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Research Article

Assessment of Tailor-Made HPMC-Based Matrix Minitablets Comprising a Weakly Basic Drug Compound

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Pages 46-52 | Published online: 25 Sep 2008

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Aleksandar Aleksovski, Rok Dreu, Mirjana Gašperlin & Odon Planinšek. (2015) Mini-tablets: a contemporary system for oral drug delivery in targeted patient groups. Expert Opinion on Drug Delivery 12:1, pages 65-84.
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Chika Taniguchi, Yohei Kawabata, Koichi Wada, Shizuo Yamada & Satomi Onoue. (2014) Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility. Expert Opinion on Drug Delivery 11:4, pages 505-516.
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Elcin Aktas, Hakan Eroglu, Umit Kockan & Levent Oner. (2013) Systematic development of pH-independent controlled release tablets of carvedilol using central composite design and artificial neural networks. Drug Development and Industrial Pharmacy 39:8, pages 1207-1216.
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Pallavi Bassi & Gurpreet Kaur. (2010) pH modulation: a mechanism to obtain pH-independent drug release. Expert Opinion on Drug Delivery 7:7, pages 845-857.
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Phuong Ha-Lien Tran, Thao Truong-Dinh Tran, Kyoung-Ho Lee, Dong-Jin Kim & Beom-Jin Lee. (2010) Dissolution-modulating mechanism of pH modifiers in solid dispersion containing weakly acidic or basic drugs with poor water solubility. Expert Opinion on Drug Delivery 7:5, pages 647-661.
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Articles from other publishers (14)

Shaolong He & Huiling Mu. (2023) Microenvironmental pH Modification in Buccal/Sublingual Dosage Forms for Systemic Drug Delivery. Pharmaceutics 15:2, pages 637.
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Hao Han R. Chang, Kuan Chen, Jamie Anne Lugtu-Pe, Nour AL-Mousawi, Xuning Zhang, Daniel Bar-Shalom, Anil Kane & Xiao Yu Wu. (2023) Design and Optimization of a Nanoparticulate Pore Former as a Multifunctional Coating Excipient for pH Transition-Independent Controlled Release of Weakly Basic Drugs for Oral Drug Delivery. Pharmaceutics 15:2, pages 547.
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Bo Wang, Matthew J. Nethercott, Akshay Narula, Michael Hanrahan, Shanming Kuang, Robert M. Wenslow & Na Li. (2021) pH-Dependent supersaturation from amorphous solid dispersions of weakly basic drugs. Pharmaceutical Research 39:11, pages 2919-2936.
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Zherui Zhang, Shumin Chen, Man Wen, Haibing He, Yu Zhang, Tian Yin, Jingxin Gou & Xing Tang. (2022) Alleviating the Influence of Circadian Rhythms and Drug Properties to the Release of Paliperidone Gel Matrix Tablets with Compression Coating Technology and Microenvironment Shaping. AAPS PharmSciTech 23:7.
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Arkadiusz Hejduk, Michał Teżyk, Emilia Jakubowska, Klaudia Krüger & Janina Lulek. (2022) Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible Minitablets (ODMTs) Containing Melatonin. AAPS PharmSciTech 23:1.
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Marius Monschke & Karl G. Wagner. (2019) Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability – An in-vitro approach. International Journal of Pharmaceutics 564, pages 162-170.
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Martin Kuentz, René Holm & David P. Elder. (2016) Methodology of oral formulation selection in the pharmaceutical industry. European Journal of Pharmaceutical Sciences 87, pages 136-163.
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Jesper Østergaard, Henrik Jensen, Susan W. Larsen, Claus Larsen & Jim Lenke. (2014) Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging. Journal of Pharmaceutical and Biomedical Analysis 100, pages 290-293.
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Gaurav Tolia & S. Kevin Li. (2013) Silicone Adhesive Matrix of Verapamil Hydrochloride to Provide pH-Independent Sustained Release. AAPS PharmSciTech 15:1, pages 1-10.
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Peter Timmins & Samuel R. Pygall. 2014. Hydrophilic Matrix Tablets for Oral Controlled Release. Hydrophilic Matrix Tablets for Oral Controlled Release 257 280 .
Amitava Mitra & Filippos Kesisoglou. (2013) Impaired Drug Absorption Due to High Stomach pH: A Review of Strategies for Mitigation of Such Effect To Enable Pharmaceutical Product Development. Molecular Pharmaceutics 10:11, pages 3970-3979.
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Chika Taniguchi, Ryo Inoue, Masashi Kato, Kazuhiro Yamashita, Yohei Kawabata, Koichi Wada, Shizuo Yamada & Satomi Onoue. (2013) New Dipyridamole Salt with Improved Dissolution and Oral Bioavailability under Hypochlorhydric Conditions. Drug Metabolism and Pharmacokinetics 28:5, pages 383-390.
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Chika Taniguchi, Ryo Inoue, Yohei Kawabata, Kazuhiro Yamashita, Koichi Wada, Yukinori Yamauchi, Shizuo Yamada & Satomi Onoue. (2012) Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria. International Journal of Pharmaceutics 434:1-2, pages 148-154.
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Phuong Ha-Lien Tran, Jae-Seung Choe, Thao Truong-Dinh Tran, Young Min Park & Beom-Jin Lee. (2010) Design and Mechanism of On–Off Pulsed Drug Release Using Nonenteric Polymeric Systems via pH Modulation. AAPS PharmSciTech 12:1, pages 46-55.
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