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Research Article

Phenobarbital Confers its Diverse Effects by Activating the Orphan Nuclear Receptor Car

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Pages 75-87 | Published online: 09 Oct 2008

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Yuki Yamasaki, Kaoru Kobayashi, Asumi Inaba, Daisuke Uehara, Hiroki Tojima, Satoru Kakizaki & Kan Chiba. (2018) Indirect activation of pregnane X receptor in the induction of hepatic CYP3A11 by high-dose rifampicin in mice. Xenobiotica 48:11, pages 1098-1105.
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Milu T Cherian, Sergio C Chai & Taosheng Chen. (2015) Small-molecule modulators of the constitutive androstane receptor. Expert Opinion on Drug Metabolism & Toxicology 11:7, pages 1099-1114.
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Zein Shaban Ibrahim, Mohamed Mohamed Ahmed, Samir Ahmed El-Shazly, Mayumi Ishizuka & Shoichi Fujita. (2014) Clofibric acid induces hepatic CYP 2B1/2 via constitutive androstane receptor not via peroxisome proliferator activated receptor alpha in rat. Bioscience, Biotechnology, and Biochemistry 78:9, pages 1550-1559.
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Vanessa Zancanella, Mery Giantin, Rosa Maria Lopparelli, Carlo Nebbia & Mauro Dacasto. (2012) Constitutive expression and phenobarbital modulation of drug metabolizing enzymes and related nuclear receptors in cattle liver and extra-hepatic tissues. Xenobiotica 42:11, pages 1096-1109.
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Haishan Li & Hongbing Wang. (2010) Activation of xenobiotic receptors: driving into the nucleus. Expert Opinion on Drug Metabolism & Toxicology 6:4, pages 409-426.
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Étienne Audet-Walsh, Sacha Auclair-Vincent & Alan Anderson. (2009) Glucocorticoids and phenobarbital induce murine CYP2B genes by independent mechanisms. Expert Opinion on Drug Metabolism & Toxicology 5:12, pages 1501-1511.
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Heike Sprenger, Josef Daniel Rasinger, Helen Hammer, Wael Naboulsi, Elke Zabinsky, Hannes Planatscher, Michael Schwarz, Oliver Poetz & Albert Braeuning. (2022) Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Archives of Toxicology 96:10, pages 2739-2754.
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Pengfei Zhao, Shicheng Fan, Yue Gao, Min Huang & Huichang Bi. (2022) Nuclear Receptor-Mediated Hepatomegaly and Liver Regeneration: An Update. Drug Metabolism and Disposition 50:5, pages 636-645.
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Yue Gao, Shicheng Fan, Hua Li, Yiming Jiang, Xinpeng Yao, Shuguang Zhu, Xiao Yang, Ruimin Wang, Jianing Tian, Frank J. Gonzalez, Min Huang & Huichang Bi. (2021) Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation. Acta Pharmaceutica Sinica B 11:3, pages 727-737.
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Siying Chang, Yang Su, Yuchen Sun, Xiangyu Meng, Baoming Shi & Anshan Shan. (2018) Response of the nuclear receptors PXR and CAR and their target gene mRNA expression in female piglets exposed to zearalenone. Toxicon 151, pages 111-118.
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Anton Bespalov, Reinhold Müller, Ana-Lucia Relo & Thomas Hudzik. (2016) Drug Tolerance: A Known Unknown in Translational Neuroscience. Trends in Pharmacological Sciences 37:5, pages 364-378.
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Lauren M. Slosky, Brandon J. Thompson, Lucy Sanchez-Covarrubias, Yifeng Zhang, Mei-Li Laracuente, Todd W. Vanderah, Patrick T. Ronaldson & Thomas P. Davis. (2013) Acetaminophen Modulates P-Glycoprotein Functional Expression at the Blood-Brain Barrier by a Constitutive Androstane Receptor–Dependent Mechanism. Molecular Pharmacology 84:5, pages 774-786.
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V. Zancanella, M. Giantin, R. M. Lopparelli, C. Nebbia & M. Dacasto. (2013) Tissue distribution and phenobarbital induction of target SLC- and ABC- transporters in cattle. Journal of Veterinary Pharmacology and Therapeutics 36:4, pages 358-369.
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Ryota Shizu, Sawako Shindo, Takemi Yoshida & Satoshi Numazawa. (2013) Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression. Toxicology Letters 219:2, pages 143-150.
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Kosuke Saito, Rick Moore & Masahiko Negishi. (2013) Nuclear Receptor CAR Specifically Activates the Two-Pore K+ Channel Kcnk1 Gene in Male Mouse Livers, Which Attenuates Phenobarbital-Induced Hepatic Hyperplasia. Toxicological Sciences 132:1, pages 151-161.
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David M. Stresser & George Zhang. 2013. High‐Throughput Screening Methods in Toxicity Testing. High‐Throughput Screening Methods in Toxicity Testing 453 477 .
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Ryota Shizu, Sawako Shindo, Takemi Yoshida & Satoshi Numazawa. (2012) MicroRNA-122 Down-Regulation Is Involved in Phenobarbital-Mediated Activation of the Constitutive Androstane Receptor. PLoS ONE 7:7, pages e41291.
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Abdelrahman S. Mayhoub. (2012) Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure–activity and resistance relationships; different scaffolds and mutations. Bioorganic & Medicinal Chemistry 20:10, pages 3150-3161.
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Hiroki Kamino & Masahiko Negishi. (2011) The nuclear receptor constitutive active/androstane receptor arrests DNA‐damaged human hepatocellular carcinoma Huh7 cells at the G2/M phase. Molecular Carcinogenesis 51:2, pages 206-212.
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Albert Braeuning, Yvonne Heubach, Thomas Knorpp, Marta Anna Kowalik, Markus Templin, Amedeo Columbano & Michael Schwarz. (2011) Gender-Specific Interplay of Signaling through β-Catenin and CAR in the Regulation of Xenobiotic-Induced Hepatocyte Proliferation. Toxicological Sciences 123:1, pages 113-122.
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Maria Pakharukova, Mariya Smetanina, Vasily Kaledin, Timofey Obut & Tatiana Merkulova. (2010) The increased CAR-dependent metabolism of thyroid hormones in mice with high cancer susceptibility. Life Sciences 87:13-14, pages 439-444.
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Subhajit Mukherjee & Sridhar Mani. (2010) Orphan Nuclear Receptors as Targets for Drug Development. Pharmaceutical Research 27:8, pages 1439-1468.
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Yu-Kun Jennifer Zhang, Kurt W. Saupe & Curtis D. Klaassen. (2010) Energy Restriction Does Not Compensate for the Reduced Expression of Hepatic Drug-Processing Genes in Mice with Aging. Drug Metabolism and Disposition 38:7, pages 1122-1131.
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Kamila Ambroziak, Konstantin Kuteykin-Teplyakov, Carlos Luna-T?rtos, Marwan Al-Falah, Maren Fedrowitz & Wolfgang L?scher. (2010) Exposure to antiepileptic drugs does not alter the functionality of P-glycoprotein in brain capillary endothelial and kidney cell lines. European Journal of Pharmacology 628:1-3, pages 57-66.
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Thomas K. H. Chang. (2009) Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines. The AAPS Journal 11:3.
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Bingning Dong, Mohammed Qatanani & David D. Moore. (2009) Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes. Hepatology 50:2, pages 622-629.
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Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz & Andrej Skerjanec. (2009) In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective. Drug Metabolism and Disposition 37:7, pages 1339-1354.
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