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original article

Therapeutic Outcome of Extranodal NK/T-Cell Lymphoma Initially Treated with Chemotherapy
Result of Chemotherapy in NK/T-Cell Lymphoma

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Pages 779-783 | Received 04 Dec 2002, Accepted 07 Apr 2003, Published online: 08 Jul 2009

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Jiwei Li, Jin Li, Meizuo Zhong, Hui Zhou & Baohua Yu. (2021) The Clinical Features and Survival Outcome of 107 Newly Diagnosed Advanced Stage Extranodal NK/T-Cell Lymphoma Cases: A Triple-Center Study. Cancer Management and Research 13, pages 1541-1549.
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Jin Li, Yajun Li, Ruolan Zeng, Jingguan Lin, Meizuo Zhong, Xianling Liu, Yizi He, Junqiao He, Zhou Ouyang, Lijun Huang, Ling Xiao & Hui Zhou. (2020) Optimal Courses of Chemotherapy Combined with Radiotherapy for Low-Risk Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: A Propensity Score Matching Analysis. Therapeutics and Clinical Risk Management 16, pages 1151-1163.
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Yi Chen, Luting Luo, Xiaoyun Zheng, Haiying Fu, Xiaozhu Yang, Wanling Huang, Lushan Chen, Zhihong Zheng, Jing Zheng, Ting Yang, Tingbo Liu & Jianda Hu. (2020) Clinical characteristics and survival of extranodal natural killer/T-cell lymphoma: a single-center 12-year retrospective analysis. Leukemia & Lymphoma 61:14, pages 3306-3318.
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Liqiang Wei, Jingwen Wang, Jin Ye, Lei Yang, Jia Cong, Xin Li, Yiping Wu, Xueying Cui, Jing Ding, Na Yao & Jing Yang. (2020) Long-term outcomes of patients treated with an EPOCHL regimen as first-line chemotherapy for newly diagnosed extranodal natural killer/T-cell lymphoma: a retrospective single-center study. Leukemia & Lymphoma 61:2, pages 337-343.
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Christopher P. Fox, Ariane Boumendil, Norbert Schmitz, Herve Finel, Jian J. Luan, Gülsan Sucak, Didier Blaise, Jürgen Finke, Karl-Heinz Pflüger, Hendrik Veelken, Norbert -Claude Gorin, Xavier Poiré, Arnold Ganser, Peter Dreger & Anna Sureda. (2015) High-dose therapy and autologous stem cell transplantation for extra-nodal NK/T lymphoma in patients from the Western hemisphere: a study from the European Society for Blood and Marrow Transplantation. Leukemia & Lymphoma 56:12, pages 3295-3300.
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Wook Youn Kim, Soo Jeong Nam, Sehui Kim, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim & Yoon Kyung Jeon. (2015) Prognostic implications of CD30 expression in extranodal natural killer/T-cell lymphoma according to treatment modalities. Leukemia & Lymphoma 56:6, pages 1778-1786.
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Li Jiang, Shao-Jun Li, Yue-Ming Jiang, Jian-Xiong Long, Ren-Sheng Wang, Jing Su & Yong Zhang. (2014) The significance of combining radiotherapy with chemotherapy for early stage extranodal natural killer/T-cell lymphoma, nasal type: a systematic review and meta-analysis. Leukemia & Lymphoma 55:5, pages 1038-1048.
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Holbrook Kohrt, Mark Lee & Ranjana Advani. (2010) Risk stratification in extranodal natural killer/T-cell lymphoma. Expert Review of Anticancer Therapy 10:9, pages 1395-1405.
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Holbrook Kohrt & Ranjana Advani. (2009) Extranodal natural killer/T-cell lymphoma: current concepts in biology and treatment. Leukemia & Lymphoma 50:11, pages 1773-1784.
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Seok Jin Kim, Byung Soo Kim, Chul Won Choi, Hee Yun Seo, Hye Ryoung Seol, Hwa Jung Sung, In Sun Kim, Chul Yong Kim, Kwang Yoon Jung & Jun Suk Kim. (2006) Treatment outcome of front-line systemic chemotherapy for localized extranodal NK/T cell lymphoma in nasal and upper aerodigestive tract. Leukemia & Lymphoma 47:7, pages 1265-1273.
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Keun-wook Lee, Tak Yun, Dong-wan Kim, Seock-ah Im, Tae-you Kim, Sung-soo Yoon, Dae Seog Heo, Yung-jue Bang, Seonyang Park, Byoung Kook Kim & Noe Kyeong Kim. (2006) First-line ifosfamide, methotrexate, etoposide and prednisolone chemotherapy ± radiotherapy is active in stage I/II extranodal NK/T-cell lymphoma. Leukemia & Lymphoma 47:7, pages 1274-1282.
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Martine BagotT. Petrella & S. Dalle. 2013. Les lymphomes cutanés. Les lymphomes cutanés 133 137 .
Ming Jiang, Hong Zhang, Yu Jiang, Qunpei Yang, Li Xie, Weiping Liu, Wenyan Zhang, Xiaohui Ji, Ping Li, Nianyong Chen, Sha Zhao, Feng Wang & Liqun Zou. (2011) Phase 2 trial of “Sandwich” L ‐asparaginase, vincristine, and prednisone chemotherapy with radiotherapy in newly diagnosed, stage IE to IIE, nasal type, extranodal natural killer/T‐cell lymphoma . Cancer 118:13, pages 3294-3301.
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Christopher P Fox, Claire Shannon-Lowe & Martin Rowe. (2011) Deciphering the role of Epstein-Barr virus in the pathogenesis of T and NK cell lymphoproliferations. Herpesviridae 2:1.
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Abeer N. AbouYabis, Pareen J. Shenoy, Rajni Sinha, Christopher R. Flowers & Mary Jo Lechowicz. (2011) A Systematic Review and Meta-Analysis of Front-line Anthracycline-Based Chemotherapy Regimens for Peripheral T-Cell Lymphoma. ISRN Hematology 2011, pages 1-14.
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Z.Y. Wang, Y.X. Li, H. Wang, W.H. Wang, J. Jin, Y.P. Liu, Y.W. Song, S.L. Wang, X.F. Liu & Z.H. Yu. (2011) Unfavorable prognosis of elderly patients with early-stage extranodal nasal-type NK/T-cell lymphoma. Annals of Oncology 22:2, pages 390-396.
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Hyun Jin LeeSang-Wook LeeCheolwon SuhJooryung HuhSang Min YoonYoung Seok KimSu San KimJong Hoon KimEun Kyung ChoiSeung Do Ahn. (2011) Treatment outcome of nasal natural killer/T-cell lymphoma. Radiation Oncology Journal 29:3, pages 174.
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Seok Jin Kim & Won Seog Kim. (2010) Treatment of localized extranodal NK/T cell lymphoma, nasal type. International Journal of Hematology 92:5, pages 690-696.
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Christopher P. FoxTracey A. HaighGraham S. TaylorHeather M. LongSteven P. LeeClaire Shannon-LoweSimon O'ConnorCatherine M. Bollard, Javeed Iqbal, Wing C. Chan, Alan B. RickinsonAndrew I. BellMartin Rowe. (2010) A novel latent membrane 2 transcript expressed in Epstein-Barr virus–positive NK- and T-cell lymphoproliferative disease encodes a target for cellular immunotherapy. Blood 116:19, pages 3695-3704.
Crossref
Seok Jin KimKihyun KimByung Soo KimChul Yong KimCheolwon SuhJooryung HuhSang-Wook LeeJin Seok KimJaeho ChoGyeong-Won LeeKi Mun KangHyeon Seok EomHong Ryull PyoYong Chan AhnYoung Hyeh KoWon Seog Kim. (2009) Phase II Trial of Concurrent Radiation and Weekly Cisplatin Followed by VIPD Chemotherapy in Newly Diagnosed, Stage IE to IIE, Nasal, Extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma Study. Journal of Clinical Oncology 27:35, pages 6027-6032.
Crossref
Tae Min Kim & Dae Seog Heo. (2009) Extranodal NK / T‐cell lymphoma, nasal type: New staging system and treatment strategies. Cancer Science 100:12, pages 2242-2248.
Crossref
Y-L. Choi, J-H. Park, J-H. Namkung, J-H. Lee, J-M. Yang, E-S. Lee, D-Y. Lee, K-T. Jang & Y-H. Ko. (2009) Extranodal NK / T-cell lymphoma with cutaneous involvement: ‘nasal’ vs. ‘nasal-type’ subgroups- a retrospective study of 18 patients. British Journal of Dermatology 160:2, pages 333-337.
Crossref
B.-S. Kim, D.-W. Kim, S.-A. Im, C.W. Kim, T.-Y. Kim, S.-S. Yoon, D.S. Heo, Y.-J. Bang, S. Park, B.K. Kim & N.K. Kim. (2009) Effective second-line chemotherapy for extranodal NK/T-cell lymphoma consisting of etoposide, ifosfamide, methotrexate, and prednisolone. Annals of Oncology 20:1, pages 121-128.
Crossref
Y. Li. 2010. Management of Rare Adult Tumours. Management of Rare Adult Tumours 73 85 .
Ye Guo, Jiade J. Lu, Xuejun Ma, Biyun Wang, Xiaonan Hong, Xiaoqiu Li & Jin Li. (2008) Combined chemoradiation for the management of nasal natural killer (NK)/T-cell lymphoma: Elucidating the significance of systemic chemotherapy. Oral Oncology 44:1, pages 23-30.
Crossref
Mei-juan Huang, Yu Jiang, Wei-ping Liu, Zhi-ping Li, Mei Li, Lin Zhou, Yong Xu, Chun-hua Yu, Qiu Li, Feng Peng, Ji-Yan Liu, Feng Luo & You Lu. (2008) Early or Up-Front Radiotherapy Improved Survival of Localized Extranodal NK/T-Cell Lymphoma, Nasal-Type in the Upper Aerodigestive Tract. International Journal of Radiation Oncology*Biology*Physics 70:1, pages 166-174.
Crossref
Yexiong Li & Jiade J. Lu. 2008. Radiation Oncology. Radiation Oncology 445 460 .
Im I. Na, Hye J. Kang, Yeon H. Park, Seung-Sook Lee, Hyung J. Yoo, Du H. Choe, Baek-Yeol Ryoo & Sung H. Yang. (2007) Prognostic factors for classifying extranodal NK/T cell lymphoma, nasal type, as lymphoid neoplasia. European Journal of Haematology 79:1, pages 1-7.
Crossref
Céline BossardKarim BelhadjFelix ReyesNadine Martin-GarciaFrançoise BergerJean Alain KummerJosette BrièreAnne-Catherine BaglinStéphane ChezeJacques BosqVincent RibragChristian Gisselbrecht, Nicolas Mounier & Philippe Gaulard. (2006) Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials. Blood 109:5, pages 2183-2189.
Crossref
L. Pagano, A. Gallamini, G. Trapè, L. Fianchi, D. Mattei, G. Todeschini, A. Spadea, S. Cinieri, E. Iannitto, M. Martelli, A. Nosari, E. Di Bona, M.E. Tosti, M.C. Petti, P. Falcucci, M. Montanaro, A. Pulsoni, L.M. Larocca & G. Leone. (2006) NK/T-cell lymphomas ‘nasal type’: an Italian multicentric retrospective survey. Annals of Oncology 17:5, pages 794-800.
Crossref
Weiben Yong, Wen Zheng, Jun Zhu, Yuntao Zhang, Yan Wei, Xiaopei Wang, Ningjing Lin, Yan Xie, Be Xu & Jiyou Li. (2006) Midline NK/T-cell lymphoma nasal-type: treatment outcome, the effect ofL-asparaginase based regimen, and prognostic factors. Hematological Oncology 24:1, pages 28-32.
Crossref
Ye-Xiong LiBo YaoJing JinWei-Hu WangYue-Ping LiuYong-Wen SongShu-Lian WangXin-Fan LiuLi-Qiang ZhouXiao-Hui HeNing LuZi-Hao Yu. (2006) Radiotherapy As Primary Treatment for Stage IE and IIE Nasal Natural Killer/T-Cell Lymphoma. Journal of Clinical Oncology 24:1, pages 181-189.
Crossref
Raymond Liang. 2006. The Lymphomas. The Lymphomas 451 455 .
Neal Luther, Jeffrey P. Greenfield, Amy Chadburn & Theodore H. Schwartz. (2005) Intracranial Nasal Natural Killer/T-cell Lymphoma: Immunopathologically-Confirmed Case and Review of Literature. Journal of Neuro-Oncology 75:2, pages 185-188.
Crossref
Jeeyun Lee, Yeon Hee Park, Won Seog Kim, Seung-Sook Lee, Baek-Yeol Ryoo, Sung Hyun Yang, Keon Woo Park, Jung Hoon Kang, Joon Oh Park, Se Hoon Lee, Kihyun Kim, Chul Won Jung, Young Suk Park, Young-Hyuck Im, Won Ki Kang, Mark H. Lee, Young H. Ko, Yong Chan Ahn & Keunchil Park. (2005) Extranodal nasal type NK/T-cell Lymphoma: Elucidating clinical prognostic factors for risk-based stratification of therapy. European Journal of Cancer 41:10, pages 1402-1408.
Crossref
J Lee, W S Kim, Y H Park, S H Park, K W Park, J H Kang, S S Lee, S I Lee, S-H Lee, K Kim, C W Jung, Y C Ahn, Y H Ko & K Park. (2005) Nasal-type NK/T cell lymphoma: clinical features and treatment outcome. British Journal of Cancer 92:7, pages 1226-1230.
Crossref

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