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Research Article

Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis: An update and proposals for guidelines

Pages 129-134 | Published online: 12 Jul 2009

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Michihiro Ogasawara, Michiaki Kageyama, Makio Kusaoi, Shin Onuma, Takayuki Kon, Fumio Sekiya, Kaoru Sugimoto, Ran Matsudaira, Masakazu Matsushita, Kurisu Tada, Kazuo Kempe, Ken Yamaji, Naoto Tamura & Yoshinari Takasaki. (2012) Recent trends in use of nonbiologic DMARDs and evaluation of their continuation rates in single and dual combination therapies in rheumatoid arthritis patients in Japan. Modern Rheumatology 22:6, pages 831-836.
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N Tugnet, SC Cooper & KM Douglas. (2012) Methotrexate therapy, rheumatoid arthritis, and life-threatening liver complications: should we be monitoring more closely?. Scandinavian Journal of Rheumatology 41:2, pages 163-164.
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T. Kuitunen, J. Malmström, E. Palva & T. Pettersson. (2005) Pancytopenia induced by low‐dose methotrexate. A study of the cases reported to the Finnish Adverse Drug Reaction Register from 1991 to 1999. Scandinavian Journal of Rheumatology 34:3, pages 238-241.
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Articles from other publishers (24)

Mepur H. Ravindranath, Narendranath M. Ravindranath, Carly J. Amato-Menker, Fatiha El Hilali, Senthamil R. Selvan, Edward J. Filippone & Luis Eduardo Morales-Buenrostro. (2023) Antibodies for β2-Microglobulin and the Heavy Chains of HLA-E, HLA-F, and HLA-G Reflect the HLA-Variants on Activated Immune Cells and Phases of Disease Progression in Rheumatoid Arthritis Patients under Treatment. Antibodies 12:2, pages 26.
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Krista L. Haines, Laura Gorenshtein, Stephanie Lumpkin, Braylee Grisel & Scott Gallagher. (2023) Optimal Nutrition in the Older Adult: Beneficial Versus Ineffective Supplements. Current Nutrition Reports 12:2, pages 231-237.
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Diane Bramley. (2021) What dose of folic acid to use with methotrexate in rheumatoid arthritis?. Drug and Therapeutics Bulletin 59:7, pages 103-106.
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Jacqueline Rodríguez, Gloria Inés Lafaurie, Wilson Bautista-Molano, Lorena Chila-Moreno, Juan Manuel Bello-Gualtero & Consuelo Romero-Sánchez. (2020) Adipokines and periodontal markers as risk indicators of early rheumatoid arthritis: a cross-sectional study. Clinical Oral Investigations 25:4, pages 1685-1695.
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S. Kreft. 2015. Dietary Supplements. Dietary Supplements 127 135 .
S.R. Zwart, C.R. Gibson & S.M. Smith. 2014. Handbook of Nutrition, Diet and the Eye. Handbook of Nutrition, Diet and the Eye 393 399 .
Stephanie Klemencic. (2010) Cotton wool spots as an indicator of methotrexate-induced blood dyscrasia. Optometry - Journal of the American Optometric Association 81:4, pages 177-180.
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Christian Pagnoux & Michelle Goulet. (2009) Role and place of methotrexate in vasculitis management. International Journal of Clinical Rheumatology 4:6, pages 697-715.
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N. Varatharajan, I. G. S. Lim, A. Anandacoomarasamy, R. Russo, K. Byth, D. G. Spencer, N. Manolios & G. B. Howe. (2009) Methotrexate: long-term safety and efficacy in an Australian consultant rheumatology practice. Internal Medicine Journal 39:4, pages 228-236.
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Patricia Worthington & Leslie Schechter. 2010. Handbook of Drug-Nutrient Interactions. Handbook of Drug-Nutrient Interactions 513 536 .
Mary Kay Koenig, Maria Perez, Sheldon Rothenberg & Ian J. Butler. (2007) Juvenile Onset Central Nervous System Folate Deficiency and Rheumatoid Arthritis. Journal of Child Neurology 23:1, pages 106-107.
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P. Goldsmith & A. Roach. (2007) Methods to enhance the safety of methotrexate prescribing. Journal of Clinical Pharmacy and Therapeutics 32:4, pages 327-331.
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E. Mitre, K. R. Talaat, M. R. Sperling & T. E. Nash. (2007) Methotrexate as a Corticosteroid-Sparing Agent in Complicated Neurocysticercosis. Clinical Infectious Diseases 44:4, pages 549-553.
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K Robien, M M Schubert, Y Yasui, P Martin, R Storb, J D Potter & C M Ulrich. (2006) Folic acid supplementation during methotrexate immunosuppression is not associated with early toxicity, risk of acute graft-versus-host disease or relapse following hematopoietic transplantation. Bone Marrow Transplantation 37:7, pages 687-692.
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Bruce E. Strober & Kavita Menon. (2005) Folate supplementation during methotrexate therapy for patients with psoriasis. Journal of the American Academy of Dermatology 53:4, pages 652-659.
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Kim Robien. (2017) Folate During Antifolate Chemotherapy: What We Know... and Do Not Know. Nutrition in Clinical Practice 20:4, pages 411-422.
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Bruce N. Cronstein. (2005) Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis. Pharmacological Reviews 57:2, pages 163-172.
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Gerry Clare, Stephen Colley, Robin Kennett & John S Elston. (2005) Reversible Optic Neuropathy Associated With Low-Dose Methotrexate Therapy. Journal of Neuro-Ophthalmology 25:2, pages 109-112.
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G M J Deeming, J Collingwood & M N Pemberton. (2005) Methotrexate and oral ulceration. British Dental Journal 198:2, pages 83-85.
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James T. Cassidy & Ross E. Petty. 2005. Textbook of Pediatric Rheumatology. Textbook of Pediatric Rheumatology 206 260 .
Sarah L. Morgan, Robert A. Oster, Jeannette Y. Lee, Graciela S. Alarcón & Joseph E. Baggott. (2004) The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate‐treated rheumatoid arthritis. Arthritis & Rheumatism 50:10, pages 3104-3111.
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Shumin M. Zhang & Walter C. Willett. 2004. Cancer Chemoprevention. Cancer Chemoprevention 559 582 .
Urspeter Masche. (2002) Basistherapie der rheumatoiden Arthritis. pharma-kritik 24:3.
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Eva Reinhold‐Keller, Claudia O. E. Fink, Karen Herlyn, Wolfgang L. Gross & Kirsten de Groot. (2002) High rate of renal relapse in 71 patients with Wegener's granulomatosis under maintenance of remission with low‐dose methotrexate. Arthritis Care & Research 47:3, pages 326-332.
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