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Research Article

Metabolism of Capsaicinoids by P450 Enzymes: A Review of Recent Findings on Reaction Mechanisms, Bio-Activation, and Detoxification Processes

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Pages 685-706 | Published online: 09 Oct 2008

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Krishnapura Srinivasan. (2016) Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review. Critical Reviews in Food Science and Nutrition 56:9, pages 1488-1500.
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Anna Lewinska, Pawel Chochrek, Karolina Smolag, Ewa Rawska & Maciej Wnuk. (2015) Oxidant-based anticancer activity of a novel synthetic analogue of capsaicin, capsaicin epoxide. Redox Report 20:3, pages 116-125.
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Hua Sun, Huan Wang, Hongming Liu, Xingwang Zhang & Baojian Wu. (2014) Glucuronidation of capsaicin by liver microsomes and expressed UGT enzymes: reaction kinetics, contribution of individual enzymes and marked species differences. Expert Opinion on Drug Metabolism & Toxicology 10:10, pages 1325-1336.
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R.-D. Treede, T. Wagner, K.-U. Kern, I.W. Husstedt, G. Arendt, F. Birklein, T. Cegla, R. Freynhagen, H.-H. Gockel, M.-L. Heskamp, H. Jager, R. Joppich, C. Maier, A. Leffler, H.-H. Nagelein, R. Rolke, S. Seddigh, C. Sommer, S. Stander, G. Wasner & R. Baron. (2013) Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain. Current Medical Research and Opinion 29:5, pages 527-538.
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Qing-Hao Zhang, Jin-Ping Hu, Bao-Lian Wang & Yan Li. (2012) Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo . Journal of Asian Natural Products Research 14:4, pages 382-395.
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Virginia M. Jones, Katrina A. Moore & David M. Peterson. (2011) Capsaicin 8% Topical Patch (Qutenza)—A Review of the Evidence. Journal of Pain & Palliative Care Pharmacotherapy 25:1, pages 32-41.
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Sunita Babbar, Sanjay Chanda & Keith Bley. (2010) Inhibition and induction of human cytochrome P450 enzymes in vitro by capsaicin. Xenobiotica 40:12, pages 807-816.
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Sudip Kumar Mandal, Santosh Kumar Rath, Rajan Logesh, Siddhartha Kumar Mishra, Hari Prasad Devkota & Niranjan Das. (2022) Capsicum annuum L. and its bioactive constituents: A critical review of a traditional culinary spice in terms of its modern pharmacological potentials with toxicological issues . Phytotherapy Research 37:3, pages 965-1002.
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Arpad Szallasi. (2022) Capsaicin for Weight Control: “Exercise in a Pill” (or Just Another Fad)?. Pharmaceuticals 15:7, pages 851.
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Marco Kreidl, Matthias Rainer, Günther K. Bonn & Herbert Oberacher. (2021) Electrochemical Simulation of the Oxidative Capsaicin Metabolism. Chemical Research in Toxicology 34:12, pages 2522-2533.
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Mary A. Robinson, Darko Stefanovski, Youwen You, Raymond C. Boston & Lawrence R. Soma. (2020) Bayesian‐based withdrawal estimates using pharmacokinetic parameters for two capsaicinoid‐containing products administered to horses. Journal of Veterinary Pharmacology and Therapeutics 44:3, pages 349-358.
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Mingting Du, Xuran Liu, Dongbo Wang, Qi Yang, Abing Duan, Hong Chen, Yiwen Liu, Qilin Wang & Bing-Jie Ni. (2021) Understanding the fate and impact of capsaicin in anaerobic co-digestion of food waste and waste activated sludge. Water Research 188, pages 116539.
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Sharon M. Gwaltney-Brant. 2021. Nutraceuticals. Nutraceuticals 117 129 .
Muwen Lu, Chengyu Chen, Yaqi Lan, Jie Xiao, Run Li, Junqing Huang, Qingrong Huang, Yong Cao & Chi-Tang Ho. (2020) Capsaicin—the major bioactive ingredient of chili peppers: bio-efficacy and delivery systems. Food & Function 11:4, pages 2848-2860.
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Jiang Zhu, Kai Tian, Christopher A. Reilly & Xinghui Qiu. (2020) Capsaicinoid metabolism by the generalist Helicoverpa armigera and specialist H. assulta: Species and tissue differences. Pesticide Biochemistry and Physiology 163, pages 164-174.
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Sibel Bayıl oguzkan & Halil İbrahim Uğraş. (2019) Kapsaisin Saflaştırılması ve Moleküler Biyolojik Aktivite Değerlendirmesi. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi.
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Sibel Bayil Oğuzkan. (2019) Extraction of Capsinoid and its Analogs From Pepper Waste of Different Genotypes. Natural Product Communications 14:7, pages 1934578X1986567.
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