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Acta Oncologica Volume 45, 2006 - Issue 3
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ORIGINAL ARTICLE

Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element

Yukio Kageyama Department of Urology, Graduate School of Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, JapanCorrespondence[email protected]
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Hiroshi Sugiyama Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101-0062, Japan; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa Oiwakecho, Sakyo-ku, Kyoto, 606-8502, Japan
,
Hirohito Ayame Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101-0062, Japan
,
Aki Iwai Department of Urology, Graduate School of Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan
,
Yasuhisa Fujii Department of Urology, Graduate School of Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan
,
L. Eric Huang Laboratory of Human Carcinogenesis, NCI, National Institute of Health, Bethesda, MD, USA
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Shinae Kizaka-Kondoh Department of Therapeutic Radiology and Oncology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Kyoto, 606-8507, Japan
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Masahiro Hiraoka Department of Therapeutic Radiology and Oncology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Kyoto, 606-8507, Japan
&
Kazunori Kihara Department of Urology, Graduate School of Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan
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Pages 317-324 | Received 15 Sep 2005, Published online: 26 Aug 2009

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Yarden Zohar & Nicola J. Mabjeesh. (2023) Targeting HIF-1 for prostate cancer: a synthesis of preclinical evidence. Expert Opinion on Therapeutic Targets 27:8, pages 715-731.
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Articles from other publishers (23)

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Jianyan Hu, Tingting Li, Xinhua Du, Qiang Wu & Yun-Zheng Le. (2017) G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases. Vision Research 139, pages 59-64.
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Luke Pett, Konstantinos Kiakos, Vijay Satam, Pravin Patil, Sarah Laughlin-Toth, Matthew Gregory, Michael Bowerman, Kevin Olson, Mia Savagian, Megan Lee, Moses Lee, W. David Wilson, Daniel Hochhauser & John A. Hartley. (2017) Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1860:5, pages 617-629.
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Tingting Li, Jianyan Hu, Fengjuan Gao, Xinhua Du, Yongdong Chen & Qiang Wu. (2017) Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy. Scientific Reports 7:1.
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AYA SATO, HIROKI NAGASE, DAISUKE OBINATA, KYOKO FUJIWARA, NOBORU FUKUDA, MASAYOSHI SOMA, KENYA YAMAGUCHI, NOZOMU KAWATA & SATORU TAKAHASHI. (2013) Inhibition of MMP-9 using a pyrrole-imidazole polyamide reduces cell invasion in renal cell carcinoma. International Journal of Oncology 43:5, pages 1441-1446.
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Chung-Hang Leung, Daniel Shiu-Hin Chan, Victor Pui-Yan Ma & Dik-Lung Ma. (2013) DNA-Binding Small Molecules as Inhibitors of Transcription Factors. Medicinal Research Reviews 33:4, pages 823-846.
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Benjamin C. Li, David C. Montgomery, James W. Puckett & Peter B. Dervan. (2012) Synthesis of Cyclic Py-Im Polyamide Libraries. The Journal of Organic Chemistry 78:1, pages 124-133.
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Joshua R. Tietjen, Leslie J. Donato, Devesh Bhimisaria & Aseem Z. Ansari. 2011. Synthetic Biology, Part A. Synthetic Biology, Part A 3 30 .
David M. Chenoweth & Peter B. Dervan. (2010) Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding. Journal of the American Chemical Society 132:41, pages 14521-14529.
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David M. Chenoweth & Peter B. Dervan. (2009) Allosteric modulation of DNA by small molecules. Proceedings of the National Academy of Sciences 106:32, pages 13175-13179.
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Michelle E. Farkas, Benjamin C. Li, Christian Dose & Peter B. Dervan. (2009) DNA sequence selectivity of hairpin polyamide turn units. Bioorganic & Medicinal Chemistry Letters 19:14, pages 3919-3923.
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Takashi Kudo, Masashi Ueda, Yuji Kuge, Takahiro Mukai, Shotaro Tanaka, Maki Masutani, Yasushi Kiyono, Shinae Kizaka-Kondoh, Masahiro Hiraoka & Hideo Saji. (2009) Imaging of HIF-1-Active Tumor Hypoxia Using a Protein Effectively Delivered to and Specifically Stabilized in HIF-1-Active Tumor Cells. Journal of Nuclear Medicine 50:6, pages 942-949.
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David M. Chenoweth, Daniel A. Harki, John W. Phillips, Christian Dose & Peter B. Dervan. (2009) Cyclic Pyrrole−Imidazole Polyamides Targeted to the Androgen Response Element. Journal of the American Chemical Society 131:20, pages 7182-7188.
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David M. Chenoweth, Daniel A. Harki & Peter B. Dervan. (2009) Solution-Phase Synthesis of Pyrrole−Imidazole Polyamides. Journal of the American Chemical Society 131:20, pages 7175-7181.
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Gudrun M. Spitzer, Bernd Wellenzohn, Patrick Markt, Johannes Kirchmair, Thierry Langer & Klaus R. Liedl. (2009) Hydrogen-Bonding Patterns of Minor Groove-Binder−DNA Complexes Reveal Criteria for Discovery of New Scaffolds. Journal of Chemical Information and Modeling 49:4, pages 1063-1069.
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Gudrun M. Spitzer, Julian E. Fuchs, Patrick Markt, Johannes Kirchmair, Bernd Wellenzohn, Thierry Langer & Klaus R. Liedl. (2008) Sequence-Specific Positions of Water Molecules at the Interface between DNA and Minor Groove Binders. ChemPhysChem 9:18, pages 2766-2771.
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Michelle E. Farkas, Sherry M. Tsai & Peter B. Dervan. (2007) α-Diaminobutyric acid-linked hairpin polyamides. Bioorganic & Medicinal Chemistry 15:22, pages 6927-6936.
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Nicholas G. Nickols, Claire S. Jacobs, Michelle E. Farkas & Peter B. Dervan. (2007) Modulating Hypoxia-Inducible Transcription by Disrupting the HIF-1–DNA Interface. ACS Chemical Biology 2:8, pages 561-571.
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Anne Viger & Peter B. Dervan. (2006) Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site. Bioorganic & Medicinal Chemistry 14:24, pages 8539-8549.
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