406
Views
78
CrossRef citations to date
0
Altmetric
Research Article

Sex and the Liver – A Journey Through Five Decades

&
Pages 197-207 | Published online: 09 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Tara L. Conforto, Yijing Zhang, Jennifer Sherman & David J. Waxman. (2012) Impact of CUX2 on the Female Mouse Liver Transcriptome: Activation of Female-Biased Genes and Repression of Male-Biased Genes. Molecular and Cellular Biology 32:22, pages 4611-4627.
Read now
Yijing Zhang, Ekaterina V. Laz & David J. Waxman. (2012) Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse Liver. Molecular and Cellular Biology 32:4, pages 880-896.
Read now
Katalin Monostory, Jean-Marc Pascussi, László Kóbori & Zdenek Dvorak. (2009) Hormonal regulation of CYP1A expression. Drug Metabolism Reviews 41:4, pages 547-572.
Read now
Mutsuko Hirata-Koizumi, Takashi Matsuyama, Toshio Imai, Akihiko Hirose, Eiichi Kamata & Makoto Ema. (2008) Lack of Gender-Related Difference in the Toxicity of 2-(2′-Hydroxy-3′,5′-di--butylphenyl)benzotriazole in Preweaning Rats. Drug and Chemical Toxicology 31:2, pages 275-287.
Read now

Articles from other publishers (74)

Alan Talevi & Carolina Leticia Bellera. 2024. ADME Processes in Pharmaceutical Sciences. ADME Processes in Pharmaceutical Sciences 81 110 .
Leandro Fernández-Pérez, Borja Guerra, Carlota Recio, Juan José Cabrera-Galván, Irma García, Juan Vladimir De La Rosa, Antonio Castrillo, Diego Iglesias-Gato & Mario Díaz. (2023) Transcriptomic and lipid profiling analysis reveals a functional interplay between testosterone and growth hormone in hypothyroid liver. Frontiers in Endocrinology 14.
Crossref
G. A. Belitsky, K. I. Kirsanov, E. A. Lesovaya, V. P. Maksimova, L. V. Krivosheeva & M. G. Yakubovskaya. (2023) Sexual dimorphism in cancer. Advances in Molecular Oncology 10:3, pages 24-35.
Crossref
Xiaoyu Zhao, Yuanyuan Zhang, Ting Yu, Ling Cai, Junlang Liang, Zhong Chen, Chenyuan Pan & Ming Yang. (2023) Transcriptomics-based analysis of sex-differentiated mechanisms of hepatotoxicity in zebrafish after long-term exposure to bisphenol AF. Ecotoxicology and Environmental Safety 262, pages 115324.
Crossref
Fatemeh Mahboobifard, Mohammad H. Pourgholami, Masoumeh Jorjani, Leila Dargahi, Mina Amiri, Somaye Sadeghi & Fahimeh Ramezani Tehrani. (2022) Estrogen as a key regulator of energy homeostasis and metabolic health. Biomedicine & Pharmacotherapy 156, pages 113808.
Crossref
Stéphanie Abo, Delaney Smith, Melissa Stadt & Anita Layton. (2022) Modelling female physiology from head to Toe: Impact of sex hormones, menstrual cycle, and pregnancy. Journal of Theoretical Biology 540, pages 111074.
Crossref
Joana I. Almeida, Miguel F. Tenreiro, Lucía Martinez-Santamaria, Sara Guerrero-Aspizua, Javier P. Gisbert, Paula M. Alves, Margarida Serra & Pedro M. Baptista. (2022) Hallmarks of the human intestinal microbiome on liver maturation and function. Journal of Hepatology 76:3, pages 694-725.
Crossref
Alan Talevi & Carolina L. Bellera. 2022. The ADME Encyclopedia. The ADME Encyclopedia 479 485 .
Tai-Jay Chang, Cheng-Yuan Hsia, Gar-Yang Chau, Liang-Tsai Hsiao, Kuang-Tzu Huang, Kung-Liang King, Wing-Yiu Lui, Anna F.-Y. Li, Chia-Lin Wang, Pin-Hsing Tsai, Yueh Chien & Ta-Hsien Lin. (2021) Characterization of Androgen Receptor Complex Associated Protein (ARCAP) in hepatocellular carcinoma and liver. Journal of the Chinese Medical Association 84:12, pages 1100-1108.
Crossref
Mariano Schiffrin, Carine Winkler, Laure Quignodon, Aurélien Naldi, Martin Trötzmüller, Harald Köfeler, Hugues Henry, Paolo Parini, Béatrice Desvergne & Federica Gilardi. (2021) Sex Dimorphism of Nonalcoholic Fatty Liver Disease (NAFLD) in Pparg-Null Mice. International Journal of Molecular Sciences 22:18, pages 9969.
Crossref
Mara H. O’Brien, Henry C. Pitot, Sang-Hyuk Chung, Paul F. Lambert, Norman R. Drinkwater & Andrea Bilger. (2021) Estrogen Receptor-α Suppresses Liver Carcinogenesis and Establishes Sex-Specific Gene Expression. Cancers 13:10, pages 2355.
Crossref
Luma MeloKaren TilmantAmit HagarJames E. Klaunig. (2021) Effect of endurance exercise training on liver gene expression in male and female mice. Applied Physiology, Nutrition, and Metabolism 46:4, pages 356-367.
Crossref
Alan Talevi & Carolina Bellera. 2021. The ADME Encyclopedia. The ADME Encyclopedia 1 7 .
Sara Della Torre. (2020) Non-alcoholic Fatty Liver Disease as a Canonical Example of Metabolic Inflammatory-Based Liver Disease Showing a Sex-Specific Prevalence: Relevance of Estrogen Signaling. Frontiers in Endocrinology 11.
Crossref
Leandro Fernández-Pérez, Mercedes de Mirecki-Garrido, Carlota Recio & Borja Guerra. 2020. Chemistry and Biological Activity of Steroids. Chemistry and Biological Activity of Steroids.
Q Hu, H Tian & H Xiao. (2019) Effects of temperature and sex steroids on sex ratio, growth, and growth-related gene expression in the Chinese giant salamander Andrias davidianus. Aquatic Biology 28, pages 79-90.
Crossref
Mathis Grossmann, Margaret E Wierman, Peter Angus & David J Handelsman. (2019) Reproductive Endocrinology of Nonalcoholic Fatty Liver Disease. Endocrine Reviews 40:2, pages 417-446.
Crossref
Nico Buettner & Robert Thimme. (2018) Sexual dimorphism in hepatitis B and C and hepatocellular carcinoma. Seminars in Immunopathology 41:2, pages 203-211.
Crossref
Seung-Soo Kim & Cheol-Koo Lee. (2019) Growth signaling and longevity in mouse models. BMB Reports 52:1, pages 70-85.
Crossref
Sara Della Torre, Nico Mitro, Clara Meda, Federica Lolli, Silvia Pedretti, Matteo Barcella, Luisa Ottobrini, Daniel Metzger, Donatella Caruso & Adriana Maggi. (2018) Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver. Cell Metabolism 28:2, pages 256-267.e5.
Crossref
T Kobets & GM. Williams. 2018. Comprehensive Toxicology. Comprehensive Toxicology 409 442 .
Qin Qiao, Séverine Le Manach, Benoit Sotton, Hélène Huet, Evelyne Duvernois-Berthet, Alain Paris, Charlotte Duval, Loïc Ponger, Arul Marie, Alain Blond, Lucrèce Mathéron, Joelle Vinh, Gérard Bolbach, Chakib Djediat, Cécile Bernard, Marc Edery & Benjamin Marie. (2016) Deep sexual dimorphism in adult medaka fish liver highlighted by multi-omic approach. Scientific Reports 6:1.
Crossref
Misaki Kojima & Masakuni Degawa. (2016) Sex differences in constitutive mRNA levels of CYP2B22, CYP2C33, CYP2C49, CYP3A22, CYP3A29 and CYP3A46 in the pig liver: Comparison between Meishan and Landrace pigs. Drug Metabolism and Pharmacokinetics 31:3, pages 185-192.
Crossref
Andrea Clocchiatti, Elisa Cora, Yosra Zhang & G. Paolo Dotto. (2016) Sexual dimorphism in cancer. Nature Reviews Cancer 16:5, pages 330-339.
Crossref
Chizuka Sakai, Shunsuke Iwano, Makiko Shimizu, Jun Onodera, Masashi Uchida, Eri Sakurada, Yuri Yamazaki, Yoshiji Asaoka, Naoko Imura, Yasuhiro Uno, Norie Murayama, Ryoji Hayashi, Hiroshi Yamazaki & Yohei Miyamoto. (2016) Analysis of gene expression for microminipig liver transcriptomes using parallel long‐read technology and short‐read sequencing. Biopharmaceutics & Drug Disposition 37:4, pages 220-232.
Crossref
Andrzej Bartke, Edward O. List & John J. Kopchick. (2016) The somatotropic axis and aging: Benefits of endocrine defects. Growth Hormone & IGF Research 27, pages 41-45.
Crossref
Leandro Fern?ndez-P?rez, Mercedes de Mirecki-Garrido, Borja Guerra, Mario D?az & Juan Carlos D?az-Chico. (2016) Sex steroids and growth hormone interactions. Endocrinolog?a y Nutrici?n 63:4, pages 171-180.
Crossref
Leandro Fern?ndez-P?rez, Mercedes de Mirecki-Garrido, Borja Guerra, Mario D?az & Juan Carlos D?az-Chico. (2016) Sex steroids and growth hormone interactions. Endocrinolog?a y Nutrici?n (English Edition) 63:4, pages 171-180.
Crossref
Valerie Leduc, Lucienne Bourque, Judes Poirier & Robert Dufour. (2016) Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia. Pharmacogenetics and Genomics 26:1, pages 1-11.
Crossref
Geert J. de Vries & Nancy G. Forger. (2015) Sex differences in the brain: a whole body perspective. Biology of Sex Differences 6:1.
Crossref
Amandeep Singh Arora, Saima Zafar, Otto Kollmar, Franc Llorens, Waqas Tahir, Sven Vanselow, Prateek Kumar, Mary Jo Schmerr, Matthias Schmitz & Inga Zerr. (2015) Application of capillary immunoelectrophoresis revealed an age‐ and gender‐dependent regulated expression of PrPC in liver. ELECTROPHORESIS 36:24, pages 3026-3033.
Crossref
Nancy G. Forger, Geert J. de Vries & S. Marc Breedlove. 2015. Knobil and Neill's Physiology of Reproduction. Knobil and Neill's Physiology of Reproduction 2109 2155 .
Christopher T. McNabb, Michelle M. White, Amber L. Harris & Perry N. Fuchs. (2014) The elusive rat model of conditioned placebo analgesia. Pain 155:10, pages 2022-2032.
Crossref
Leandro Fern?ndez-P?rez, Ruym?n Santana-Farr?Mercedes de Mirecki-Garrido, Irma Garc?a, Borja Guerra, Carlos Mateo-D?az, Diego Iglesias-Gato, Juan Carlos D?az-Chico, Amilcar Flores-Morales & Mario D?az. (2014) Lipid Profiling and Transcriptomic Analysis Reveals a Functional Interplay between Estradiol and Growth Hormone in Liver. PLoS ONE 9:5, pages e96305.
Crossref
Misaki Kojima & Masakuni Degawa. (2014) Sex Differences in the Constitutive Gene Expression of Sulfotransferases and UDP-glucuronosyltransferases in the Pig Liver: Androgen-mediated Regulation. Drug Metabolism and Pharmacokinetics 29:2, pages 192-197.
Crossref
Kerstin Albertsson-Wikland, Berit Kriström, Elena Lundberg, A. Stefan Aronson, Jan Gustafsson, Lars Hagenäs, Sten-A. Ivarsson, Björn Jonsson, Martin Ritzén, Torsten Tuvemo, Ulf Westgren, Otto Westphal & Jan Åman. (2014) Growth Hormone Dose-Dependent Pubertal Growth: A Randomized Trial in Short Children with Low Growth Hormone Secretion. Hormone Research in Paediatrics 82:3, pages 158-170.
Crossref
Xinna LiAndrzej BartkeDarlene E. Berryman, Kevin FunkJohn J. Kopchick, Edward O. List, Liou SunRichard A. Miller. (2013) Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes. American Journal of Physiology-Endocrinology and Metabolism 305:8, pages E942-E950.
Crossref
Martin Rasmussen, Bo Ekstrand & Galia Zamaratskaia. (2013) Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase: A Review. International Journal of Molecular Sciences 14:9, pages 17926-17942.
Crossref
Maria Konstandi, Jie Cheng & Frank J. Gonzalez. (2013) Sex steroid hormones regulate constitutive expression of Cyp2e1 in female mouse liver . American Journal of Physiology-Endocrinology and Metabolism 304:10, pages E1118-E1128.
Crossref
Ned A. Porter. (2013) A Perspective on Free Radical Autoxidation: The Physical Organic Chemistry of Polyunsaturated Fatty Acid and Sterol Peroxidation. The Journal of Organic Chemistry 78:8, pages 3511-3524.
Crossref
Weiling Zheng, Hongyan Xu, Siew Hong Lam, Huaien Luo, R. Krishna Murthy Karuturi & Zhiyuan Gong. (2013) Transcriptomic Analyses of Sexual Dimorphism of the Zebrafish Liver and the Effect of Sex Hormones. PLoS ONE 8:1, pages e53562.
Crossref
Misaki Kojima & Masakuni Degawa. (2013) Serum androgen level is determined by autosomal dominant inheritance and regulates sex-related CYP genes in pigs. Biochemical and Biophysical Research Communications 430:2, pages 833-838.
Crossref
Mercedes de Mirecki-Garrido, Borja Guerra, Carlos Mateos-Díaz, Roberto Jiménez-Monzón, Nicolás Díaz-Chico, Juan C. Díaz-Chico & Leandro Fernández-Pérez. (2012) The Influence of Estrogens on the Biological and Therapeutic Actions of Growth Hormone in the Liver. Pharmaceuticals 5:7, pages 758-778.
Crossref
Alexander V. LyubimovThomas K. H. Chang & David J. Waxman. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 19 .
Tara L Conforto & David J Waxman. (2012) Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood. Biology of Sex Differences 3:1, pages 9.
Crossref
Bernard Weiss. (2011) Same sex, no sex, and unaware sex in neurotoxicology. NeuroToxicology 32:5, pages 509-517.
Crossref
Heidi Marja Viitaniemi & Erica Helen Leder. (2011) Sex-Biased Protein Expression in Threespine Stickleback, Gasterosteus aculeatus . Journal of Proteome Research 10:9, pages 4033-4040.
Crossref
Gianpaolo Rando & Walter Wahli. (2011) Sex differences in nuclear receptor-regulated liver metabolic pathways. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1812:8, pages 964-973.
Crossref
Z. HochbergR. FeilM. ConstanciaM. FragaC. JunienJ.-C. CarelP. BoileauY. Le BoucC. L. DealK. LillycropR. ScharfmannA. SheppardM. SkinnerM. SzyfR. A. WaterlandD. J. WaxmanE. WhitelawK. OngK. Albertsson-Wikland. (2011) Child Health, Developmental Plasticity, and Epigenetic Programming. Endocrine Reviews 32:2, pages 159-224.
Crossref
Claudia Sanchez-CardenasPierre FontanaudZhenhe HeChrystel LafontAnne-Cécile MeunierMarie Schaeffer, Danielle CarmignacFrançois MolinoNathalie CoutryXavier BonnefontLaurie-Anne Gouty-ColomerElodie Gavois, David J. HodsonPaul Le TissierIain C. A. F. RobinsonPatrice Mollard. (2010) Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood. Proceedings of the National Academy of Sciences 107:50, pages 21878-21883.
Crossref
N. S. Kushnareva & O. V. Smirnova. (2010) Changes in Gender-Related Redistribution of Bilirubin Pools in Hyperprolactinemic Rats during Induction and Relieving of Cholestasis. Bulletin of Experimental Biology and Medicine 149:5, pages 562-566.
Crossref
Daniel M. GattiNi ZhaoElissa J. CheslerBlair U. BradfordAndrey A. ShabalinRoumyana Yordanova, Lu Lu & Ivan Rusyn. (2010) Sex-specific gene expression in the BXD mouse liver. Physiological Genomics 42:3, pages 456-468.
Crossref
Magnus Ingelman-Sundberg & Sarah C. Sim. (2010) Pharmacogenetic biomarkers as tools for improved drug therapy; emphasis on the cytochrome P450 system. Biochemical and Biophysical Research Communications 396:1, pages 90-94.
Crossref
Christopher J. Krebs & Diane M. Robins. (2010) A Pair of Mouse KRAB Zinc Finger Proteins Modulates Multiple Indicators of Female Reproduction1. Biology of Reproduction 82:4, pages 662-668.
Crossref
Valerie Wauthier, Aarathi Sugathan, Rosana D. Meyer, Alan A. Dombkowski & David J. Waxman. (2010) Intrinsic Sex Differences in the Early Growth Hormone Responsiveness of Sex-Specific Genes in Mouse Liver. Molecular Endocrinology 24:3, pages 667-678.
Crossref
Susan R. Crowell, W. Matthew Henderson, Jeffrey W. Fisher & John F. Kenneke. (2010) Gender and species differences in triadimefon metabolism by rodent hepatic microsomes. Toxicology Letters 193:1, pages 101-107.
Crossref
Tamara J. Nicolson, Howard R. Mellor & Ruth R.A. Roberts. (2010) Gender differences in drug toxicity. Trends in Pharmacological Sciences 31:3, pages 108-114.
Crossref
G.M. Williams. 2010. Comprehensive Toxicology. Comprehensive Toxicology 221 250 .
Weida Tong, Qiang Shi, William Salminen, Minjun Chen, Hong Fang, Ayako Suzuki & Donna L. Mendrick. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
David J. Waxman & Minita G. Holloway. (2009) Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes. Molecular Pharmacology 76:2, pages 215-228.
Crossref
Arthur P. Arnold. (2009) The organizational?activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues. Hormones and Behavior 55:5, pages 570-578.
Crossref
Stefanie D. Krämer & Bernard Testa. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:12, pages 2465-2578.
Crossref
K. Bouyer, A. Faivre‐Bauman, I. C. A. F. Robinson, J. Epelbaum & C. Loudes. (2008) Sexually Dimorphic Distribution of sst2A Receptors on Growth Hormone‐Releasing Hormone Neurones in Mice: Modulation by Gonadal Steroids. Journal of Neuroendocrinology 20:11, pages 1278-1287.
Crossref
Jay B. Silkworth, Erik A. Carlson, Colin McCulloch, Kati Illouz, Shirlean Goodwin & Thomas R. Sutter. (2008) Toxicogenomic Analysis of Gender, Chemical, and Dose Effects in Livers of TCDD- or Aroclor 1254–Exposed Rats Using a Multifactor Linear Model. Toxicological Sciences 102:2, pages 291-309.
Crossref
Jeffrey S. Davies, Pia Kotokorpi, Ulrika Lindahl, Jan Oscarsson, Timothy Wells & Agneta Mode. (2008) Effects of the synthetic liver X receptor agonist T0901317 on the growth hormone and thyroid hormone axes in male rats. Endocrine 33:2, pages 196-204.
Crossref
Misaki Kojima, Masashi Sekimoto & Masakuni Degawa. (2008) A novel gender-related difference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs. Biochemical Pharmacology 75:5, pages 1076-1082.
Crossref
Meena R. Sharma, Rathnagiri Polavarapu, Daniel Roseman, Viraj Patel, Eric Eaton, P.B. Kavi Kishor & Amin A. Nanji. (2008) Increased severity of alcoholic liver injury in female verses male rats: A microarray analysis. Experimental and Molecular Pathology 84:1, pages 46-58.
Crossref
Agnieszka M. Lichanska & Michael J. Waters. (2008) How growth hormone controls growth, obesity and sexual dimorphism. Trends in Genetics 24:1, pages 41-47.
Crossref
Joel D. Greenspan, Rebecca M. Craft, Linda LeResche, Lars Arendt-Nielsen, Karen J. Berkley, Roger B. Fillingim, Michael S. Gold, Anita Holdcroft, Stefan Lautenbacher, Emeran A. Mayer, Jeffrey S. Mogil, Anne Z. Murphy & Richard J. Traub. (2007) Studying sex and gender differences in pain and analgesia: A consensus report. Pain 132:Supplement 1, pages S26-S45.
Crossref
Karl H. Clodfelter, Gregory D. Miles, Valerie Wauthier, Minita G. Holloway, Xiaohua Zhang, Paul Hodor, William J. Ray & David J. Waxman. (2007) Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis. Physiological Genomics 31:1, pages 63-74.
Crossref
Ganesh Cherala, Bernard H. Shapiro & Anil P. D'mello. (2007) Effect of Perinatal Low Protein Diets on the Ontogeny of Select Hepatic Cytochrome P450 Enzymes and Cytochrome P450 Reductase in the Rat. Drug Metabolism and Disposition 35:7, pages 1057-1063.
Crossref
Simon McArthur, Hilary E. Murray, Alihusein Dhankot, David T. Dexter & Glenda E. Gillies. (2006) Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition. Journal of Neurochemistry 100:3, pages 678-692.
Crossref
J?rg Isensee & Patricia Ruiz Noppinger. (2007) Sexually Dimorphic Gene Expression in Mammalian Somatic Tissue. Gender Medicine 4, pages S75-S95.
Crossref
B. J. P. CrulJoel D. Greenspan, Rebecca M. Craft, Linda LeResche, Lars Arendt-Nielsen, Karen J. Berkley, Roger B. Fillingim, Michael S. Gold, Anita Holdcroft, Stefan Lautenbacher, Emeran A. Mayer, Jeffrey S. Mogil, Anne Z. Murphy & Richard J. Traub. 2009. Pijn Info. Pijn Info 1287 1301 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.