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Research Article

Organophosphorus Chemicals: Potent Inhibitors of the Human Metabolism of Steroid Hormones and Xenobiotics

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Pages 149-162 | Published online: 09 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Juan Pablo Martínez-Mercado, Adolfo Sierra-Santoyo, Francisco Alberto Verdín-Betancourt, Aurora Elizabeth Rojas-García & Betzabet Quintanilla-Vega. (2022) Temephos, an organophosphate larvicide for residential use: a review of its toxicity. Critical Reviews in Toxicology 52:2, pages 113-124.
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Lisa Chedik, Arnaud Bruyere & Olivier Fardel. (2019) Interactions of organophosphorus pesticides with solute carrier (SLC) drug transporters. Xenobiotica 49:3, pages 363-374.
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James Gomes & OwenL. Lloyd. (2009) Oral exposure of mice to formulations of organophosphorous pesticides: gestational and litter outcomes. International Journal of Environmental Health Research 19:2, pages 125-137.
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Kamil Musilek, Ondrej Holas, Kamil Kuca, Daniel Jun, Vlastimil Dohnal, Veronika Opletalova & Martin Dolezal. (2008) Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry 23:1, pages 70-76.
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Lesley A. Stanley. 2003. Patty's Toxicology. Patty's Toxicology 1 24 .
Dileshwar Kumar, Sukesh Narayan Sinha & Kasturi Vasudev. (2023) Development and Validation of a New UFLC–MS/MS Method for the Detection of Organophosphate Pesticide Metabolites in Urine. Molecules 28:15, pages 5800.
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Homa Sadeghi, Charles F. Lynch, William R. Field, Linda G. Snetselaar, Michael P. Jones, Rashmi Sinha & James C. Torner. (2023) Dietary omega-6/omega-3 fatty acids and risk of prostate cancer; Is there any potential interaction by organophosphate insecticides among the agricultural health study population. Cancer Epidemiology 85, pages 102410.
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Ángel Ramos-Flores, Israel Camacho-Hernández, Adolfo Sierra-Santoyo, María de Jesús Solís-Heredia, Francisco Alberto Verdín-Betancourt, Lyda Yuliana Parra-Forero, Ma de Lourdes López-González, Isabel Hernández-Ochoa & Betzabet Quintanilla-Vega. (2021) Temephos Decreases Sperm Quality and Fertilization Rate and Is Metabolized in Rat Reproductive Tissues at Low-Dose Exposure. Toxicological Sciences 184:1, pages 57-66.
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Francisco Alberto Verdín-Betancourt, Mario Figueroa, Alicia Guadalupe Soto-Ramos, Ma. de Lourdes López-González, Gilberto Castañeda-Hernández, Yael Yvette Bernal-Hernández, Aurora Elizabeth Rojas-García & Adolfo Sierra-Santoyo. (2021) Toxicokinetics of temephos after oral administration to adult male rats. Archives of Toxicology 95:3, pages 935-947.
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Karen E. Larsen, Adrián L. Lifschitz, Carlos E. Lanusse & Guillermo L. Virkel. (2019) In vitro and in vivo effects of chlorpyrifos and cypermethrin on blood cholinesterases in sheep. Journal of Veterinary Pharmacology and Therapeutics 42:5, pages 548-555.
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Fangwei Yang, Jinwang Li, Guofang Pang, Fazheng Ren & Bing Fang. (2019) Effects of Diethyl Phosphate, a Non-Specific Metabolite of Organophosphorus Pesticides, on Serum Lipid, Hormones, Inflammation, and Gut Microbiota. Molecules 24:10, pages 2003.
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Traci Clymer, Vanessa Vargas, Eric Corcoran, Robin Kleinberg & Jakub Kostal. (2019) Redesigning hazardous chemicals by learning from structure-based drug discovery. Green Chemistry 21:8, pages 1935-1946.
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E. Hodgson & S.A. Meyer. 2018. Comprehensive Toxicology. Comprehensive Toxicology 538 574 .
Lawrence S. Engel, Emily Werder, Jaya Satagopan, Aaron Blair, Jane A. Hoppin, Stella Koutros, Catherine C. Lerro, Dale P. Sandler, Michael C. Alavanja & Laura E. Beane Freeman. (2017) Insecticide Use and Breast Cancer Risk among Farmers’ Wives in the Agricultural Health Study. Environmental Health Perspectives 125:9.
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GURPREET KAUR, A. K. JAIN & SANDEEP SINGH. (2017) CYP/PON genetic variations as determinant of organophosphate pesticides toxicity. Journal of Genetics 96:1, pages 187-201.
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Jonathan G. Stine & Naga P. Chalasani. (2017) Drug Hepatotoxicity. Clinics in Liver Disease 21:1, pages 103-113.
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Carol H. Christensen, Kathryn Hughes Barry, Gabriella Andreotti, Michael C. R. Alavanja, Michael B. Cook, Scott P. Kelly, Laurie A. Burdett, Meredith Yeager, Laura E. Beane Freeman, Sonja I. Berndt & Stella Koutros. (2016) Sex Steroid Hormone Single-Nucleotide Polymorphisms, Pesticide Use, and the Risk of Prostate Cancer: A Nested Case–Control Study within the Agricultural Health Study. Frontiers in Oncology 6.
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Lalit K. S. Chauhan, Meenu Varshney, Vibha Pandey, Preeti Sharma, Vipin K. Verma, P. Kumar & Sudhir K. Goel. (2016) ROS-dependent genotoxicity, cell cycle perturbations and apoptosis in mouse bone marrow cells exposed to formulated mixture of cypermethrin and chlorpyrifos. Mutagenesis 31:6, pages 635-642.
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Alessia De Felice, Aldina Venerosi, Laura Ricceri, Mara Sabbioni, Maria Luisa Scattoni, Flavia Chiarotti & Gemma Calamandrei. (2014) Sex-dimorphic effects of gestational exposure to the organophosphate insecticide chlorpyrifos on social investigation in mice. Neurotoxicology and Teratology 46, pages 32-39.
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T. Berman, R. Goldsmith, T. Göen, J. Spungen, L. Novack, H. Levine, Y. Amitai, T. Shohat & I. Grotto. (2013) Urinary concentrations of organophosphate pesticide metabolites in adults in Israel: Demographic and dietary predictors. Environment International 60, pages 183-189.
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Vasilis P. Androutsopoulos, Antonio F. Hernandez, Jyrki Liesivuori & Aristidis M. Tsatsakis. (2013) A mechanistic overview of health associated effects of low levels of organochlorine and organophosphorous pesticides. Toxicology 307, pages 89-94.
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Jane A Hoppin, Stuart Long, David M Umbach, Jay H Lubin, Sarah E Starks, Fred Gerr, Kent Thomas, Cynthia J Hines, Scott Weichenthal, Freya Kamel, Stella Koutros, Michael Alavanja, Laura E Beane Freeman & Dale P Sandler. (2012) Lifetime organophosphorous insecticide use among private pesticide applicators in the Agricultural Health Study. Journal of Exposure Science & Environmental Epidemiology 22:6, pages 584-592.
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Corie A. Ellison, Alice L. Crane & James R. Olson. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 685 702 .
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Stella Koutros, Gabriella Andreotti, Sonja I. Berndt, Kathryn Hughes Barry, Jay H. Lubin, Jane A. Hoppin, Freya Kamel, Dale P. Sandler, Laurie A. Burdette, Jeffrey Yuenger, Meredith Yeager, Michael C.R. Alavanja & Laura E. Beane Freeman. (2011) Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer. Pharmacogenetics and Genomics 21:10, pages 615-623.
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Andrew C. Povey. (2010) Gene–environmental interactions and organophosphate toxicity. Toxicology 278:3, pages 294-304.
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N. Schmeisser, L. Kaerlev, N. Bourdon-Raverdy, O. Ganry, A. Llopis-González, P. Guénel, L. Hardell, F. Merletti, P. Zambon, M. Morales-Suárez-Varela, J. Olsen, H. Olsson, M. Vyberg & W. Ahrens. (2010) Occupational exposure to pesticides and bile tract carcinoma in men: results from a European multicenter case–control study. Cancer Causes & Control 21:9, pages 1493-1502.
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J Gomes, OL Lloyd & Z Hong. (2008) Oral exposure of male and female mice to formulations of organophosphorous pesticides: congenital malformations. Human & Experimental Toxicology 27:3, pages 231-240.
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Thérèse Sergent, Laurence Ribonnet, Anna Kolosova, Serge Garsou, Annelore Schaut, Sarah De Saeger, Carlos Van Peteghem, Yvan Larondelle, Luc Pussemier & Yves-Jacques Schneider. (2008) Molecular and cellular effects of food contaminants and secondary plant components and their plausible interactions at the intestinal level. Food and Chemical Toxicology 46:3, pages 813-841.
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Kamil Musilek, Ondrej Holas, Kamil Kuca, Daniel Jun, Vlastimil Dohnal & Martin Dolezal. (2006) Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters 16:21, pages 5673-5676.
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