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A.B. Sanchez-Spitman, J.J. Swen, V.O. Dezentje, D.J.A.R. Moes, H. Gelderblom & H.J. Guchelaar. (2019) Clinical pharmacokinetics and pharmacogenetics of tamoxifen and endoxifen. Expert Review of Clinical Pharmacology 12:6, pages 523-536.
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Jing Luo, Bowei Zhang, Likun Cui, Tong Liu & Yi Gu. (2019)
Fmo1 Gene Expression Independently Predicts Favorable Recurrence-Free Survival of Classical Papillary Thyroid Cancer. Future Oncology 15:12, pages 1303-1311.
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Barbara Fedejko-Kap, Magdalena Niemira, Anna Radominska-Pandya & Zofia Mazerska. (2011) Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells. Xenobiotica 41:12, pages 1044-1055.
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Elizabeth A Shephard & Ian R Phillips. (2010) The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 6:9, pages 1083-1094.
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Meike S Motika, Jun Zhang & John R Cashman. (2007) Flavin-containing monooxygenase 3 and human disease. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 831-845.
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Articles from other publishers (40)
Melissa De Angelis, Silvia Schobesberger, Florian Selinger, Viktor Laurin Sedlmayr, Martin Frauenlob, Orsola Corcione, Shiman Dong, Gianfranco Gilardi, Peter Ertl & Sheila J. Sadeghi. (2024) A multi-channel microfluidic platform based on human flavin-containing monooxygenase 3 for personalised medicine. RSC Advances 14:19, pages 13209-13217.
Crossref
Crossref
Marta Gawryś-Kopczyńska, Mateusz Szudzik, Emilia Samborowska, Marek Konop, Dawid Chabowski, Maksymilian Onyszkiewicz & Marcin Ufnal. (2024) Spontaneously hypertensive rats exhibit increased liver flavin monooxygenase expression and elevated plasma TMAO levels compared to normotensive and Ang II-dependent hypertensive rats. Frontiers in Physiology 15.
Crossref
Crossref
Sandy Che-Eun S. Lee, Andrea Hye An Pyo & Marianne Koritzinsky. (2023) Longitudinal dynamics of the tumor hypoxia response: From enzyme activity to biological phenotype. Science Advances 9:47.
Crossref
Crossref
Longfei Wang, Hongchu Zha, Jing Huang & Lang Shi. (2023) Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation. International Journal of Molecular Medicine 52:5.
Crossref
Crossref
Shiqi Zhang, Dong Yi, Guang-xun Li, Yun Deng, Xin Cui, Yin Tian & Zhuo Tang. (2023)
Biomimetic Dynamic Kinetic Asymmetric
N
-Oxidation with H
2
O
2
and O
2
. ACS Catalysis 13:18, pages 11954-11962.
Crossref
Crossref
Xumeng Gong, Dong Hou, Shengning Zhou, Jianan Tan, Guangyu Zhong, Bing Yang, Lang Xie, Fanghai Han & Lin Zhong. (2023) FMO family may serve as novel marker and potential therapeutic target for the peritoneal metastasis in gastric cancer. Frontiers in Oncology 13.
Crossref
Crossref
Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
Crossref
Crossref
Hanna Cheropkina, Gianluca Catucci, Arianna Marucco, Ivana Fenoglio, Gianfranco Gilardi & Sheila J. Sadeghi. (2021) Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate. Biochemical Pharmacology 193, pages 114763.
Crossref
Crossref
David E. Williams. (2021) Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane. Frontiers in Nutrition 8.
Crossref
Crossref
Kong-Xiang Zhu, Pei-Yuan Song, He-Li, Mu-Peng Li, Yin-xiao Du, Qi-lin Ma, Li-Ming Peng & Xiao-Ping Chen. (2020) Association of FMO3 rs1736557 polymorphism with clopidogrel response in Chinese patients with coronary artery disease. European Journal of Clinical Pharmacology 77:3, pages 359-368.
Crossref
Crossref
Stefania Bortolussi, Gianluca Catucci, Gianfranco Gilardi & Sheila J. Sadeghi. (2021) N- and S-oxygenation activity of truncated human flavin-containing monooxygenase 3 and its common polymorphic variants. Archives of Biochemistry and Biophysics 697, pages 108663.
Crossref
Crossref
Gianluca Catucci, Gianfranco Gilardi & Sheila J. Sadeghi. (2020) Production of drug metabolites by human FMO3 in Escherichia coli. Microbial Cell Factories 19:1.
Crossref
Crossref
G. Catucci, D. Aramini, S.J. Sadeghi & G. Gilardi. (2020) Ligand stabilization and effect on unfolding by polymorphism in human flavin-containing monooxygenase 3. International Journal of Biological Macromolecules 162, pages 1484-1493.
Crossref
Crossref
Callum R. Nicoll, Gautier Bailleul, Filippo Fiorentini, María Laura Mascotti, Marco W. Fraaije & Andrea Mattevi. (2019) Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs. Nature Structural & Molecular Biology 27:1, pages 14-24.
Crossref
Crossref
Gianluca Catucci, Stefania Bortolussi, Giulia Rampolla, Debora Cusumano, Gianfranco Gilardi & Sheila J. Sadeghi. (2018) Flavin‐Containing Monooxygenase 3 Polymorphic Variants Significantly Affect Clearance of Tamoxifen and Clomiphene. Basic & Clinical Pharmacology & Toxicology 123:6, pages 687-691.
Crossref
Crossref
Myeong-Sang Yu, Hyang-Mi Lee, Aaron Park, Chungoo Park, Hyithaek Ceong, Ki-Hyeong Rhee & Dokyun Na. (2018) In silico prediction of potential chemical reactions mediated by human enzymes. BMC Bioinformatics 19:S8.
Crossref
Crossref
Marco E. Franco, Grace E. Sutherland & Ramon Lavado. (2018) Xenobiotic metabolism in the fish hepatic cell lines Hepa-E1 and RTH-149, and the gill cell lines RTgill-W1 and G1B: Biomarkers of CYP450 activity and oxidative stress. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 206-207, pages 32-40.
Crossref
Crossref
J.R. Cashman. 2018. Comprehensive Toxicology. Comprehensive Toxicology
87
125
.
Hye In Woo, Se Kyung Lee, Jiyoung Kim, Seok Won Kim, Jonghan Yu, Soo Youn Bae, Jeong Eon Lee, Seok Jin Nam & Soo-Youn Lee. (2017) Variations in plasma concentrations of tamoxifen metabolites and the effects of genetic polymorphisms on tamoxifen metabolism in Korean patients with breast cancer. Oncotarget 8:59, pages 100296-100311.
Crossref
Crossref
Barry C. Jones, Abhishek Srivastava, Nicola Colclough, Joanne Wilson, Venkatesh Pilla Reddy, Sara Amberntsson & Danxi Li. (2017) An Investigation into the Prediction of In Vivo Clearance for a Range of Flavin-containing Monooxygenase Substrates. Drug Metabolism and Disposition 45:10, pages 1060-1067.
Crossref
Crossref
Silvia Castrignanò, Stefania Bortolussi, Gianluca Catucci, Omkolsum Gholami, Francesca Valetti, Gianfranco Gilardi & Sheila J. Sadeghi. (2017) Bioelectrochemical profiling of two common polymorphic variants of human FMO3 in presence of graphene oxide. Electrochimica Acta 228, pages 611-618.
Crossref
Crossref
Kui-Jin Kim, Kye-Yoon Yoon, Hee-Do Hong & Boo-Yong Lee. (2015) Role of the Red Ginseng in Defense against the Environmental Heat Stress in Sprague Dawley Rats. Molecules 20:11, pages 20240-20253.
Crossref
Crossref
Yeon-Su Lee, Bo Hyun Kim, Byung Chul Kim, Aesun Shin, Jin Sook Kim, Seung-Hyun Hong, Jung-Ah Hwang, Jung Ahn Lee, Seungyoon Nam, Sung Hoon Lee, Jong Bhak & Joong-Won Park. (2015) SLC15A2 genomic variation is associated with the extraordinary response of sorafenib treatment: whole-genome analysis in patients with hepatocellular carcinoma. Oncotarget 6:18, pages 16449-16460.
Crossref
Crossref
Silvia Castrignanò, Gianfranco Gilardi & Sheila J. Sadeghi. (2015) Human Flavin-Containing Monooxygenase 3 on Graphene Oxide for Drug Metabolism Screening. Analytical Chemistry 87:5, pages 2974-2980.
Crossref
Crossref
Nadine A. Binai, Gert Carra, Johannes Löwer, Roswitha Löwer & Silja Wessler. (2013) Differential gene expression in ERα-positive and ERα-negative breast cancer cells upon leptin stimulation. Endocrine 44:2, pages 496-503.
Crossref
Crossref
Martin Otto Behm. 2013. Pediatric Drug Development. Pediatric Drug Development
292
305
.
Duygu Yeniceli, Xiaolan Deng, Erwin Adams, Dilek Dogrukol‐Ak & Ann Van Schepdael. (2012) Development of a CD‐MEKC method for investigating the metabolism of tamoxifen by flavin‐containing monooxygenases and the inhibitory effects of methimazole, nicotine and DMXAA. ELECTROPHORESIS 34:3, pages 463-470.
Crossref
Crossref
Jennifer Gjerde, Sara Gandini, Aliana Guerrieri-Gonzaga, Line L. Haugan Moi, Valentina Aristarco, Gunnar Mellgren, Andrea DeCensi & Ernst A. Lien. (2012) Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide. Breast Cancer Research and Treatment 134:2, pages 693-700.
Crossref
Crossref
Vita Dolžan. 2012. Pharmacogenetics and Individualized Therapy. Pharmacogenetics and Individualized Therapy
13
80
.
Hui Lin, Jing-Yuan Liu, Hai-Bo Wang, Abeer Ahmed Qaed Ahmed & Zhong-Liu Wu. (2011) Biocatalysis as an alternative for the production of chiral epoxides: A comparative review. Journal of Molecular Catalysis B: Enzymatic 72:3-4, pages 77-89.
Crossref
Crossref
Bhupendra Singh, Nimee K. Bhat & Hari K. Bhat. (2011) Partial Inhibition of Estrogen-Induced Mammary Carcinogenesis in Rats by Tamoxifen: Balance between Oxidant Stress and Estrogen Responsiveness. PLoS ONE 6:9, pages e25125.
Crossref
Crossref
Agnieszka Potega, Emilia Dabrowska, Magdalena Niemira, Agata Kot-Wasik, Sebastien Ronseaux, Colin J. Henderson, C. Roland Wolf & Zofia Mazerska. (2011) The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s. Drug Metabolism and Disposition 39:8, pages 1423-1432.
Crossref
Crossref
S.F. Teunissen, H. Rosing, M. Dominguez Seoane, L. Brunsveld, J.H.M. Schellens, A.H. Schinkel & J.H. Beijnen. (2011) Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques. Journal of Pharmaceutical and Biomedical Analysis 55:3, pages 518-526.
Crossref
Crossref
Annica Tevell Åberg, Helena Löfgren, Ulf Bondesson & Mikael Hedeland. (2010)
Structural elucidation of
N
‐oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of
Cunninghamella elegans
to facilitate drug metabolite identification
. Rapid Communications in Mass Spectrometry 24:10, pages 1447-1456.
Crossref
Crossref
Sheila J. SadeghiRita MeirinhosGianluca CatucciVikash R. DodhiaGiovanna Di NardoGianfranco Gilardi. (2009) Direct Electrochemistry of Drug Metabolizing Human Flavin-Containing Monooxygenase: Electrochemical Turnover of Benzydamine and Tamoxifen. Journal of the American Chemical Society 132:2, pages 458-459.
Crossref
Crossref
J.R. Cashman & M.S. Motika. 2010. Comprehensive Toxicology. Comprehensive Toxicology
77
110
.
Bernard Testa & Stefanie D. Krämer. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:5, pages 591-684.
Crossref
Crossref
Ahmed Kousba, Richard Soll, Shiyin Yee & Michael Martin. (2007)
Cyclic Conversion of the Novel Src Kinase Inhibitor [7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its
N
-Oxide Metabolite by Flavin-Containing Monoxygenases and Cytochrome P450 Reductase
. Drug Metabolism and Disposition 35:12, pages 2242-2251.
Crossref
Crossref
Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha & Michael Martin. (2007)
Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active
N
-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
. Drug Metabolism and Disposition 35:6, pages 929-936.
Crossref
Crossref
Reuven Rasooly, Darshan S. Kelley, Jeff Greg & Bruce E. Mackey. (2007)
Dietary
trans
10,
cis
12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver
. British Journal of Nutrition 97:1, pages 58-66.
Crossref
Crossref