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Scandinavian Journal of Rheumatology Volume 34, 2005 - Issue 4
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A powder made from seeds and shells of a rose‐hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double‐blind, placebo‐controlled clinical trial

K. Winther Department of Clinical Biochemistry, Copenhagen County Hospital GentofteCorrespondence[email protected]
,
K. Apel Department of Rheumatology, Copenhagen County Hospital Glostrup, University of Copenhagen, Denmark
&
G. Thamsborg Department of Rheumatology, Copenhagen County Hospital Glostrup, University of Copenhagen, Denmark
Pages 302-308 | Received 19 Aug 2004, Accepted 07 Jan 2005, Published online: 12 Jul 2009

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Alicia B. Pomilio, Nicolas A. Szewczuk & Pablo R. Duchowicz. (2022) Dietary anthocyanins balance immune signs in osteoarthritis and obesity – update of human in vitro studies and clinical trials. Critical Reviews in Food Science and Nutrition 0:0, pages 1-39.
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Akifumi Nagatomo, Norihisa Nishida, Ikuo Fukuhara, Akira Noro, Yoshimichi Kozai, Hisao Sato & Yoichi Matsuura. (2015) Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial. Diabetes, Metabolic Syndrome and Obesity 8, pages 147-156.
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L Phetcharat, K Wongsuphasawat & K Winther. (2015) The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity. Clinical Interventions in Aging 10, pages 1849-1856.
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S. Chrubasik-Hausmann, C. Chrubasik, E. Neumann & U. Müller-Ladner. (2014) A Pilot Study on the Effectiveness of a Rose Hip Shell Powder in Patients Suffering from Chronic Musculoskeletal Pain. Phytotherapy Research 28:11, pages 1720-1726.
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Rod Hughes. (2014) Non-surgical management of osteoarthritis: Latest guidelines. Nurse Prescribing 12:7, pages 328-329.
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Melainie Cameron & Sigrun Chrubasik. (2014) Oral herbal therapies for treating osteoarthritis. Cochrane Database of Systematic Reviews 2016:4.
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Sunmin Park, Sun Young Park, Kwang Soo Kim, Geun Young Seo & Suna Kang. (2014) Rose hip alleviates pain and disease progression in rats with monoiodoacetate induced osteoarthritis. Journal of the Korean Society for Applied Biological Chemistry 57:2, pages 143-151.
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Joseph Schwager, Nathalie Richard, Rotraut Schoop & Swen Wolfram. (2014) A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects. Mediators of Inflammation 2014, pages 1-10.
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Michael A. Malone & Kathryn Gloyer. (2013) Complementary and Alternative Treatments in Sports Medicine. Primary Care: Clinics in Office Practice 40:4, pages 945-968.
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Seema Patel. (2012) Rose hips as complementary and alternative medicine: overview of the present status and prospects. Mediterranean Journal of Nutrition and Metabolism 6:2, pages 89-97.
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Crossref
. 2013. Principles and Practice of Phytotherapy. Principles and Practice of Phytotherapy 183 350 .
. 2013. Principles and Practice of Phytotherapy. Principles and Practice of Phytotherapy 140 182 .
U Andersson, K Berger, A Högberg, M Landin-Olsson & C Holm. (2011) Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. European Journal of Clinical Nutrition 66:5, pages 585-590.
Crossref
Y. Henrotin & J.‐Y. Reginster. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Joseph Schwager, Ulrich Hoeller, Swen Wolfram & Nathalie Richard. (2011) Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression. BMC Complementary and Alternative Medicine 11:1.
Crossref
V. De Silva, A. El-Metwally, E. Ernst, G. Lewith & G. J. Macfarlane. (2010) Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review. Rheumatology 50:5, pages 911-920.
Crossref
Bokyung Sung, Gautam Sethi, Kwang Ahn, Manoj Pandey, Ajaikumar Kunnumakkara & Bharat Aggarwal. 2011. Arthritis. Arthritis 295 323 .
. 2011. A Guide to Evidence-based Integrative and Complementary Medicine. A Guide to Evidence-based Integrative and Complementary Medicine 670 693 .
M. J. M. Smulders, P. Arens, C. F. S. Koning-Boucoiran, V. W. Gitonga, F. A. Krens, A. Atanassov, I. Atanassov, K. E. Rusanov, M. Bendahmane, A. Dubois, O. Raymond, J. C. Caissard, S. Baudino, L. Crespel, S. Gudin, S. C. Ricci, N. Kovatcheva, J. Van Huylenbroeck, L. Leus, V. Wissemann, H. Zimmermann, I. Hensen, G. Werlemark & H. Nybom. 2011. Wild Crop Relatives: Genomic and Breeding Resources. Wild Crop Relatives: Genomic and Breeding Resources 243 275 .
. (2010) Patients with rheumatoid arthritis may benefit from a standardised powder of Rosa canina (rose hip) . Focus on Alternative and Complementary Therapies 15:2, pages 114-115.
Crossref
S.N. Willich, K. Rossnagel, S. Roll, A. Wagner, O. Mune, J. Erlendson, A. Kharazmi, H. Sörensen & K. Winther. (2010) Rose hip herbal remedy in patients with rheumatoid arthritis – a randomised controlled trial. Phytomedicine 17:2, pages 87-93.
Crossref
Heather M. Gillespie & William W. Dexter. 2010. The Hip and Pelvis in Sports Medicine and Primary Care. The Hip and Pelvis in Sports Medicine and Primary Care 297 315 .
Melainie Cameron, Joel J. Gagnier, Christine V. Little, Tessa J. Parsons, Anette Blümle & Sigrun Chrubasik. (2009) Evidence of Effectiveness of Herbal Medicinal Products in the Treatment of Arthritis. Phytotherapy Research 23:11, pages 1497-1515.
Crossref
Gun Werlemark & Hilde Nybom. 2009. Horticultural Reviews. Horticultural Reviews 199 255 .
Joyce Silva dos Santos, Ana Beatriz Duarte Vieira & Ivone Kamada. (2009) A Rosa Mosqueta no tratamento de feridas abertas: uma revisão. Revista Brasileira de Enfermagem 62:3, pages 457-462.
Crossref
Izabela Fecka. (2009) Qualitative and quantitative determination of hydrolysable tannins and other polyphenols in herbal products from meadowsweet and dog rose. Phytochemical Analysis 20:3, pages 177-190.
Crossref
Motoo Kikuchi, Kentaro Matsuura, Yoshifuji Matsumoto, Toshiaki Inagaki & Ryuzo Ueda. (2009) Bibliographical investigation of complementary alternative medicines for osteoarthritis and rheumatoid arthritis. Geriatrics & Gerontology International 9:1, pages 29-40.
Crossref
Zhi-Qiong Zhou, Wei-Kai Bao & Ning Wu. (2009) Dormancy and germination in Rosa multibracteata Hemsl. & E. H. Wilson. Scientia Horticulturae 119:4, pages 434-441.
Crossref
Hilde Nybom. 2009. Genetics and Genomics of Rosaceae. Genetics and Genomics of Rosaceae 339 351 .
R. Christensen, E.M. Bartels, R.D. Altman, A. Astrup & H. Bliddal. (2008) Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients? – a meta-analysis of randomized controlled trials. Osteoarthritis and Cartilage 16:9, pages 965-972.
Crossref
Luis Vitetta, Flavia Cicuttini & Avni Sali. (2008) Alternative therapies for musculoskeletal conditions. Best Practice & Research Clinical Rheumatology 22:3, pages 499-522.
Crossref
Cosima Chrubasik, Basil D. Roufogalis, Ulf Müller‐Ladner & Sigrun Chrubasik. (2008) A systematic review on the Rosa canina effect and efficacy profiles . Phytotherapy Research 22:6, pages 725-733.
Crossref
Kaj Winther. (2008) A standardized powder made from rosehips (Rosa canina L.) improves function and reduces pain and the consumption of rescue medication in osteoarthritis. Osteoarthritis and Cartilage 16, pages S8-S9.
Crossref
Arsalan Kharazmi. (2008) Laboratory and preclinical studies on the anti-inflammatory and anti-oxidant properties of rosehip powder – Identification and characterization of the active component GOPO®. Osteoarthritis and Cartilage 16, pages S5-S7.
Crossref
ERIK LARSEN & LARS P. CHRISTENSEN. (2007) COMMON VEGETABLES AND FRUITS AS A SOURCE OF 1,2-DI-O-?-LINOLENOYL-3-O-?-D-GALACTOPYRANOSYL-sn-GLYCEROL, A POTENTIAL ANTI-INFLAMMATORY AND ANTITUMOR AGENT. Journal of Food Lipids 14:3, pages 272-279.
Crossref
Didem Deliorman Orhan, Ali Hartevioğlu, Esra Küpeli & Erdem Yesilada. (2007) In vivo anti-inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina L. fruits. Journal of Ethnopharmacology 112:2, pages 394-400.
Crossref
Goetz Paul. (2006) Actualités en phytothérapie. Phytothérapie 4:4, pages 198-204.
Crossref
Margaret Rayman & Alison Callaghan. 2006. Nutrition and Arthritis. Nutrition and Arthritis 204 217 .

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