Advanced search
Publication Cover
Acta Oncologica Volume 48, 2009 - Issue 4
Journal homepage
4,549
Views
64
CrossRef citations to date
0
Altmetric
Original Article

Hypofractionated radiotherapy denoted as the “Christie scheme”: An effective means of palliating patients with head and neck cancers not suitable for curative treatment

Abrahim Al-mamgani Erasmus Medical Center-Daniel den Hoed Cancer Center, Department of Radiation Oncology, Rotterdam, The NetherlandsCorrespondence[email protected]
,
Lisa Tans Erasmus Medical Center-Daniel den Hoed Cancer Center, Department of Radiation Oncology, Rotterdam, The Netherlands
,
Peter H. E. Van rooij Erasmus Medical Center-Daniel den Hoed Cancer Center, Department of Radiation Oncology, Rotterdam, The Netherlands
,
Inge Noever Erasmus Medical Center-Daniel den Hoed Cancer Center, Department of Radiation Oncology, Rotterdam, The Netherlands
,
Robert J. Baatenburg de jong Erasmus Medical Center-Department of Otorhinolaryngology, Rotterdam, The Netherlands
&
Peter C. Levendag Erasmus Medical Center-Daniel den Hoed Cancer Center, Department of Radiation Oncology, Rotterdam, The Netherlands
Pages 562-570 | Received 14 Nov 2008, Published online: 08 Jul 2009

Citations (64)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Daniel R Dickstein, Ann E Powers, Dragan Vujovic, Scott Roof & Richard L Bakst. (2023) Clinical and Therapeutic Considerations for Older Adults with Head and Neck Cancer. Clinical Interventions in Aging 18, pages 409-422.
Read now
Zhenzhen Yin, Ximei Zhang, Youyou Wang, Peiguo Wang & Zhiyong Yuan. (2017) The combination of systemic therapy and locoregional radiotherapy prolongs survival in newly diagnosed metastatic nasopharyngeal carcinoma patients. OncoTargets and Therapy 10, pages 5677-5683.
Read now
Andrew G Shuman, Joseph J Fins & Mark E Prince. (2012) Improving end-of-life care for head and neck cancer patients. Expert Review of Anticancer Therapy 12:3, pages 335-343.
Read now
Claire McLarnon, Praneta Kulloo, Hisham Mehanna, Charles Kelly & Vinidh Paleri. (2010) Quality-of-life considerations in treatment of unresectable, recurrent head and neck cancer. Expert Review of Anticancer Therapy 10:3, pages 345-352.
Read now

Articles from other publishers (60)

Amardeep Grewal & Spencer Chung-Tang Liu. 2024. Palliative Radiation Oncology. Palliative Radiation Oncology 141 154 .
Gerda M. Verduijn, Nienke D. Sijtsema, Yvette van Norden, Wilma D. Heemsbergen, Hetty Mast, Aniel Sewnaik, Denzel Chin, Sarah Baker, Marta E. Capala, Aad van der Lugt, Esther van Meerten, Mischa S. Hoogeman & Steven F. Petit. (2023) Accounting for fractionation and heterogeneous dose distributions in the modelling of osteoradionecrosis in oropharyngeal carcinoma treatment. Radiotherapy and Oncology 188, pages 109889.
Crossref
Jian Liu, Bin Zhang, Yixin Su, Guanjie Qin, Xiangyun Kong, Yunyan Mo, Rongjun Zhang & Wei Jiang. (2023) Hypofractionated radiotherapy compared with conventionally fractionated radiotherapy to treat initial distant metastases in nasopharyngeal carcinoma: A multicenter, prospective, randomized, phase II trial. Radiotherapy and Oncology 187, pages 109815.
Crossref
Marie-Luise Weiss, Justus Domschikowski, David Krug, Mathias Sonnhoff, Mirko Nitsche, Wolfgang Hoffmann, Martina Becker-Schiebe, Felix Bock, Markus Hoffmann, Claudia Schmalz, Jürgen Dunst & Alexander Fabian. (2023) The impact of palliative radiotherapy on health-related quality of life in patients with head and neck cancer – results of a multicenter prospective cohort study. Clinical and Translational Radiation Oncology, pages 100633.
Crossref
Ehab Saad, Maha Kamaleldin, Asmaa Zaghloul, Emad Habib & Karim Mashhour. (2023) Hypofractionated Accelerated Radiotherapy with Concurrent Chemotherapy Versus Conventional Fractionation for LAHNSCC Using IMRT/VMAT: A Pilot Study. Clinical Cancer Investigation Journal 12:2, pages 44-50.
Crossref
Sankalp Singh, Niharika Bisht, Arti Sarin, Rekha Vashisht, Nishant Lohia, Vikas Gupta & Gaurav Trivedi. (2023) Use of split-course hypofractionated radiotherapy in palliative treatment of head and neck cancers: how does our regimen compare with others?. Journal of Radiotherapy in Practice 22.
Crossref
Cecília Melo-Alvim, Maria Eduarda Neves, Jorge Leitão Santos, André N. Abrunhosa-Branquinho, Tiago Barroso, Luís Costa & Leonor Ribeiro. (2022) Radiotherapy, Chemotherapy and Immunotherapy—Current Practice and Future Perspectives for Recurrent/Metastatic Oral Cavity Squamous Cell Carcinoma. Diagnostics 13:1, pages 99.
Crossref
C. van Herpen, V. Vander Poorten, A. Skalova, C. Terhaard, R. Maroldi, A. van Engen, B. Baujat, L.D. Locati, A.D. Jensen, L. Smeele, J. Hardillo, V. Costes Martineau, A. Trama, E. Kinloch, C. Even & J.-P. Machiels. (2022) Salivary gland cancer: ESMO–European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up. ESMO Open 7:6, pages 100602.
Crossref
Prachi Upadhyay, Piyush Kumar, Arvind Kumar Chauhan, Pavan Kumar, Jitendra Nigam & Navitha S. (2022) Comparison of Dosimetric Parameters in Dysphagia Aspiration-Related Structures and Clinical Correlation in Head and Neck Cancer Patients Treated With Radiotherapy. Cureus.
Crossref
Whoon Jong Kil. (2022) Rapid physical and emotional palliation from QUAD shot radiotherapy to a frail elderly patient with stage IV parotid gland cancer-associated facial paralysis and pain when no other palliative intervention was available during COVID-19 pandemic. Oral Oncology 130, pages 105930.
Crossref
Daniel R. Dickstein, Eric J. Lehrer, Kristin Hsieh, Alexandra Hotca, Brianna M. Jones, Ann Powers, Sonam Sharma, Jerry Liu, Vishal Gupta, Loren Mell, Zain Husain, Diana Kirke, Krzysztof Misiukiewicz, Marshall Posner, Eric Genden & Richard L. Bakst. (2022) Management of Older Adults with Locally Advanced Head and Neck Cancer. Cancers 14:11, pages 2809.
Crossref
Gianluca Ferini, Paolo Palmisciano, Stefano Forte, Anna Viola, Emanuele Martorana, Silvana Parisi, Vito Valenti, Corrado Fichera, Giuseppe Emmanuele Umana & Stefano Pergolizzi. (2022) Advanced or Metastatic Cutaneous Squamous Cell Carcinoma: The Current and Future Role of Radiation Therapy in the Era of Immunotherapy. Cancers 14:8, pages 1871.
Crossref
Morena Fasano, Ida D’Onofrio, Maria Paola Belfiore, Antonio Angrisani, Valentina Caliendo, Carminia Maria Della Corte, Mario Pirozzi, Sergio Facchini, Marianna Caterino, Cesare Guida, Valerio Nardone, Alfonso Reginelli & Salvatore Cappabianca. (2022) Head and Neck Squamous Cell Carcinoma in Elderly Patients: Role of Radiotherapy and Chemotherapy. Cancers 14:3, pages 472.
Crossref
SKanmani Velarasan & Deivanayagam Ramasundaram. (2022) Palliative hypofractionated radiation therapy in incurable head-and-neck cancer patients – 2-year follow-up experience from a tertiary center from South India. Journal of Radiation and Cancer Research 13:2, pages 60.
Crossref
I. Desideri, C. Becherini, L. Belgioia, A. Merlotti, L.P. Ciccone, C. Franzese, M. Loi, F. De Felice, R. Mazzola, S. Caini, L. Livi & P. Bonomo. (2021) Palliative radiotherapy in older adults with head and neck squamous cell carcinoma: A systematic review. Oral Oncology 119, pages 105355.
Crossref
Alexander Fabian, Justus Domschikowski, Markus Hoffmann, Oliver Weiner, Claudia Schmalz, Jürgen Dunst & David Krug. (2021) Patient-Reported Outcomes Assessing the Impact of Palliative Radiotherapy on Quality of Life and Symptom Burden in Head and Neck Cancer Patients: A Systematic Review. Frontiers in Oncology 11.
Crossref
Roopesh Reddy YothamDr.Dr., Tamohan ChaudhuriDr.Dr. & Gautam BhattacharjeeDr.Dr.. (2021) A PROSPECTIVE OBSERVATIONAL STUDY TO DETERMINE RESPONSE AND QUALITY OF LIFE IN ADVANCED HEAD&NECK CANCERS FOLLOWING HYPOFRACTIONATED PALLIATIVE EXTERNAL BEAM RADIOTHERAPY.. INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, pages 77-79.
Crossref
Milena Ferro, Gabriella Macchia, Alessia Re, Milly Buwenge, Marica Ferro, Mariangela Boccardi, Vincenzo Picardi, Anna Ianiro, Eleonora Arena, Alice Zamagni, Eleonora Farina, Savino Cilla, Vincenzo Valentini, Alessio Giuseppe Morganti & Francesco Deodato. (2021) Advanced head and neck cancer in older adults: Results of a short course accelerated radiotherapy trial. Journal of Geriatric Oncology 12:3, pages 441-445.
Crossref
María J. García‐Anaya, Rafael Ordoñez, María D. Toledo, Raquel C. Correa, Ana Otero, Alicia Román, Isabel García‐Ríos, José A. Medina & Jaime Gómez‐Millán. (2020) Importance of dose in palliative treatment for incurable head and neck cancer with radiotherapy. Head & Neck 43:3, pages 798-804.
Crossref
Gulafshan Jabi, Mohsin Khan & PavanDeepak MandigalaVenkataRamana. (2021) Role of palliative chemoradiation in locally advanced head and neck cancer: A case series done in a tertiary care center in Uttar Pradesh. Bengal Journal of Cancer 1:2, pages 98.
Crossref
S. Benhmida, R. Sun, E. Gherga, Y. Hammoud, J. Rouvier, O. Mauvais, S. Bockel, A. Louvrier, A. Lebbad, P. Bontemps, C. Ortholan, J. Bourhis, L. Lestrade & X.S. Sun. (2020) Split-course hypofractionated radiotherapy for aged and frail patients with head and neck cancers. A retrospective study of 75 cases. Cancer/Radiothérapie 24:8, pages 812-819.
Crossref
Alexander Fabian, David Krug & Jürgen Dunst. (2020) Randomisierte, kontrollierte Studie zur palliativen Radiotherapie von Kopf-Hals-Tumoren – Herausforderungen bleiben bestehenRandomized controlled trial for palliative radiotherapy of head and neck cancer—challenges remain. Strahlentherapie und Onkologie 196:11, pages 1062-1064.
Crossref
Emile Gogineni, Zaker Rana, Prashant Vempati, Jessie Karten, Anurag Sharma, Peter Taylor, Lucio Pereira, Douglas Frank, Doru Paul, Nagashree Seetharamu & Maged Ghaly. (2020) Stereotactic body radiotherapy as primary treatment for elderly and medically inoperable patients with head and neck cancer. Head & Neck 42:10, pages 2880-2886.
Crossref
Dan Fan, Jung J. Kang, Ming Fan, Huili Wang, Anna Lee, Yao Yu, Linda Chen, C. Jillian Tsai, Sean M. McBride, Nadeem Riaz, Daphna Y. Gelblum, Brian P. Neal, James Fetten, Lara A. Dunn, Loren S. Michel, Jay O. Boyle, Marc A. Cohen, Benjamin R. Roman, Ian Ganly, Bhuvanesh Singh, Richard J. Wong, Eric J. Sherman & Nancy Y. Lee. (2020) Last-line local treatment with the Quad Shot regimen for previously irradiated head and neck cancers. Oral Oncology 104, pages 104641.
Crossref
Amardeep S. Grewal, Joshua Jones & Alexander Lin. (2019) Palliative Radiation Therapy for Head and Neck Cancers. International Journal of Radiation Oncology*Biology*Physics 105:2, pages 254-266.
Crossref
P.V. Chernyshov, A. Lallas, L. Tomas‐Aragones, M. Arenbergerova, M. Samimi, L. Manolache, A. Svensson, S.E. Marron, F. Sampogna, S. Spillekom‐vanKoulil, A. Bewley, A.M. Forsea, G.B. Jemec, J.C. Szepietowski, M. Augustin & A.Y. Finlay. (2019) Quality of life measurement in skin cancer patients: literature review and position paper of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes, Melanoma and Non‐Melanoma Skin Cancer. Journal of the European Academy of Dermatology and Venereology 33:5, pages 816-827.
Crossref
Akansha Choudhary & Ajay Gupta. (2019) Conventional fractionation versus quad shot in advanced head-and-neck cancers: A randomized controlled trial. Indian Journal of Palliative Care 25:4, pages 527.
Crossref
AswinChandran Veluthattil, ShyamaPrem Sudha, Saravanan Kandasamy & SunithaVellathussery Chakkalakkoombil. (2019) Effect of hypofractionated, palliative radiotherapy on quality of life in late-stage oral cavity cancer: A prospective clinical trial. Indian Journal of Palliative Care 25:3, pages 383.
Crossref
C. Ortholan, A. Auperin, C. Mertens, H. Le Caer & J. Guigay. (2018) Radiothérapie hypofractionnée des cancers ORL chez le sujet âgé. Cancer/Radiothérapie 22:6-7, pages 640-643.
Crossref
Jennifer MaBenjamin H. LokJingfeng ZongStanley I. Gutiontov, Xin Cai, Andrew C. Bell, Marina Shcherba, Han Xiao, Eric J. Sherman, Chiaojung Jillian Tsai, Nadeem Riaz, Sean M. McBride, Oren Cahlon & Nancy Y. Lee. (2018) Proton Radiotherapy for Recurrent or Metastatic Head and Neck Cancers with Palliative Quad Shot. International Journal of Particle Therapy 4:4, pages 10-19.
Crossref
Michael Laursen, Lena Specht, Claus Andrup Kristensen, Anita Gothelf, Mogens Bernsdorf, Ivan Vogelius & Jeppe Friborg. (2018) An Extended Hypofractionated Palliative Radiotherapy Regimen for Head and Neck Carcinomas. Frontiers in Oncology 8.
Crossref
Muhammad Shahid Iqbal, Charles Kelly, Josef Kovarik, Bojidar Goranov, Ghazia Shaikh, David Morgan, Werner Dobrowsky & Vinidh Paleri. (2018) Palliative radiotherapy for locally advanced non-metastatic head and neck cancer: A systematic review. Radiotherapy and Oncology 126:3, pages 558-567.
Crossref
T. Heinonen, V. Loimu, K. Saarilahti, T. Saarto & A. Mäkitie. (2017) End-of-life care pathway of head and neck cancer patients: single-institution experience. European Archives of Oto-Rhino-Laryngology 275:2, pages 545-551.
Crossref
Pierluigi Bonomo, Isacco Desideri, Mauro Loi, Monica Lo Russo, Emanuela Olmetto, Virginia Maragna, Giulio Francolini, Camilla Delli Paoli, Roberta Grassi, Donato Pezzulla, Daniela Greto, Icro Meattini & Lorenzo Livi. (2017) Elderly patients affected by head and neck squamous cell carcinoma unfit for standard curative treatment: Is de-intensified, hypofractionated radiotherapy a feasible strategy?. Oral Oncology 74, pages 142-147.
Crossref
Linda W. Sommers, Roel J.H.M. Steenbakkers, Henk P. Bijl, Johanna G.M. Vemer-van den Hoek, Jan L.N. Roodenburg, Sjoukje F. Oosting, Gyorgy B. Halmos, Sophia E. de Rooij & Johannes A. Langendijk. (2017) Survival Patterns in Elderly Head and Neck Squamous Cell Carcinoma Patients Treated With Definitive Radiation Therapy. International Journal of Radiation Oncology*Biology*Physics 98:4, pages 793-801.
Crossref
Randy L. Wei, Bo A. Wan, Edward Chow & Stephen Lutz. 2017. Clinical Radiation Oncology. Clinical Radiation Oncology 141 157 .
Whoon Jong Kil & Kevin Camphausen. (2017) Cyclical hypofractionated radiotherapy also known as “QUAD Shot” alone using intensity-modulated radiotherapy for squamous cell carcinoma of the parotid gland in an 85-year-old patient with multiple comorbidities. Head & Neck 39:4, pages E55-E60.
Crossref
Mioko Matsuo, Toshimitsu Nishijima & Koji Koike. (2017) Utility of chemoradiotherapy for head and neck cancer with distant metastases at initial presentation. Toukeibu Gan 43:4, pages 488-492.
Crossref
AH Rudresha, T Chaudhuri, KC Lakshmaiah, KG Babu, L Dasappa, LA Jacob, MC Suresh Babu, KN Lokesh & LK Rajeev. (2017) Induction chemotherapy in locally advanced T4b oral cavity squamous cell cancers: A regional cancer center experience. Indian Journal of Cancer 54:1, pages 35.
Crossref
T.J. Wilhite & J.D. Schoenfeld. 2017. Handbook of Supportive and Palliative Radiation Oncology. Handbook of Supportive and Palliative Radiation Oncology 275 296 .
Justin Lee, Georges Farha, Ian Poon, Irene Karam, Kevin Higgins, Samuel Pichardo, Kullervo Hynynen & Danny Enepekides. (2016) Magnetic resonance-guided high-intensity focused ultrasound combined with radiotherapy for palliation of head and neck cancer—a pilot study. Journal of Therapeutic Ultrasound 4:1.
Crossref
Petr Szturz & Jan B. Vermorken. (2016) Treatment of Elderly Patients with Squamous Cell Carcinoma of the Head and Neck. Frontiers in Oncology 6.
Crossref
Bernard Fortin, Nader Khaouam, Edith Filion, Phuc Felix Nguyen-Tan, Alexis Bujold & Louise Lambert. (2016) Palliative Radiation Therapy for Advanced Head and Neck Carcinomas: A Phase 2 Study. International Journal of Radiation Oncology*Biology*Physics 95:2, pages 647-653.
Crossref
Kirsty M. van Beek, Johannes H. A. M. Kaanders, Geert O. Janssens, Robert P. Takes, Paul N. Span & Cornelia G. Verhoef. (2015) Effectiveness and toxicity of hypofractionated high‐dose intensity‐modulated radiotherapy versus 2‐ and 3‐dimensional radiotherapy in incurable head and neck cancer. Head & Neck 38:S1.
Crossref
Benjamin H. Lok, Ginger Jiang, Stanley Gutiontov, Ryan M. Lanning, Sudeepta Sridhara, Eric J. Sherman, Chiaojung Jillian Tsai, Sean M. McBride, Nadeem Riaz & Nancy Y. Lee. (2015) Palliative head and neck radiotherapy with the RTOG 8502 regimen for incurable primary or metastatic cancers. Oral Oncology 51:10, pages 957-962.
Crossref
N-T A Nguyen, L Doerwald-Munoz, H Zhang, D-H Kim, S Sagar, J R Wright & D I Hodson. (2015) 0-7-21 hypofractionated palliative radiotherapy: an effective treatment for advanced head and neck cancers. The British Journal of Radiology 88:1049, pages 20140646.
Crossref
John A. Vargo, Robert L. Ferris, David A. Clump & Dwight E. Heron. (2014) Stereotactic Body Radiotherapy as Primary Treatment for Elderly Patients with Medically Inoperable Head and Neck Cancer. Frontiers in Oncology 4.
Crossref
Laurie Monnier, Emmanuel Touboul, Catherine Durdux, Philippe Lang, Jean Lacau St Guily & Florence Huguet. (2013) Hypofractionated palliative radiotherapy for advanced head and neck cancer: The IHF2SQ regimen. Head & Neck 35:12, pages 1683-1688.
Crossref
Vassilios Vassiliou & Haris Charalambous. 2013. Radiation Oncology in Palliative Cancer Care. Radiation Oncology in Palliative Cancer Care 31 42 .
Albert Tiong & June Corry. 2013. Radiation Oncology in Palliative Cancer Care. Radiation Oncology in Palliative Cancer Care 126 144 .
Jasenka Gugić & Primož Strojan. (2013) Squamous cell carcinoma of the head and neck in the elderly. Reports of Practical Oncology & Radiotherapy 18:1, pages 16-25.
Crossref
Hiram A. Gay, Jian-Yue Jin, Albert J. Chang & Randall K. Ten Haken. (2013) Utility of Normal Tissue-to-Tumor α/β Ratio When Evaluating Isodoses of Isoeffective Radiation Therapy Treatment Plans. International Journal of Radiation Oncology*Biology*Physics 85:1, pages e81-e87.
Crossref
Jeffrey Wu, Susan McCloskey & Michael L. Steinberg. 2012. Management of Cancer in the Older Patient. Management of Cancer in the Older Patient 65 77 .
Christiaan M. Stevens, Shao Hui Huang, Sharon Fung, Andrew J. Bayley, John B. Cho, Bernard J. Cummings, Laura A. Dawson, Andrew J. Hope, John J. Kim, Brian O'Sullivan, John N. Waldron & Jolie Ringash. (2011) Retrospective Study of Palliative Radiotherapy in Newly Diagnosed Head and Neck Carcinoma. International Journal of Radiation Oncology*Biology*Physics 81:4, pages 958-963.
Crossref
Paul Schwarzenberger, Louis Linares, Anna Fariss, Lucien Nedzi & Omar M. Salazar. (2011) Dose Escalation of Once Weekly Oral Vinorelbine Concurrent With Weekly Split Dose Hypofractionated Chest Radiation for Palliation of Advanced Non–Small Cell Lung Cancer: A Phase I/II Study. The American Journal of the Medical Sciences 341:6, pages 454-459.
Crossref
Andrew G. Shuman, Ye Yang, Jeremy M. G. Taylor & Mark E. Prince. (2011) End‐of‐Life Care among Head and Neck Cancer Patients. Otolaryngology–Head and Neck Surgery 144:5, pages 733-739.
Crossref
R.A. Pearson, R.H. Bannister-Young, D. Ivison, C.G. Kelly & S. Chatterjee. (2010) Split-course Hypofractionated Palliative Radiotherapy for Patients with Head and Neck Squamous Cell Carcinoma — a Worthwhile Treatment Schedule in the UK?. Clinical Oncology 22:10, pages 890-891.
Crossref
Stephen Lutz, Timothy Korytko, Janet Nguyen, Luluel Khan, Edward Chow & Benjamin Corn. (2010) Palliative Radiotherapy. The Cancer Journal 16:5, pages 473-482.
Crossref
M.A. Tunio, A. Hashmi & M. Rafi. (2010) Need for a new trial to evaluate postoperative radiotherapy in renal cell carcinoma: a meta-analysis of randomized controlled trials. Annals of Oncology 21:9, pages 1839-1845.
Crossref
. (2010) Current World Literature. Current Opinion in Otolaryngology & Head & Neck Surgery 18:2, pages 134-145.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.