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Research Article

Efficacy and tolerability of tropisetron in primary fibromyalgia - a highly selective and competitive 5-HT3 receptor antagonist

Pages 49-54 | Published online: 12 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (21)

Elena P Calandre, Fernando Rico-Villademoros & Mahmoud Slim. (2015) An update on pharmacotherapy for the treatment of fibromyalgia. Expert Opinion on Pharmacotherapy 16:9, pages 1347-1368.
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Mustafa Arı, Yasin Bez, Mehmet Cemal Kaya, Fatma Aslan & Hayal Guler. (2012) Childhood Abuse and Anxiety in Treatment-Resistant Fibromyalgia Syndrome. MYOPAIN 0:0, pages 1-5.
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Kim Francis Le Marshall & Geoffrey Owen Littlejohn. (2011) Management strategies for fibromyalgia. Open Access Rheumatology: Research and Reviews 3, pages 47-51.
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Matthias F Seidel & Wolfgang Müller. (2011) Differential pharmacotherapy for subgroups of fibromyalgia patients with specific consideration of 5-HT3 receptor antagonists. Expert Opinion on Pharmacotherapy 12:9, pages 1381-1391.
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Ali Gur & Pelin Oktayoglu. (2009) Advances in diagnostic and treatment options in patients with fibromyalgia syndrome. Open Access Rheumatology: Research and Reviews 1, pages 193-209.
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Richard E Harris & Daniel J Clauw. (2008) Newer treatments for fibromyalgia syndrome. Therapeutics and Clinical Risk Management 4:6, pages 1331-1342.
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Grazyna Zareba. (2008) New treatment options in the management of fibromyalgia: role of pregabalin. Neuropsychiatric Disease and Treatment 4:6, pages 1193-1201.
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Edward J. Calabrese. (2008) Pain and U-Shaped Dose Responses: Occurrence, Mechanisms, and Clinical Implications. Critical Reviews in Toxicology 38:7, pages 579-590.
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Patrick B Wood, Andrew J Holman & Kim D Jones. (2007) Novel pharmacotherapy for fibromyalgia. Expert Opinion on Investigational Drugs 16:6, pages 829-841.
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Richard N. Podell. (2007) Fibromyalgia Syndrome's New Paradigm: Neural Sensitization and Its Implications for Treatment. Journal of Musculoskeletal Pain 15:2, pages 45-54.
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Gary McCleane. (2005) Emerging trends in the management of neuropathic pain. Expert Review of Neurotherapeutics 5:5, pages 617-623.
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Gary McCleane. (2005) Do 5HT3 Antagonists Antinociceptive Have an Effect?. Journal of Neuropathic Pain & Symptom Palliation 1:1, pages 101-107.
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Gary McCleane, Rie Suzuki & Anthony Dickenson. (2005) The 5HT3 Receptor Antagonist Ondansetron Can Have an Analgesic Effect in Chronic Human Neuropathic Pain. Journal of Neuropathic Pain & Symptom Palliation 1:1, pages 77-79.
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M Späth, T Stratz, G Neeck, I Kötter, B Hammel, CC Amberger, U Haus, L Färber, D Pongratz & W Müller. (2004) Efficacy and tolerability of intravenous tropisetron in the treatment of fibromyalgia. Scandinavian Journal of Rheumatology 33:4, pages 267-270.
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J Tolk, R Kohnen & W Müller. (2004) Intravenous treatment of fibromyalgia with the 5‐HT3 receptor antagonist tropisetron in a rheumatological practice. Scandinavian Journal of Rheumatology 33:sup119, pages 72-75.
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R Kohnen, L Färber & M Späth. (2004) The assessment of vegetative and functional symptoms in fibromyalgia patients: the tropisetron experience. Scandinavian Journal of Rheumatology 33:sup119, pages 67-71.
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M Späth, T Stratz, L Färber, U Haus & D Pongratz. (2004) Treatment of fibromyalgia with tropisetron – dose and efficacy correlations. Scandinavian Journal of Rheumatology 33:sup119, pages 63-66.
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W Müller & T Stratz. (2004) Local treatment of tendinopathies and myofascial painsyndromes with the 5‐HT3 receptor antagonist tropisetron. Scandinavian Journal of Rheumatology 33:sup119, pages 44-48.
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T Stratz, B Fiebich, U Haus & W Müller. (2004) Influence of tropisetron on the serum substance P levels in fibromyalgia patients. Scandinavian Journal of Rheumatology 33:sup119, pages 41-43.
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EM Schneider, X Ma, T Stratz, W Müller, I Lorenz & WD Seeling. (2004) Immunomodulatory function of the 5‐HT3 receptor antagonist tropisetron. Scandinavian Journal of Rheumatology 33:sup119, pages 34-40.
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U Haus, M Späth & L Färber. (2004) Spectrum of use and tolerability of 5‐HT3 receptor antagonists. Scandinavian Journal of Rheumatology 33:sup119, pages 12-18.
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Ryan Patel & Anthony H. Dickenson. (2018) Modality selective roles of pro-nociceptive spinal 5-HT2A and 5-HT3 receptors in normal and neuropathic states. Neuropharmacology 143, pages 29-37.
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Gary W. Jay & Robert L. Barkin. (2015) Fibromyalgia. Disease-a-Month 61:3, pages 66-111.
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Janice E. Sumpton & Dwight E. Moulin. 2014. Neurologic Aspects of Systemic Disease Part I. Neurologic Aspects of Systemic Disease Part I 513 527 .
Iboro C. Umana, Claire A. Daniele & Daniel S. McGehee. (2013) Neuronal nicotinic receptors as analgesic targets: It's a winding road. Biochemical Pharmacology 86:8, pages 1208-1214.
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Elina Tiippana, Katri Hamunen, Vesa Kontinen & Eija Kalso. (2012) The Effect of Paracetamol and Tropisetron on Pain: Experimental Studies and a Review of Published Data. Basic & Clinical Pharmacology & Toxicology 112:2, pages 124-131.
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Christian Stratz, Harsharan S. Bhatia, Ravi Shankar Akundi, Thomas Nührenberg, Dietmar Trenk, Eduardo Muñoz & Bernd L. Fiebich. (2012) The anti-inflammatory effects of the 5-HT3 receptor antagonist tropisetron are mediated by the inhibition of p38 MAPK activation in primary human monocytes. International Immunopharmacology 13:4, pages 398-402.
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C. Sommer, W. Häuser, R. Alten, F. Petzke, M. Späth, T. Tölle, N. Üçeyler, A. Winkelmann, E. Winter & K.J. Bär. (2012) Medikamentöse Therapie des FibromyalgiesyndromsDrug therapy of fibromyalgia syndrome. Der Schmerz 26:3, pages 297-310.
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Alban Y. Neziri, Martina Dickenmann, Pasquale Scaramozzino, Ole K. Andersen, Lars Arendt-Nielsen, Anthony H. Dickenson & Michele Curatolo. (2012) Effect of intravenous tropisetron on modulation of pain and central hypersensitivity in chronic low back pain patients. Pain 153:2, pages 311-318.
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Oliver Bandschapp, Joerg Filitz, Albert Urwyler, Wolfgang Koppert & Wilhelm Ruppen. (2011) Tropisetron blocks analgesic action of acetaminophen: A human pain model study. Pain 152:6, pages 1304-1310.
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Pascale Vergne‐Sallel, Carine Dufauret‐Lombardl, Christine Bonnetl, Anne Simonl, Richard Trèvesl, Henri Bonnabaul & Philippe Bertinl. (2012) A randomised, double‐blind, placebo‐controlled trial of dolasetron, a 5‐hydroxytryptamine 3 receptor antagonist, in patients with fibromyalgia. European Journal of Pain 15:5, pages 509-514.
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Daniel J. Clauw. 2011. Rheumatology. Rheumatology 769 782.e3 .
BaoXi Gao, Markus Hierl, Kristie Clarkin, Todd Juan, Hung Nguyen, Marissa van der Valk, Hong Deng, Wenhong Guo, Sonya G. Lehto, David Matson, Jeff S. McDermott, Johannes Knop, Kevin Gaida, Lei Cao, Dan Waldon, Brian K. Albrecht, Alessandro A. Boezio, Katrina W. Copeland, Jean-Christophe Harmange, Stephanie K. Springer, Annika B. Malmberg & Stefan I. McDonough. (2010) Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain. Pain 149:1, pages 33-49.
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Claudia Sommer. 2010. Handbook of the Behavioral Neurobiology of Serotonin. Handbook of the Behavioral Neurobiology of Serotonin 457 471 .
William S. Wilke, Abby Abelson & Ravindran Padmanabhan. 2010. Current Clinical Medicine. Current Clinical Medicine 1124 1128.e1 .
Lesley M. Arnold. (2009) Strategies for Managing Fibromyalgia. The American Journal of Medicine 122:12, pages S31-S43.
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Malin Ernberg. 2009. Peripheral Receptor Targets for Analgesia. Peripheral Receptor Targets for Analgesia 243 274 .
Daniel Clauw. 2009. Fibromyalgia. Fibromyalgia 1 25 .
Michael Schneider, Howard Vernon, Gordon Ko, Gordon Lawson & Jerome Perera. (2009) Chiropractic Management of Fibromyalgia Syndrome: A Systematic Review of the Literature. Journal of Manipulative and Physiological Therapeutics 32:1, pages 25-40.
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Lucy Bee & Anthony Dickenson. 2009. Synaptic Plasticity in Pain. Synaptic Plasticity in Pain 307 335 .
Lucy A. Bee & Anthony H. Dickenson. (2008) Descending facilitation from the brainstem determines behavioural and neuronal hypersensitivity following nerve injury and efficacy of pregabalin. Pain 140:1, pages 209-223.
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A. C. Dutton & N. M. Barnes. 2008. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 171 212 .
M. Martinez-Lavin. (2008) Dysfonctions du système nerveux sympathique dans la fibromyalgieSympathetic nervous system dysfunction in fibromyalgia. Douleur et Analgésie 20:4, pages 219-226.
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W. Müller, M. Schneider, T. Joos, H.Y. Hsu & T. Stratz. (2007) Ein Modell zur Einteilung des FibromyalgiesyndromsSubgroups of fibromyalgia. Der Schmerz 21:5, pages 424-429.
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W. Müller, E. M. Schneider & T. Stratz. (2007) The classification of fibromyalgia syndrome. Rheumatology International 27:11, pages 1005-1010.
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R. Norman Harden, Gadi Revivo, Sharon Song, Devi Nampiaparampil, Gary Golden, Marie Kirincic & Timothy T. Houle. (2007) A Critical Analysis of the Tender Points in Fibromyalgia. Pain Medicine 8:2, pages 147-156.
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Wissam El-Hage, Céline Lamy, Philippe Goupille, Philippe Gaillard & Vincent Camus. (2006) Fibromyalgie : une maladie du traumatisme psychique ?. La Presse Médicale 35:11, pages 1683-1689.
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Rie Suzuki, Frank Porreca & Anthony H. Dickenson. (2006) Evidence for spinal dorsal horn hyperexcitability in rats following sustained morphine exposure. Neuroscience Letters 407:2, pages 156-161.
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