1,451
Views
57
CrossRef citations to date
0
Altmetric
Review Article

Synthetic cathinone pharmacokinetics, analytical methods, and toxicological findings from human performance and postmortem cases

, &
Pages 237-265 | Received 24 Mar 2016, Accepted 06 May 2016, Published online: 01 Jun 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

João L. Gonçalves, Vera L. Alves, Joselin Aguiar, Helena M. Teixeira & José S. Câmara. (2019) Synthetic cathinones: an evolving class of new psychoactive substances. Critical Reviews in Toxicology 49:7, pages 549-566.
Read now
Katrina J. Debnam, Shonali Saha & Catherine P. Bradshaw. (2018) Synthetic and Other Drug Use among High School Students: The Role of Perceived Prevalence, Access, and Harms. Substance Use & Misuse 53:12, pages 2069-2076.
Read now
Rosa A. S. Couto, Luís Moreira Gonçalves, Félix Carvalho, José A. Rodrigues, Cecília M. P. Rodrigues & M. Beatriz Quinaz. (2018) The Analytical Challenge in the Determination of Cathinones, Key-Players in the Worldwide Phenomenon of Novel Psychoactive Substances. Critical Reviews in Analytical Chemistry 48:5, pages 372-390.
Read now
Bhavana R. Shivankar, Vishwambhar Vishnu Bhandare, Krati Joshi, Vishal S. Patil, Priyanka Shrikant Dhotare, Kailas Dasharath Sonawane & Sailaja Krishnamurty. Investigation of cathinone analogs targeting human dopamine transporter using molecular modeling. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-16.
Read now

Articles from other publishers (53)

Abdulaziz A. Aldubayyan, Erika Castrignanò, Simon Elliott & Vincenzo Abbate. (2024) Short- and long-term stability of synthetic cathinones and dihydro-metabolites in human urine samples. Forensic Toxicology.
Crossref
Bartłomiej Feigel, Piotr Adamowicz & Sławomir Wybraniec. (2023) Recent advances in analysis of new psychoactive substances by means of liquid chromatography coupled with low-resolution tandem mass spectrometry. Analytical and Bioanalytical Chemistry 416:1, pages 107-124.
Crossref
Gábor Kovács, Péter Gergely, Sándor Kosztya, Zsolt Kozma, Gábor Simon, György Szabados, Réka Anita Tóth, Klára Törő & Roland Weiczner. (2023) Módszertani ajánlás A járművezetés bódult állapotban bűncselekmény orvosszakértői véleményezésének egyes kérdéseirőlRecommendation. Key aspects of medical expert’s opinion (report) on the crime of driving under the influence of drugs (DRUID). Belügyi Szemle 71:7, pages 1141-1168.
Crossref
Gábor Kovács, Péter Gergely, Sándor Kosztya, Zsolt Kozma, Gábor Simon, György Szabados, Réka Anita Tóth, Klára Törő & Roland Weiczner. (2023) Módszertani ajánlás A járművezetés bódult állapotban bűncselekmény orvosszakértői véleményezésének egyes kérdéseiről. Belügyi Szemle 71:7, pages 1141-1168.
Crossref
Grace Chen, Shafiqur Rahman & Kabirullah Lutfy. (2023) E-cigarettes may serve as a gateway to conventional cigarettes and other addictive drugs. Advances in Drug and Alcohol Research 3.
Crossref
A.S. Ripanda, B. Bal Lal Srivastava, A.A. Nyundo, H. Miraji & S.A.H. Vuai. (2023) Prevalence and factors associated with designer cathinones and amphetamine use among Outpatients attending methadone Clinic at Mwananyamala Hospital Dar es salaam, Tanzania. Ethics, Medicine and Public Health 28, pages 100892.
Crossref
Rita P. Lopes, Raquel A. Ferro, Margarida Milhazes, Margarida Figueira, Maria João Caldeira, Alexandra M. M. Antunes & Helena Gaspar. (2023) Metabolic stability and metabolite profiling of emerging synthetic cathinones. Frontiers in Pharmacology 14.
Crossref
Michelle Jin Yee Neoh, Alessandro Carollo, Mengyu Lim, Ornella Corazza, Aurora Coppola & Gianluca Esposito. (2023) The novel psychoactive substances epidemic: A scientometric perspective. Addiction Neuroscience 5, pages 100060.
Crossref
Elena Lendoiro & Ana de-Castro-Ríos. 2023. Methods for Novel Psychoactive Substance Analysis. Methods for Novel Psychoactive Substance Analysis 21 43 .
Selina Hemmer, Lea Wagmann, Benedikt Pulver, Folker Westphal & Markus R. Meyer. (2022) In Vitro and In Vivo Toxicometabolomics of the Synthetic Cathinone PCYP Studied by Means of LC-HRMS/MS. Metabolites 12:12, pages 1209.
Crossref
Yuji Sakai, Yoshifumi Morikawa, Yukino Nagao, Junta Hattori, Koichi Suenami, Emiko Yanase, Tomohiro Takayama, Akira Ikari & Toshiyuki Matsunaga. (2022) 4′-Iodo-α-Pyrrolidinononanophenone Provokes Differentiated SH-SY5Y Cell Apoptosis Through Downregulating Nitric Oxide Production and Bcl-2 Expression. Neurotoxicity Research 40:5, pages 1322-1336.
Crossref
Bárbara Silva, Joana Saraiva Rodrigues, Ana Sofia Almeida, Ana Rita Lima, Carla Fernandes, Paula Guedes de Pinho, Joana Paiva Miranda & Fernando Remião. (2022) Enantioselectivity of Pentedrone and Methylone on Metabolic Profiling in 2D and 3D Human Hepatocyte-like Cells. Pharmaceuticals 15:3, pages 368.
Crossref
Dan Wang, Xueguo Chen, Zhu Ming, Limin Jiang & Yan Zhou. (2021) Simultaneous Determination of 16 Kinds of Synthetic Cathinones in Human Urine Using a Magnetic Nanoparticle Solid-Phase Extraction Combined with Gas Chromatography-Mass Spectrometry. Separations 9:1, pages 3.
Crossref
Lea Wagmann, Tanja M. Gampfer & Markus R. Meyer. (2021) Recent trends in drugs of abuse metabolism studies for mass spectrometry–based analytical screening procedures. Analytical and Bioanalytical Chemistry 413:22, pages 5551-5559.
Crossref
Akira Mochizuki, Noboru Adachi & Hideki Shojo. (2021) Detection of 4-FMC, 4-MeO-α-PVP, 4-F-α-PVP, and PV8 in blood in a forensic case using liquid chromatography–electrospray ionization linear ion trap mass spectrometry. Forensic Science International 325, pages 110888.
Crossref
F. Palazzoli, A.L. Santunione, P. Verri, D. Vandelli & E. Silingardi. (2021) Post-mortem distribution of mephedrone and its metabolites in body fluids and organ tissues of an intoxication case. Journal of Pharmaceutical and Biomedical Analysis 201, pages 114093.
Crossref
Sevasti Karampela, Jessica Smith & Irene Panderi. (2021) Determination of 19 Psychoactive Substances in Premortem and Postmortem Whole Blood Samples Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry. Separations 8:6, pages 78.
Crossref
Michal Ordak, Aleksandra Zmysłowska, Miłosz Bielski, Daniel Rybak, Maja Tomaszewska, Katarzyna Wyszomierska, Aleksandra Kmiec, Natalia Garlicka, Maria Zalewska, Michal Zalewski, Tadeusz Nasierowski, Elzbieta Muszynska & Magdalena Bujalska-Zadrozny. (2021) Pharmacotherapy of Patients Taking New Psychoactive Substances: A Systematic Review and Analysis of Case Reports. Frontiers in Psychiatry 12.
Crossref
Hans H. Maurer. (2020) Hyphenated high-resolution mass spectrometry—the “all-in-one” device in analytical toxicology?. Analytical and Bioanalytical Chemistry 413:9, pages 2303-2309.
Crossref
Mónica Antunes, Margarida Sequeira, Mariana de Caires Pereira, Maria João Caldeira, Susana Santos, João Franco, Mário Barroso & Helena Gaspar. (2021) Determination of Selected Cathinones in Blood by Solid-Phase Extraction and GC–MS. Journal of Analytical Toxicology 45:3, pages 233-242.
Crossref
Yousef A. Bin Jardan, Khaled Mohamed, Nagwan Abbas, Manal El-Gendy, Nawaf Alsaif, Mohammed Alanazi, Mostafa Mohammed, Mohammed Abounassif & Mohamed Hefnawy. (2021) Development and validation of GC–MS method for determination of methcathinone and its main metabolite in mice plasma and brain tissue after SPE: Pharmacokinetic and distribution study. Journal of Pharmaceutical and Biomedical Analysis 194, pages 113798.
Crossref
Rossella Gottardo, Daniela Sorio, Giulia Soldati, Marco Ballotari, Nadia Maria Porpiglia & Franco Tagliaro. (2020) Optimization and validation of a new approach based on CE‐HRMS for the screening analysis of novel psychoactive substances (cathinones, phenethylamines, and tryptamines) in urine. ELECTROPHORESIS 42:4, pages 450-459.
Crossref
Beatriz T. Lopes, Maria João Caldeira, Helena Gaspar & Alexandra M. M. Antunes. (2021) Metabolic Profile of Four Selected Cathinones in Microsome Incubations: Identification of Phase I and II Metabolites by Liquid Chromatography High Resolution Mass Spectrometry. Frontiers in Chemistry 8.
Crossref
A.V. Voronin, T.L. Malkova & I.V. Synbulatov. (2021) Molecularly imprinted sorbent for biological fluids sample preparation in forensic toxicology. Sudebno-meditsinskaya ekspertiza 64:6, pages 39.
Crossref
Sascha K. Manier, Florian Schwermer, Lea Wagmann, Niels Eckstein & Markus R. Meyer. (2020) Liquid Chromatography-High-Resolution Mass Spectrometry-Based In Vitro Toxicometabolomics of the Synthetic Cathinones 4-MPD and 4-MEAP in Pooled Human Liver Microsomes. Metabolites 11:1, pages 3.
Crossref
Shiyang Qin, Ying Zhang, Genye He, Guobin Xin, Jing Qiao, Zizhen Xu, Yongtao Liu, Hua Liu, Yuanfeng Wang & Jianghai Lu. (2020) Mass spectrometric characterization and identification of new methcathinone metabolites in human blood (plasma), urine and hair by liquid chromatography-high field quadrupole exactive orbitrap mass spectrometer. Microchemical Journal 159, pages 105423.
Crossref
Joana Carrola, Noélia Duarte, Pedro Florindo, Sara Henriques, Gustavo da Silva, Lubertus Bijlsma, Rui Moreira, Catarina Correia, Maria de Jesus Perry, Álvaro Lopes, Cristina de Mello-Sampayo & Maria do Rosário Bronze. (2020) Metabolism of N-ethylhexedrone and buphedrone: An in vivo study in mice using HPLC-MS/MS. Journal of Chromatography B 1159, pages 122340.
Crossref
I. Vaz, T. Carvalho, M.J. Valente, A. Castro, A.M. Araújo, M.L. Bastos & M. Carvalho. (2020) The interplay between autophagy and apoptosis mediates toxicity triggered by synthetic cathinones in human kidney cells. Toxicology Letters 331, pages 42-52.
Crossref
J. Tyler Davidson, Zachary J. Sasiene & Glen P. Jackson. (2020) Fragmentation pathways of odd- and even-electron N-alkylated synthetic cathinones. International Journal of Mass Spectrometry 453, pages 116354.
Crossref
J. Tyler Davidson, Zachary J. Sasiene, Younis Abiedalla, J. DeRuiter, C. Randall Clark & Glen P. Jackson. (2020) Fragmentation pathways of α-pyrrolidinophenone synthetic cathinones and their application to the identification of emerging synthetic cathinone derivatives. International Journal of Mass Spectrometry 453, pages 116343.
Crossref
Ramon R. ContrucciTibor M. Brunt, Funda InanEric J. F. FranssenLaura Hondebrink. (2020) Synthetic Cathinones and Their Potential Interactions with Prescription Drugs. Therapeutic Drug Monitoring 42:1, pages 75-82.
Crossref
Nicole S. Jones & Jeffrey H. Comparin. (2020) Interpol review of controlled substances 2016–2019. Forensic Science International: Synergy 2, pages 608-669.
Crossref
Sergi Pascual-Caro, Núria Fontanals, Francesc Borrull, Carme Aguilar & Marta Calull. (2019) Solid-phase extraction based on cation-exchange sorbents followed by liquid chromatography high-resolution mass spectrometry to determine synthetic cathinones in urine. Forensic Toxicology 38:1, pages 185-194.
Crossref
Lea Wagmann, Sascha K. Manier, Niels Eckstein, Hans H. Maurer & Markus R. Meyer. (2019) Toxicokinetic studies of the four new psychoactive substances 4-chloroethcathinone, N-ethylnorpentylone, N-ethylhexedrone, and 4-fluoro-alpha-pyrrolidinohexiophenone. Forensic Toxicology 38:1, pages 59-69.
Crossref
Zebin Lin, Hao Wang, Luyuyan Hu, Jiaolun Li, Junyi Lin, Baonian Liu, Ziqin Zhao & Yulan Rao. (2019) Simultaneous determination of N ‐ethylpentylone, dopamine, 5‐hydroxytryptamine and their metabolites in rat brain microdialysis by liquid chromatography tandem mass spectrometry . Biomedical Chromatography 33:10.
Crossref
Weijuan Yang, Haixiang Yu, Obtin Alkhamis, Yingzhu Liu, Juan Canoura, Fengfu Fu & Yi Xiao. (2019) In vitro isolation of class-specific oligonucleotide-based small-molecule receptors. Nucleic Acids Research 47:12, pages e71-e71.
Crossref
Francesca Freni, Sara Bianco, Claudia Vignali, Angelo Groppi, Matteo Moretti, Antonio Marco Maria Osculati & Luca Morini. (2019) A multi-analyte LC–MS/MS method for screening and quantification of 16 synthetic cathinones in hair: Application to postmortem cases. Forensic Science International 298, pages 115-120.
Crossref
Piotr Adamowicz & Bogdan Tokarczyk. 2019. LC-MS in Drug Analysis. LC-MS in Drug Analysis 165 180 .
Andreas K. Breitbarth, Jody Morgan & Alison L. Jones. (2018) E-cigarettes—An unintended illicit drug delivery system. Drug and Alcohol Dependence 192, pages 98-111.
Crossref
Laurent Karila, Geneviève Lafaye, Amandine Scocard, Olivier Cottencin & Amine Benyamina. (2018) MDPV and α-PVP use in humans: The twisted sisters. Neuropharmacology 134, pages 65-72.
Crossref
Rachel R. Horsley, Eva Lhotkova, Katerina Hajkova, Barbara Feriancikova, Michal Himl, Martin Kuchar & Tomas Páleníček. (2018) Behavioural, Pharmacokinetic, Metabolic, and Hyperthermic Profile of 3,4-Methylenedioxypyrovalerone (MDPV) in the Wistar Rat. Frontiers in Psychiatry 9.
Crossref
María Luisa Soria. (2018) New psychoactive substances: Popular and dangerous. Spanish Journal of Legal Medicine 44:2, pages 64-72.
Crossref
María Luisa Soria. (2018) Las nuevas drogas psicoactivas: populares y peligrosas. Revista Española de Medicina Legal 44:2, pages 64-72.
Crossref
P.S. Lager, M.E. Attema-de Jonge, M.P. Gorzeman, L.E. Kerkvliet & E.J.F. Franssen. (2018) Clinical value of drugs of abuse point of care testing in an emergency department setting. Toxicology Reports 5, pages 12-17.
Crossref
Dariusz Zuba & Piotr Adamowicz. 2018. Synthetic Cathinones. Synthetic Cathinones 41 69 .
Markus R. Meyer. 2018. New Psychoactive Substances. New Psychoactive Substances 441 459 .
Lea Wagmann & Hans H. Maurer. 2018. New Psychoactive Substances. New Psychoactive Substances 413 439 .
N. Fontanals, R.M. Marcé & F. Borrull. (2017) Solid-phase extraction followed by liquid chromatography-high resolution mass spectrometry to determine synthetic cathinones in different types of environmental water samples. Journal of Chromatography A 1524, pages 66-73.
Crossref
Daniel Pasin, Adam Cawley, Sergei Bidny & Shanlin Fu. (2017) Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances: a critical review. Analytical and Bioanalytical Chemistry 409:25, pages 5821-5836.
Crossref
María Jesús Andrés-Costa, Vicente Andreu & Yolanda Picó. (2017) Liquid chromatography–mass spectrometry as a tool for wastewater-based epidemiology: Assessing new psychoactive substances and other human biomarkers. TrAC Trends in Analytical Chemistry 94, pages 21-38.
Crossref
Briana Miller, Jiyoung Kim & Marta Concheiro. (2017) Stability of synthetic cathinones in oral fluid samples. Forensic Science International 274, pages 13-21.
Crossref
Sarah M.R. Wille, Joy Eliaerts, Vincent Di Fazio & Nele Samyn. (2017) Challenges concerning new psychoactive substance detection in oral fluid. Toxicologie Analytique et Clinique 29:1, pages 11-17.
Crossref
Michael H. Baumann, Mohammad O. Bukhari, Kurt R. Lehner, Sebastien Anizan, Kenner C. Rice, Marta Concheiro & Marilyn A. Huestis. 2017. Neuropharmacology of New Psychoactive Substances (NPS). Neuropharmacology of New Psychoactive Substances (NPS) 93 117 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.