959
Views
50
CrossRef citations to date
0
Altmetric
Review Article

A comprehensive review of cytochrome P450 2E1 for xenobiotic metabolism

, , , , ORCID Icon &
Pages 178-195 | Received 02 Apr 2019, Accepted 13 Jun 2019, Published online: 28 Jun 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki & Yasuhiro Uno. (2023) Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p-nitrophenol. Xenobiotica 53:10-11, pages 573-580.
Read now
Li Zhang, Fugui Zhang, Yifei Xiao, Jianhao Du, Xingwang Zhang, Min Chen & Baojian Wu. (2022) The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity. Xenobiotica 52:6, pages 633-643.
Read now
Jie Liu, Yuan-Fu Lu, J. Christopher Corton & Curtis D. Klaassen. (2021) Expression of cytochrome P450 isozyme transcripts and activities in human livers. Xenobiotica 51:3, pages 279-286.
Read now
Yollada Sriset, Waranya Chatuphonprasert & Kanokwan Jarukamjorn. (2021) Bergenin Attenuates Sodium Selenite-Induced Hepatotoxicity via Improvement of Hepatic Oxidant-Antioxidant Balance in HepG2 Cells and ICR Mice. Journal of Biologically Active Products from Nature 11:2, pages 97-115.
Read now
Keguang Chen, Ruichen Guo & Chunmin Wei. (2020) Synonymous Mutation rs2515641 Affects CYP2E1 mRNA and Protein Expression and Susceptibility to Drug-Induced Liver Injury. Pharmacogenomics 21:7, pages 459-470.
Read now

Articles from other publishers (45)

Karli R. LeFort, Wiramon Rungratanawanich & Byoung-Joon Song. (2024) Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction. Cellular and Molecular Life Sciences 81:1.
Crossref
Lan Jiang, Ya Ni, Cong Zhao, Dexin Gao, Xiaochun Gai, Ke Xiong & Jinyu Wang. (2024) Folic acid protects against isoniazid-induced liver injury via the m6A RNA methylation of cytochrome P450 2E1 in mice. Frontiers in Nutrition 11.
Crossref
Weiliang Bai, Hui Su, Shengqun Xu, Zhao Gao, Ziwen Chang, Xun Sun & Tiancong Liu. (2024) Cyp2e1 protects against OVA-induced allergic rhinitis through the inhibition of Th2 cell activation and differentiation: Mediated by MAFB. International Immunopharmacology 132, pages 112003.
Crossref
Amine Elbouzidi, Mohamed Taibi, Salah Laaraj, El Hassania Loukili, Mounir Haddou, Naoufal El Hachlafi, Hanae Naceiri Mrabti, Abdellah Baraich, Reda Bellaouchi, Abdeslam Asehraou, Mohammed Bourhia, Hiba-Allah Nafidi, Yousef A. Bin Jardan, Khalid Chaabane & Mohamed Addi. (2024) Chemical profiling of volatile compounds of the essential oil of grey-leaved rockrose (Cistus albidus L.) and its antioxidant, anti-inflammatory, antibacterial, antifungal, and anticancer activity in vitro and in silico. Frontiers in Chemistry 12.
Crossref
Matteo Rosellini, Ejlal A. Omer, Alicia Schulze, Nadeen T. Ali, Joelle C. Boulos, Federico Marini, Jan-Heiner Küpper & Thomas Efferth. (2023) Impact of plastic-related compounds on the gene expression signature of HepG2 cells transfected with CYP3A4. Archives of Toxicology 98:2, pages 525-536.
Crossref
Hussam Aly Sayed Mura, Abdullah Abdulaziz Aljahdail, Faisal Abdulaziz Almarashi, Renad Nabel Saleem & Rimas Mohammed Alnefaie. (2024) Eucalyptol Ameliorates Rifampicin-Induced Hepatotoxicity via Inhibiting Inflammation, Oxidant Stress and CYP2E1 Gene Expression in a Model of Modest Inflammation in Rats. International Journal of Pharmacology 20:1, pages 121-127.
Crossref
Alexey V. Kuzikov, Rami A. Masamrekh, Tatiana A. Filippova, Anastasiya M. Tumilovich, Natallia V. Strushkevich, Andrei A. Gilep, Yulia Yu. Khudoklinova & Victoria V. Shumyantseva. (2024) Bielectrode Strategy for Determination of CYP2E1 Catalytic Activity: Electrodes with Bactosomes and Voltammetric Determination of 6-Hydroxychlorzoxazone. Biomedicines 12:1, pages 152.
Crossref
Karli R. LeFort, Wiramon Rungratanawanich & Byoung-Joon Song. (2023) Melatonin Prevents Alcohol- and Metabolic Dysfunction- Associated Steatotic Liver Disease by Mitigating Gut Dysbiosis, Intestinal Barrier Dysfunction, and Endotoxemia. Antioxidants 13:1, pages 43.
Crossref
David L. Eaton & Julia Cui. 2003. Patty's Toxicology. Patty's Toxicology 1 44 .
Tadeusz H Wroblewski, Kelsey E Witt, Seung-been Lee, Ripan S Malhi, David Peede, Emilia Huerta-Sánchez, Fernando A Villanea & Katrina G Claw. (2023) Pharmacogenetic Variation in Neanderthals and Denisovans and Implications for Human Health and Response to Medications. Genome Biology and Evolution 15:12.
Crossref
Lin Jia, Fei Gao, Guiming Hu, Yan Fang, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu & Hailing Qiao. (2023) A Novel Cytochrome P450 2E1 Inhibitor Q11 Is Effective on Lung Cancer via Regulation of the Inflammatory Microenvironment. Advanced Science 10:35.
Crossref
Przemysław J. Danek & Władysława A. Daniel. (2023) The Novel Atypical Antipsychotic Lurasidone Affects Cytochrome P450 Expression in the Liver and Peripheral Blood Lymphocytes. International Journal of Molecular Sciences 24:23, pages 16796.
Crossref
Farooq Hassan, Asmat Ullah Khan, Syed Zahoor ul Hassan Zaidi, Madiha Khan Niazi & Muhammad Amjed ismail. (2023) In Vitro Antioxidant and Inhibitory Study of Picrorhiza kurroa (Kutki), Syzygium aromaticum (Loung), Lawsonia inermis (Henna), Rheum emodi (Revand Chini), Curcuma longa (Haldi) Against Lipid Per-Oxidation in Mice Brain and Liver . Dose-Response 21:4.
Crossref
Carolina Gutiérrez-Repiso, Antonio Cantarero-Cuenca, Andrés González-Jiménez, Teresa Linares-Pineda, Nerea Peña-Montero, Luis Ocaña-Wilhelmi, Francisco J. Tinahones & Sonsoles Morcillo. (2023) Epigenetic Marks as Predictors of Metabolic Response to Bariatric Surgery: Validation from an Epigenome Wide Association Study. International Journal of Molecular Sciences 24:19, pages 14778.
Crossref
Guiming Hu, Yan Fang, Haiwei Xu, Guanzhe Wang, Rui Yang, Fei Gao, Qingda Wei, Yuhan Gu, Cunzhen Zhang, Jinhuan Qiu, Na Gao, Qiang Wen & Hailing Qiao. (2023) Identification of Cytochrome P450 2E1 as a Novel Target in Glioma and Development of Its Inhibitor as an Anti‐Tumor Agent. Advanced Science 10:23.
Crossref
Arnold Kukowka, Bogusław Brzuchalski, Mateusz Kurzawski, Damian Malinowski & Monika Anna Białecka. (2023) ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder. Genes 14:7, pages 1392.
Crossref
Yang Sun, Karla M. Ramos-Torres & Pedro Brugarolas. (2023) Metabolic Stability of the Demyelination Positron Emission Tomography Tracer [ 18 F]3-Fluoro-4-Aminopyridine and Identification of Its Metabolites . Journal of Pharmacology and Experimental Therapeutics 386:1, pages 93-101.
Crossref
Yifu Pu, Qingqing Liu, Kaifeng Hu, Xinghui Liu, Huai Bai, Yujie Wu, Mi Zhou & Ping Fan. (2023) CYP2E1 C-1054T and 96-bp I/D genetic variations and risk of gestational diabetes mellitus in chinese women: a case-control study. BMC Pregnancy and Childbirth 23:1.
Crossref
Guoxiu Wang, Qian Zhang, Zhanyu Chen, Yongliang Huang, Weimin Wang, Xiaoxue Zhang, Jiale Jia, Qihao Gao, Haoyu Xu & Chong Li. (2023) Transcriptome Analysis to Elucidate the Effects of Milk Replacer Feeding Level on Intestinal Function and Development of Early Lambs. Animals 13:11, pages 1733.
Crossref
Xuedong Gu, Xinping Chang, Lin Yang, Yangzom Chamba & Fang Geng. (2023) Quantitative Proteomic Analysis of Tibetan Pig Livers at Different Altitudes. Molecules 28:4, pages 1694.
Crossref
Vesna Benković, Mirta Milić, Nada Oršolić, Anica Horvat Knežević, Gordana Brozović & Nikola Borojević. (2023) Brain DNA damaging effects of volatile anesthetics and 1 and 2 Gy gamma irradiation in vivo : Preliminary results . Toxicology and Industrial Health 39:2, pages 67-80.
Crossref
Yan Fang, Hongming Yang, Guiming Hu, Jiakun Lu, Jun Zhou, Na Gao, Yuhan Gu, Cunzhen Zhang, Jinhuan Qiu, Yuanyuan Guo, Yunfei Zhang, Qiang Wen & Hailing Qiao. (2022) The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics. Journal of Translational Medicine 20:1.
Crossref
Mohamad Ayub Khan Sharzehan, Hilary Sito, Noraidatulakma Abdullah, Athanasios Alexiou, Marios Papadakis, Rahman Jamal & Shing Cheng Tan. (2022) Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis. Scientific Reports 12:1.
Crossref
Medjda Bellamri, Scott J. Walmsley, Christina Brown, Kyle Brandt, Dmitri Konorev, Abderrahman Day, Chia-Fang Wu, Ming Tsang Wu & Robert J. Turesky. (2022) DNA Damage and Oxidative Stress of Tobacco Smoke Condensate in Human Bladder Epithelial Cells. Chemical Research in Toxicology 35:10, pages 1863-1880.
Crossref
Ananth Kumar Kammala, Ryan C.V. Lintao, Natasha Vora, Angela Mosebarger, Kamil Khanipov, George Golovko, Jerome L. Yaklic, Morgan R. Peltier, Thomas P. Conrads & Ramkumar Menon. (2022) Expression of CYP450 enzymes in human fetal membranes and its implications in xenobiotic metabolism during pregnancy. Life Sciences 307, pages 120867.
Crossref
Y. Pu, Q. Liu, H. Liu, H. Bai, W. Huang, M. Xi & P. Fan. (2022) Association between CYP2E1 C-1054T and 96-bp I/D genetic variations and the risk of polycystic ovary syndrome in Chinese women. Journal of Endocrinological Investigation 46:1, pages 67-78.
Crossref
Shripad Bairagi, Prashant Ghule & Ritu Gilhotra. (2022) Molecular Docking, In vitro Antioxidant, and In vivo Hepatoprotective Activity of Methanolic Extract of Calotropis gigantea leaves in Carbon Tetrachloride-induced Liver Injury in Rats. Current Enzyme Inhibition 18:2, pages 110-126.
Crossref
CS Bae & T Ahn. (2022) Albumin infusion ameliorates liver injury in streptozotocin-induced diabetic rats. Veterinární medicína 67:5, pages 245-256.
Crossref
Youbo Zhang, Tingting Yan, Tianxia Wang, Xiaoyan Liu, Keisuke Hamada, Dongxue Sun, Yizheng Sun, Yanfang Yang, Jing Wang, Shogo Takahashi, Qiong Wang, Kristopher W. Krausz, Changtao Jiang, Cen Xie, Xiuwei Yang & Frank J. Gonzalez. (2022) Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity. Acta Pharmaceutica Sinica B 12:5, pages 2224-2238.
Crossref
Innokenty Savin, Andrey Markov, Marina Zenkova & Aleksandra Sen’kova. (2022) Asthma and Post-Asthmatic Fibrosis: A Search for New Promising Molecular Markers of Transition from Acute Inflammation to Pulmonary Fibrosis. Biomedicines 10:5, pages 1017.
Crossref
A’edah Abu-Bakar, Boon Hooi Tan, Hasseri Halim, Salfarina Ramli, Yan Pan & Chin Eng Ong. (2022) Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers. Current Drug Metabolism 23:5, pages 355-373.
Crossref
Yujie Wu, Aiqing Qiao, Shu Lin & Lijia Chen. (2022) In vitro evaluation of the inhibition potential of echinacoside on human cytochrome P450 isozymes. BMC Complementary Medicine and Therapies 22:1.
Crossref
Julie Massart, Karima Begriche, Jessica H. Hartman & Bernard Fromenty. (2022) Role of Mitochondrial Cytochrome P450 2E1 in Healthy and Diseased Liver. Cells 11:2, pages 288.
Crossref
Mathieu Schwartz, Fabrice Neiers, Jean‐Philippe Charles, Jean‐Marie Heydel, Carolina Muñoz‐González, Gilles Feron & Francis Canon. (2021) Oral enzymatic detoxification system: Insights obtained from proteome analysis to understand its potential impact on aroma metabolization. Comprehensive Reviews in Food Science and Food Safety 20:6, pages 5516-5547.
Crossref
Yan Ren, Callum MacPhillamy, Thu-Hien To, Timothy P.L. Smith, John L. Williams & Wai Yee Low. (2021) Adaptive selection signatures in river buffalo with emphasis on immune and major histocompatibility complex genes. Genomics 113:6, pages 3599-3609.
Crossref
Lenah S. Binmahfouz & Amina M. Bagher. (2021) Genetic polymorphism of the drug-metabolizing enzyme Cytochrome P4502E1 (CYP2E1) in a healthy Saudi population. Saudi Pharmaceutical Journal 29:11, pages 1355-1360.
Crossref
Przemysław J. Danek, Wojciech Kuban & Władysława A. Daniel. (2021) The Effect of Chronic Iloperidone Treatment on Cytochrome P450 Expression and Activity in the Rat Liver: Involvement of Neuroendocrine Mechanisms. International Journal of Molecular Sciences 22:16, pages 8447.
Crossref
Albert P. Li. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity 79 137 .
Clyde J. Wright. (2021) Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?. The Journal of Pediatrics 235, pages 264-276.e1.
Crossref
Wenhao Ge, Tao Wang, Yang Zhao, Yunxia Yang, Qi Sun, Xiao Yang, Yan Gao, Xi Xu & Jianfa Zhang. (2021) Period1 mediates rhythmic metabolism of toxins by interacting with CYP2E1. Cell Death & Disease 12:1.
Crossref
Nayara Cristina Perez de Albuquerque, Daniel Blascke Carrão, Maísa Daniela Habenschus, Franciele Saraiva Fonseca, Rodrigo Moreira da Silva, Norberto Peporine Lopes, Bruno Alves Rocha, Fernando Barbosa Júnior & Anderson Rodrigo Moraes de Oliveira. (2020) Risk assessment of the chiral pesticide fenamiphos in a human model: Cytochrome P450 phenotyping and inhibition studies. Food and Chemical Toxicology 146, pages 111826.
Crossref
Lucas D. Dias & Ivan S. Mfouo-Tynga. (2020) Learning from Nature: Bioinspired Chlorin-Based Photosensitizers Immobilized on Carbon Materials for Combined Photodynamic and Photothermal Therapy. Biomimetics 5:4, pages 53.
Crossref
Vanessa Allwardt, Alexander J. Ainscough, Priyalakshmi Viswanathan, Stacy D. Sherrod, John A. McLean, Malcolm Haddrick & Virginia Pensabene. (2020) Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption. Bioengineering 7:3, pages 112.
Crossref
Susana L. H. Rebelo, Sónia M. G. Pires, Mário M. Q. Simões, Baltazar de Castro, M. Graça P. M. S. Neves & Craig J. Medforth. (2020) Biomimetic Oxidation of Benzofurans with Hydrogen Peroxide Catalyzed by Mn(III) Porphyrins. Catalysts 10:1, pages 62.
Crossref
Kelli Gerth, Sunitha Kodidela, Madeline Mahon, Sanjana Haque, Neha Verma & Santosh Kumar. (2019) Circulating Extracellular Vesicles Containing Xenobiotic Metabolizing CYP Enzymes and Their Potential Roles in Extrahepatic Cells Via Cell–Cell Interactions. International Journal of Molecular Sciences 20:24, pages 6178.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.