548
Views
49
CrossRef citations to date
0
Altmetric
Articles

Intra‐articular sodium hyaluronate 2 mL versus physiological saline 20 mL versus physiological saline 2 mL for painful knee osteoarthritis: a randomized clinical trial

, , , &
Pages 142-150 | Accepted 16 Nov 2007, Published online: 12 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Vibeke Strand, Louis F McIntyre, William R Beach, Larry E Miller & Jon E Block. (2015) Safety and efficacy of US-approved viscosupplements for knee osteoarthritis: a systematic review and meta-analysis of randomized, saline-controlled trials. Journal of Pain Research 8, pages 217-228.
Read now
Tracy R. Ray. (2013) Using Viscosupplementation to Treat Knee Osteoarthritis. The Physician and Sportsmedicine 41:4, pages 16-24.
Read now
Sanford H. Roth & Shane Anderson. (2011) The NSAID Dilemma: Managing Osteoarthritis in High-Risk Patients. The Physician and Sportsmedicine 39:3, pages 62-74.
Read now
Daniel Brzusek & David Petron. (2008) Treating knee osteoarthritis with intra-articular hyaluronans. Current Medical Research and Opinion 24:12, pages 3307-3322.
Read now

Articles from other publishers (45)

Tae Woo Kim, Moon Jong Chang, Chung Yeop Shin, Chong Bum Chang & Seung-Baik Kang. (2023) A randomized controlled trial for comparing efficacy and safety between intraarticular polynucleotide and hyaluronic acid for knee osteoarthritis treatment. Scientific Reports 13:1.
Crossref
Marie Bettonville, Marc Léon, Joëlle Margaux, Didier Urbin-Choffray, Emilie Theunissen, Tatiana Besse-Hammer, Yves Fortems, Séverine Verlinden, Olivier Godeaux, Anne-Sophie Delmarcelle & Jean-François Kaux. (2021) Safety and efficacy of a single intra-articular injection of a novel enhanced protein solution (JTA-004) compared to hylan G-F 20 in symptomatic knee osteoarthritis: a randomized, double-blind, controlled phase II/III study. BMC Musculoskeletal Disorders 22:1.
Crossref
David Webner, Yili Huang & Charles D. HummerIIIIII. (2021) Intraarticular Hyaluronic Acid Preparations for Knee Osteoarthritis: Are Some Better Than Others?. CARTILAGE 13:1_suppl, pages 1619S-1636S.
Crossref
Davide Previtali, Giulia Merli, Giorgio Di Laura Frattura, Christian Candrian, Stefano Zaffagnini & Giuseppe Filardo. (2020) The Long-Lasting Effects of “Placebo Injections” in Knee Osteoarthritis: A Meta-Analysis. CARTILAGE 13:1_suppl, pages 185S-196S.
Crossref
Larry E. Miller, Samir Bhattacharyya, William R. Parrish, Michael Fredericson, Brad Bisson & Roy D. Altman. (2019) Safety of Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: Systematic Review and Meta-Analysis of Randomized Trials Involving More than 8,000 Patients. CARTILAGE 13:1_suppl, pages 351S-363S.
Crossref
Ankit Kotia, Sunil More, Aman Yadav, Thota Venkata Sai Yaswanth Mohan, Arnepaplli Harshavardhan Naidu, Golusu Rajesh & Ioannis E. Sarris. (2021) Rheological Properties and Its Effect on the Lubrication Mechanism of PVP K30 and PVP 40-50 G as Artificial Synovial Fluids. Inventions 6:4, pages 61.
Crossref
Di Zhao, Jian-ke Pan, Wei-yi Yang, Yan-hong Han, Ling-feng Zeng, Gui-hong Liang & Jun Liu. (2021) Intra-Articular Injections of Platelet-Rich Plasma, Adipose Mesenchymal Stem Cells, and Bone Marrow Mesenchymal Stem Cells Associated With Better Outcomes Than Hyaluronic Acid and Saline in Knee Osteoarthritis: A Systematic Review and Network Meta-analysis. Arthroscopy: The Journal of Arthroscopic & Related Surgery 37:7, pages 2298-2314.e10.
Crossref
Vito Pavone, Andrea Vescio, Matteo Turchetta, Serena Maria Chiara Giardina, Annalisa Culmone & Gianluca Testa. (2021) Injection-Based Management of Osteoarthritis of the Knee: A Systematic Review of Guidelines. Frontiers in Pharmacology 12.
Crossref
Patrice VINCENT. (2021) Acide hyaluronique intra-articulaire dans la gonarthrose: résultats cliniques d'une famille de produits (ARTHRUM), avec méta-analyses comparatives. Current Therapeutic Research 95, pages 100652.
Crossref
Patrice Vincent. (2021) Intra-articular hyaluronic acid in knee osteoarthritis: clinical data for a product family (ARTHRUM), with comparative meta-analyses. Current Therapeutic Research 95, pages 100637.
Crossref
Charles D. Hummer, Felix Angst, Wilson Ngai, Craig Whittington, Sophie S. Yoon, Lionel Duarte, Colleen Manitt & Emil Schemitsch. (2020) High molecular weight Intraarticular hyaluronic acid for the treatment of knee osteoarthritis: a network meta-analysis. BMC Musculoskeletal Disorders 21:1.
Crossref
S. More, A. Kotiya, A. Kotia, S.K. Ghosh, L.A. Spyrou & I.E. Sarris. (2020) Rheological properties of synovial fluid due to viscosupplements: A review for osteoarthritis remedy. Computer Methods and Programs in Biomedicine 196, pages 105644.
Crossref
GanesanRam Ganesan & RaghavRavi Veeraraghavan. (2020) Evidence-based practice versus experience-based practice in orthopedics. Journal of Orthopedics, Traumatology and Rehabilitation 12:1, pages 13.
Crossref
Ilie ONU, Daniela MATEI & Anca GALACTION. (2019) Efficacy of intra-articular hyaluronic acid injections in the rehabilitation programme of Knee Osteoarthritis. Balneo Research Journal 10:Vol.10, No.3, pages 225-230.
Crossref
Carrie Richardson, Anna Plaas & Joel A. Block. (2019) Intra-articular Hyaluronan Therapy for Symptomatic Knee Osteoarthritis. Rheumatic Disease Clinics of North America 45:3, pages 439-451.
Crossref
Germain Honvo, Jean-Yves Reginster, Francois Rannou, Xavier Rygaert, Anton Geerinck, Véronique Rabenda, Tim McAlindon, Alexia Charles, Nicholas Fuggle, Cyrus Cooper, Elizabeth Curtis, Nigel Arden, Bernard Avouac & Olivier Bruyère. (2019) Safety of Intra-articular Hyaluronic Acid Injections in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. Drugs & Aging 36:S1, pages 101-127.
Crossref
Mathew Nicholls, Peter Shaw, Faizan Niazi, Mohit Bhandari & Asheesh Bedi. (2018) The Impact of Excluding Patients with End-Stage Knee Disease in Intra-Articular Hyaluronic Acid Trials: A Systematic Review and Meta-Analysis. Advances in Therapy 36:1, pages 147-161.
Crossref
Steven Bowman, Mohamed E. Awad, Mark W. Hamrick, Monte Hunter & Sadanand Fulzele. (2018) Recent advances in hyaluronic acid based therapy for osteoarthritis. Clinical and Translational Medicine 7:1.
Crossref
David S. Jevsevar, Peter B. Shores, Kyle Mullen, Danielle M. Schulte, Gregory A. Brown & Deborah S. Cummins. (2018) Mixed Treatment Comparisons for Nonsurgical Treatment of Knee Osteoarthritis: A Network Meta-analysis. Journal of the American Academy of Orthopaedic Surgeons 26:9, pages 325-336.
Crossref
Andrew Concoff, Parag Sancheti, Faizan Niazi, Peter Shaw & Jeffrey Rosen. (2017) The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis. BMC Musculoskeletal Disorders 18:1.
Crossref
Bryan M. Saltzman, Timothy Leroux, Maximilian A. Meyer, Bryce A. Basques, Jaskarndip Chahal, Bernard R. BachJrJr, Adam B. Yanke & Brian J. Cole. (2016) The Therapeutic Effect of Intra-articular Normal Saline Injections for Knee Osteoarthritis: A Meta-analysis of Evidence Level 1 Studies. The American Journal of Sports Medicine 45:11, pages 2647-2653.
Crossref
Arup K. Bhadra, Roy Altman, Vinod Dasa, Karen Myrick, Jeffrey Rosen, Vijay Vad, Peter VitanzoJr.Jr., Michelle Bruno, Hillary Kleiner & Caryn Just. (2016) Appropriate Use Criteria for Hyaluronic Acid in the Treatment of Knee Osteoarthritis in the United States. CARTILAGE 8:3, pages 234-254.
Crossref
Claire E. O’Hanlon, Sydne J. Newberry, Marika Booth, Sean Grant, Aneesa Motala, Margaret A. Maglione, John D. FitzGerald & Paul G. Shekelle. (2016) Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews. Systematic Reviews 5:1.
Crossref
Roy D. Altman, Tahira Devji, Mohit Bhandari, Anke Fierlinger, Faizan Niazi & Robin Christensen. (2016) Clinical benefit of intra-articular saline as a comparator in clinical trials of knee osteoarthritis treatments: A systematic review and meta-analysis of randomized trials. Seminars in Arthritis and Rheumatism 46:2, pages 151-159.
Crossref
Roy D. Altman, Asheesh Bedi, Jon Karlsson, Parag Sancheti & Emil Schemitsch. (2016) Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. The American Journal of Sports Medicine 44:8, pages 2158-2165.
Crossref
Yang Xin, Lin Jianhao, Sun Tiansheng, Hao Yongqiang, Fan Weimin, Chen Ming, Sun Tiezheng, Yao Jianhua, Xuan Liang, Gu Xiaoyuan & Cao Yongping. (2016) The efficacy and safety of sodium hyaluronate injection (Adant ® ) in treating degenerative osteoarthritis: a multi-center, randomized, double-blind, positive-drug parallel-controlled and non-inferiority clinical study . International Journal of Rheumatic Diseases 19:3, pages 271-278.
Crossref
Jeffrey RosenVictoria AvramAnke FierlingerFaizan NiaziParag SanchetiAsheesh Bedi. (2016) Clinicians’ Perspectives on the Use of Intra-Articular Hyaluronic Acid as a Treatment for Knee Osteoarthritis: A North American, Multidisciplinary Survey. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 9, pages CMAMD.S34496.
Crossref
Seong Hoon Lim, Bo Young Hong, Jee Hae Oh & Jong In Lee. (2016) Effects of joint effusion on quadriceps muscles in patients with knee osteoarthritis. Physical Therapy in Sport 17, pages 14-18.
Crossref
David Jevsevar, Patrick Donnelly, Gregory A Brown & Deborah S Cummins. (2015) Viscosupplementation for Osteoarthritis of the Knee. The Journal of Bone and Joint Surgery-American Volume 97:24, pages 2047-2060.
Crossref
Raveendhara R. BannuruTimothy E. McAlindonMatthew C. SullivanJohn B. WongDavid M. KentChristopher H. Schmid. (2015) Effectiveness and Implications of Alternative Placebo Treatments. Annals of Internal Medicine 163:5, pages 365-372.
Crossref
Maurizio Rossini, Silvano Adami, Elena Fracassi, Ombretta Viapiana, Giovanni Orsolini, Maria Rosaria Povino, Luca Idolazzi & Davide Gatti. (2014) Effects of intra-articular clodronate in the treatment of knee osteoarthritis: results of a double-blind, randomized placebo-controlled trial. Rheumatology International 35:2, pages 255-263.
Crossref
R. Holtedahl, J. I. Brox & O. Tjomsland. (2015) Placebo effects in trials evaluating 12 selected minimally invasive interventions: a systematic review and meta-analysis. BMJ Open 5:1, pages e007331-e007331.
Crossref
Philip W. H. Peng & Hariharan Shankar. (2014) Ultrasound-Guided Interventional Procedures in Pain Medicine. Regional Anesthesia and Pain Medicine 39:5, pages 368-380.
Crossref
Larry E. MillerJon E. Block. (2013) US-Approved Intra-Articular Hyaluronic Acid Injections are Safe and Effective in Patients with Knee Osteoarthritis: Systematic Review and Meta-Analysis of Randomized, Saline-Controlled Trials. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 6, pages CMAMD.S12743.
Crossref
Sascha Colen, Michel P.J. van den Bekerom, Michiel Mulier & Daniël Haverkamp. (2012) Hyaluronic Acid in the Treatment of Knee Osteoarthritis. BioDrugs 26:4, pages 257-268.
Crossref
Sascha Colen, Michel P. J. van den Bekerom, Michiel Mulier & Daniël Haverkamp. (2012) Hyaluronic Acid in the Treatment of Knee Osteoarthritis. BioDrugs 26:4, pages 257-268.
Crossref
A. Borrás-Verdera, V. Calcedo-Bernal, J. Ojeda-Levenfeld & C. Clavel-Sainz. (2012) Efficacy and safety of a single intra-articular injection of 2% hyaluronic acid plus mannitol injection in knee osteoarthritis over a 6-month period. Revista Española de Cirugía Ortopédica y Traumatología (English Edition) 56:4, pages 274-280.
Crossref
A. Borrás-Verdera, V. Calcedo-Bernal, J. Ojeda-Levenfeld & C. Clavel-Sainz. (2012) Eficacia y seguridad de una única inyección intraarticular de ácido hialurónico al 2% más manitol en artrosis de rodilla durante un periodo de 6 meses. Revista Española de Cirugía Ortopédica y Traumatología 56:4, pages 274-280.
Crossref
Elizaveta Kon, Giuseppe Filardo, Matej Drobnic, Henning Madry, Mislav Jelic, Niek van Dijk & Stefano Della Villa. (2011) Non-surgical management of early knee osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy 20:3, pages 436-449.
Crossref
R.R. Bannuru, N.S. Natov, U.R. Dasi, C.H. Schmid & T.E. McAlindon. (2011) Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis – meta-analysis. Osteoarthritis and Cartilage 19:6, pages 611-619.
Crossref
Bo Young Hong, Jong In Lee, Hye Won Kim, Ye Rim Cho, Seong Hoon Lim & Young Jin Ko. (2011) Detectable Threshold of Knee Effusion by Ultrasonography in Osteoarthritis Patients. American Journal of Physical Medicine & Rehabilitation 90:2, pages 112-118.
Crossref
Y.R. Cho, B.Y. Hong, S.H. Lim, H.W. Kim, Y.J. Ko, S.A. Im & J.I. Lee. (2011) Effects of joint effusion on proprioception in patients with knee osteoarthritis: a single-blind, randomized controlled clinical trial. Osteoarthritis and Cartilage 19:1, pages 22-28.
Crossref
Don Kevin Lester & Kuan Zhang. (2010) Gait Analysis of Knee Arthritis Treated With Hyaluronic Acid. The Journal of Arthroplasty 25:8, pages 1290-1294.
Crossref
Mathilde Michon, Jérémie Sellam & Francis Berenbaum. 2010. Targeted Treatment of the Rheumatic Diseases. Targeted Treatment of the Rheumatic Diseases 303 316 .
Raveendhara R. Bannuru, Nikola S. Natov, Isi E. Obadan, Lori L. Price, Christopher H. Schmid & Timothy E. McAlindon. (2009) Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: A systematic review and meta-analysis. Arthritis & Rheumatism 61:12, pages 1704-1711.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.