Induced Cataract Formation in Rats. Journal of the Korean Ophthalmological Society 50:10, pages 1555.
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