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Research Article

Subconjunctival Bevacizumab Injection for Corneal Neovascularization in Recurrent Pterygium

Irit Bahar Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
,
Igor Kaiserman Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
,
Penny McAllum Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
,
David Rootman Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
&
Allan Slomovic Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Pages 23-28 | Received 17 Aug 2007, Accepted 05 Nov 2007, Published online: 02 Jul 2009

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Jung Eun Lee, Koung Li Kim, Danbi Kim, Yeongju Yeo, Hyounkoo Han, Myung Goo Kim, Sun Hwa Kim, Hyuncheol Kim, Ji Hoon Jeong & Wonhee Suh. (2017) Apatinib-loaded nanoparticles suppress vascular endothelial growth factor-induced angiogenesis and experimental corneal neovascularization. International Journal of Nanomedicine 12, pages 4813-4822.
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Volkan Hurmeric, Pravin Vaddavalli, Anat Galor, Victor L Perez, Janika San Roman & Sonia H Yoo. (2013) Single and multiple injections of subconjunctival ranibizumab for early, recurrent pterygium. Clinical Ophthalmology 7, pages 467-473.
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Ting Liu, Yangwuyue Liu, Lin Xie, Xiangge He & Ji Bai. (2013) Progress in the Pathogenesis of Pterygium. Current Eye Research 38:12, pages 1191-1197.
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Irene A Barbazetto. (2011) Using synergistic effects in targeting angiogenesis: combination therapy for corneal neovascularization. Expert Review of Ophthalmology 6:2, pages 155-158.
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Mohammad Reza Fallah, Keivan Khosravi, Mohammad Nasser Hashemian, Amir Hoshang Beheshtnezhad, Mohammad Taher Rajabi & Mohsen Gohari. (2010) Efficacy of Topical Bevacizumab for Inhibiting Growth of Impending Recurrent Pterygium. Current Eye Research 35:1, pages 17-22.
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John Mauro & C. Stephen Foster. (2009) Pterygia: Pathogenesis and the Role of Subconjunctival Bevacizumab in Treatment. Seminars in Ophthalmology 24:3, pages 130-134.
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Joo Youn Oh, Mee Kum Kim, Mi Sun Shin, Hyun Ju Lee, Jin Hak Lee & Won Ryang Wee. (2009) The Anti-inflammatory Effect of Subconjunctival Bevacizumab on Chemically Burned Rat Corneas. Current Eye Research 34:2, pages 85-91.
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Wen-yan Peng, Li-wen He, Xiao-fang Yin, Bin-Bing Zhou, Tao Zhou & Shi-you Zhou. (2023) Successful regression of newly formed corneal neovascularization by subconjunctival injection of bevacizumab in patients with chemical burns. Frontiers in Medicine 10.
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Alexander C. Rokohl, Ludwig M. Heindl & Claus Cursiefen. 2023. Die Augenheilkunde. Die Augenheilkunde 1 13 .
Brendon W.H. Lee, Amitouj S. Sidhu, Ian C. Francis & Minas T. Coroneo. (2022) 5-Fluorouracil in primary, impending recurrent and recurrent pterygium: Systematic review of the efficacy and safety of a surgical adjuvant and intralesional antimetabolite. The Ocular Surface 26, pages 128-141.
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Purnamanita Syawal, Budu Budu, Mochammad Hatta, Muhammad Nasrum Massi, Andi Muhammad Ichsan & Rahmawati Minhajat. (2022) Comparison between the triamcinolone and bevacizumab subconjunctivals and changes in Interleukin-1 mRNA expression in pterygium. Journal of Taibah University Medical Sciences 17:1, pages 67-71.
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Ahmad Razif Omar, Mohtar Ibrahim, Hasnan Jaafar, Ab Hamid Siti-Azrin & Embong Zunaina. (2021) Evaluation of Cyclooxygenase-2 and p53 Expression in Pterygium Tissue Following Preoperative Intralesional Ranibizumab Injection. Frontiers in Medicine 8.
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Alexander C. Rokohl, Ludwig M. Heindl & Claus Cursiefen. (2021) Pterygium: Pathogenese, Diagnose und TherapiePterygium: pathogenesis, diagnosis and treatment. Der Ophthalmologe 118:7, pages 749-763.
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Matthew P. Nicholas & Naveen Mysore. (2021) Corneal neovascularization. Experimental Eye Research 202, pages 108363.
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Giuseppe Giannaccare, Marco Pellegrini, Cristina Bovone, Rossella Spena, Carlotta Senni, Vincenzo Scorcia & Massimo Busin. (2020) Anti-VEGF Treatment in Corneal Diseases. Current Drug Targets 21:12, pages 1159-1180.
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Sunil Kumar. (2020) Comparasion of intraoperative triamcinolone and Bevacizumab with conjuctival autograft alone in pterygium surgery. Indian Journal of Clinical and Experimental Ophthalmology 6:1, pages 84-86.
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Ali Kurt, Raşit Kılıç, Murat Tad & Osman Ahmet Polat. (2018) YKL-40 expression in pterygium: a potential role in the pathogenesis. International Ophthalmology 39:7, pages 1445-1450.
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Noha Ghoz, Mohamed Elalfy, Dalia Said & Harminder Dua. (2018) Healing of autologous conjunctival grafts in pterygium surgery. Acta Ophthalmologica 96:8, pages e979-e988.
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Ellen Carrara Fonseca, Eduardo Melani Rocha & Gustavo Viani Arruda. (2018) Comparison among adjuvant treatments for primary pterygium: a network meta-analysis. British Journal of Ophthalmology 102:6, pages 748-756.
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Siyin Liu, Vito Romano, Bernhard Steger, Stephen B. Kaye, Kevin J. Hamill & Colin E. Willoughby. (2018) Gene-based antiangiogenic applications for corneal neovascularization. Survey of Ophthalmology 63:2, pages 193-213.
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Linda Rose, Julia M. Byrd & Yousuf Qaseem. (2017) Subtenon Injections of Ranibizumab Arrest Growth in Early Recurrent Pterygium. Eye & Contact Lens: Science & Clinical Practice 43:6, pages 399-405.
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Hong Kyu Kim, Ji-Young Choi, Sang Min Park, Chang Rae Rho, Kyong Jin Cho & Sangmee Ahn Jo. (2017) Tyrosine Kinase Inhibitor, Vatalanib, Inhibits Proliferation and Migration of Human Pterygial Fibroblasts. Cornea 36:9, pages 1116-1123.
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Yeoun-Hee Kim, Jae-Chang Jung, Sang Il Gum, Su-Bin Park, Jin Yeul Ma, Yong Il Kim, Kyoo Won Lee & Young Jeung Park. (2017) Inhibition of Pterygium Fibroblast Migration and Outgrowth by Bevacizumab and Cyclosporine A Involves Down-Regulation of Matrix Metalloproteinases-3 and -13. PLOS ONE 12:1, pages e0169675.
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Angel Nava-CastañedaIsabel Ulloa-OrozcoLilia Garnica-HayashiJoaquín Hernandez-OrgazMaria Carmen Jimenez-MartinezYonathan Garfias. (2015) Triple Subconjunctival Bevacizumab Injection for Early Corneal Recurrent Pterygium: One-Year Follow-Up. Journal of Ocular Pharmacology and Therapeutics 31:2, pages 106-113.
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Catherine Vumien Tonthat & Nick Di Girolamo. (2014) Nestin expression in pterygia: potential role in angiogenesis. British Journal of Ophthalmology 98:6, pages 801-807.
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Koray Gumus, Sarper Karakucuk, G Ertugrul Mirza, Hulya Akgun, Hatice Arda & Ayse O Oner. (2014) Overexpression of vascular endothelial growth factor receptor 2 in pterygia may have a predictive value for a higher postoperative recurrence rate. British Journal of Ophthalmology 98:6, pages 796-800.
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Sezin Akca Bayar, Cem Kucukerdonmez, Ozlem Oner & Yonca A. Akova. (2013) Subconjunctival bevacizumab in the impending recurrent pterygia. International Ophthalmology 34:3, pages 541-547.
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Alejandro Lichtinger, Sonia N. Yeung, Peter Kim, Maoz D. Amiran, Uri Elbaz & Allan R. Slomovic. (2013) Corneal endothelial safety following subconjunctival and intrastromal injection of bevacizumab for corneal neovascularization. International Ophthalmology 34:3, pages 597-601.
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Mihai G. Poenaru Sava, Marius L. Raica & Anca Maria G. Cimpean. (2014) VEGF mRNA Assessment in Human Pterygium: A New ‘Scope' for a Future Hope. Ophthalmic Research 52:3, pages 130-135.
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Hamid Hosseini, Mohammad H Nowroozzadeh, Ramin Salouti & Mahmood Nejabat. (2012) Anti-VEGF Therapy With Bevacizumab for Anterior Segment Eye Disease. Cornea 31:3, pages 322-334.
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Kaevalin Lekhanont, Thanikan Patarakittam, Prakairut Thongphiew, Olan Suwan-apichon & Prut Hanutsaha. (2012) Randomized Controlled Trial of Subconjunctival Bevacizumab Injection in Impending Recurrent Pterygium: A Pilot Study. Cornea 31:2, pages 155-161.
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Yuan Liu, Jianhai Yang, Peng Zhang, Changjun Liu, Wei Wang & Wenguang Liu. (2012) ZnO quantum dots-embedded collagen/polyanion composite hydrogels with integrated functions of degradation tracking/inhibition and gene delivery. J. Mater. Chem. 22:2, pages 512-519.
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Orapin Enkvetchakul, Onsiri Thanathanee, Ram Rangsin, Kaevalin Lekhanont & Olan Suwan-apichon. (2011) A Randomized Controlled Trial of Intralesional Bevacizumab Injection on Primary Pterygium: Preliminary Results. Cornea 30:11, pages 1213-1218.
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Abdollah Shenasi, Farideh Mousavi, Solmaz Shoa-Ahari, Babak Rahimi-Ardabili & Rohollah Fadaei Fouladi. (2011) Subconjunctival Bevacizumab Immediately After Excision of Primary Pterygium: The First Clinical Trial. Cornea 30:11, pages 1219-1222.
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Jae Hoon Jeong, Yeoun Suk Chun, Eung Suk Kim & Jae Chan Kim. (2011) Compensatory Growth Factor and Cytokine Response in Tears After Subconjunctival Bevacizumab Injection. Cornea 30:10, pages 1071-1077.
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Deepak Gupta & Chris Illingworth. (2011) Treatments for Corneal Neovascularization: A Review. Cornea 30:8, pages 927-938.
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Mohammad Reza Fallah Tafti, Keivan Khosravifard, Mehrdad Mohammadpour, Mohammad Naser Hashemian & Mohammad Yaser Kiarudi. (2011) Efficacy of Intralesional Bevacizumab Injection in Decreasing Pterygium Size. Cornea 30:2, pages 127-129.
Crossref
Ahmed A. Zaki & Samar F. Farid. (2010) Subconjunctival bevacizumab for corneal neovascularization. Acta Ophthalmologica 88:8, pages 868-871.
Crossref
Achilleas Mandalos, Dimitrios Tsakpinis, Georgia Karayannopoulou, Ioannis Tsinopoulos, Georgios Karkavelas, Nikolaos Chalvatzis & Stavros Dimitrakos. (2010) The Effect of Subconjunctival Ranibizumab on Primary Pterygium: A Pilot Study. Cornea 29:12, pages 1373-1379.
Crossref
Weiqi Xu, Hong Wang, Fenghua Wang, Yuan Jiang, Xian Zhang, Wenqiu Wang, Jin Qian, Xun Xu & Xiaodong Sun. (2010) Testing toxicity of multiple intravitreal injections of bevacizumab in rabbit eyes. Canadian Journal of Ophthalmology 45:4, pages 386-392.
Crossref
Richard J Symes & Thomas R G Poole. (2010) Corneal Graft Surgery Combined with Subconjunctival Bevacizumab (Avastin). Cornea 29:6, pages 691-693.
Crossref
Anat Galor, Sonia H. Yoo, Fernanda V.R. Piccoli, Artur J. Schmitt, Victoria Chang & Victor L. Perez. (2010) Phase I Study of Subconjunctival Ranibizumab in Patients With Primary Pterygium Undergoing Pterygium Surgery. American Journal of Ophthalmology 149:6, pages 926-931.e2.
Crossref
L.M. Heindl & C. Cursiefen. (2010) PterygiumPterygium. Der Ophthalmologe 107:6, pages 517-524.
Crossref
David Ellenberg, Dimitri T. Azar, Joelle A. Hallak, Faisal Tobaigy, Kyu Yeon Han, Sandeep Jain, Zhongjun Zhou & Jin-Hong Chang. (2010) Novel aspects of corneal angiogenic and lymphangiogenic privilege. Progress in Retinal and Eye Research 29:3, pages 208-248.
Crossref
Chih-Wei Wu, David Ellenberg & Jin-Hong Chang. 2010. Ocular Disease. Ocular Disease 74 82 .
Domenico Ribatti, Beatrice Nico, Maria Teresa Perra, Cristina Maxia, Franca Piras, Daniela Murtas, Enrico Crivellato & Paola Sirigu. (2009) Correlation between NGF/TrkA and microvascular density in human pterygium. International Journal of Experimental Pathology 90:6, pages 615-620.
Crossref
Wei-Li Chen, Yan-Ming Chen, Hsiao-Sang Chu, Ying-Han Lin, Tzu-Yun Tsai & Fung-Rong Hu. (2009) Bevacizumab for the Treatment of Corneal Neovascularization. Cornea 28:11, pages S26-S30.
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Joo Youn Oh, Mee Kum Kim & Won Ryang Wee. (2009) Subconjunctival and Intracorneal Bevacizumab Injection for Corneal Neovascularization in Lipid Keratopathy. Cornea 28:9, pages 1070-1073.
Crossref
Mario Saravia, Gustavo Zapata, Paula Ferraiolo, Lourdes Racca & Alejandro Berra. (2009) Anti-VEGF monoclonal antibody-induced regression of corneal neovascularization and inflammation in a rabbit model of herpetic stromal keratitis. Graefe's Archive for Clinical and Experimental Ophthalmology 247:10, pages 1409-1416.
Crossref
Christopher C Teng, Nandesh N Patel & Lawrence Jacobson. (2009) Effect of Subconjunctival Bevacizumab on Primary Pterygium. Cornea 28:4, pages 468-470.
Crossref
S. Leippi, F. Grehn & G. Geerling. (2009) Antiangiogene Therapie bei PterygiumrezidivenAntiangiogenic therapy for pterygium recurrence. Der Ophthalmologe 106:5, pages 413-419.
Crossref
Mete Güler, Turgut Yilmaz, İbrahim Özercan & Tamer Elkiran. (2009) The Inhibitory Effects of Trastuzumab on Corneal Neovascularization. American Journal of Ophthalmology 147:4, pages 703-708.e2.
Crossref
Jae Hoon JeongYeoun Sook ChunJae Chan Kim. (2009) The Effects of a Subtenoncapsular Injection of Bevacizumab for Ocular Surface Disease With Corneal Neovascularization. Journal of the Korean Ophthalmological Society 50:10, pages 1475.
Crossref
V. Sarda, L. Gheck & G. Chaine. (2009) Ptérygions. EMC - Ophtalmologie 6:3, pages 1-13.
Crossref
Birgit RegenfussFelix BockAnand ParthasarathyClaus Cursiefen. (2008) Corneal (Lymph)angiogenesis—From Bedside to Bench and Back: A Tribute to Judah Folkman. Lymphatic Research and Biology 6:3-4, pages 191-201.
Crossref

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