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Research Article

Synthetic Drugs and Natural Products as Modulators of Constitutive Androstane Receptor (Car) and Pregnane X Receptor (PXR)

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Pages 51-73 | Published online: 09 Oct 2008

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Jie Zhang, Petr Pavek, Rajamanikkam Kamaraj, Li Ren & Tiehua Zhang. (2023) Dietary phytochemicals as modulators of human pregnane X receptor. Critical Reviews in Food Science and Nutrition 63:19, pages 3279-3301.
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David E. Amacher. (2016) The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors. Expert Opinion on Drug Metabolism & Toxicology 12:12, pages 1463-1477.
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Janne Hukkanen. (2012) Induction of cytochrome P450 enzymes: a view on human in vivo findings. Expert Review of Clinical Pharmacology 5:5, pages 569-585.
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Imen Ayed-Boussema, Jean Marc Pascussi, Karima Rjiba, Patrick Maurel, Hassen Bacha & Wafa Hassen. (2012) The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes. Drug and Chemical Toxicology 35:3, pages 241-250.
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J.-H. Tu, D.-L. Hu, L.-L. Dai, Y. Sun, L. Fan, M. Zhang, Z.-R. Tan, Y. Chen, Z. Li & H.-H. Zhou. (2010) Effect of glycyrrhizin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes. Xenobiotica 40:6, pages 393-399.
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Haishan Li & Hongbing Wang. (2010) Activation of xenobiotic receptors: driving into the nucleus. Expert Opinion on Drug Metabolism & Toxicology 6:4, pages 409-426.
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C. Emoto, Y. Yamato, Y. Sato, H. Ohshita, M. Katoh, C. Tateno, T. Yokoi, K. Yoshizato & K. Iwasaki. (2008) Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver. Xenobiotica 38:3, pages 239-248.
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